The market for longevity supplements is booming, but not all formulas are created equal. While the right supplement may help support slower biological aging and long-term health, others may lack key compounds and proper dosages to achieve these goals.
In this comparison, we break down NOVOS and Elysium Health, whose product line includes Basis, Signal, and the Longevity Starter Pack. While both aim to improve cellular health and promote healthy aging, only NOVOS Core targets all 12 aging pathways. When bundled with NOVOS Boost for NAD+ support, it’s an all-in-one longevity solution.
If you’re exploring Elysium Health alternatives in your search for longevity supplements, here’s what you need to know.
Key Takeaways
- NOVOS Core targets all 12 hallmarks of aging with 12 synergistic, clinically studied ingredients. Pairing Core with Boost provides a comprehensive longevity solution.
- Elysium Health focuses on NAD+ support with NR and NMN, with less transparency and limited scientific validation. Even its Longevity Starter Pack does not target all aging pathways.
- NOVOS Core is patent-pending. The company publishes peer-reviewed research and shows real-world improvements in biological aging markers.
- Elysium has published peer-reviewed human studies on individual compounds like nicotinamide riboside (NR) that demonstrate NAD+ level increases. However, it has not yet published peer-reviewed results showing that its full product combinations, such as the Longevity Starter Pack, slow biological aging or improve healthspan.
- If you’re looking for the best longevity supplement backed by science and full-spectrum support, NOVOS is the clear leader.
Why Explore Elysium Health Alternatives?
Understanding how longevity supplements impacts aging requires more than scanning an ingredient list. Here’s how Elysium’s products compare to NOVOS Core when we look at actual scientific outcomes.
Elysium
Basis
Elysium Health earned early recognition for its NAD+ boosting supplement, Basis. This product combines nicotinamide riboside (NR) with pterostilbene in an effort to raise NAD+ and support sirtuin activity. And while NAD+ supports mitochondrial energy and cellular repair, real-world results from Elysium’s approach are lacking.
NR, the key ingredient in Basis, has a short elimination half-life, and long-term effectiveness remains unclear. While it can temporarily raise NAD+ levels, these biomarker shifts haven’t been linked to improvements in healthspan or longevity in clinical trials.
Signal
Elysium’s Signal product is a separate supplement containing NMN, which appears more bioavailable and stable than NR. However, to date, no peer-reviewed clinical studies have been published on Signal or its combined effects with other Elysium products.
Longevity Starter Pack
Both Basis and Signal are included in the Longevity Starter Pack, a bundle of four products: Basis (NR), Signal (NMN), Matter (brain health), and Format (immune support and senolytics). While marketed as a complete solution for healthy aging, the pack focuses primarily on NAD+ metabolism, with minimal transparency on ingredient interactions or rationale.
Of these, only Basis and Signal are intended to influence aging-related biology. They do not address the broader range of mechanisms known to drive aging, such as cellular senescence, DNA damage, or stem cell exhaustion.
Lack of Supporting Research
- Elysium has published peer-reviewed research on Basis, including a randomized, placebo-controlled human trial showing that it increases NAD+ levels. Additional clinical studies have been conducted on Basis and other compounds like NR-E, some of which report outcomes related to liver health, inflammation, and muscle recovery. However, many of these studies are either pending publication or are not yet peer-reviewed. As of now, Elysium has not released peer-reviewed results demonstrating that its full product bundles — such as the Longevity Starter Pack — slow biological aging or improve healthspan.
- Elysium’s bundle formulas remain largely proprietary at the full‑bundle level. While multiple trials are ongoing, published outcomes measuring aging‑specific factors (e.g., epigenetic clocks, lifespan) are not currently available.
- The Starter Pack is also more expensive than the NOVOS Core and Boost bundle. It requires taking multiple separate formulas daily and monthly, adding complexity to a user’s daily routine.Â
A More Transparent, Science-Driven Alternative
In contrast, NOVOS Core was designed from the ground up to target all 12 hallmarks of aging in one daily formula. Each ingredient is selected based on scientific evidence and included at transparent, research-backed doses — with no proprietary blends or hidden combinations.
NOVOS
Core
NOVOS Core’s 12 ingredients were selected to target the 12 hallmarks of aging synergistically. These include:
- Alpha-ketoglutarate (AKG): A metabolite shown to extend lifespan in animal studies. Supports mitochondrial function and protein synthesis
- Fisetin: A senolytic compound that helps eliminate senescent cells
- Glycine: Balances methylation, supports detoxification, and aids collagen production
- Magnesium malate and L-theanine: Aid energy metabolism and stress resilience
- Hyaluronic acid and rhodiola: Improve skin elasticity and support stress adaptation
- Pterostilbene: Acts as an antioxidant, protects cells, and enhances metabolism
These ingredients have demonstrated measurable results (more on this below):
- Reduction in Pace of Aging (via DunedinPACE)
- Improvements in skin firmness (pilot human study)
- Lifespan extension in aged mice (18% increase)
- Reduction in DNA damage and markers of cellular senescence
Boost
For additional support specifically around NAD+ levels, users can bundle NOVOS Core with NOVOS Boost. It features >99% pure NMN, a highly bioavailable NAD+ precursor that supports cellular energy, DNA repair, and metabolic resilience — key pillars of healthy aging.
- Each serving delivers 250 mg of ultra-pure NMN to promote NAD+ production and cellular repair.
- It’s shown to enhance mitochondrial function, energy metabolism, and cognitive performance in early research.
- The NMN in Boost is backed by longevity research.
Combine Boost with NOVOS Core to target all 12 hallmarks of aging, from senescence to inflammation. Together, Core and Boost offer a complete, multi-pathway longevity strategy without the complexity or guesswork.
Scientific Validation and Third-Party Recognition
NOVOS is one of the most scientifically rigorous brands in the longevity space. Its formulas are backed by multiple independent studies demonstrating both lifespan extension and improved biological aging markers in humans and animals.
Key scientific highlights include:
- Formulation research: Validation for the NOVOS Core formulation includes over 400 studies, a human preliminary study, and human in vitro and animal in vivo studies.
- Lifespan extension in aged mice: A study conducted at Newcastle University found that NOVOS Core extended lifespan by 18% in aged mice — a stronger result than any other consumer supplement tested under similar conditions. The study also showed reductions in frailty and cognitive decline, outperforming even prescription-grade senolytic drugs in both safety and efficacy.
- Reduction in biological aging (DunedinPACE): In a case study using the DunedinPACE epigenetic clock, participants taking NOVOS Core and Boost for six months showed a statistically significant 6.1% reduction in biological aging rate. 73% of participants improved beyond the test’s margin of error, with zero reporting an increased pace of aging.
- Protection against DNA damage: In vitro research at Ichor Life Sciences found that the full NOVOS formula reduced radiation-induced DNA damage by up to 77%, supporting its role in protecting cellular integrity at the genetic level.
- Skin health improvements: A pilot human study using an indentometer showed that six months of NOVOS Core supplementation improved skin firmness by an average of 22%, with user-reported enhancements in elasticity, texture, and appearance.
- Senescence-targeting effects: Additional lab studies showed that NOVOS ingredients have senostatic effects, helping to suppress harmful senescent cells without damaging healthy ones — a gentler alternative to senolytics that preserves beneficial cellular functions.
Recognition and Credibility
- Third-party coverage from Forbes, The Wall Street Journal, Business Insider, and Fortune recognizes NOVOS as a science-first company.
- NOVOS is the only consumer supplement brand accepted into the Longevity Biotechnology Association.
- NOVOS is one of two consumer brands selected in the top 100 teams for the $101M XPRIZE for Healthspan Extension.
NOVOS is also a Public Benefit Corporation and offers a free mobile app (NOVOS Age) to help users understand and track their biological age.
Longevity Supplements Comparison at a Glance
| Category | NOVOS Core (Core & Boost Bundle) | Elysium Health (Longevity Starter Pack) |
| Primary Focus | Targets all 12 aging pathways | Primarily NAD+ metabolism; limited support for aging pathways like senescence and inflammation |
| Key Ingredients | Core: Single, synergistic formula that includes Glycine, AKG, Fisetin, Magnesium Malate, Hyaluronic Acid, Rhodiola, L-Theanine, Pterostilbene & more. Boost: NMN, a precursor to NAD+. | Multiple formulas; NR + Pterostilbene (Basis), NMN + SIRT3 Activators (Signal), Tri-Vitamin Complex + Omega-3 (Matter), Fisetin + Quercetin + Senolytics (Format) |
| Ingredient Transparency | Fully disclosed dosages | Proprietary blends/Partial disclosure |
| Scientific Validation | Human case studies show improved Pace of Aging and cellular resilience; NOVOS Core found to extend aged mouse lifespan more than any supplement ever studied | No peer-reviewed human studies on complete formulas |
| Mechanisms Addressed | NAD+, senescence, inflammation, autophagy, DNA damage repair, mitochondrial health | Limited support of aging pathways |
| Price | ~$153/month per bundle or less with subscription | ~$199/month per bundle |
| Best Suited For | Individuals seeking comprehensive, research-backed longevity support | Consumers interested primarily in NAD+ boosting |
NOVOS: The Smarter Longevity Supplement
If your goal is to live longer and healthier, the decision becomes clear:
- Elysium: Primarily targets NAD+ metabolism through NR and NMN. Transparent about some ingredients but lacks full-formula validation. Lack of peer-reviewed data showing impact on healthspan or lifespan.
- NOVOS: Targets all 12 hallmarks of aging with Core. Transparent, evidence-based, and backed by both human and animal studies. Recognized by global longevity organizations and media.
NOVOS offers a research-backed longevity platform built to support healthy aging with science and transparency. Try NOVOS Core today.
Curious how NOVOS stacks up against other longevity supplements and wellness supplements? Check out our comparisons with Blueprint, AG1, and Tally Health.
FAQ on Longevity Supplements: NOVOS vs. Elysium Health
Is NOVOS Core better than Elysium Basis?
Yes. NOVOS Core targets 12 aging mechanisms, while Basis focuses mainly on NAD+ and lacks full-formula clinical validation.
Can I take both NOVOS and Elysium?
It’s unnecessary. NOVOS already supports NAD+ metabolism through ingredients like AKG, glycine, and rhodiola. You can also add NOVOS Boost for NMN.
What makes NOVOS different from other longevity supplements?
Its science-first approach: peer-reviewed studies, transparent dosages, and a team of world-class longevity researchers.
Does Elysium have human studies on aging?
Not on their complete formulas. Their research has shown NAD+ level increases, but not slowed aging, improved skin, or biological pace outcomes.
What’s the best longevity supplement overall?
NOVOS Core, for its comprehensive mechanism targeting, scientific rigor, transparent formulation, and proven impact on markers of biological aging.
