The complete NOVOS protocol · One year

NOVOS Longevity Kit

4.8214 ratings

Your longevity protocol for a year, and the test that tells you where you’re starting from.

The NOVOS Longevity Kit is a year of the full NOVOS protocol, delivered in one shipment. Start with the NOVOS Age test to establish where you are. Then take one serving of the clinically studied NOVOS Core and NOVOS Boost formulas each morning for the next twelve months. The NOVOS Life mobile app gives you the personalized guidance you need for success.

  • Twelve boxes of NOVOS Core, one for each month
  • Fourteen bottles of NOVOS Boost, two of them included as a free bonus gift
  • One NOVOS Age test: Biological Age, Pace of Aging, Organ Ages, and Telomere Length from a single blood sample
  • NOVOS Life for free
  • One delivery. No monthly boxes to manage.

Pause, skip, or cancel your subscription anytime from your account.

Free shipping – Subscribe to save – Flexible plans

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Everything arrives at once.

Both NOVOS Core and NOVOS Boost are shelf-stable. No refrigeration needed. Store in a cool, dry place, away from light.

NOVOS Core boxes

30 single-serve sachets each. One box per month.

NOVOS Boost bottles

60 capsules each. Twelve for the year, plus two included at no extra cost, for the days you need that extra Boost.

NOVOS Age test

Biological Age, Pace of Aging, Organ Ages, and Telomere Length from one blood sample.

NOVOS Life

Your AI Longevity Coach.

For overachievers: NOVOS Vital and NOVOS Bar are not included in the Longevity Kit. You can add them separately if you want organ optimization and longevity nutrition alongside the foundational protocol.

A year, from the number you start at.

Individual results may vary. Manuscript under peer review.

Month 0 · Measure

Take the NOVOS Age test in your first week

A finger-prick blood sample, posted back in the prepaid envelope. Results arrive in two to four weeks and give you four measurements: Biological Age, Pace of Aging, Organ Ages across 11 systems, and Telomere Length. Start the daily protocol right away. Your sample is already taken, so your results reflect where you began.

Baseline Learn more
+3.9%
Day 1 · From the first dose

The formula is already at work

In our placebo-controlled clinical trial, NOVOS Core showed an improvement in flow-mediated dilation (FMD), a measure of blood vessel function, after the first dose.*

Cardiovascular markers Learn more
81%
Months 1 to 3 · Start strong

One sachet, two capsules, every morning

Many customers notice subtle changes in clarity and energy in the first few days. Steadier energy and a calmer, more rested feeling are the changes most often reported in the first few weeks. 81% of customers report noticing a difference across six areas of daily wellbeing.

Energy · Sleep · Clarity Learn more
Months 3 to 6 · Build

Skin, focus, and overall well-being

These are the changes customers mention building over the first months.

Skin · Focus Learn more
+2.9% FMD
Month 6 · Longevity-relevant outcomes

Six months is the third time point measured in the clinical trial

In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, conducted at the University of Surrey, NOVOS Core showed sustained benefits to cardiovascular aging markers predictive of healthspan and lifespan at six months. Six months is also where the DunedinPACE case study measured.

Cardiovascular · Pace of aging Learn more
Months 7 to 12 · Accrue the benefits

Longevity is built over years, not weeks

Diet, exercise, and sleep create the foundation. Supporting healthy aging means building on that foundation consistently, day after day. There is no finish line at six months. The benefits of a longevity-focused lifestyle accrue over time, making what you do today an investment in your future self.

Consistency Learn more

Built for the years ahead.

The trial ran six months. The Kit runs twelve.

NOVOS Longevity Kit

Why a full year matters.

Measurable results have been demonstrated in as early as six months. The Longevity Kit is designed to help you keep going.

NOVOS Core’s finished formula was studied in a randomized, double-blind, placebo-controlled human trial in healthy adults aged 40 and older, conducted at the University of Surrey by Prof. Christian Heiss. Participants took one serving of NOVOS Core daily for six months. Benefits to cardiovascular aging markers were observed shortly after the first dose and not only sustained at six months, but extended to additional aging-relevant markers.

In a separate case study, 12 participants aged 39 to 76 took NOVOS Core and NOVOS Boost daily for six months. 73% showed a measurable reduction in biological aging pace on the DunedinPACE algorithm. No participant’s pace increased.

Randomized, double-blind, placebo-controlled human clinical research in healthy adults 40+. Manuscript under peer review.

Read the clinical trial

The evidence, end to end.

From placebo-controlled human research to lifespan, pace-of-aging, skin, and Core + Boost combination studies — the Kit sits on the full NOVOS evidence stack.

Read the clinical trial
05

Core + Boost together · In vitro

68% less DNA oxidative damage.

In a laboratory study conducted by Ichor Life Sciences, the combination of the ingredients in NOVOS Core and the NMN in NOVOS Boost showed an average 68% reduction in DNA oxidative damage from irradiation in human endothelial cells.

In vitro laboratory study; results may not translate to human outcomes. Individual results may vary.

What you’ll be able to measure.

Four measurements. One blood sample.

Biological Age

How old your body reads, against the calendar.

Learn more about Biological Age

Pace of Aging

How fast you are currently aging, measured on the DunedinPACE algorithm developed by Columbia University and Duke University researchers.

Learn more about Pace of Aging

Organ Ages

11 systems, measured individually.

Learn more about Organ Ages

Telomere Length

One of the twelve Hallmarks of Aging, measured directly.

Learn more about Telomere Length

A finger-prick blood sample, posted back in the prepaid envelope. Results in three to five weeks, delivered in the NOVOS Life app.

DunedinPACE is a research-use algorithm correlated with biological pace of aging, not a direct or definitive measure of aging. NOVOS Age is not a diagnostic test and does not replace medical care.

Measure, follow the protocol, measure again.

Three ways to run a longevity year — and what each typically includes.

Feature Complete protocolNOVOS Longevity Kit DIYAssembling it yourself Clinic pathLongevity clinic
The Kit includes one NOVOS Age test measuring Biological Age, Pace of Aging, Organ Ages, and Telomere Length from a single blood sample. NOVOS Age is not a diagnostic test and does not replace medical care. IncludedBought separatelyTypically included
NOVOS Core’s finished formula was studied in a randomized, double-blind, placebo-controlled human trial in healthy adults aged 40+ at the University of Surrey. NOVOS Boost is made with one ingredient, NMN, evaluated in multiple human clinical studies. Most supplements, if studied at all, rely on research into single ingredients rather than the finished product. Manuscript under peer review. YesRare and depends what you buyTypically not clinically studied
The Kit arrives as a single shipment. One delivery covers a yearTwelve or more reorders per yearOngoing appointments and purchases across the year
$1,684 on annual subscription, which is $140.33 per month or $4.61 per day. HSA and FSA eligible. $1,684VariesTypically several thousand and up

Real scientists. Real doctors.

NOVOS is built with guidance from scientists and physicians from Harvard Medical School and MIT, whose expertise spans aging biology, genomics, neurobiology, nutrition, and clinical medicine.

Scientific advisors: Dr. Pamela Maher (Salk Institute), Dr. J. Pedro Magalhães (Harvard Medical School), Dr. George Church (Harvard Medical School and MIT), Dr. Robert Lufkin (USC School of Medicine), Dr. Diogo Barardo (University of Singapore), Dr. Oliver Medvedik (Cooper Union), and Dr. Avi Rosenbaum (scientist and biotech consultant).

8 yrsof research
7scientists & MDs formulated
7whole formulation studies
950+ingredient studies
2,000+verified clinicians recommend
3rdparty-tested for purity & potency
“NOVOS takes a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”
Dr. Doina Kulick, M.D.Lead Physician, Longevity Medicine · Mayo Clinic Arizona

Available at

NOVOS available at Mayo Clinic Store, Bumrungrad International Hospital, Erewhon, Equinox, Remedy Place, Four Seasons, and Sunlife Organics.

Verified customer reviews.

4.8

Based on 214 ratings

· Lisa H.

One month in

I’m coming up on my first month of core + boost—and it’s really already changing my energy levels. I just feel BETTER. I can’t wait to see the benefits at the 3,6, and 12 month mark!!

· Manuel M.

Antidotally, it helps

Antidotally, I think it helps my ability to think and organize.

· Sean H.

It's great!

I’ve been using NOVOS for almost 3 years now and I think it’s great. I only wish they could add Urolithin A to it so I don’t have to buy another expensive supplement as well.

· Community Member

Already love it

I’m only a couple weeks in, but already I love how the drink and the boost makes me feel. Alert and more energy!!I’m really excited to see what this does for me long term!!

· Martha R.

Younger

I feel younger every day with Novos Boost. I also take the Novos Core. Good products!

· Community Member

Fast shipping

Fast shipping of product. Thanks!

Individual experiences may vary and are distinct from results observed in controlled clinical research.

FAQs.

Questions, answered.

Is NOVOS Age available where I live?
NOVOS Age is currently available in the United States and Canada only. If you are outside these countries, you can still take NOVOS Core and NOVOS Boost daily, and NOVOS Life will track your progress using your lifestyle data. Contact our support team about the Kit if you are ordering from elsewhere.
How does the Kit arrive?
In one delivery. Twelve boxes of NOVOS Core, fourteen bottles of NOVOS Boost, and your NOVOS Age test all arrive together. Both supplements are shelf-stable and need no refrigeration.
When should I take the NOVOS Age test?
In your first week, before the protocol has had time to work. Results take two to four weeks to arrive. Start taking NOVOS Core and NOVOS Boost right away, since your sample is already taken.
Can I measure again at the end?
Your Kit includes one NOVOS Age test to establish your baseline. You can add a second test to measure again at six or twelve months, on the same algorithm.
Is NOVOS Vital included?
No. NOVOS Vital is sold separately and can be added to your routine at any time.
Is the Longevity Kit HSA/FSA eligible?
Yes. The Longevity Kit may qualify for HSA/FSA reimbursement through our partner Truemed. Look for the Truemed option at checkout.
When will I feel results?
Many customers notice subtle changes in clarity and energy in the first few days. Broader changes (energy, sleep, skin) typically build over weeks to months. Biological-age changes develop over a longer horizon and depend on baseline health and consistent use. Individual results may vary.
Is it safe with my other supplements or medications?
Both products are formulated for tolerability and long-term daily use. If you take prescription medications, manage a medical condition, or are preparing for surgery, share the ingredient list with your healthcare provider before starting.
Who is the Longevity Kit not for?
It is designed for healthy adults. It is not intended for anyone under 18, or for those who are pregnant or nursing.
Where are the products made?
In the U.S.A., in cGMP facilities, using rigorously tested ingredients from trusted partners worldwide.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

Healthy aging

Aging is complex.

Scientists have identified twelve underlying biological processes that drive how our bodies change over time. NOVOS Core is designed to target all 12 at once, rather than a single pathway.

  • Genomic
  • Cellular
  • Metabolic
  • Systemic
01Genomic InstabilityDNA fails to remain structurally intact or faithfully replicated over time.
02Telomere ShorteningWith each cell division, telomeres get shorter, until a cell becomes senescent or dies.
03Epigenetic AlterationsChanges in how genes are expressed, without altering the DNA sequence itself.
04Loss of ProteostasisProteins can fold incorrectly and become toxic to the cell.
05Disabled AutophagyCells don’t recycle as well as they used to, so old or damaged parts build up.
06Mitochondrial DysfunctionMitochondria produce free radicals, which can damage cells.
07Deregulated Nutrient SensingCells can no longer sense when they have enough nutrients.
08Cellular SenescenceCells stop dividing and take on a zombie-like state, producing chemicals that can damage nearby cells.
09Stem Cell ExhaustionCells gradually lose their ability to divide and renew themselves.
10Altered Cellular CommunicationAccumulation of harmful proteins in cells, leading to age-related conditions.
11InflammagingChronic low-level inflammation that can damage tissues and organs.
12Microbiome DysbiosisThe balance of microbes gets disrupted, and harmful bacteria start to take over.
  • Most supplements address one mechanism. Aging runs on many at once.
  • NOVOS Core is formulated to target all 12 Hallmarks of Aging together.

Reference: López-Otín et al., “Hallmarks of Aging: An expanding universe” (Cell, 2023).

Pilot study · Skin firmness

All participants improved skin firmness over 6 months

In a pilot study (n=4), all participants who took NOVOS Core daily for six months improved skin firmness, averaging 22% (range 12% to 40%), as measured by a medical doctor using the industry standard indentometer device by Courage + Khazaka.

  • n=4
  • 6 months
  • Avg 22%

Methods

Pilot study in four participants taking NOVOS Core daily for six months. Skin firmness measured by indentometer. The small sample size means results should be read as preliminary observations. NOVOS is planning a larger dermatological study.

Participantsn=4
Duration6 mo
Change12% to 40% (avg 22%)
  • All four participants improved skin firmness
  • Average improvement 22%, ranging from 12% to 40%
  • With only four participants, these are preliminary observations

Pilot study (n=4). Small sample size; individual results may vary. A larger dermatological study is planned.

Energy

Many customers report steadier energy throughout the day

In a self-reported customer survey, 81% of NOVOS customers feel a difference within 2 weeks across six areas of daily wellbeing, including energy. Steadier energy is among the changes customers commonly report within Month 1.

  • Rhodiola Rosea
  • Magnesium Malate
  • Self-reported
  • 81% feel a difference
  • Month 1+

NOVOS Core includes Rhodiola Rosea, an adaptogen studied in connection with fatigue resistance and stamina, and Magnesium Malate, a form of magnesium that acts as a cofactor in cellular (ATP) energy production.

  • Energy is one of the most frequently mentioned benefits in NOVOS Core reviews
  • The reported quality is steady, day-long energy, not a stimulant spike
  • NOVOS Core contains no caffeine

Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

Sleep & Mood

Better sleep is one of the changes customers report most

Better sleep is among the most frequently mentioned benefits in NOVOS Core reviews, and one of the six areas of wellbeing in the survey where 81% of NOVOS customers feel a difference within 2 weeks. NOVOS Core is formulated with ingredients commonly associated with calm and restful sleep.

  • Self-reported
  • Glycine
  • L-Theanine
  • Magnesium
  • Micro-dosed Lithium

NOVOS Core includes Glycine, L-Theanine, micro-dosed lithium, and Magnesium Malate, ingredients widely studied in connection with relaxation and restful sleep.

  • Sleep is one of the most-mentioned benefits across NOVOS Core customers
  • Customers describe a calmer, well-rested quality rather than sedation
  • Many notice changes to sleep within the first few weeks

Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

Cell study · DNA integrity

NOVOS Core ingredients supported DNA integrity in irradiated skin cells

In an in vitro study, ingredients in NOVOS Core supported DNA integrity, with up to 77% protection in human skin cells exposed to irradiation (for example, UV rays).

  • In vitro
  • Skin cells
  • Irradiation challenge

Methods

Laboratory study in skin cells exposed to irradiation. Researchers measured the degree to which NOVOS Core ingredients supported DNA integrity against the irradiation challenge.

SettingIn vitro
CellsSkin cells
Protectionup to 77%
  • Ingredients when combined in NOVOS Core supported DNA integrity by up to 77% under irradiation
  • DNA integrity is one mechanism studied in skin, cellular, and whole body aging
  • A laboratory readout, measured in human cells (in vitro) rather than in people (in vivo)

In vitro laboratory study; results may not translate to human outcomes. Individual results may vary.

Animal study · Lifespan

NOVOS Core extended lifespan by over 18% in aged mice

In a study of aged mice (equivalent to starting at 60 human years), NOVOS Core extended lifespan by over 18%, a record for an over-the-counter supplement in aged-mouse models.

  • Aged mice
  • Newcastle University
  • +18%

Methods

Lifespan study in aged mice (equivalent to starting around 60 human years), conducted at Newcastle University. Across separately published animal studies (different protocols and mouse strains, not head-to-head), popular NAD+ boosters such as nicotinamide riboside have shown only modest 0 to 5% lifespan increases in similar aged-mouse models.

ModelAged mice
SiteNewcastle University
Lifespanover 18%
Chart showing NOVOS Core lifespan extension in aged mice versus control
  • Over 18% lifespan extension, a record for an over-the-counter supplement in aged-mouse models
  • Comparator NAD+ boosters: 0 to 5% in separately published studies (not head-to-head)
  • Animal findings do not directly translate to humans

Animal studies are not relied upon to support any representations of health benefit in humans. Not a head-to-head comparison. Results may not translate to humans.

Case study · Pace of aging

73% reduced their biological pace of aging score

In a case study of 12 participants ages 39 to 76 who used NOVOS Core and NOVOS Boost daily for six months, 73% showed a measurable reduction in their DunedinPACE score. No participant’s score increased.

  • n=12
  • Ages 39–76
  • 6 months

Methods

Case study conducted February to August 2022. 12 participants (6 male, 6 female, ages 39 to 76) received epigenetic test kits plus six months of daily NOVOS Core and NOVOS Boost. Kit shipment and blood analysis conducted by a third-party lab. Pace of aging measured by the DunedinPACE algorithm from Columbia University and Duke University researchers.

  • 73% showed a measurable reduction in pace of aging
  • Average reduction in aging was 8.7%, equivalent to 1 month per year
  • 100% of participants maintained or slowed their pace of aging; no participant’s pace of aging increased

Case study, n=12; not a controlled trial. DunedinPACE is a research-use algorithm by Columbia University and Duke University researchers correlated with biological pace of aging, not a direct or definitive measure of aging. Individual results may vary.

Case study · Pace of aging

73% improved their biological pace of aging (measured by DunedinPACE)

In a case study of 12 participants (ages 39 to 76) using NOVOS Core and NOVOS Boost daily for six months, 73% showed a measurable reduction in biological aging pace on the DunedinPACE algorithm. No participant’s pace increased.

  • n=12
  • Ages 39–76
  • 6 months

Methods

Case study conducted February to August 2022. 12 participants (6 male, 6 female, ages 39 to 76) received epigenetic test kits plus six months of daily NOVOS Core and NOVOS Boost. Kit shipment and blood analysis conducted by a third-party lab. Pace of aging measured by the DunedinPACE algorithm from Columbia University and Duke University researchers.

  • 73% showed a measurable reduction in pace of aging
  • Average reduction in aging was 8.7% equivalent to 1 month per year
  • 100% of participants maintained or slowed their pace of aging; no participant’s pace of aging increased

Case study; not a clinical trial and does not establish causation. DunedinPACE is a research biomarker that estimates pace of biological aging, not a direct measure of biological age or clinical outcomes. Results may not be typical.

Randomized human trial · Cardiovascular

NOVOS Core provides rapid and durable support for healthy endothelial function

In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core showed benefits to flow-mediated dilation (a measure of healthy endothelial function), with statistically significant differences versus placebo observed during the trial and sustained at six months (p < 0.0001).

  • Randomized
  • Placebo-controlled
  • Double-blind

Methods

Single-center, double-blind, randomized, placebo-controlled trial in generally healthy adults aged 40 and older. Participants took one serving of NOVOS Core daily for six months. Senior author: Prof. Christian Heiss, Professor of Cardiovascular Medicine, University of Surrey.

Participantsn=61
Age40+
Duration6 mo
  • Benefits to flow-mediated dilation observed versus placebo, achieved at one hour after first dose, and sustained at six months, fasted
  • Approximately 2 to 5 times greater effect in support of healthy endothelial function than the most effective studied supplements (polyphenols, cocoa, and beet root)
  • Effects observed in already-healthy adults, who are typically more difficult to achieve benefits in than sick populations

Individual responses vary. Not every person will experience the same magnitude of change. Comparator estimates derived from published human RCTs and meta-analyses; no head-to-head comparisons were conducted. Individual results may vary.

Randomized human trial · Cardiovascular

NOVOS Core Improved Three Markers of Cardiovascular Aging

Versus placebo in generally healthy adults ages 40 to 65, with measurements taken at baseline, one hour, and six months.

  • Randomized
  • Placebo-controlled
  • Double-blind
  • Under peer review
Blood Vessel Function +2.9% Flow-Mediated Dilation (FMD) Measures how well blood vessels widen in response to increased blood flow. NOVOS Core improved FMD in just one hour and by 2.9% versus placebo at six months. A 1% improvement is considered clinically meaningful.
Vascular Flexibility −1.2 m/s Pulse Wave Velocity (PWV) Measures how quickly pressure waves travel through the arteries. Slower speeds indicate more flexible arteries. NOVOS Core improved PWV by 1.2 m/s versus placebo at six months.
Blood Pressure −6.1 mmHg Systolic Blood Pressure (SBP) Measures the pressure in the arteries when the heart contracts. NOVOS Core reduced systolic blood pressure by 6.1 mmHg versus placebo at six months in participants whose blood pressure was already within the normal range.

Across all three cardiovascular markers, NOVOS Core’s measured effects were comparable to or greater than those reported for aerobic exercise, HIIT, and DASH-style diets. Based on comparisons with published placebo-controlled studies in similar populations, not head-to-head trials. See the full breakdown below.

Endothelial function over the trial

FMD measured at baseline, 1 hour, and 6 months. Significant vs placebo at both.

FMD response (illustrative shape)Baseline1 hour6 months+2.9% vs placebo
NOVOS Core Placebo

∗ p < 0.001 vs placebo. The 1-hour and 6-month points are study measurement timepoints, not a promised timeline of individual results.

Systolic Blood Pressure: NOVOS Core vs. Placebo

Change from baseline at six months. Both groups stayed within the normal range.

NOVOS Core −8.5 mmHg
Placebo −1.5 mmHg

Placebo-adjusted difference: −6.1 mmHg (for blood pressures already in normal range).

How NOVOS Core compares

Outperformed Most Single-Ingredient Supplements Across Every Major Vascular Aging Marker Studied

Based on comparisons with published studies of nutritional interventions. These were not head-to-head trials. No two people respond precisely the same way to nutritional interventions. Individual results will vary, and some may experience no benefit.

Sustained FMD benefit (%)

NOVOS Core2.9
Tea (green/black)2.3
Resistance training2.11
Blueberries2.01
CoQ101.69
Nitric oxide booster1.6
Folic acid1.51
Resveratrol1.4
These benefits were observed in healthy adults already within normal ranges, where further change is typically harder to achieve.
Study details
Single-center, double-blind, randomized, placebo-controlled trial in generally healthy adults aged 40 and older. Participants took one serving of NOVOS Core daily for six months. Senior author: Prof. Christian Heiss, Professor of Cardiovascular Medicine, University of Surrey. Manuscript under peer review (SSRN preprint).

“Taken together, improvements across endothelial function, arterial flexibility, and systolic blood pressure point to a coherent pattern consistent with a favorable shift in vascular aging biology.”

Professor Christian Heiss, MD · University of Surrey · Professor of Cardiovascular Medicine, Associate Head of Medical School Senior Author of the NOVOS Core study

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This comparison is a visual representation of the relative magnitude of change observed in human clinical studies measuring cardiovascular function. Relative values are normalized to a clinically meaningful change reported in the scientific literature. Comparator ranges are derived from meta-analyses of human randomized controlled trials measuring FMD, PWV, and systolic blood pressure. Acute-only effects and extreme outliers were excluded. No head-to-head studies were conducted.

Individual responses vary. Not every person will experience the same magnitude of change. This study did not assess clinical disease outcomes. Individual results may vary.

Click-through evidence · Cellular energy and endurance

Cellular energy and endurance

NAD+ is the molecule your cells use to turn food into usable energy. Levels fall as we age. NOVOS Boost is made with human clinically studied NMN, which your body uses to support its own NAD+ production.

  • Human NMN research
  • 250 mg per serving
  • No caffeine, no stimulants

In a published human study of NMN supplementation, researchers observed that after 30 days, 67% of participants in the 600 mg and 900 mg groups showed measurable changes in walking distance (up to 38%); the trial also reported up to 50% improvement by day 60.

NOVOS Core also includes Rhodiola Rosea, an adaptogen studied in connection with fatigue resistance and stamina, and Magnesium Malate, a form of magnesium that acts as a cofactor in cellular (ATP) energy production. Energy is one of the most frequently mentioned benefits in NOVOS Core reviews, and the reported quality is steady, day-long energy rather than a stimulant spike. Neither product contains caffeine.

Published research on the NMN ingredient, not on NOVOS Boost, and conducted at daily doses of 600 mg to 900 mg. NOVOS Boost provides 250 mg per 2-capsule serving; recommended range 250 mg to 500 mg per day. Study population results are not a guarantee of individual outcomes. Individual results may vary. Customer-reported energy is based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing).

Click-through evidence · DNA repair and metabolic health

DNA repair and metabolic health

NMN is a building block of NAD+, an important molecule that enzymes need in order to support healthy DNA, maintain the epigenome, and ensure cellular integrity. NAD+ also sits at the center of how cells sense and use nutrients. That machinery changes with age.

  • Human NMN research
  • Telomere markers
  • 300 mg/day, 90 days
  • 10 weeks

In a published human study of men aged 40 to 60, researchers reported significant changes in telomere-length markers in peripheral blood mononuclear cells at the 300 mg/day NMN dose over a 90-day observation period.

In a laboratory study conducted by Ichor Life Sciences, the combination of the ingredients in NOVOS Core and the NMN in NOVOS Boost showed an average 68% reduction in DNA oxidative damage from irradiation in human endothelial cells.

In a human trial, NMN supplementation was associated with a 25% change in muscle insulin sensitivity markers after 10 weeks in older adults, along with enhanced metabolic signaling and physical activity.

Published research on the NMN ingredient, not on NOVOS Boost. Single study, small sample size; replication pending. The Ichor study is an in vitro laboratory study; results may not translate to human outcomes. Study population results are not a guarantee of individual outcomes. Individual results may vary.

Timeline · Within weeks

Supports higher NAD+ levels

NAD+ is a molecule cells rely on for energy production and DNA repair, and it declines with age. NOVOS Boost supplies NMN, a direct precursor your body uses to make its own NAD+.

  • NAD+ metabolism
  • Human NMN research

Human studies of NMN have shown increases in blood NAD+ and related NAD+ metabolites, typically observed within weeks of daily supplementation.

Published research on the NMN ingredient, not on NOVOS Boost. Study population results are not a guarantee of individual outcomes. Individual results may vary.

Click-through evidence · Biological Age

Biological Age

NOVOS Age uses latest-generation (3rd) epigenetic technology, the only generation trained on longitudinal analysis of people across their lifetimes. It is built on the MethylationEPIC array, which measures 850,000 DNA methylation sites, and analyzes over 150 biomarkers from a single at-home blood test.

  • 3rd-generation clock
  • 850,000 DNA sites
  • Blood-based

Epigenetic measurement. Informational, not diagnostic. Individual results may vary.

Click-through evidence · Pace of Aging

Pace of Aging

Pace of Aging is measured on DunedinPACE, developed by scientists at Columbia and Duke Universities. It carries a precision score greater than 0.96 ICC and is the only epigenetic algorithm shown to respond in a significant way to validated interventions such as caloric restriction, published in Nature. It has been validated across diverse populations in multiple international longitudinal studies.

  • DunedinPACE
  • Columbia and Duke
  • ICC > 0.96

Biological Age tells you where you are. Pace of Aging tells you which direction you are heading, which is the number that responds when you change something.

Peer-reviewed, open-source algorithm. Informational, not diagnostic. Individual results may vary.

Click-through evidence · Organ Ages

Organ Ages

Organ Age was developed at Yale and reports each system on the same scale, so you can see which are tracking younger and which are tracking older than the rest. Aging is not uniform across the body, and a whole-body average can hide that.

  • 11 systems
  • Yale algorithm
  • Single blood sample

Use these results as a starting point for conversation with your healthcare provider, not as a diagnosis.

Wellness information. Organ Ages are not a clinical assessment of organ health and are not intended to diagnose any condition. Individual results may vary.

Click-through evidence · Telomere Length

Telomere Length

Telomere shortening is one of the 12 Hallmarks of Aging. Telomere Length is included in every NOVOS Age kit alongside the other three results, from the same sample. Algorithmic estimate of telomere length based on epigenetics.

  • Single blood sample
  • Included at no extra cost

Research-grade measurement. Informational, not diagnostic. Individual results may vary.

Methodology

How NOVOS Age measures your results

NOVOS Age analyzes over 150 biomarkers and tracks over 850,000 DNA methylation sites using the modern MethylationEPIC array. The DunedinPACE algorithm was developed by scientists at Columbia and Duke Universities; the Organ Age algorithm was developed at Yale.

  • 150+ biomarkers
  • 850,000 DNA sites
  • 3rd generation

Validated in the Family and Community Health Study of African American Families, MESA (Multi-Ethnic Study of Atherosclerosis), and the Cebu Longitudinal Health and Nutrition Survey, among others. Diagnostic testing and data handling are conducted in compliance with federal CLIA and CAP accreditation standards.

Peer-reviewed published algorithms. Informational, not diagnostic. Individual results may vary.

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