Track your biological aging and the impact of lifestyle changes
The best biological aging test
- PRIMARY: Rate of aging via the DunedinPACE epigenetic clock, developed by Columbia University and Duke University scientists. This is the primary emphasis of NOVOS Age
- SECONDARY: Biological age according to an epigenetic clock collaborated on by top longevity scientists
- TERTIARY: Telomere length, which protects your DNA and shortens with age
At NOVOS, we pride ourselves on offering you the best biological aging tests available, based on the latest science and validated by independent scientists. We empower you to take your health and aging process into your own hands.
We offer this service of epigenetic analysis for biological age metrics, as well as telomere length, so that we can help you live a longer, better-quality life.
Use NOVOS Age to understand how your longevity lifestyle is impacting your rate of aging, and in the longer-term, to see how your biological age and telomeres are impacted.
$349 for one and $299 for each additional kit. Currently ships within the US only.
Recommendation: We encourage you to retest your epigenetic Rate of Aging every 12 months, ideally on the same day, week or month (to minimize confounding factors). With your first at-home blood test, you’ll be able to see how your current lifestyle is impacting your rate of aging, as well as your lifelong accumulated biological age and telomere length. With subsequent tests you will see how your newly adopted longevity lifestyle or tweaks to it can favorably impact your aging process.
Epigenetic Age Report: 3 Test Results
DunedinPACE Rate of Aging Clock
Test Result #1 – PRIMARY EMPHASISThe DunedinPACE Value is a measurement of your rate of aging. DunedinPACE is the most relevant epigenetic clock for gaining a better understanding of your biological aging process. This result is the primary emphasis of NOVOS Age.
Biological Age Clock
Test Result #2 – SECONDARY METRICYour biological age is how old your cells, organs, and body are biologically. This clock looks at all the damage and changes that cells have accumulated in their DNA’s epigenome, which you should compare versus your chronological age over the long term (i.e., look for changes over years, not months).
Test Result #3 – TERTIARY METRICYour telomeres are the endcaps of your chromosomes that protect your DNA. With each cell division, and with age, your telomeres shorten. Telomeres that become too short can be an indicator of a higher likelihood for certain diseases of aging. It is possible to slow down your telomeres’ shortening and even lengthen them via supplementation, diet, and lifestyle.
The DunedinPACE Rate of Aging Clock that we offer in NOVOS Age is the most advanced epigenetic clock on the market, and is the most accurate way currently available to detect changes to your biological aging. In fact, the innovative algorithms use machine learning to improve. That means, each time you test, the clocks become increasingly accurate.
By tracking your rate of aging, you’ll be able to see how your lifestyle is impacting your biological age in significantly less time than by looking at your biological age: it is more sensitive to change, and changes more quickly.
During your Longevity Journey, NOVOS will provide you with valuable information and insights on how to slow your aging process. This epigenetic aging report is a great and important start.
NOVOS Age gives you the 2 clocks that matter, plus telomere length.
|Rate of Aging Clock –The DunedinPACE (included)||Biological Age Clock (included)||Other Clocks|
|Type||Measures rate of aging – how fast the clock is ticking – the most sensitive & quickest to react to lifestyle changes||Measures biological age: how much time has passed on the clock||Almost always biological age clocks, not rate of aging clocks|
|Precision||Widely agreed to currently be the best overall epigenetic clock by qualified geneticists||Precise epigenetic clock||Many clocks are not sufficiently precise|
|Scientists||Developed by scientists from Columbia University and Duke University||Developed in collaboration with top longevity scientists||Often not developed by top experts in the field|
|Mortality||Measures mortality (risk of dying) and morbidity (risk of disease and frailty)||Mainly measures mortality, less focus on measuring morbidity||Mainly measures mortality, less focus on measuring morbidity|
|Training data||Trained on more than 1,000 people with 20+ years of follow-up||Trained on the most human samples (16,000) of any chronologically trained clock||Often small sample size or less-representative groups|
|Epigenetic marks||Trained on 850,000 epigenetic marks||Trained on 850,000 epigenetic marks||Often trained on much fewer epigenetic marks (27,000 epigenetic marks)|
|Correlation||High correlation with various biomarkers of aging (e.g., brain shrinkage, dental health, grip strength, etc.)||High correlation with chronological age (which is correlated with mortality)||Often not as highly correlated with chronological age and mortality risk|
|Peer-reviewed||Clock has been published in peer-reviewed scientific journals and validated by other independent scientists||Based on a clock published in a peer-reviewed scientific journal||Often not published in peer-reviewed scientific journals and often not validated by other scientists|
|Improvements||Deploys various statistical methods to improve precision, including elastic net regression||Intra-class correlation (ICC) value above 0.9, which is considered excellent||Often don’t use advanced statistical methods|
Prolong your lifespan with our expertise
Our world-renowned team of longevity scientists and doctors developed innovative supplements to slow your aging and unlock your vitality. With ongoing, cutting-edge research, we continue to offer you new possibilities.
“I’m impressed by… how they approach aging as a complex phenomenon — aiming at all pathways and hallmarks of aging simultaneously.”
Dr. George Church, PhD — Harvard Medical School & MIT Professor
“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”
Dr. Pamela Maher — University of British Columbia
“The NOVOS formulation is informed by science and is the current state-of-the-art in longevity supplements.”
Dr. J. Pedro Magalhães — Harvard Medical School
“NOVOS Core… has been reviewed by scientists within the aging research community to ensure the most effective and safest ingredients.”
Dr. Oliver Medvedik — Harvard Medical School
– Dr. Avi Rosenbaum, PhD — Harvard Medical School
Scientist and Consultant, with deep knowledge of the biotech industry. Experience and international network in Genomics, Personalized Medicine, Gene Therapy and Synthetic Biology. Built the first academic Next Generation Sequencing platform.
Two general categories of biological age tests exist:
– Tests that measure your rate of aging
– Tests that measure your biological age
Tests that measure your rate of aging determine how fast you are aging.
Tests that measure your biological age determine how old you are biologically.
You can compare the rate of aging to how fast a clock is ticking (how fast you are aging), and you can compare biological age to the time a clock displays (how old you really are).
Changing the speed that the clock is ticking can be noticed in significantly less time than seeing change in a clock that has been ticking for decades. This is one of the multiple reasons we emphasize the Rate of Aging clock as the primary focus of Age (80% of the emphasis should be on this clock).
Biological age tests can be based off of the epigenome, proteome, microbiome, and more. Certain epigenetic tests are among the most accurate of all biological age tests, which is why NOVOS decided to offer these tests over alternatives.
To that point, there are already many epigenetic clocks in existence, and some are better than others.
Most epigenetic clocks measure biological age, to varying degrees of accuracy; very few of them measure the rate of aging.
The DunedinPACE rate of aging clock is currently considered by many in the field to be the most relevant and accurate test available with regards to mortality and disease risk.
It’s also the most actionable, since its outputs are based on your current lifestyle.
These are some of the reasons that we chose to offer the DunedinPACE clock to our customers.
Your rate of aging is a measurement of how fast you age. It calculates how much you age biologically for each chronological year.
The lower the value, the better.
An average rate of aging would be a rate of one biological year for every chronological year you aged. If your rate of aging is lower than 1, you age slower than average.
For example, if your rate of aging is 0.9, you only aged 0.9 years biologically for each chronological year that passed, or 10% slower than average.
If your rate of aging is higher than 1, you age faster than an average person would be expected to age.
For example, if your rate of aging is 1.2, you age biologically 1.2 years for each chronological year that passes, which is 20% faster than normal.
You want your rate of aging to be below 1; this means you’re aging more slowly than normal.
The epigenetic rate of aging clock NOVOS uses has been developed by scientists from Duke University and Columbia University. The clock is called DunedinPACE. Multiple studies have been published about the DunedinPACE clock, including comparisons against other well-regarded epigenetic tests, in which DunedinPACE proved to be even more accurate.
Many experts in the field believe that DunedinPACE is currently the best clock available to measure your rate of aging.
Besides the Rate of Aging clock, NOVOS Age also includes a biological age clock.
The biological age clock determines how old you are biologically.
If you are biologically older than your chronological age, this implies you have aged faster over the course of your lifetime.
As a result, you could be at a higher risk of dying compared to someone with a lower biological age, or you could be at a higher risk of getting aging-related diseases and symptoms.
We emphasize risk, because we’re dealing with statistical probabilities. This risk can also be offset by making improvements to your lifestyle, via diet, activity, supplementation, sleep, stress management, etc., which we cover in our blog.
If your biological age is lower than your chronological age, this implies you have aged more slowly over the years.
You could therefore have a lower risk of dying than someone with a higher biological age, or have a lower risk of aging-related diseases and symptoms.
It’s important to note that changes to your biological age will be more gradual than changes to your pace of aging, because the pace of aging measures your current speed, whereas your biological age measures a historical lifetime of aging.
Some may see changes in their biological age – either positive or negative – in very short timeframes (i.e., if they test every few weeks or months). These changes are most likely predominantly based on the error margins of the test and should not be interpreted literally.
Biological age tests are best looked at over the course of a year or more. You should accumulate a few results to see the overall trend relative to your chronological age.
In the meantime, focusing on your pace of aging will give you the appropriate guidance to know that what you’re doing is working.
The DunedinPACE clock is one of the most accurate epigenetic clocks. Nonetheless, it can be difficult to measure the impact of any single intervention, given the innumerable lifestyle factors that may counteract the positive effects on the clock.
For example, taking a supplement or exercising may have a positive impact on the clock that may be counteracted by other lifestyle variables (e.g., stress, sleep, diet, overindulging as a reward for exercising, other supplements, your microbiome, infections or activation of the immune system). In such a case, the net result is neutral or negative, meanwhile the wrong conclusion may be drawn – that the supplement or exercise did not confer any benefits.
This is even more the case for the biological age clock, which measures many forms of accumulated damage and lifestyle interventions you underwent throughout your life (including factors you were exposed to decades ago).
Using this clock to measure whether one intervention (e.g., exercising more) changes the clock will be difficult in the short-term, given the clock is, in most cases, currently not accurate enough on an individual level (some studies, using dozens or hundreds of participants, can find effects of one or multiple interventions).
Therefore, use the biological age clock to get an overview of all lifestyle interventions and habits accumulated over a lifetime.
Use the rate of aging clock to get a general overview of your health and how fast you are aging right now, being mindful of the innumerable lifestyle and (epi)genetic factors that are playing a role.
We help you keep track of confounding factors by providing you with a short survey for you to complete with each NOVOS Age test. This will enable you to compare your lifestyle changes between tests in a more precise way than relying on your memory, and may help you make sense of your results.
Ideally, you get tested every year, at the same time, to minimize seasonal confounding factors and to have an insight on how you’re faring on your Longevity Journey.
We encourage you to retest your epigenetic age regularly (e.g., every 12 months), and not to expect changes too soon. However, what if you were biologically younger during one test and now older after retesting? Or vice versa?
This result can be due to the change being within the margin of error of the test. So, if it’s plus or minus one to two years, consider this to be a possible explanation. Additionally, there may be lifestyle factors that impacted your results that you may not be fully aware of.
It’s possible that in the time between two tests, you were exposed to factors that accelerated or decreased your aging rate or biological age. For example, psychological or physical stress, alcohol consumption, dietary patterns (what, when and how much you eat), activity types and levels, time spent in green spaces and sun exposure, air pollution and smoking or vaping, supplements or prescriptions, etc.
Ideally, you continue to test yourself over the long term to see the trend and to discover what lifestyle approaches work best for you on your Longevity Journey.
Epigenetic clocks are becoming increasingly accurate, trained on larger and more specific data sets.
NOVOS will update its clocks as they evolve and adequate research supports their value, so that we can offer you the best science-based, validated clocks available to assess your health and biological age.
Telomeres are the endcaps on your chromosomes that serve to protect your DNA. With each cell division, and with age, your telomeres shorten.
Once thought of as holding promise to possibly determine one’s biological age, scientists have since found that the range of telomere length is too wide given one’s age. Further, telomere length doesn’t predict disease risk or mortality – that is, until they become too short.
Telomeres can also be protected so that they shorten more slowly; they can also be lengthened. For example, certain ingredients in NOVOS Core, like pterostilbene, magnesium and lithium, have been found to have these favorable effects.
With this in mind, you should look at your telomere length as a biomarker that is relevant to understanding your overall aging process, but you should not look at it for your biological age. Specifically, if your telomere length is very short for your age, consider ways to slow down or reverse its shortening.
Currently, epigenetic clocks are arguably the best tools to paint a holistic picture of your health, aging, and longevity.
Regularly testing your epigenetic rate of aging and biological age (e.g., every 12 months) can help you to assess your health and longevity potential. It can also give you insights into which lifestyle changes are moving you in the right direction.
The lower your epigenetic rate of aging and biological age, the healthier you are, and the lower your mortality risk.
Go to novoslabs.com/registerage to register your kit. Use your kit’s bar code and complete your 5 minute health assessment.
Tips: Write down your barcode number for future reference.
Don’t forget, we are unable to process your sample until it is registered and your online health assessment is completed.
You’ll receive an email when the lab receives your sample. Your results will be ready 2-4 weeks after that date.
Once your results are ready, you will be able to access them by signing into your secure online account.
- Blood spot card
- Alcohol wipe
- Gauze pad
- Biohazard bag
- Prepaid return envelope
- Instruction manual
For NOVOS Age, due to the nature of the product, all sales are final. Currently, we only ship in the United States. Please be sure that your shipping address is accurate before submitting your order.
No, we do not ship NOVOS Age outside of the United States at the moment. You can purchase NOVOS Core and NOVOS Boost in many non-US countries.
Yes. While you can’t change the number of birthdays that have passed (chronological age), science has proven it is possible to slow down or accelerate your biological age based upon lifestyle changes.