We target the 12 primary causes of aging using a patent-pending, science-backed formula
Most anti-aging companies lack understanding of what causes aging. At best, they may address signs of aging, without impacting underlying causes.
NOVOS is the only company to target the 12 causes of aging using multiple proven ingredients – an approach backed by top scientists and 435+ studies.
What ages your body? The latest scientific research uncovered 12 key causes:
01 Mitochondrial Dysfunction
During aging, mitochondria — the power plants of our cells — become dysfunctional. Without adequate power, cells — and by extension, organs — are not able to perform as well as when they were young.
02 Cellular Senescence
Senescent cells are former healthy cells that stopped dividing and secrete substances that damage healthy surrounding cells. Commonly referred to as “zombie cells,” these cells increase exponentially with age and lead to tissue and organ damage.
03 Loss of Proteostasis
Over time, more and more proteins accumulate inside and outside our cells. These proteins should be cleaned up, and when they aren’t, interfere with the cells’ proper functioning.
04 Altered Cellular Communication
When we get older, our cells become increasingly exposed to a hostile environment, characterized by pro-inflammatory and other deleterious substances that hinder cells, including stem cells, to function properly.
05 Genomic Instability
During aging, our DNA becomes damaged, especially in stem cells and fast-dividing cells. Damaged DNA may result in improper cell function which impacts proper functioning of tissues and organs.
06 Epigenetic Alterations
During aging, the epigenome — the molecular machinery that regulates our genes’ activity — becomes disorganized. This leads to certain beneficial genes being turned off when they should be on, and genes that can cause trouble being turned on when they should be off.
07 Telomere Shortening
As we age, the ends of chromosomes, known as telomeres, get shorter and cannot protect DNA any longer. This can increase the likelihood of genomic instability and impair cell function.
08 Deregulated Nutrient Sensing
During aging, our cells become less tuned to nutrient signals, which disrupts a cell’s ability to utilize and produce energy. This can result in reduced energy and metabolic dysfunction.
09 Stem Cell Exhaustion
With age, stem cells become dysfunctional or die off. Since stem cells are responsible for producing new copies of our cells when they’re needed, having fewer or dysfunctional stem cells leads to our tissues being less replenished & maintained.
10 Disabled Macroautophagy
Macroautophagy disablement occurs when a body’s cells are unable perform a cellular self-cleaning known as autophagy. This leads to the accumulation of damaged or dysfunctional cellular components and is associated with cancer, metabolic and neurological disorders.
Inflammaging is a chronic, low-grade inflammatory state that occurs as part of aging, and can be influenced by lifestyle factors. It can contribute to age-related diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders.
12 Microbiome Dysbiosis
Dysbiosis is a disruption in the normal microbial community that inhabits an environment, like our guts. It can lead to digestive disorders, immune system dysfunction, and increased risk of infection and chronic disease.
1. The hallmarks of aging. Cell, 2013
2. Epigenetics of aging and disease: a brief overview. Aging Clinical and Experimental Research, 2021
3. The ageing epigenome and its rejuvenation. Nature, 2020
4. Epigenetics of Aging and Aging-Associated Diseases. Int. J. Mol. Sci. 2021
5. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front. Cell Dev. Biol., 2021
6. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 2014
7. Therapeutic interventions for aging: the case of cellular senescence. Drug Discov., 2017
8. Mitochondrial Dysfunction in Aging and Diseases of Aging, Biology, 2019
9. The role of mitochondria in aging. The Journal of Clinical Investigation, 2018
10. The Mitochondrial Basis of Aging. Molecular Cell, 2016
11. Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science, 2015
12. Hallmarks of Aging: An Autophagic Perspective. Front. Endocrinol., 09 January 2019
13. Autophagy in healthy aging and disease. Nature Aging, 2021
14. Autophagy in ageing and ageing-related neurodegenerative diseases. Ageing Neur Dis, 2021
15. Autophagy in aging and longevity. Human Genetics, 2019
16. Metabolic Control of Longevity. Cell, 2016
17. Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease. Subcell Biochem, 2018
18. mTOR is a key modulator of ageing and age-related disease. Nature, 2013
19. Regulation of reproduction and longevity by nutrient-sensing pathways. J Cell Biol, 2018
20. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Nature Communications Biology, 2020
21. Stem Cell Aging in Lifespan and Disease: A State-of-the-Art Review. Curr Stem Cell Res Ther., 2020
22. The Mechanism of Stem Cell Aging. Stem Cell Reviews and Reports, 2022
23. Cellular and epigenetic drivers of stem cell ageing. Nature Reviews Molecular Cell Biology, 2018
24. Impact of genomic damage and ageing on stem cell function. Nat Cell Biol., 2014
25. Mice with hyper-long telomeres show less metabolic aging and longer lifespans. Nature Communications, 2019
26. Telomeres: history, health, and hallmarks of aging. Cell, 2021
27. Stochastic non-enzymatic modification of long-lived macromolecules – A missing hallmark of aging. Ageing Research Reviews, 2020
28. Advanced Glycation End-Products in Skeletal Muscle Aging. Bioengineering, 2021
29. The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases. Molecules, 2020
30. Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging, 2014
31. Nuclear genomic instability and aging. Annu. Rev. Biochem., 2018
We've got you covered
Go beyond the longevity solutions and get an insider view of the latest breakthrough science. NOVOS is a Public Benefit Corporation that provides science-based tips, actionable guidance, and expert-backed tools to the public for free.
Join our NOVOS community today to be Younger For Longer!