NOVOS is rooted in science, supported by studies validating its patent-pending formulations and ingredients

Table of Contents

Click below to navigate directly to a specific section.

NOVOS Studies | direct studies done on NOVOS

General Studies | 190+ ingredient studies

Bonus Resources | PDF and other overviews


Note: for an overview of the 10 principles that make up our unique approach to longevity formulations click here.



Scientific studies done on NOVOS Formulations

Study 1: NOVOS Core improves skin suppleness in humans

Participants who took NOVOS Core for 6 months all showed improvements in skin firmness as measured by an indentometer. 

An indentometer is a device that measures skin suppleness and firmness. 

Besides these objective measurements, participants also mentioned noticeable improvements in their skin, such as improved elasticity, smoothness, and firmness. 

Results

The study was a small pilot study, done in 4 patients. The device used to test is a state-of-the-art device used for scientific studies.

Gray bars show skin firmness before taking NOVOS (the higher the bar, the less firm the skin is). Orange bars show skin firmness after taking NOVOS 6 months (the lower the bar, the more firm the skin).

NOVOS users saw a minimum improvement of 12%, max of 40% and an average of 22% in skin firmness. 

NOVOS is planning to conduct an additional and more extensive dermatological study with more participants.

Ingredients improving skin health

These results on skin health are not that surprising given NOVOS Core contains various longevity ingredients that are also known to improve skin health, such hyaluronic acid, alpha ketoglutarate, glycine, vitamin C, and glucosamine. 

Oral hyaluronic acid improves skin health and reduces wrinkles. Hyaluronic acid is a component of the extracellular matrix, the “glue” that keeps skin cells sticking together. 

Alpha ketoglutarate improves skin stem cell health, and plays a role in collagen production. Alpha ketoglutarate also works together with vitamin C, given vitamin C also improves collagen production. Additionally, alpha ketoglutarate and vitamin C both work synergistically to improve the epigenome, including that of skin cells. Alpha ketoglutarate can also extend lifespan.

Glucosamine is a component of the extracellular matrix, and glycine is an important building block of collagen. 

These are some examples of how ingredients in NOVOS can improve skin health. 

Not just addressing signs of aging, but the underlying causes

What is even more important is that all these ingredients inhibit fundamental aging mechanisms and have shown to extend lifespan in various species.  

In other words, NOVOS Core is the only skin supplement that actually addresses the root causes of aging, including skin aging.


Study 2: NOVOS Core significantly reduces DNA damage in human cells after irradiation

A study found that a combination of the 12 ingredients in NOVOS Core and the nicotinamide mononucleotide (NMN) in NOVOS Boost significantly protects cells against DNA damage over a wide dose range. 

The study was done by Ichor Life Sciences, an independent third-party US-based lab specialized in DNA damage, cellular senescence, and aging.

In the study, HUVEC cells (human umbilical vein endothelial cells) were treated with the 13-ingredient NOVOS formulation and then irradiated. Irradiation typically causes pronounced DNA damage. However, the cells exposed to NOVOS before irradiation had significantly less DNA damage after being exposed to radiation, as measured via 8-hydroxy-2′-deoxyguanosine (8-OHdG or 8-oxodG) levels. 8-OHdG is a measure of oxidative DNA damage. When DNA gets damaged, 8-OHdG is formed. 

Treating cells with NOVOS was able to reduce DNA damage as measured by 8-OHdG by up to 77% and on average 68% compared to controls:

Irradiated cells treated with the NOVOS formulation (orange bars; different concentrations of NOVOS ranging from 50.0uM to 0.2 uM) showed significantly less DNA damage (as measured by 8-OHdG levels; the lower the bars, the less DNA damage) versus irradiated cells that weren’t treated with the NOVOS formulation (gray bars).


Researchers demonstrated that the NOVOS formulation protects against DNA damage over a wide range of doses, an effect mediated by DNA protective effects of multiple NOVOS ingredients at different doses and synergy between ingredients.


Study 3: NOVOS ingredients demonstrate synergistic senostatic effects on senescent human cells

This study was conducted at the Ageing Research Laboratories at Newcastle University (UK), specialized in cellular senescence and aging. The study was done under the guidance of Professor Von Zglinicki, Professor for Cell Gerontology.

The study found that the combination of multiple NOVOS ingredients could help the body better deal with senescent cells.

Senescent cells occur during aging and play an important role in the aging process. These cells accumulate various forms of damage, including DNA and epigenetic damage, and secrete substances that harm healthy surrounding cells. 

Research has shown that countering senescent cells using senostatic drugs (which suppress senescent cells) can support the body to deal better with aging. In the study, researchers using cell size as marker for the senescent phenotype found that specific NOVOS ingredients had a senostatic effect, while not impacting normal, non-senescent cells:

The cell size of senescent cells is reduced with NOVOS ingredients (orange line, on the right). Normal cells are not impacted (blue line), demonstrating that the combination of specific NOVOS ingredients targets senescent cells and not normal healthy cells.

A senostatic effect comprising a reduction in senescent cell size has also been observed with rapamycin, a prescription drug associated with increased longevity in multiple animal models:

The cell size of senescent cells is reduced by rapamycin (orange graph, on the right). Rapamycin, not being a senolytic, has however senomorphic effects.

Normal non-senescent cells were not impacted by the NOVOS formulation, demonstrating that specific NOVOS ingredients used in a synergistic combination can impact senescent cells while not impacting healthy cells — a common pitfall of “senolytic” molecules which seek to destroy senescent cells. 



190+ Studies Supporting NOVOS Selection of Ingredients

Click on an ingredient name to get a non-exhaustive list of representative scientific studies:


You can download a brief description of our ingredients and their health effects below:

Table overview of scientific studies for NOVOS ingredients

IngredientStudy TypeStudy LinkOutcome (FDA Conform)HallmarkLearn MoreSummary
GlycineHumanGlycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetesSupports a healthy anti-inflammatory status and promotes a healthy glucose metabolism.Altered cellular communication.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalD-Glucosamine supplementation extends life span of nematodes and of ageing miceIncrease in lifespan (6% increase in males and 4% in female mice).Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanThe metabolic response to ingested glycineGlycine supports healthy levels of glucose. Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalDietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 ratsMedian lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats. Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanPlasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectorisHigher levels of glycine are associated with improved heart health. Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanMetabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysisHigher levels of glycine are associated with healthy glucose metabolism. Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanAltered amino acid concentrations in NAFLD: Impact of obesity and insulin resistanceHigher levels of glycine are associated with healthy liver metabolism. Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanAssociations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose toleranceHigher levels of glycine are associated with healthy metabolism.Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanBiomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant PhenotypesHigher levels of glycine are associated with healthy metabolism.Deregulated nutrient sensing.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanNeuroprotective effects of glycine for therapy of acute ischaemic strokeGlycine helps to support brain health. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanBeneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged AdultsGlycine maintains healthy cognition in young and midle-aged people. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanGlycine metabolism in skeletal muscleGlycine supports healthy muscle function during physiological stress. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanDeficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementationGlycine infusions improve oxidative stress.Altered cellular communication.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineHumanTaking a supplement of glycine, a food additive, helps to prevent degenerative diseases such as arthrosis or osteoporosisGlycine supports healthy joints and bones. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalDietary Glycine Supplementation Extends Lifespan of Genetically Heterogeneous MiceMedian lifespan was increased in mice by 3.7% in females and 1.3% inmales, and the 90th percentile lifespan was increased by 1.8% in females and 3.6% in males.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalGlycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashionA 19% increase in lifespan in C elegans worms.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalEnhancing S-adenosyl-methionine catabolism extends Drosophila lifespanImproving glycine metabolism extends lifespan in Drosophila.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalGlycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed ratsGlycine promotes a healthy metabolism in rats. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalDietary glycine blunts lung inflammatory cell influx following acute endotoxinGlycine promotes a healthy inflammatory response in lungs in rats.Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalGlycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic ratsGlycine supports eye health in rats. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
GlycineAnimalDietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride ChannelGlycine improves joint health in rodents. Learn MoreGlycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Alpha-ketoglutarateHumanCalcium Alpha-Ketoglutarate Supplementation Reduces Epigenetic Age in HumansA small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. Epigenetic dysregulation.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanRejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation testA small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. Epigenetic dysregulation.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanα-ketoglutarate for myocardial protection in heart surgeryAlpha-ketoglutarate supports heart health during physiological stress.Mitochondrial dysfuction.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanAddition of α-Ketoglutarate to Blood Cardioplegia Improves CardioprotectionAlpha-ketoglutarate supports heart health during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanRenal Effects of a-Ketoglutarate Early After Coronary OperationsAlpha-ketoglutarate supports healthy kidney function during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanAlpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgeryAlpha-ketoglutarate suports healthy muscle function during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanAlpha-ketoglutarate and postoperative muscle catabolismAlpha-ketoglutarate suports healthy muscle function during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanPrevention of decrease of protein synthesis after total hip replacementAlpha-ketoglutarate suports healthy muscle function during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanBinding of phosphate in chronic hemodialysis patientsAlpha-ketoglutarate suports healthy kidney function during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanImprovement of arginine levels in malnourished hemodialsysis patientsAlpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanalpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolismAlpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanTreatment of hyperphosphataemia in haemodialysis patientsAlpha-ketoglutarate supports a healthy phosphate metabolism during physiological stress.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanTelopeptide of type I collagen in postmenopausal women with osteopeniaAlpha-ketoglutarate supports healthy bones. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateHumanAlfa ketoglutarate (AKG) inhibit osteoporoses development in postmenopausal womenAlpha-ketoglutarate supports healthy bones. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging miceLifespan and healthspan extension in mice. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging MiceLifespan and healthspan extension in mice. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalThe metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TORLifespan exention in C elegans by 50%.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK15% lifespan extension in Drosophila.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalEffects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies. Ukr Biochem J. 2018Females had 23% and 11% longer mean lifespan and 22% and 19% longer maximum lifespan on food supplemented with alpha-ketoglutarate compared to controls.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalDietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster)Diet with 10 mM AKG improved climbing activity in middle-aged flies.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalDietary alphaketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner. J Therm Biol. 2016Improves cold tolerance and antioxidant system capacity in Drosophila. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylationsAlpha-ketoglutarate rejuvenates mesenchymal stem cells and supports healthy aging of bones in mice. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-ketoglutarate stabilizes redox homeostasis and elasticity in aged miceAlpha-ketoglutarate supports healthy blood vessel elasticity in mice.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalHealthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly miceAlpha-ketoglutarate supports healthy blood vessel elasticity in elderly mice.Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalOral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese ratsAlpha-ketoglutarate supports healthy blood vessels and a healthy fat metoblism in obese rats. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarateAnimalAlpha-Ketoglutarate: Physiological Functions and ApplicationsReview article. Learn MoreAlpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Rhodiola roseaHumanThe effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trialsRhodiola rosea supports healthy cognition and normal energy levels. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaHumanRhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night dutyRhodiola rosea helps to maintain normal energy levels under stressful conditions. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaHumanEffects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary resultsRhodiola rosea promotes healthy muscle function during intensive exercise. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaHumanRhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical TrialRhodiola promotes healthy energy levels.Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalExtension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restrictionRhodiola rosea extends lifespan in fruit flies.Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalRhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalPlant adaptogens increase lifespan and stress resistance in C. elegansRhodiola rosea extends lifespan and improves stress resistance in C elegans worms. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalRhodiola: a promising anti-aging Chinese herbRhodiola rosea has anti-aging properties. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalThe golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiaeRhodiola rosea extends lifespan in yeast.Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalPretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective EffectsRhodiola rosea supports normal brain function during physiological stress in rats. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalProtective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the ratRhodiola rosea supports normal brain function during physiological stress in rats. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalDecreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola roseaRhodiola rosea supports normal brain function during physiological stress in fruit flies. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalSalidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in ratsSalidroside, a component in Rhodiola, supports healthy regeneration of nerves. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalSalidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivoSalidroside, a component in Rhodiola, supports healthy regeneration of nerves. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalRhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetesRhodiola supports healthy metabolism in rats Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalSalidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathwayReview/meta-analysis.Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola roseaAnimalRhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible MechanismsRhodiola promotes healthy cognition and memory in rodents. Learn MoreRhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
GlucosamineHumanTotal mortality risk in relation to use of less-common dietary supplements. Glucosamine is associated with reduced mortality in humans.Decreased mortality.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanUse of glucosamine and chondroitin in relation to mortality. Glucosamine is associated with reduced mortality in humans.Decreased mortality.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanAssociation of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK BiobankGlucosamine is associated with improved heart health in humans.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanGlucosamine/Chondroitin and Mortality in a US NHANES CohortGlucosamine is associated with improved heart health and reduced mortality in humans.Decreased mortality.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanOral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox StateGlucosamine promotes heart health. Altered intercellular communication.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanAssociation between use of specialty dietary supplements and C-reactive protein concentrations. American Journal of Epidemiology, 2012Glucosamine supports a healthy inflammatory status. Altered intercellular communication.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanAssociations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic InflammationGlucosamine supports a healthy inflammatory status. Altered intercellular communication.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanAssociations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle studyGlucosamine has been associated with healthy colon cell growth. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanUse of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up studyGlucosamine has been associated with healthy colon cell growth. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanUse of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohortGlucosamine has been associated with healthy lung cell growth. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineHumanEfficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical TrialGlucosamine improves skin health during aging. Altered intercellular communication.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineAnimalsD-Glucosamine supplementation extends life span of nematodes and of ageing mice10% lifespan extension in mice.Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineAnimalsGlucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction30% lifespan extension in C elegans. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineAnimalsGlucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasomeGlucosamine promotes a healthy anti-inflammatory response. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineAnimalsEffect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritisGlucosamine promotes a healthy anti-inflammatory response and supports healthy blood vessels. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
GlucosamineAnimalsDistinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: Evidence for a protective role for glucosamine in atherosclerosisGlucosamine helps to maintain healthy blood vessels. Learn MoreIn animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Vitamin CHumanImpact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of StayVitamin C supports a healthy recovery after trauma. Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CHumanVitamin C: An Epigenetic RegulatorVitamin C promotes a healthy epigenome. Epigenetic alterations.Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CHumanThe role of vitamin C in epigenetic regulationVitamin C promotes a healthy epigenome. Epigenetic alterations.Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CHumanAscorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-HydroxymethylcytosineVitamin C promotes a healthy epigenome and works synergistically with alpha-ketoglutarate. Epigenetic alterations.Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CHumanReprogramming the Epigenome With Vitamin CVitamin C promotes a healthy epigenome. Epigenetic alterations.Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CAnimalVitamin C and Lifespan in Model OrganismsVitamin C extends lifespan in C elegans. Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CAnimalVitamin C, Aging and Alzheimer’s DiseaseVitamin C has anti-aging effects. Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CAnimalAscorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory FunctionVitamin C supports healthy brain function in mice exposed to physiological stress. Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin CAnimalAscorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic ModulationVitamin C supports healthy regeneration of nerves in rodents. Learn MoreVitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
PterostilbeneHumanAnalysis of Safety from a Human Clinical Trial with PterostilbenePterostilbene is safe to take (based on hepatic, renal and glucose markers).Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneHumanPterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trialPterostilbene supports healthy blood pressure levels. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneHumanCombination of pterostilbene and nicotinamide riboside (NR) in ALSPterostilbene, in combination with an NAD-booster, supports healthy lung function and muscle function under physiological stress. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneHumanRepeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled studyPterostilbene, in combination with an NAD-booster, increases NAD+ levels in humans safely and sustainably.Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalBlueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegansPterostilbene increases lifespan in C elegans.Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalEffect of resveratrol and pterostilbene on aging and longevityReview article.Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalLow-dose Pterostilbene, but Not Resveratrol, Is a Potent Neuromodulator in Aging and Alzheimer's DiseasePterostilbene supports healthy brain aging in an accelerated-aging mice model. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo StudyPterostilbene supports healthy brain and cognitive function in aged rats. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalCerebroprotective effect of pterostilbene against global cerebral ischemia in ratsPterostilbene promotes healthy DNA stabilization and protects the brain against physiological stress in rats. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalOrally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in micePterostilbene supports normal brain function during physiological stress in rodents. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalCellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of AgingPterostilbene promotes normal brain function in aging rats. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathwayPterostilbene promotes healthy blood vessel function. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale modelPterostilbene supports heart health during physiological stress. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in ratsPterostilbene helps to maintain normal liver function during physiological stress in rats. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liverPterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic dietPterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese RatsPterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
PterostilbeneAnimalPterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2Pterostilbene helps to maintain a healthy glucose metabolism under physiological stress in rodents.Learn MorePterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
FisetinHumanEffect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patientsFisetin supports a healthy inflammatory response. Altered intercellular communicationLearn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinHumanFisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical TrialFisetin can support brain health under physiological stress.Altered intercellular communicationLearn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinHumanAt least 16 clinical trials with fisetin in humans are underway. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin is a senotherapeutic that extends health and lifespanLifespan extension in mice.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanLifespan extension in Saccharomyces cerevisiae by 55%.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouseLifespan extension.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalSirtuin activators mimic caloric restriction and delay ageing in metazoansLifespan extension.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalPreventing and Treating Neurological Disorders with the Flavonol FisetinFisetin can help to support normal brain function during aging.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS FunctionFisetin can help to support normal brain function during aging.Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo. Fisetin supports blood vessel health in mice. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalModulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic miceFisetin supports brain aging in mice. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetesFisetin supports a healthy metabolism in mice. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalEffects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementiaFisetin supports brain and vascular health in rodents. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalFisetin regulates obesity by targeting mTORC1 signalingFisetin promotes a healthy metabolism in mice fed a hig-fat diet. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalNeuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult MiceFisetin promotes healthy brain aging in mice. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
FisetinAnimalThe flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in miceFisetin helps to maintain normal brain function in rodents under physiological stress. Learn MoreFisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Micro-dosed LithiumHumanLithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trialsLithium is associated with reduced all-cause death in people with mood disorders. Decreased mortality.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanAssociation between lithium use and the incidence of dementia and its subtypes: A retrospective cohort studyLithium is associated with improved brain aging. Decreased mortality.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanLow-dose lithium uptake promotes longevity in humans and metazoansLow-dose lithium increases lifespan in C elegans and is associated with reduced mortality in humans.Decreased mortality.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanTrace lithium in Texas tap water is negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018Higher levels of lithium in tap water are associated with reduced mortality in humans. Decreased mortality.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanExamining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in TexasHigher levels of lithium in drinking water are associated with reduced mortality and improved metabolic health in humans. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanAssociation between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studiesHigher levels of lithium in drinking water are associated with healthier mood. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanLithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictionsHigher levels of lithium in the drinking water are associated with less crime stemming from drug addictions. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanLithium in drinking water and suicide prevention: The largest nationwide epidemiological study from Japan Higher levels of lithium in the drinking water are associated with a healthier mood. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanEffects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug usersMicrodosed lithium can support healthy mood. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanAssociation of Lithium in Drinking Water With the Incidence of DementiaHigher levels of lithium in the drinking water supports healthy brain aging. Improved proteostasisLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanDisease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trialLithium intake is associated with improved cognition and healthy brain aging. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanMicrodose lithium treatment stabilized cognitive impairment in patients with Alzheimer's diseaseMicrodosed lihium supports healthy brain aging. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanStandard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefitsLithium supports healthy brain aging. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanLithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-AnalysisLithium supports healthy brain aging. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanClinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trialLithium supports healthy brain aging. Improved proteostasisLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanInfluence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's diseaserLithium supports healthy brain aging. Altered intercellular communicationLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanIncrease of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease.Lithium supports healthy brain aging. Altered intercellular communicationLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanAlterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithiumLithium supports healthy brain aging. Telomere attritionLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanThe polygenic nature of telomere length and the anti-ageing properties of lithiumLithium supports healthy aging. Telomere attritionLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanDifferences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatmentLithium supports healthy aging. Telomere attritionLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanExpression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorderLithium supports healthy aging. Telomere attritionLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumHumanLeukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patientsLithium supports healthy aging. Telomere attritionLearn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalLow-dose lithium uptake promotes longevity in humans and metazoans36% lifespan extension in C elegans.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalLithium treatment and mechanisms of agingNature Review article on the role of lithium treatment in aging. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalPharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans46% lifespan increase in C elegans.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalEffects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans10% lifespan increase in C elegans.Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalLithium Promotes Longevity through GSK3/NRF2-Dependent HormesisLithium extends lifespan in Drosophila. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalPharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegansUp to 46% median increase of lifespan in C elegans, probably by improving epigenetic health. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalBeneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice modelLong-term microdosed lithium improves brain health in mice. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalChronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's DiseaseMicrodosed lithium improves brain health. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalChronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic deathMicrodosed lithium supports brain health under physiological stress. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalChronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse modelLithium helps to support proper protein metabolism in the brain in mice. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed LithiumAnimalNP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic RatsLithium helps to support proper protein metabolism in the brain in rats. Learn MoreVarious studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
GingerHumanMetanalysis: The effect of Ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysisGinger promotes a healthy anti-inflammatory response and healthy metabolism. Altered cellular communicationLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerHumanInvestigation of the effect of ginger on the lipid levels. A double blind controlled clinical trialGinger promotes a healthy cholesterol metabolism. Deregulated nutrient sensingLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerHumanEffect of ginger and fasting blood supar, HbA1c and lipids in diabetes patientsGinger helps to maintain a healthy glucose metabolism. Deregulated nutrient sensingLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerHumanThe effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med, 2014Ginger helps to maintain a healthy glucose metabolism. Deregulated nutrient sensingLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerHumanAnti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current EvidenceGinger reduces oxidative stress and supports a healthy anti-inflamamtory status. Altered cellular communicationLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerHumanEffects of a ginger extract on knee pain in patients with osteoarthritisGinger supports healthy joints. Altered cellular communicationLearn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerAnimalGinger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunctionLifespan extension in Drosophila.Learn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerAnimalZingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditionsLifespan extension in Drosophila.Learn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerAnimalInfluence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiationGinger strongly protects mice against lethal doses of radiation.Learn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerAnimalProtective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in RatsGinger can support healthy brain aging in rats.Learn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
GingerAnimalZingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune responseGinger can support a healthy inflammatory response in mice under physiological stress. Learn MoreGinger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Malate (as magnesium malate)HumanTreatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot studyMalate can support normal energy levels. Deregulated nutrient sensingLearn MoreMalate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health.
Malate (as magnesium malate)AnimalMalate and Fumarate Extend Lifespan in Caenorhabditis elegans14% increase in lifespan in C elegans. Learn MoreMalate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health.
Magnesium (as magnesium malate)HumanDietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studiesMagnesium promotes a healthy metabolism. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanLow serum magnesium concentrations predict cardiovascular and all-cause mortality.Magnesium promotes healthy cardiovascular function and reduces all cause mortality. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanMagnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young ManMagnesium supports healthy DNA. Genomic instabilityLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanAcute and chronic oral magnesium supplementation: effects on endothelial function, exercise capacity, and quality of life in patients with symptomatic heart failureMagnesium supports heart health. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanRole of magnesium in genomic stability.Magnesium supports healthy DNA. Altered cellular communicationLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanDietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. Magnesium conributes to a normal anti-inflammatory response. Deregulated nutrient sensingLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanOral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trialMagnesium supports a healthy glucose metabolism. Deregulated nutrient sensingLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanMagnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled StudyMagnesium supports a healthy glucose metabolism. Deregulated nutrient sensingLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanEffect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trialsMagnesium supports a healthy glucose metabolism. Mitochondrial dysfunctionLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanModern Nutrition in Health and Disease. Magnesium supports a healthy metabolism. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanMagnesium Role in Health and LongevityMagnesium supports a healthy metabolism. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanMagnesium for the prevention and treatment of cardiovascular diseaseLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)HumanDietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studiesLearn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)AnimalDietary magnesium supplementation improves lifespan in a mouse model of progeriaMagnesium extends lifespan in an accelerated aging mice model. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)AnimalMagnesium supplementation improves diabetic mitochondrial and cardiac diastolic functionMagnesium can help to maintain proper mitochondrial function. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)AnimalDietary magnesium supplementation improves lifespan in a mouse model of progeriaMagnesium can slow down aging in an accelerated aging mice model. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)AnimalDietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic ratsMagnesium can support blood vessel health. Learn MorePeople who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Hyaluronic acidHumanOral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week periodHyaluronic acid taken orally improves the appearance of wrinkles, skin luster and elasticity. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanIngestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical StudyOral hyaluronic acid improves the appearance of wrinkles, hydration of skin and elasticity. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanEffects of low molecular weight hyaluronic acid by oral intake to beautify skin: -Placebo-controlled double-blind comparative study-Oral hyaluronic acid improves skin moisture, elasticity and the appearance of wrinkles.Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanIngested hyaluronan moisturizes dry skinOral hyaluronic acid improves skin moisture.Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanOral hyaluronan relieves knee pain: a reviewOral hyaluronic acid supports healthy knee joints. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanOral hyaluronan for the treatment of knee osteoarthritis: A systematic reviewOral hyaluronic acid supports healthy knee joints. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidHumanOral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month periodOral hyaluronic acid supports healthy knee joints. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidAnimalHexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong LifeA component of hyaluronic acid (acetyl-glucosamine) extends lifespan in mice and C elegans.Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidAnimalLow-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathwayLow-molecular-weight hyaluronan can cross the gut lining and is absorbed into the bloodstream.Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acidAnimalAbsorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogsOral hyaluronic acid is systemically absorbed. Learn MoreHyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
L-theanineHumanTheanine consumption, stress and anxiety in human clinical trials: A systematic reviewTheanine contributes to a healthy response to stress. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineHumanEffects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 2019Theanine contributes to a healthy response to stress. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineHumanTheanine reduces psychological and physiological stress responsesTheanine contributes to a healthy response to stress. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineHumanSalivary cortisol and alpha-amylase responses to repeated bouts of downhill runningTheanine contributes to a healthy response to stress. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineHumanAcute effects of theanine, caffeine and theanine-caffeine combination on attention.Theanine supports healthy cognition. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineHumanAcute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysisTheanine supports healthy cognition. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimall-Theanine extends lifespan of adult Caenorhabditis elegansL-theanine extends lifespan in C elegans. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalTheanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in miceL-theanine extends lifespan in mice under stressful conditions. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalL-Theanine attenuates liver aging by inhibiting advanced glycation end products in D-galactose-induced rats and reversing an imbalance of oxidative stress and inflammationL-theanine improves liver aging during physiological stress in aging rats. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalPrevention of brain aging by green tea components: Role of catechins and theanineL-theanine supports healthy brain aging. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimall-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathwaysL-teanine supports healthy brain aging. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalSelective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain WellnessL-theanine supports brain stem cell health and proper neurogenesis. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalDaily oral intake of L-theanine prevents the decline of 5-bromo-20 -deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress L-theanine supports brain health under physiological stress in mice. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalFacilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memoryL-theanine improves healthy cognitive development and neurogenesis in young ice. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalL-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro StudyL-theanine supports joint health. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanineAnimalModulation of irinotecan-induced genomic DNA damage by theanineL-theanine helps to protect DNA against damage in mice. Learn MoreTheanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
Nicotinamide mononucleotide (NMN)HumanEffect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese menNMN given to humans is safe. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenNMN promotes a healthy glucose metabolism. Deregulated nutrient sensingLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanChronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old menNMN promotes healthy muscles in old men. Mitochondrial dysfunctionLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanNicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind studyNMN supports exercise endurance. Deregulated nutrient sensingLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanNAD⁺ metabolism: a therapeutic target for age-related metabolic diseaseDuring aging, NAD+ levels decline.Deregulated nutrient sensingLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanAge-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE 7, e42357 (2012).During aging, NAD+ levels decline.Deregulated nutrient sensingLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)HumanIn vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl Acad. Sci. USA 112, 2876–2881 (2015).During aging, NAD+ levels decline.Deregulated nutrient sensingLearn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice NMN supports healthy brain aging and blood vessels in mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effectsNMN promotes neurvascular rejuvenation in aged mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in miceNMN promotes rejuvenation of the blood vessels in aging mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effectsNMN promotes blood vessel health in aging mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalImpairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular agingNMN promotes blood vessel health in aging mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalDeclining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during agingNMN supports healthy mitochondrial function in mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrowNMN promotes mesenchymal stem cell health in aging mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in MiceNMN supports a healthy glucose metabolism. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNAD+ controls neural stem cell fate in the aging brainNMN supports healthy brain aging in rodents. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)AnimalNAD+ Repletion Rescues Female Fertility during Reproductive AgingNMN can support proper fertility and egg cell function in aging mice. Learn MoreIn humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.

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