NOVOS is rooted in science, supported by studies validating its patent-pending formulations and ingredients

Table of Contents
Click below to navigate directly to a specific section.
NOVOS Case Studies | case studies done on NOVOS
NOVOS Studies | direct studies done on NOVOS
General Studies | 400+ ingredient studies
Bonus Resources | PDF and other overviews
Note: for an overview of the 8 principles that make up our unique approach to longevity formulations click here.
Case studies done on NOVOS Formulations
Case Study 1: Statistically Significant Reduction of Biological Pace of Aging with NOVOS Core and Boost
NOVOS initiated a case study from February 2022 to August 2022. For the study, 12 participants were provided with an epigenetic test kit (the same test behind NOVOS Age), plus six months’ daily use of NOVOS Core and NOVOS Boost. The population was composed of six males and six females aged 39 to 76.
Participants were instructed to submit a blood sample for epigenetic testing prior to ever having used NOVOS Core or Boost, then to begin taking one sachet of Core and two pills of Boost (250 mg NMN dosage) daily. They were also asked not to make any significant changes to their lifestyles unless medically necessary and to notify the NOVOS R&D team if any significant changes had taken place.
After six months, eleven subjects submitted a blood sample for followup epigenetic testing. One male participant dropped out due to lack of compliance.
Principal Component DunedinPACE clock outputs were compared for each subject’s start and end samples. The group had a statistically significant reduction in biological pace of aging, with eight of the eleven subjects (73%) reducing their pace of aging well beyond the test’s error margin. The average percentage change was minus 6.1% and one participant’s result was minus 14%.

Among the small group who did not improve, there was no statistical change, meaning they maintained their pace of aging, which might indicate a positive result. Their longevity might have worsened had they not taken NOVOS products. Zero participants had an increase in their pace of aging.
Note that the p-value for the results, at 0.001, far exceeds the minimum benchmark of statistical significance of 0.05. In other words, the results are 50 times less likely to be by random chance than what scientists ordinarily require to consider something as “statistically significant” (i,e., it is not coincidental).
Extending beyond the case study, multiple anecdotal customer accounts reflect similar outcomes. One verified customer had this to say: “I tested my biological age with an epigenetic test prior to starting NOVOS Core. I was 1.8 years younger than my chronological age. I started daily NOVOS Core packets, and six months later, I repeated the test. I was 8.4 years younger than my chrono age! I am excited about the results!” (Amy B., MSN, APRN, FNP-C.)
Another said this: “I took a blood epigenetic test before starting on NOVOS. I was 72 years old and the result said bio age 71. I then took Core and Boost consistently over 6 months, made sure not to add or remove any other supplements or make any significant lifestyle changes, then retested. I turned 73 and the result came back as bio age 63 – minus 10 years! I asked the lab to check if there were any errors in their analysis. To my delight, there wasn’t! Over those 6 months I noticed subtle improvements in my energy and got compliments from friends and family on my complexion. Here I am two years later and I’m still being complimented on my skin.” (Len M., New York)
The impressive results come after remarkable results from two studies demonstrating that the combination of ingredients in NOVOS Core and NOVOS Boost protect human cells against DNA damage and cellular aging (senescence). PR Newswire: Original Article
Scientific studies done on NOVOS Formulations
Study 1: NOVOS Core improves skin suppleness in humans
Participants who took NOVOS Core for 6 months all showed improvements in skin firmness as measured by an indentometer.
An indentometer is a device that measures skin suppleness and firmness.
Besides these objective measurements, participants also mentioned noticeable improvements in their skin, such as improved elasticity, smoothness, and firmness.
Results
The study was a small pilot study, done in 4 patients. The device used to test is a state-of-the-art device used for scientific studies.

NOVOS users saw a minimum improvement of 12%, max of 40% and an average of 22% in skin firmness.
NOVOS is planning to conduct an additional and more extensive dermatological study with more participants.
Ingredients improving skin health
These results on skin health are not that surprising given NOVOS Core contains various longevity ingredients that are also known to improve skin health, such hyaluronic acid, alpha ketoglutarate, glycine, vitamin C, and glucosamine.
Oral hyaluronic acid improves skin health and reduces wrinkles. Hyaluronic acid is a component of the extracellular matrix, the “glue” that keeps skin cells sticking together.
Alpha ketoglutarate improves skin stem cell health, and plays a role in collagen production. Alpha ketoglutarate also works together with vitamin C, given vitamin C also improves collagen production. Additionally, alpha ketoglutarate and vitamin C both work synergistically to improve the epigenome, including that of skin cells. Alpha ketoglutarate can also extend lifespan.
Glucosamine is a component of the extracellular matrix, and glycine is an important building block of collagen.
These are some examples of how ingredients in NOVOS can improve skin health.
Not just addressing signs of aging, but the underlying causes
What is even more important is that all these ingredients inhibit fundamental aging mechanisms and have shown to extend lifespan in various species.
In other words, NOVOS Core is the only skin supplement that actually addresses the root causes of aging, including skin aging.
Study 2: NOVOS Core significantly reduces DNA damage in human cells after irradiation
A study found that a combination of the 12 ingredients in NOVOS Core and the nicotinamide mononucleotide (NMN) in NOVOS Boost significantly protects cells against DNA damage over a wide dose range.
The study was done by Ichor Life Sciences, an independent third-party US-based lab specialized in DNA damage, cellular senescence, and aging.
In the study, HUVEC cells (human umbilical vein endothelial cells) were treated with the 13-ingredient NOVOS formulation and then irradiated. Irradiation typically causes pronounced DNA damage. However, the cells exposed to NOVOS before irradiation had significantly less DNA damage after being exposed to radiation, as measured via 8-hydroxy-2′-deoxyguanosine (8-OHdG or 8-oxodG) levels. 8-OHdG is a measure of oxidative DNA damage. When DNA gets damaged, 8-OHdG is formed.
Treating cells with NOVOS was able to reduce DNA damage as measured by 8-OHdG by up to 77% and on average 68% compared to controls:

Researchers demonstrated that the NOVOS formulation protects against DNA damage over a wide range of doses, an effect mediated by DNA protective effects of multiple NOVOS ingredients at different doses and synergy between ingredients.
Study 3: NOVOS ingredients demonstrate synergistic senostatic effects on senescent human cells
This study was conducted at the Ageing Research Laboratories at Newcastle University (UK), specialized in cellular senescence and aging. The study was done under the guidance of Professor Von Zglinicki, Professor for Cell Gerontology.
The study found that the combination of multiple NOVOS ingredients could help the body better deal with senescent cells.
Senescent cells occur during aging and play an important role in the aging process. These cells accumulate various forms of damage, including DNA and epigenetic damage, and secrete substances that harm healthy surrounding cells.
Research has shown that countering senescent cells using senostatic drugs (which suppress senescent cells) can support the body to deal better with aging. In the study, researchers using cell size as marker for the senescent phenotype found that specific NOVOS ingredients had a senostatic effect, while not impacting normal, non-senescent cells:

A senostatic effect comprising a reduction in senescent cell size has also been observed with rapamycin, a prescription drug associated with increased longevity in multiple animal models:

Normal non-senescent cells were not impacted by the NOVOS formulation, demonstrating that specific NOVOS ingredients used in a synergistic combination can impact senescent cells while not impacting healthy cells — a common pitfall of “senolytic” molecules which seek to destroy senescent cells.
400+ Longevity-relevant Scientific Studies Behind Ingredients in NOVOS’ Formulations
Ingredient | Study Type | Study Link | Outcome | Hallmark | Learn More | Summary |
---|---|---|---|---|---|---|
Glycine | Human | Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetes | Supports a healthy anti-inflammatory status and promotes a healthy glucose metabolism. | Altered cellular communication. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | D-Glucosamine supplementation extends life span of nematodes and of ageing mice | Increase in lifespan (6% increase in males and 4% in female mice). | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | The metabolic response to ingested glycine | Glycine supports healthy levels of glucose. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats | Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris | Higher levels of glycine are associated with improved heart health. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis | Higher levels of glycine are associated with healthy glucose metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance | Higher levels of glycine are associated with healthy liver metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance | Higher levels of glycine are associated with healthy metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes | Higher levels of glycine are associated with healthy metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Neuroprotective effects of glycine for therapy of acute ischaemic stroke | Glycine helps to support brain health. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults | Glycine maintains healthy cognition in young and middle-aged people. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Glycine metabolism in skeletal muscle | Glycine supports healthy muscle function during physiological stress. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation | Glycine infusions improve oxidative stress. | Altered cellular communication. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Taking a supplement of glycine, a food additive, helps to prevent degenerative diseases such as arthrosis or osteoporosis | Glycine supports healthy joints and bones. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary Glycine Supplementation Extends Lifespan of Genetically Heterogeneous Mice | Median lifespan was increased in mice by 3.7% in females and 1.3% inmales, and the 90th percentile lifespan was increased by 1.8% in females and 3.6% in males. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion | A 19% increase in lifespan in C elegans worms. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan | Improving glycine metabolism extends lifespan in Drosophila. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats | Glycine promotes a healthy metabolism in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary glycine blunts lung inflammatory cell influx following acute endotoxin | Glycine promotes a healthy inflammatory response in lungs in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats | Glycine supports eye health in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride Channel | Glycine improves joint health in rodents. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Alpha-ketoglutarate | Human | Calcium Alpha-Ketoglutarate Supplementation Reduces Epigenetic Age in Humans | A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. | Epigenetic dysregulation. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test | A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. | Epigenetic dysregulation. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | α-ketoglutarate for myocardial protection in heart surgery | Alpha-ketoglutarate supports heart health during physiological stress. | Mitochondrial dysfuction. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | Addition of α-Ketoglutarate to Blood Cardioplegia Improves Cardioprotection | Alpha-ketoglutarate supports heart health during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Renal Effects of a-Ketoglutarate Early After Coronary Operations | Alpha-ketoglutarate supports healthy kidney function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alpha-ketoglutarate and postoperative muscle catabolism | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Prevention of decrease of protein synthesis after total hip replacement | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Binding of phosphate in chronic hemodialysis patients | Alpha-ketoglutarate suports healthy kidney function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Improvement of arginine levels in malnourished hemodialsysis patients | Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | alpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolism | Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Treatment of hyperphosphataemia in haemodialysis patients | Alpha-ketoglutarate supports a healthy phosphate metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Telopeptide of type I collagen in postmenopausal women with osteopenia | Alpha-ketoglutarate supports healthy bones. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alfa ketoglutarate (AKG) inhibit osteoporoses development in postmenopausal women | Alpha-ketoglutarate supports healthy bones. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice | Lifespan and healthspan extension in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice | Lifespan and healthspan extension in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR | Lifespan exention in C elegans by 50%. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK | 15% lifespan extension in Drosophila. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Effects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies. Ukr Biochem J. 2018 | Females had 23% and 11% longer mean lifespan and 22% and 19% longer maximum lifespan on food supplemented with alpha-ketoglutarate compared to controls. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Dietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster) | Diet with 10 mM AKG improved climbing activity in middle-aged flies. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Dietary alphaketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner. J Therm Biol. 2016 | Improves cold tolerance and antioxidant system capacity in Drosophila. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations | Alpha-ketoglutarate rejuvenates mesenchymal stem cells and supports healthy aging of bones in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate stabilizes redox homeostasis and elasticity in aged mice | Alpha-ketoglutarate supports healthy blood vessel elasticity in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice | Alpha-ketoglutarate supports healthy blood vessel elasticity in elderly mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats | Alpha-ketoglutarate supports healthy blood vessels and a healthy fat metoblism in obese rats. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-Ketoglutarate: Physiological Functions and Applications | Review article. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Rhodiola rosea | Human | The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials | Rhodiola rosea supports healthy cognition and normal energy levels. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty | Rhodiola rosea helps to maintain normal energy levels under stressful conditions. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results | Rhodiola rosea promotes healthy muscle function during intensive exercise. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial | Rhodiola promotes healthy energy levels. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction | Rhodiola rosea extends lifespan in fruit flies. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1 | Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Plant adaptogens increase lifespan and stress resistance in C. elegans | Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola: a promising anti-aging Chinese herb | Rhodiola rosea has anti-aging properties. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae | Rhodiola rosea extends lifespan in yeast. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects | Rhodiola rosea supports normal brain function during physiological stress in rats. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat | Rhodiola rosea supports normal brain function during physiological stress in rats. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea | Rhodiola rosea supports normal brain function during physiological stress in fruit flies. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats | Salidroside, a component in Rhodiola, supports healthy regeneration of nerves. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo | Salidroside, a component in Rhodiola, supports healthy regeneration of nerves. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes | Rhodiola supports healthy metabolism in rats | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway | Review/meta-analysis. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms | Rhodiola promotes healthy cognition and memory in rodents. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Glucosamine | Human | Total mortality risk in relation to use of less-common dietary supplements. | Glucosamine is associated with reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Use of glucosamine and chondroitin in relation to mortality. | Glucosamine is associated with reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank | Glucosamine is associated with improved heart health in humans. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Glucosamine/Chondroitin and Mortality in a US NHANES Cohort | Glucosamine is associated with improved heart health and reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Oral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox State | Glucosamine promotes heart health. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Association between use of specialty dietary supplements and C-reactive protein concentrations. American Journal of Epidemiology, 2012 | Glucosamine supports a healthy inflammatory status. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation | Glucosamine supports a healthy inflammatory status. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study | Glucosamine has been associated with healthy colon cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study | Glucosamine has been associated with healthy colon cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort | Glucosamine has been associated with healthy lung cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial | Glucosamine improves skin health during aging. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Animals | D-Glucosamine supplementation extends life span of nematodes and of ageing mice | 10% lifespan extension in mice. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction | 30% lifespan extension in C elegans. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome | Glucosamine promotes a healthy anti-inflammatory response. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis | Glucosamine promotes a healthy anti-inflammatory response and supports healthy blood vessels. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: Evidence for a protective role for glucosamine in atherosclerosis | Glucosamine helps to maintain healthy blood vessels. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Vitamin C | Human | Impact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of Stay | Vitamin C supports a healthy recovery after trauma. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Human | Vitamin C: An Epigenetic Regulator | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | The role of vitamin C in epigenetic regulation | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine | Vitamin C promotes a healthy epigenome and works synergistically with alpha-ketoglutarate. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Reprogramming the Epigenome With Vitamin C | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Animal | Vitamin C and Lifespan in Model Organisms | Vitamin C extends lifespan in C elegans. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Vitamin C, Aging and Alzheimer’s Disease | Vitamin C has anti-aging effects. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function | Vitamin C supports healthy brain function in mice exposed to physiological stress. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation | Vitamin C supports healthy regeneration of nerves in rodents. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Pterostilbene | Human | Analysis of Safety from a Human Clinical Trial with Pterostilbene | Pterostilbene is safe to take (based on hepatic, renal and glucose markers). | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial | Pterostilbene supports healthy blood pressure levels. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Combination of pterostilbene and nicotinamide riboside (NR) in ALS | Pterostilbene, in combination with an NAD-booster, supports healthy lung function and muscle function under physiological stress. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study | Pterostilbene, in combination with an NAD-booster, increases NAD+ levels in humans safely and sustainably. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans | Pterostilbene increases lifespan in C elegans. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Effect of resveratrol and pterostilbene on aging and longevity | Review article. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Low-dose Pterostilbene, but Not Resveratrol, Is a Potent Neuromodulator in Aging and Alzheimer's Disease | Pterostilbene supports healthy brain aging in an accelerated-aging mice model. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study | Pterostilbene supports healthy brain and cognitive function in aged rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats | Pterostilbene promotes healthy DNA stabilization and protects the brain against physiological stress in rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice | Pterostilbene supports normal brain function during physiological stress in rodents. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging | Pterostilbene promotes normal brain function in aging rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway | Pterostilbene promotes healthy blood vessel function. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model | Pterostilbene supports heart health during physiological stress. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats | Pterostilbene helps to maintain normal liver function during physiological stress in rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2 | Pterostilbene helps to maintain a healthy glucose metabolism under physiological stress in rodents. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Fisetin | Human | Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients | Fisetin supports a healthy inflammatory response. | Altered intercellular communication | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Fisetin | Human | Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial | Fisetin can support brain health under physiological stress. | Altered intercellular communication | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Fisetin | Human | At least 16 clinical trials with fisetin in humans are underway. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | ||
Fisetin | Animal | Fisetin is a senotherapeutic that extends health and lifespan | Lifespan extension in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Lifespan extension in Saccharomyces cerevisiae by 55%. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse | Lifespan extension. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Sirtuin activators mimic caloric restriction and delay ageing in metazoans | Lifespan extension. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Preventing and Treating Neurological Disorders with the Flavonol Fisetin | Fisetin can help to support normal brain function during aging. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function | Fisetin can help to support normal brain function during aging. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo. | Fisetin supports blood vessel health in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice | Fisetin supports brain aging in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes | Fisetin supports a healthy metabolism in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia | Fisetin supports brain and vascular health in rodents. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin regulates obesity by targeting mTORC1 signaling | Fisetin promotes a healthy metabolism in mice fed a hig-fat diet. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice | Fisetin promotes healthy brain aging in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice | Fisetin helps to maintain normal brain function in rodents under physiological stress. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Micro-dosed Lithium | Human | Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials | Lithium is associated with reduced all-cause death in people with mood disorders. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study | Lithium is associated with improved brain aging. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Low-dose lithium uptake promotes longevity in humans and metazoans | Low-dose lithium increases lifespan in C elegans and is associated with reduced mortality in humans. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018 | Higher levels of lithium in tap water are associated with reduced mortality in humans. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in Texas | Higher levels of lithium in drinking water are associated with reduced mortality and improved metabolic health in humans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies | Higher levels of lithium in drinking water are associated with healthier mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions | Higher levels of lithium in the drinking water are associated with less crime stemming from drug addictions. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium in drinking water and suicide prevention: The largest nationwide epidemiological study from Japan | Higher levels of lithium in the drinking water are associated with a healthier mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users | Microdosed lithium can support healthy mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Association of Lithium in Drinking Water With the Incidence of Dementia | Higher levels of lithium in the drinking water supports healthy brain aging. | Improved proteostasis | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial | Lithium intake is associated with improved cognition and healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease | Microdosed lihium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits | Lithium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis | Lithium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial | Lithium supports healthy brain aging. | Improved proteostasis | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's diseaser | Lithium supports healthy brain aging. | Altered intercellular communication | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Increase of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease. | Lithium supports healthy brain aging. | Altered intercellular communication | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium | Lithium supports healthy brain aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | The polygenic nature of telomere length and the anti-ageing properties of lithium | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Animal | Low-dose lithium uptake promotes longevity in humans and metazoans | 36% lifespan extension in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Lithium treatment and mechanisms of aging | Nature Review article on the role of lithium treatment in aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans | 46% lifespan increase in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans | 10% lifespan increase in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis | Lithium extends lifespan in Drosophila. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans | Up to 46% median increase of lifespan in C elegans, probably by improving epigenetic health. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model | Long-term microdosed lithium improves brain health in mice. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease | Microdosed lithium improves brain health. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death | Microdosed lithium supports brain health under physiological stress. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model | Lithium helps to support proper protein metabolism in the brain in mice. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats | Lithium helps to support proper protein metabolism in the brain in rats. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Ginger | Human | Metanalysis: The effect of Ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis | Ginger promotes a healthy anti-inflammatory response and healthy metabolism. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial | Ginger promotes a healthy cholesterol metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effect of ginger and fasting blood supar, HbA1c and lipids in diabetes patients | Ginger helps to maintain a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med, 2014 | Ginger helps to maintain a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence | Ginger reduces oxidative stress and supports a healthy anti-inflamamtory status. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effects of a ginger extract on knee pain in patients with osteoarthritis | Ginger supports healthy joints. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Animal | Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction | Lifespan extension in Drosophila. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions | Lifespan extension in Drosophila. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation | Ginger strongly protects mice against lethal doses of radiation. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Protective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in Rats | Ginger can support healthy brain aging in rats. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response | Ginger can support a healthy inflammatory response in mice under physiological stress. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Malate (as magnesium malate) | Human | Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study | Malate can support normal energy levels. | Deregulated nutrient sensing | Learn More | Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health. |
Malate (as magnesium malate) | Animal | Malate and Fumarate Extend Lifespan in Caenorhabditis elegans | 14% increase in lifespan in C elegans. | Learn More | Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health. | |
Magnesium (as magnesium malate) | Human | Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies | Magnesium promotes a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Low serum magnesium concentrations predict cardiovascular and all-cause mortality. | Magnesium promotes healthy cardiovascular function and reduces all cause mortality. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man | Magnesium supports healthy DNA. | Genomic instability | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Acute and chronic oral magnesium supplementation: effects on endothelial function, exercise capacity, and quality of life in patients with symptomatic heart failure | Magnesium supports heart health. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Role of magnesium in genomic stability. | Magnesium supports healthy DNA. | Altered cellular communication | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. | Magnesium conributes to a normal anti-inflammatory response. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial | Magnesium supports a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study | Magnesium supports a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials | Magnesium supports a healthy glucose metabolism. | Mitochondrial dysfunction | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Modern Nutrition in Health and Disease. | Magnesium supports a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium Role in Health and Longevity | Magnesium supports a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium for the prevention and treatment of cardiovascular disease | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | ||
Magnesium (as magnesium malate) | Human | Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | ||
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation improves lifespan in a mouse model of progeria | Magnesium extends lifespan in an accelerated aging mice model. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function | Magnesium can help to maintain proper mitochondrial function. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation improves lifespan in a mouse model of progeria | Magnesium can slow down aging in an accelerated aging mice model. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats | Magnesium can support blood vessel health. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Hyaluronic acid | Human | Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period | Hyaluronic acid taken orally improves the appearance of wrinkles, skin luster and elasticity. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study | Oral hyaluronic acid improves the appearance of wrinkles, hydration of skin and elasticity. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Effects of low molecular weight hyaluronic acid by oral intake to beautify skin: -Placebo-controlled double-blind comparative study- | Oral hyaluronic acid improves skin moisture, elasticity and the appearance of wrinkles. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Ingested hyaluronan moisturizes dry skin | Oral hyaluronic acid improves skin moisture. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral hyaluronan relieves knee pain: a review | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral hyaluronan for the treatment of knee osteoarthritis: A systematic review | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life | A component of hyaluronic acid (acetyl-glucosamine) extends lifespan in mice and C elegans. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway | Low-molecular-weight hyaluronan can cross the gut lining and is absorbed into the bloodstream. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs | Oral hyaluronic acid is systemically absorbed. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
L-theanine | Human | Theanine consumption, stress and anxiety in human clinical trials: A systematic review | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 2019 | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Theanine reduces psychological and physiological stress responses | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Salivary cortisol and alpha-amylase responses to repeated bouts of downhill running | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Acute effects of theanine, caffeine and theanine-caffeine combination on attention. | Theanine supports healthy cognition. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis | Theanine supports healthy cognition. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | l-Theanine extends lifespan of adult Caenorhabditis elegans | L-theanine extends lifespan in C elegans. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice | L-theanine extends lifespan in mice under stressful conditions. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | L-Theanine attenuates liver aging by inhibiting advanced glycation end products in D-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation | L-theanine improves liver aging during physiological stress in aging rats. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Prevention of brain aging by green tea components: Role of catechins and theanine | L-theanine supports healthy brain aging. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways | L-teanine supports healthy brain aging. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness | L-theanine supports brain stem cell health and proper neurogenesis. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Daily oral intake of L-theanine prevents the decline of 5-bromo-20 -deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress | L-theanine supports brain health under physiological stress in mice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory | L-theanine improves healthy cognitive development and neurogenesis in young ice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro Study | L-theanine supports joint health. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Modulation of irinotecan-induced genomic DNA damage by theanine | L-theanine helps to protect DNA against damage in mice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
Nicotinamide mononucleotide (NMN) | Human | Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men | NMN given to humans is safe. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Human | Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women | NMN promotes a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old men | NMN promotes healthy muscles in old men. | Mitochondrial dysfunction | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study | NMN supports exercise endurance. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | NAD⁺ metabolism: a therapeutic target for age-related metabolic disease | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE 7, e42357 (2012). | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl Acad. Sci. USA 112, 2876–2881 (2015). | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice | NMN supports healthy brain aging and blood vessels in mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects | NMN promotes neurvascular rejuvenation in aged mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice | NMN promotes rejuvenation of the blood vessels in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects | NMN promotes blood vessel health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging | NMN promotes blood vessel health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging | NMN supports healthy mitochondrial function in mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow | NMN promotes mesenchymal stem cell health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice | NMN supports a healthy glucose metabolism. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | NAD+ controls neural stem cell fate in the aging brain | NMN supports healthy brain aging in rodents. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | NAD+ Repletion Rescues Female Fertility during Reproductive Aging | NMN can support proper fertility and egg cell function in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Glycine | Animal | GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage | Helps in extending lifespan, increases the production of intracellular antioxidant, promotes mitochondrial function and mitophagy | Dysregulated nutrient sensing; inflammaging; reduced autophagy efficacy | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial | Help in the production of antioxidant; supports a healthy anti-inflammatory status; improve physical function and cognitive performance | Inflammaging; mitochondrial dysfunction | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial | Helps to improve antioxidant defense; supports a healthy anti-inflammatory status; improve physical function | Inflammaging; mitochondrial dysfunction | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis | Supports a healthy anti-inflammatory status; may promotes macrophage activation; promote healthy liver function; promote cardiovascular health | Inflammaging; reduced autophagy efficacy; microbiome dysbiosis | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | Glycine supplementation extends lifespan of male and female mice | Increase healthy lifespan in mice | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors | Improves cardiovascular function; improves mitochondrial function; supports a healthy anti-inflammatory status | Inflammaging | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice | Improves cardiovascular health; enhance mitophagy; improve antioxidant defense; | Inflammaging; reduced autophagy efficacy | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Animal | Ornithine α-Ketoglutarate Alleviates Inflammation via Regulating Ileal Mucosa Microbiota and Metabolites in Enterotoxigenic Escherichia coli-Infected Pigs | Supports a healthy anti-inflammatory status; regulates immunity, and ileal mucosa microbiota and its metabolites | Inflammaging; microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Animal | Alpha-Ketoglutarate Attenuates Colitis in Mice by Increasing Lactobacillus Abundance and Regulating Stem Cell Proliferation via Wnt-Hippo Signaling | Supports a healthy mucosal anti-inflammatory status; promote a better gut microflora status | Inflammaging; microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Animal | Intervention with α-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome | Protect against inflammation-related Colitis-Related Colorectal Carcinoma | Inflammaging; microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Rhodiola rosea | Human | Effect and mechanism of Sofren injection in the treatment of stable angina petoris | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation | Salidroside (bioactive compound found in Rhodiola rosea) promote healthy cardiovasucular status by inhibiting apoptosis and inflammation | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | The Nuclear Factor NF-κB Pathway in Inflammation | Salidroside (bioactive compound found in Rhodiola rosea) promote better heart status | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease | Salidroside (bioactive compound found in Rhodiola rosea) improve cognitive capacity by inhibiting neuroinflammation and affecting apoptosis-related proteins in hippocampus. | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway | Salidroside (bioactive compound found in Rhodiola rosea) improve cognitive capacity by inhibiting neuroinflammation | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | Salidroside inhibits inflammatory factor release in BV-2 cells through p38 and JNK pathways | Salidroside (bioactive compound found in Rhodiola rosea) improve cognitive capacity by inhibiting neuroinflammation | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Animal | Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking-Induced Liver Injury | Salidroside (bioactive compound found in Rhodiola rosea) promotes healthy inflammatory status | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Rhodiola rosea | Cell line | Effects of salidroside on the secretion of inflammatory mediators induced by lipopolysaccharide in murine macrophage cell line J774.1 | Salidroside (bioactive compound found in Rhodiola rosea) promotes healthy inflammatory status | Inflammaging | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. |
Glucosamine | Human | Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial | Glucosamine shows an improvement in knee osteoarthritis patient by supporting a healthy inflammatory status | Inflammaging | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Effect of celecoxib combined with glucosamine hydrochloride in promoting the functional recovery and decreasing the inflammatory factor levels in patients with knee osteoarthritis | Glucosamine (with the combination of celecoxib) shows an improvement in knee osteoarthritis patient by decreasing the inflammatory factor levels | Inflammaging | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Vitamin C | Human | The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial | Supports a healthy anti-inflammatory status by lowering oxidative stress molecules (with vitamin E) | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Effect of six weeks 1000 mg/day vitamin C supplementation and healthy training in elderly women on genes expression associated with the immune response - a randomized controlled trial | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Antioxidant supplementation reduces endometriosis-related pelvic pain in humans | Supports a healthy anti-inflammatory status (with vitamin E) | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Effect of guava and vitamin C supplementation on experimental gingivitis: A randomized clinical trial | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Animal | Vitamin C and vitamin E supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters | Supports a healthy anti-inflammatory status by alleviaing the oxidative stress induced by dexamethasone | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Vitamins C and E Associated With Cryotherapy in the Recovery of the Inflammatory Response After Resistance Exercise: A Randomized Clinical Trial | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Pterostilbene | Human | Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. |
Fisetin | Human | Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Fisetin | Human cell & Animal | Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Micro-dosed Lithium | Human | Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study | May supports a healthy anti-inflammatory status as lithium is associated with inflammatory cytokines | Inflammaging | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Ginger | Human | Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial | May plays an important role in protecting the joints against destructive factor by its anti inflammatory property | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Anti-inflammatory and antioxidant effect of ginger in tuberculosis | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Asymmetric dimethylarginine and soluble inter-cellular adhesion molecule-1 serum levels alteration following ginger supplementation in patients with type 2 diabetes: a randomized double-blind, placebo-controlled clinical trial | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Magnesium (as magnesium malate) | Human | Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration? | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Serum magnesium and C-reactive protein levels | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Magnesium and the inflammatory response: potential pathophysiological implications in the management of patients with aneurysmal subarachnoid hemorrhage? | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Hyaluronic acid | Human | Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis | May support a healthy anti-inflammatory status | Inflammaging | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. |
Hyaluronic acid | Human | The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. |
Hyaluronic acid | Human | The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. |
Hyaluronic acid | Human | The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. |
Hyaluronic acid | Human | Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. |
L-theanine | Human | The effect of L-theanine supplementation on the immune system of athletes exposed to strenuous physical exercise | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. |
Nicotinamide mononucleotide (NMN) | Human | Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death | Supports a healthy anti-inflammatory status by eliminating accumulation of reactive oxygen species (ROS) | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal Cell Line | Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal | Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human cell & Animal | Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE | Supports a healthy anti-inflammatory status | Inflammaging | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Alpha-ketoglutarate | Animal | Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets | Improves bone growth; improves colonic microbial profile | Microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate (AKG) lowers body weight and affects intestinal innate immunity through influencing intestinal microbiota | Promotes a healthier intestinal microbiota status | Microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Animal | Effect of dietary α-ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs | Improved cecal microbial composition and diversity | Microbiome dysbiosis | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
You can download a brief description of our ingredients and their health effects below: