We target the 12 primary causes of aging using a patent-pending, science-backed formula

Most anti-aging companies lack understanding of what causes aging. At best, they may address signs of aging, without impacting underlying causes.

NOVOS is the only company to target the 12 causes of aging using multiple proven ingredients – an approach backed by top scientists and 950+ studies.

What ages your body? The latest scientific research uncovered 12 key causes:

02 Cellular Senescence

Senescent cells are former healthy cells that stopped dividing and secrete substances that damage healthy surrounding cells. Commonly referred to as “zombie cells,” these cells increase exponentially with age and lead to tissue and organ damage.

Substances that help the body the manage senescent cells: Fisetin – contained in NOVOS Core

Learn more about Cellular Senescence

06 Epigenetic Alterations

During aging, the epigenome — the molecular machinery that regulates our genes’ activity — becomes disorganized. This leads to certain beneficial genes being turned off when they should be on, and genes that can cause trouble being turned on when they should be off.

Substances that support a healthy epigenome: Lithium | Glycine | Alpha-ketoglutarate | Vitamin C | Ginger | Pterostilbene – all contained in NOVOS Core
NMN – contained in NOVOS Boost

Learn more about Epigenetic Alterations

09 Stem Cell Exhaustion

With age, stem cells become dysfunctional or die off. Since stem cells are responsible for producing new copies of our cells when they’re needed, having fewer or dysfunctional stem cells leads to our tissues being less replenished & maintained.

Substances that support stem cell health: Glycine | Alpha-ketoglutarate – all contained in NOVOS Core

Learn more about Stem Cell Exhaustion

10 Disabled Macroautophagy

Macroautophagy disablement occurs when a body’s cells are unable perform a cellular self-cleaning known as autophagy. This leads to the accumulation of damaged or dysfunctional cellular components and is associated with cancer, metabolic and neurological disorders.

Substances that help the body to manage disabled macroautophagy: Lithium | Glucosamine | Fisetin | Pterostilbene | Glycine – all contained in NOVOS Core
NMN – contained in NOVOS Boost

12 Microbiome Dysbiosis

Dysbiosis is a disruption in the normal microbial community that inhabits an environment, like our guts. It can lead to digestive disorders, immune system dysfunction, and increased risk of infection and chronic disease.

Substances that help the body to manage microbiome dysbiosis: Ginger | Pterostilbene | Fisetin | Rhodiola rosea | Lithium – all contained in NOVOS Core

References

  1. The hallmarks of aging. Cell, 2013
  2. Epigenetics of aging and disease: a brief overview. Aging Clinical and Experimental Research, 2021
  3. The ageing epigenome and its rejuvenation. Nature, 2020
  4. Epigenetics of Aging and Aging-Associated Diseases. Int. J. Mol. Sci. 2021
  5. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front. Cell Dev. Biol., 2021
  6. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 2014
  7. Therapeutic interventions for aging: the case of cellular senescence. Drug Discov., 2017
  8. Mitochondrial Dysfunction in Aging and Diseases of Aging, Biology, 2019
  9. The role of mitochondria in aging. The Journal of Clinical Investigation, 2018
  10. The Mitochondrial Basis of Aging. Molecular Cell, 2016
  11. Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science, 2015
  12. Hallmarks of Aging: An Autophagic Perspective. Front. Endocrinol., 09 January 2019
  13. Autophagy in healthy aging and disease. Nature Aging, 2021
  14. Autophagy in ageing and ageing-related neurodegenerative diseases. Ageing Neur Dis, 2021
  15. Autophagy in aging and longevity. Human Genetics, 2019
  16. Metabolic Control of Longevity. Cell, 2016
  17. Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease. Subcell Biochem, 2018
  18. mTOR is a key modulator of ageing and age-related disease. Nature, 2013
  19. Regulation of reproduction and longevity by nutrient-sensing pathways. J Cell Biol, 2018
  20. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Nature Communications Biology, 2020
  21. Stem Cell Aging in Lifespan and Disease: A State-of-the-Art Review. Curr Stem Cell Res Ther., 2020
  22. The Mechanism of Stem Cell Aging. Stem Cell Reviews and Reports, 2022
  23. Cellular and epigenetic drivers of stem cell ageing. Nature Reviews Molecular Cell Biology, 2018
  24. Impact of genomic damage and ageing on stem cell function. Nat Cell Biol., 2014
  25. Mice with hyper-long telomeres show less metabolic aging and longer lifespans. Nature Communications, 2019
  26. Telomeres: history, health, and hallmarks of aging. Cell, 2021
  27. Stochastic non-enzymatic modification of long-lived macromolecules – A missing hallmark of aging. Ageing Research Reviews, 2020
  28. Advanced Glycation End-Products in Skeletal Muscle Aging. Bioengineering, 2021
  29. The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases. Molecules, 2020
  30. Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging, 2014
  31. Nuclear genomic instability and aging. Annu. Rev. Biochem., 2018
These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

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