Available at Mayo Clinic Store & select health retailers • Recommended by 1,500+ clinicians • 7+ years R&D

Built On Human Evidence, Not Marketing
A system built around how aging actually works and studied as a complete formulation in double-blind, randomized, placebo-controlled human research.
Cardiovascular function was selected as the first system to study because vascular aging is among the earliest measurable indicators of whole-body aging. And NOVOS Core Clinical doesn’t stop there.
“NOVOS takes a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”
— Dr. Doina Kulick, Lead Physician, Longevity Medicine, Mayo Clinic Arizona
Science You Can Trust

Placebo-controlled
Human Research

Formulated by Harvard
& MIT Scientists

Patent-pending
Formulation

Preclinical
Lifespan Research
Human Clinical Trial Results
In a randomized, double-blind, placebo-controlled human clinical trial, NOVOS Core Clinical demonstrated statistically significant improvements versus placebo across validated cardiovascular biomarkers used in aging research.*
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Validated Across Three Levels of Research
**Results from in vitro and animal studies are preclinical and do not necessarily translate to outcomes in humans. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
81% of customers
notice meaningful improvements in skin, mood, energy, or sleep within two weeks of taking NOVOS Core Clinical*.
Other benefits like vascular function may not be perceptible but reached statistically significant improvements in placebo-controlled human research*.
*Results based on post-purchase customer surveys and clinical results reflect outcomes observed in a randomized, placebo-controlled study population. Individual experiences may vary.

Trusted By a Global Community
Rated 4.8 out of 5 stars
Based on more than 1330 reviews
10+ Million Servings Taken
Loyal customers have taken NOVOS for 5+ years
Slower Pace of Aging**
Based on epigenetic biological age test results
** Based on observed changes in DNA methylation biomarkers measured using the DunedinPACE epigenetic algorithm, which estimates biological rate of aging, in an observational analysis of customer biomarker data. Epigenetic biomarkers are investigational tools and do not diagnose disease or predict lifespan. Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Real People. Measurable Change.
How real customers feel and function after consistent daily use.
Inventing the Future of Longevity
NOVOS Core Clinical is Built on Human Evidence
Majority of Competitors

How NOVOS works
A Smarter Way To Age Well
NOVOS is a science-driven longevity system designed to support the biological processes that shape how you age.
Built Alongside World-Class Scientists in Aging Biology
Scientific advisors and collaborators from Harvard, MIT, the Salk Institute, and leading medical institutions help guide our research, formulation, and innovation.
Dr. George Church, PhD
Dr. Pamela Maher, PhD
Scientific advisors provide research guidance. Individual views expressed are their own.
Perspectives From Leading Longevity Scientists
Independent experts share their perspective on NOVOS’ research-driven approach to longevity.
Professor of Genetics, Harvard Medical School & MIT
NOVOS Scientific Advisory Board
Frmr. Professor of Pathology & Biology of Aging, University of Washington
Advised on NOVOS Core Clinical formulation
Longevity Tools Backed by Science
Explore NOVOS’ evidence-based tools, protocols, and research to help you measure, understand, and improve your biological aging.
Everything You Need for Longevity
Select the product based on your biggest priorities.
Start With What’s Clinically Studied
NOVOS Core Clinical is our most researched formulation, the foundation of the NOVOS longevity system, and one of the most powerful clinically studied supplements to date.
Not Sure Where To Start?
Answer a few quick questions and we’ll recommend the right NOVOS system for your goals, biology, and lifestyle.
*These statements have not been evaluated by the Food and Drug Administration. The NOVOS ecosystem is not intended to diagnose, treat, cure, or prevent any disease.
Questions, answered.
Longevity supplements are formulations designed to support healthy aging by targeting biological processes that influence how your body ages. NOVOS supplements use ingredients shown in scientific research to support cellular energy, metabolic health, mitochondrial function, genomic stability, and long-term organ health. They work by providing nutrients your body uses to maintain healthier, more resilient cells as you age.
NOVOS formulations are created specifically to support healthy aging using research-backed ingredients that work together rather than in isolation. Unlike general multivitamins, NOVOS focuses on the biological processes associated with aging, combining supplements, testing, and education to help you make measurable progress over time.
NOVOS products are formulated using well-studied ingredients and responsible dosing. While many people take NOVOS alongside their daily routine, you should always consult your healthcare provider if you are pregnant, breastfeeding, taking medication, or have a medical condition. NOVOS products are not intended to diagnose, treat, cure, or prevent disease.
All NOVOS ingredients are permitted for use in dietary supplements under FDA regulations and meet the safety standards required for over-the-counter use.
For most people, NOVOS Core is the best place to start. It’s the foundational daily mix that targets all 12 causes of aging in one drink, and is designed for early-adult, middle-aged and older adults who want a simple, science-backed anti-aging supplement. Once you’re consistent with Core, you can layer in NOVOS Boost for extra NAD+ support, NOVOS Vital for organ-focused longevity gummies, and NOVOS Bar as a complete longevity nutrition bar that fits into your routine.
Early benefits, such as improved energy, focus, or recovery, often appear within weeks. Customer data shows 81% report improvements in skin, mood, energy, or sleep within two weeks of starting NOVOS Core.
Biological aging changes develop more gradually, with the most significant results emerging after consistent daily use over several months.
NOVOS Age is an advanced biological aging test that uses leading epigenetic algorithms like the DunedinPACE (Columbia & Duke) and Organ Age (Yale) to measure your biological age, the age of key organ systems, and the pace at which you’re aging. This gives you a baseline and helps you track improvements over time as you implement longevity-focused habits and supplements.
Yes. While you can’t change the number of birthdays that have passed (chronological age), it is possible to slow down or accelerate your biological age based upon lifestyle changes.
NOVOS is often taken alongside multivitamins or specific health supplements, but it’s important to review overlapping ingredients and total dosages. If you use prescription medications or have concerns about combining products, you should speak with a qualified healthcare professional.
For the best experience, take NOVOS products as directed. Taking your supplements consistently and pairing them with supportive habits like sleep, nutrition, and movement will help maximise long-term benefits.
NOVOS is designed for adults who want to proactively support healthy aging and take a science-led approach to longevity. Whether you’re already focused on wellbeing or just beginning to explore anti-aging supplements, NOVOS provides a structured system to help you progress in a measurable way.
Yes. We ship NOVOS Core, NOVOS Boost, NOVOS Vital and NOVOS Bars to many countries. Currently, NOVOS Age is only available in the United States. International shipping usually takes 7–10 business days, depending on location, customs and time of year. Read more about our shipping policy.
Unopened U.S. orders can be returned within 30 days and include a prepaid return label (shipping and restocking fees apply unless you choose store credit). International orders are final sale. Damaged or defective items must be reported within 2 days of delivery for replacement. Read more about our return policy.













