NOVOS is rooted in science, supported by studies validating its patent-pending formulations and ingredients

Table of Contents
Click below to navigate directly to a specific section.
NOVOS Studies | direct studies done on NOVOS
General Studies | 190+ ingredient studies
Bonus Resources | PDF and other overviews
Note: for an overview of the 10 principles that make up our unique approach to longevity formulations click here.
Scientific studies done on NOVOS Formulations
Study 1: NOVOS Core improves skin suppleness in humans
Participants who took NOVOS Core for 6 months all showed improvements in skin firmness as measured by an indentometer.
An indentometer is a device that measures skin suppleness and firmness.
Besides these objective measurements, participants also mentioned noticeable improvements in their skin, such as improved elasticity, smoothness, and firmness.
Results
The study was a small pilot study, done in 4 patients. The device used to test is a state-of-the-art device used for scientific studies.

NOVOS users saw a minimum improvement of 12%, max of 40% and an average of 22% in skin firmness.
NOVOS is planning to conduct an additional and more extensive dermatological study with more participants.
Ingredients improving skin health
These results on skin health are not that surprising given NOVOS Core contains various longevity ingredients that are also known to improve skin health, such hyaluronic acid, alpha ketoglutarate, glycine, vitamin C, and glucosamine.
Oral hyaluronic acid improves skin health and reduces wrinkles. Hyaluronic acid is a component of the extracellular matrix, the “glue” that keeps skin cells sticking together.
Alpha ketoglutarate improves skin stem cell health, and plays a role in collagen production. Alpha ketoglutarate also works together with vitamin C, given vitamin C also improves collagen production. Additionally, alpha ketoglutarate and vitamin C both work synergistically to improve the epigenome, including that of skin cells. Alpha ketoglutarate can also extend lifespan.
Glucosamine is a component of the extracellular matrix, and glycine is an important building block of collagen.
These are some examples of how ingredients in NOVOS can improve skin health.
Not just addressing signs of aging, but the underlying causes
What is even more important is that all these ingredients inhibit fundamental aging mechanisms and have shown to extend lifespan in various species.
In other words, NOVOS Core is the only skin supplement that actually addresses the root causes of aging, including skin aging.
Study 2: NOVOS Core significantly reduces DNA damage in human cells after irradiation
A study found that a combination of the 12 ingredients in NOVOS Core and the nicotinamide mononucleotide (NMN) in NOVOS Boost significantly protects cells against DNA damage over a wide dose range.
The study was done by Ichor Life Sciences, an independent third-party US-based lab specialized in DNA damage, cellular senescence, and aging.
In the study, HUVEC cells (human umbilical vein endothelial cells) were treated with the 13-ingredient NOVOS formulation and then irradiated. Irradiation typically causes pronounced DNA damage. However, the cells exposed to NOVOS before irradiation had significantly less DNA damage after being exposed to radiation, as measured via 8-hydroxy-2′-deoxyguanosine (8-OHdG or 8-oxodG) levels. 8-OHdG is a measure of oxidative DNA damage. When DNA gets damaged, 8-OHdG is formed.
Treating cells with NOVOS was able to reduce DNA damage as measured by 8-OHdG by up to 77% and on average 68% compared to controls:

Researchers demonstrated that the NOVOS formulation protects against DNA damage over a wide range of doses, an effect mediated by DNA protective effects of multiple NOVOS ingredients at different doses and synergy between ingredients.
Study 3: NOVOS ingredients demonstrate synergistic senostatic effects on senescent human cells
This study was conducted at the Ageing Research Laboratories at Newcastle University (UK), specialized in cellular senescence and aging. The study was done under the guidance of Professor Von Zglinicki, Professor for Cell Gerontology.
The study found that the combination of multiple NOVOS ingredients could help the body better deal with senescent cells.
Senescent cells occur during aging and play an important role in the aging process. These cells accumulate various forms of damage, including DNA and epigenetic damage, and secrete substances that harm healthy surrounding cells.
Research has shown that countering senescent cells using senostatic drugs (which suppress senescent cells) can support the body to deal better with aging. In the study, researchers using cell size as marker for the senescent phenotype found that specific NOVOS ingredients had a senostatic effect, while not impacting normal, non-senescent cells:

A senostatic effect comprising a reduction in senescent cell size has also been observed with rapamycin, a prescription drug associated with increased longevity in multiple animal models:

Normal non-senescent cells were not impacted by the NOVOS formulation, demonstrating that specific NOVOS ingredients used in a synergistic combination can impact senescent cells while not impacting healthy cells — a common pitfall of “senolytic” molecules which seek to destroy senescent cells.
190+ Studies Supporting NOVOS Selection of Ingredients
Click on an ingredient name to get a non-exhaustive list of representative scientific studies:
- Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018
- Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse. J Gerontol A Biol Sci Med Sci, 2018
- Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function. Front Biosci, 2015
- The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. Int J Mol Sci, 2019
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature, 2003
- How fisetin reduces the impact of age and disease on CNS function. Front Biosci, 2015
- Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo. Inflammation Research, 2014
- Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One, 2011
- Fisetin regulates obesity by targeting mTORC1 signaling. The Journal of nutritional biochemistry, 2013
- -Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell, 2020
- The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR. Nature, 2014
- Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK. Aging, 2019
- Alpha-ketoglutarate stabilizes redox homeostasis and elasticity in aged mice. J Physiol Pharmacol. 2011
- Effects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies. Ukr Biochem J, 2018
- Dietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster. Biologia, 2017
- Dietary alphaketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner. J Therm Biol, 2016
- Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process. Cell Signal, 2014
- Anti-osteopenic effect of alpha-ketoglutarate. Journal of Bone and Mineral Metabolism, 2012
- Alfa ketoglutarate (AKG) inhibit osteoporoses development in postmenopausal women. Journal of Bone and Mineral Research, 2003
- Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice. Journal of Pre-clin and Clin research, 2009
- Addition of α-ketoglutarate to blood cardioplegia improves cardioprotection. The Annals of Thoracic Surgery, 1997
- α-ketoglutarate for myocardial protection in heart surgery. The Lancet, 1995
- Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Therap, 2016
- D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Nature Communications, 2014
- Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction. Journal of Applied Glycoscience, 2018
- Total mortality risk in relation to use of less-common dietary supplements. The American Journal of Clinical Nutrition, 2010
- Use of glucosamine and chondroitin in relation to mortality. European journal of epidemiology, 2012
- Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. British Medical Journal, 2019
- Association between use of specialty dietary supplements and C-reactive protein concentrations. American Journal of Epidemiology, 2012
- New functions of glucosamine as a scavenger of the lipid peroxidation product malondialdehyde. Chem Res Toxicol, 2007
- Glucosamine induces autophagy via an mTOR-independent pathway. Biochem Biophysic Research Comm, 2010
- Assessment of protective effects of glucosamine and N-acetyl glucosamine against DNA damage induced by hydrogen peroxide in human lymphocytes. Drug Chem Toxicol, 2014
- Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study. Cancer Epidemiol Biomarkers Prev, 2009
- Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury. Am J Physiol Heart Circ Physiol, 2008
- Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: evidence for a protective role for glucosamine in atherosclerosis. Cardiovasc Diabetol, 2005
- Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis. Am J Physiol Heart Circ, 2009
- Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartil, 2003
- Low-dose lithium uptake promotes longevity in humans and metazoans. Eur J Nutr, 2011
- Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018
- Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem, 2009
- Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis Cell Rep, 2016
- Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease. Curr Alzheimer Res, 2013
- Association of Lithium in Drinking Water With the Incidence of Dementia. JAMA Psychiatry, 2017
- Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. The Journals of Gerontology, 2014
- Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry, 2011
- Lithium treatment and risk for dementia in adults with bipolar disorder: population-based cohort study. Br J Psychiatry, 2015
- Is lithium a neuroprotective agent? Ann Clin Psychiatry, 2015
- Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease. Curr Alzheimer Res, 2013
- Chronic Treatment With a Low Dose of Lithium Protects the Brain Against Ischemic Injury by Reducing Apoptotic Death. Stroke, 2003
- Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. Journal of Alzheimer’s disease, 2003
- Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits. Aust N Z J Psychiatry, 2014
- Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders. ACS Chem Neurosci, 2014
- Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer’s disease. Current Alzheimer Research, 2011
- Lithium-induced neuroprotection is associated with epigenetic modification of specific BDNF gene promoter and altered expression of apoptotic-regulatory proteins. Front Neurosci, 2015
- A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts. Neuropsychiatr Dis Treat, 2016
- Glycine supplementation extends lifespan of male and female mice. Aging Cell, 2019
- Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats, FASEB, 2011
- Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PloS Genet, 2019
- Glycine treatment decreases proinflammatory cytokines and increases interferon‐gamma in patients with type 2 diabetes. Journal of Endocrinological Investigation, 2008.
- Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. Nature Communications, 2015
- Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris. J Am Heart Assoc, 2016
- Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integ Comp Physiol, 2004
- The metabolic response to ingested glycine. Am J Clin Nutr, 2002
- Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab, 2017
- Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology, 2019
- Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell, 2016
- Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging. Cell, 2018
- Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. Geroscience, 2019
- NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell, 2020
- NAD+ supplementation rejuvenates aged gut adult stem cells. Aging Cell, 2019
- NAD+ controls neural stem cell fate in the aging brain. EBJornal, 2014
- Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging. Cell, 2018
- Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death & Disease, 2019
- Effect of resveratrol and pterostilbene on aging and longevity. Biofactors, 2018
- Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging. Journ of Agricult Food Chemistry, 2008
- Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Phys & Biochem, 2019
- Low-dose Pterostilbene, but Not Resveratrol, Is a Potent Neuromodulator in Aging and Alzheimer’s Disease. Neurbiol Aging, 2012
- Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene. J Food Drug Anal, 2017
- Effects of pterostilbene and resveratrol on brain and behavior. Neurochem Int, 2015
- Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model. Br J Pharmacol, 2017
- Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway. Brain Research, 2016
- Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective. Journal of Functional Foods, 2014
- Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2. Chem Res Toxicol, 2016
- Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo. Apoptosis, 2012
- Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells. The Journal of nutritional biochemistry, 2013
- Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. Journal of agricultural and food chemistry, 2008
- Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Journal of agricultural and food chemistry. J Agric Food Chem, 2002
- Pterostilbene and cancer: current review. J Surg Res, 2012
- Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling. Int Immunopharmacol, 2017
- Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence. Eur J Pharmacol, 2016
- In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis. Neuro Endocrinology Letters, 2009
- L-Theanine extends lifespan of adult Caenorhabditis elegans. Eur J Nutr, 2012
- L-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. Experimental Gerontology, 2020
- Prevention of brain aging by green tea components: Role of catechins and theanine. Journ of Physic Fitness, 2016
- l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. Free Radic Biol Med, 2009
- Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness. Molecules, 2020
- Daily oral intake of L-theanine prevents the decline of 5-bromo-20 -deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress. J. Pharmacol. Sci, 2015
- Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell Mol Neurobiol, 2011
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 2019
- Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology, 2008
- Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life. Cell, 2014
- Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol, 2017
- Ingested hyaluronan moisturizes dry skin. Nutr J, 2014
- Oral hyaluronan relieves knee pain: a review. Nutr J, 2016
- Oral hyaluronan for the treatment of knee osteoarthritis: a systematic review. Progress in Nutrition, 2018
- Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. Scient Wo Journ, 2012
- Vitamin C: An Epigenetic Regulator. Vitamin C – an Update on Current Uses and Functions, 2019
- Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation. Cells, 2020
- An epigenetic role for ascorbic acid in neurodegenerative diseases. CNS Neurosci Ther, 2018
- Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nature Genetics, 2012
- Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. J Am Chem Soc, 2013
- Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation. Cell Reports, 2020
- Upregulation of TET Activity with Ascorbic Acid Induces Epigenetic Modulation of Lymphoma Cells. Clinic Lymph, Myel and Leukem, 2017
- Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma. Oncology, 2019
- Understanding and targeting epigenetic dysregulation, aberrant metabolism, and immune evasion in cancer with ascorbic acid. Doctoral thesis Niraj Shenoy, 2020
- Ascorbic Acid as an Epigenetic Therapy for Osteosarcoma. Stanford University thesis Shin Mei Chan, 2018
- The role of vitamin C in epigenetic regulation. Adv Hyg and Exper Medicine, 2017
- Breathing-in epigenetic change with vitamin C. EMBO Rep, 2013
- The role of α-ketoglutarate-dependent proteins in pluripotency acquisition and maintenance. J Biol CHem, 2019
- Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Arch Immun Therap Exper, 2016
- Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function. Nutrients, 2019
- Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS One, 2013
- Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. 2009
- The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae. Phytomedicine, 2011
- Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res, 2007
- Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport, 2013
- Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo. Nature, 2017
- Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects. Biom & Environ Scien, 2009
- Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat. PLoS ONE, 2012
- Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res, 2009
- Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Front Pharmacol, 2018
- Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness, 2010
- The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine, 2011
- Rhodiola Rosea In Stress Induced Fatigue–a Double Blind Cross-over Study Of A Standardized Extract SHR-5 With A Repeated Low-dose Regimen On The Mental Performance Of Healthy Physicians During Night Duty. Phytomedicine, 2000
- Malate and Fumarate Extend Lifespan in Caenorhabditis elegans. PloS, 2013
- Magnesium Role in Health and Longevity. Trace Elements and Minerals in Health and Longevity. Healthy Ageing and Longevity, vol 8. Springer, 2018
- Role of magnesium in genomic stability. Mutat Res, 2001
- Association of dietary magnesium and DNA repair capacity with lung cancer risk. Cancer Epid. & Biomarkers & Prevention, 2006
- Dietary magnesium supplementation improves lifespan in a mouse model of progeria. EMBO Mol Med, 2020
- Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction. Journal of Funct Foods, 2018
- Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions. Frontiers in biology, 2018
- Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res, 2003
- Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J, 2008
- The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis. Food Nutr Res, 2016
- Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. Int J Prev Med, 2013
- Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum, 2001
- Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response. Pharm Biol, 2015
- The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. Int J Endocrinol Metab, 2017
- The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med, 2014
- Protective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in Rats. Rejuven Research, 2012
You can download a brief description of our ingredients and their health effects below:
Table overview of scientific studies for NOVOS ingredients
Ingredient | Study Type | Study Link | Outcome (FDA Conform) | Hallmark | Learn More | Summary |
---|---|---|---|---|---|---|
Glycine | Human | Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetes | Supports a healthy anti-inflammatory status and promotes a healthy glucose metabolism. | Altered cellular communication. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | D-Glucosamine supplementation extends life span of nematodes and of ageing mice | Increase in lifespan (6% increase in males and 4% in female mice). | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | The metabolic response to ingested glycine | Glycine supports healthy levels of glucose. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Animal | Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats | Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats. | Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris | Higher levels of glycine are associated with improved heart health. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis | Higher levels of glycine are associated with healthy glucose metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance | Higher levels of glycine are associated with healthy liver metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance | Higher levels of glycine are associated with healthy metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes | Higher levels of glycine are associated with healthy metabolism. | Deregulated nutrient sensing. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Neuroprotective effects of glycine for therapy of acute ischaemic stroke | Glycine helps to support brain health. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults | Glycine maintains healthy cognition in young and midle-aged people. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Glycine metabolism in skeletal muscle | Glycine supports healthy muscle function during physiological stress. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Human | Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation | Glycine infusions improve oxidative stress. | Altered cellular communication. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. |
Glycine | Human | Taking a supplement of glycine, a food additive, helps to prevent degenerative diseases such as arthrosis or osteoporosis | Glycine supports healthy joints and bones. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary Glycine Supplementation Extends Lifespan of Genetically Heterogeneous Mice | Median lifespan was increased in mice by 3.7% in females and 1.3% inmales, and the 90th percentile lifespan was increased by 1.8% in females and 3.6% in males. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion | A 19% increase in lifespan in C elegans worms. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan | Improving glycine metabolism extends lifespan in Drosophila. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats | Glycine promotes a healthy metabolism in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary glycine blunts lung inflammatory cell influx following acute endotoxin | Glycine promotes a healthy inflammatory response in lungs in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats | Glycine supports eye health in rats. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Glycine | Animal | Dietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride Channel | Glycine improves joint health in rodents. | Learn More | Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism. | |
Alpha-ketoglutarate | Human | Calcium Alpha-Ketoglutarate Supplementation Reduces Epigenetic Age in Humans | A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. | Epigenetic dysregulation. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test | A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation. | Epigenetic dysregulation. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | α-ketoglutarate for myocardial protection in heart surgery | Alpha-ketoglutarate supports heart health during physiological stress. | Mitochondrial dysfuction. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. |
Alpha-ketoglutarate | Human | Addition of α-Ketoglutarate to Blood Cardioplegia Improves Cardioprotection | Alpha-ketoglutarate supports heart health during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Renal Effects of a-Ketoglutarate Early After Coronary Operations | Alpha-ketoglutarate supports healthy kidney function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alpha-ketoglutarate and postoperative muscle catabolism | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Prevention of decrease of protein synthesis after total hip replacement | Alpha-ketoglutarate suports healthy muscle function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Binding of phosphate in chronic hemodialysis patients | Alpha-ketoglutarate suports healthy kidney function during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Improvement of arginine levels in malnourished hemodialsysis patients | Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | alpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolism | Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Treatment of hyperphosphataemia in haemodialysis patients | Alpha-ketoglutarate supports a healthy phosphate metabolism during physiological stress. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Telopeptide of type I collagen in postmenopausal women with osteopenia | Alpha-ketoglutarate supports healthy bones. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Human | Alfa ketoglutarate (AKG) inhibit osteoporoses development in postmenopausal women | Alpha-ketoglutarate supports healthy bones. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice | Lifespan and healthspan extension in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice | Lifespan and healthspan extension in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR | Lifespan exention in C elegans by 50%. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK | 15% lifespan extension in Drosophila. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Effects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies. Ukr Biochem J. 2018 | Females had 23% and 11% longer mean lifespan and 22% and 19% longer maximum lifespan on food supplemented with alpha-ketoglutarate compared to controls. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Dietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster) | Diet with 10 mM AKG improved climbing activity in middle-aged flies. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Dietary alphaketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner. J Therm Biol. 2016 | Improves cold tolerance and antioxidant system capacity in Drosophila. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations | Alpha-ketoglutarate rejuvenates mesenchymal stem cells and supports healthy aging of bones in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-ketoglutarate stabilizes redox homeostasis and elasticity in aged mice | Alpha-ketoglutarate supports healthy blood vessel elasticity in mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice | Alpha-ketoglutarate supports healthy blood vessel elasticity in elderly mice. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats | Alpha-ketoglutarate supports healthy blood vessels and a healthy fat metoblism in obese rats. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Alpha-ketoglutarate | Animal | Alpha-Ketoglutarate: Physiological Functions and Applications | Review article. | Learn More | Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age. | |
Rhodiola rosea | Human | The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials | Rhodiola rosea supports healthy cognition and normal energy levels. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty | Rhodiola rosea helps to maintain normal energy levels under stressful conditions. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results | Rhodiola rosea promotes healthy muscle function during intensive exercise. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Human | Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial | Rhodiola promotes healthy energy levels. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction | Rhodiola rosea extends lifespan in fruit flies. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1 | Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Plant adaptogens increase lifespan and stress resistance in C. elegans | Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola: a promising anti-aging Chinese herb | Rhodiola rosea has anti-aging properties. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae | Rhodiola rosea extends lifespan in yeast. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects | Rhodiola rosea supports normal brain function during physiological stress in rats. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat | Rhodiola rosea supports normal brain function during physiological stress in rats. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea | Rhodiola rosea supports normal brain function during physiological stress in fruit flies. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats | Salidroside, a component in Rhodiola, supports healthy regeneration of nerves. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo | Salidroside, a component in Rhodiola, supports healthy regeneration of nerves. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes | Rhodiola supports healthy metabolism in rats | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway | Review/meta-analysis. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Rhodiola rosea | Animal | Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms | Rhodiola promotes healthy cognition and memory in rodents. | Learn More | Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration. | |
Glucosamine | Human | Total mortality risk in relation to use of less-common dietary supplements. | Glucosamine is associated with reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Use of glucosamine and chondroitin in relation to mortality. | Glucosamine is associated with reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank | Glucosamine is associated with improved heart health in humans. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Glucosamine/Chondroitin and Mortality in a US NHANES Cohort | Glucosamine is associated with improved heart health and reduced mortality in humans. | Decreased mortality. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Oral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox State | Glucosamine promotes heart health. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Association between use of specialty dietary supplements and C-reactive protein concentrations. American Journal of Epidemiology, 2012 | Glucosamine supports a healthy inflammatory status. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation | Glucosamine supports a healthy inflammatory status. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Human | Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study | Glucosamine has been associated with healthy colon cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study | Glucosamine has been associated with healthy colon cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort | Glucosamine has been associated with healthy lung cell growth. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Human | Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial | Glucosamine improves skin health during aging. | Altered intercellular communication. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. |
Glucosamine | Animals | D-Glucosamine supplementation extends life span of nematodes and of ageing mice | 10% lifespan extension in mice. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction | 30% lifespan extension in C elegans. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome | Glucosamine promotes a healthy anti-inflammatory response. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis | Glucosamine promotes a healthy anti-inflammatory response and supports healthy blood vessels. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Glucosamine | Animals | Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: Evidence for a protective role for glucosamine in atherosclerosis | Glucosamine helps to maintain healthy blood vessels. | Learn More | In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy. | |
Vitamin C | Human | Impact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of Stay | Vitamin C supports a healthy recovery after trauma. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Human | Vitamin C: An Epigenetic Regulator | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | The role of vitamin C in epigenetic regulation | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine | Vitamin C promotes a healthy epigenome and works synergistically with alpha-ketoglutarate. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Human | Reprogramming the Epigenome With Vitamin C | Vitamin C promotes a healthy epigenome. | Epigenetic alterations. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. |
Vitamin C | Animal | Vitamin C and Lifespan in Model Organisms | Vitamin C extends lifespan in C elegans. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Vitamin C, Aging and Alzheimer’s Disease | Vitamin C has anti-aging effects. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function | Vitamin C supports healthy brain function in mice exposed to physiological stress. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Vitamin C | Animal | Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation | Vitamin C supports healthy regeneration of nerves in rodents. | Learn More | Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth. | |
Pterostilbene | Human | Analysis of Safety from a Human Clinical Trial with Pterostilbene | Pterostilbene is safe to take (based on hepatic, renal and glucose markers). | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial | Pterostilbene supports healthy blood pressure levels. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Combination of pterostilbene and nicotinamide riboside (NR) in ALS | Pterostilbene, in combination with an NAD-booster, supports healthy lung function and muscle function under physiological stress. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Human | Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study | Pterostilbene, in combination with an NAD-booster, increases NAD+ levels in humans safely and sustainably. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans | Pterostilbene increases lifespan in C elegans. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Effect of resveratrol and pterostilbene on aging and longevity | Review article. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Low-dose Pterostilbene, but Not Resveratrol, Is a Potent Neuromodulator in Aging and Alzheimer's Disease | Pterostilbene supports healthy brain aging in an accelerated-aging mice model. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study | Pterostilbene supports healthy brain and cognitive function in aged rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats | Pterostilbene promotes healthy DNA stabilization and protects the brain against physiological stress in rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice | Pterostilbene supports normal brain function during physiological stress in rodents. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging | Pterostilbene promotes normal brain function in aging rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway | Pterostilbene promotes healthy blood vessel function. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model | Pterostilbene supports heart health during physiological stress. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats | Pterostilbene helps to maintain normal liver function during physiological stress in rats. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats | Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Pterostilbene | Animal | Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2 | Pterostilbene helps to maintain a healthy glucose metabolism under physiological stress in rodents. | Learn More | Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function. | |
Fisetin | Human | Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients | Fisetin supports a healthy inflammatory response. | Altered intercellular communication | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Fisetin | Human | Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial | Fisetin can support brain health under physiological stress. | Altered intercellular communication | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. |
Fisetin | Human | At least 16 clinical trials with fisetin in humans are underway. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | ||
Fisetin | Animal | Fisetin is a senotherapeutic that extends health and lifespan | Lifespan extension in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Lifespan extension in Saccharomyces cerevisiae by 55%. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse | Lifespan extension. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Sirtuin activators mimic caloric restriction and delay ageing in metazoans | Lifespan extension. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Preventing and Treating Neurological Disorders with the Flavonol Fisetin | Fisetin can help to support normal brain function during aging. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function | Fisetin can help to support normal brain function during aging. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo. | Fisetin supports blood vessel health in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice | Fisetin supports brain aging in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes | Fisetin supports a healthy metabolism in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia | Fisetin supports brain and vascular health in rodents. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Fisetin regulates obesity by targeting mTORC1 signaling | Fisetin promotes a healthy metabolism in mice fed a hig-fat diet. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice | Fisetin promotes healthy brain aging in mice. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Fisetin | Animal | The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice | Fisetin helps to maintain normal brain function in rodents under physiological stress. | Learn More | Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age. | |
Micro-dosed Lithium | Human | Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials | Lithium is associated with reduced all-cause death in people with mood disorders. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study | Lithium is associated with improved brain aging. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Low-dose lithium uptake promotes longevity in humans and metazoans | Low-dose lithium increases lifespan in C elegans and is associated with reduced mortality in humans. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018 | Higher levels of lithium in tap water are associated with reduced mortality in humans. | Decreased mortality. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in Texas | Higher levels of lithium in drinking water are associated with reduced mortality and improved metabolic health in humans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies | Higher levels of lithium in drinking water are associated with healthier mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions | Higher levels of lithium in the drinking water are associated with less crime stemming from drug addictions. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium in drinking water and suicide prevention: The largest nationwide epidemiological study from Japan | Higher levels of lithium in the drinking water are associated with a healthier mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users | Microdosed lithium can support healthy mood. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Association of Lithium in Drinking Water With the Incidence of Dementia | Higher levels of lithium in the drinking water supports healthy brain aging. | Improved proteostasis | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial | Lithium intake is associated with improved cognition and healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease | Microdosed lihium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits | Lithium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis | Lithium supports healthy brain aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Human | Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial | Lithium supports healthy brain aging. | Improved proteostasis | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's diseaser | Lithium supports healthy brain aging. | Altered intercellular communication | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Increase of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease. | Lithium supports healthy brain aging. | Altered intercellular communication | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium | Lithium supports healthy brain aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | The polygenic nature of telomere length and the anti-ageing properties of lithium | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Human | Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients | Lithium supports healthy aging. | Telomere attrition | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. |
Micro-dosed Lithium | Animal | Low-dose lithium uptake promotes longevity in humans and metazoans | 36% lifespan extension in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Lithium treatment and mechanisms of aging | Nature Review article on the role of lithium treatment in aging. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans | 46% lifespan increase in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans | 10% lifespan increase in C elegans. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis | Lithium extends lifespan in Drosophila. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans | Up to 46% median increase of lifespan in C elegans, probably by improving epigenetic health. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model | Long-term microdosed lithium improves brain health in mice. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease | Microdosed lithium improves brain health. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death | Microdosed lithium supports brain health under physiological stress. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model | Lithium helps to support proper protein metabolism in the brain in mice. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Micro-dosed Lithium | Animal | NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats | Lithium helps to support proper protein metabolism in the brain in rats. | Learn More | Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth. | |
Ginger | Human | Metanalysis: The effect of Ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis | Ginger promotes a healthy anti-inflammatory response and healthy metabolism. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial | Ginger promotes a healthy cholesterol metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effect of ginger and fasting blood supar, HbA1c and lipids in diabetes patients | Ginger helps to maintain a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med, 2014 | Ginger helps to maintain a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence | Ginger reduces oxidative stress and supports a healthy anti-inflamamtory status. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Human | Effects of a ginger extract on knee pain in patients with osteoarthritis | Ginger supports healthy joints. | Altered cellular communication | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. |
Ginger | Animal | Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction | Lifespan extension in Drosophila. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions | Lifespan extension in Drosophila. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation | Ginger strongly protects mice against lethal doses of radiation. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Protective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in Rats | Ginger can support healthy brain aging in rats. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Ginger | Animal | Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response | Ginger can support a healthy inflammatory response in mice under physiological stress. | Learn More | Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age. | |
Malate (as magnesium malate) | Human | Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study | Malate can support normal energy levels. | Deregulated nutrient sensing | Learn More | Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health. |
Malate (as magnesium malate) | Animal | Malate and Fumarate Extend Lifespan in Caenorhabditis elegans | 14% increase in lifespan in C elegans. | Learn More | Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health. | |
Magnesium (as magnesium malate) | Human | Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies | Magnesium promotes a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Low serum magnesium concentrations predict cardiovascular and all-cause mortality. | Magnesium promotes healthy cardiovascular function and reduces all cause mortality. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man | Magnesium supports healthy DNA. | Genomic instability | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Acute and chronic oral magnesium supplementation: effects on endothelial function, exercise capacity, and quality of life in patients with symptomatic heart failure | Magnesium supports heart health. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Role of magnesium in genomic stability. | Magnesium supports healthy DNA. | Altered cellular communication | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. | Magnesium conributes to a normal anti-inflammatory response. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial | Magnesium supports a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study | Magnesium supports a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials | Magnesium supports a healthy glucose metabolism. | Mitochondrial dysfunction | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. |
Magnesium (as magnesium malate) | Human | Modern Nutrition in Health and Disease. | Magnesium supports a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium Role in Health and Longevity | Magnesium supports a healthy metabolism. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Human | Magnesium for the prevention and treatment of cardiovascular disease | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | ||
Magnesium (as magnesium malate) | Human | Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | ||
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation improves lifespan in a mouse model of progeria | Magnesium extends lifespan in an accelerated aging mice model. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function | Magnesium can help to maintain proper mitochondrial function. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation improves lifespan in a mouse model of progeria | Magnesium can slow down aging in an accelerated aging mice model. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Magnesium (as magnesium malate) | Animal | Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats | Magnesium can support blood vessel health. | Learn More | People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age. | |
Hyaluronic acid | Human | Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period | Hyaluronic acid taken orally improves the appearance of wrinkles, skin luster and elasticity. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study | Oral hyaluronic acid improves the appearance of wrinkles, hydration of skin and elasticity. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Effects of low molecular weight hyaluronic acid by oral intake to beautify skin: -Placebo-controlled double-blind comparative study- | Oral hyaluronic acid improves skin moisture, elasticity and the appearance of wrinkles. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Ingested hyaluronan moisturizes dry skin | Oral hyaluronic acid improves skin moisture. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral hyaluronan relieves knee pain: a review | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral hyaluronan for the treatment of knee osteoarthritis: A systematic review | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Human | Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period | Oral hyaluronic acid supports healthy knee joints. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life | A component of hyaluronic acid (acetyl-glucosamine) extends lifespan in mice and C elegans. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway | Low-molecular-weight hyaluronan can cross the gut lining and is absorbed into the bloodstream. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
Hyaluronic acid | Animal | Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs | Oral hyaluronic acid is systemically absorbed. | Learn More | Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age. | |
L-theanine | Human | Theanine consumption, stress and anxiety in human clinical trials: A systematic review | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 2019 | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Theanine reduces psychological and physiological stress responses | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Salivary cortisol and alpha-amylase responses to repeated bouts of downhill running | Theanine contributes to a healthy response to stress. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Acute effects of theanine, caffeine and theanine-caffeine combination on attention. | Theanine supports healthy cognition. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Human | Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis | Theanine supports healthy cognition. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | l-Theanine extends lifespan of adult Caenorhabditis elegans | L-theanine extends lifespan in C elegans. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice | L-theanine extends lifespan in mice under stressful conditions. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | L-Theanine attenuates liver aging by inhibiting advanced glycation end products in D-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation | L-theanine improves liver aging during physiological stress in aging rats. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Prevention of brain aging by green tea components: Role of catechins and theanine | L-theanine supports healthy brain aging. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways | L-teanine supports healthy brain aging. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness | L-theanine supports brain stem cell health and proper neurogenesis. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Daily oral intake of L-theanine prevents the decline of 5-bromo-20 -deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress | L-theanine supports brain health under physiological stress in mice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory | L-theanine improves healthy cognitive development and neurogenesis in young ice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro Study | L-theanine supports joint health. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
L-theanine | Animal | Modulation of irinotecan-induced genomic DNA damage by theanine | L-theanine helps to protect DNA against damage in mice. | Learn More | Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress. | |
Nicotinamide mononucleotide (NMN) | Human | Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men | NMN given to humans is safe. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Human | Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women | NMN promotes a healthy glucose metabolism. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old men | NMN promotes healthy muscles in old men. | Mitochondrial dysfunction | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study | NMN supports exercise endurance. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | NAD⁺ metabolism: a therapeutic target for age-related metabolic disease | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE 7, e42357 (2012). | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Human | In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl Acad. Sci. USA 112, 2876–2881 (2015). | During aging, NAD+ levels decline. | Deregulated nutrient sensing | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice | NMN supports healthy brain aging and blood vessels in mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects | NMN promotes neurvascular rejuvenation in aged mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice | NMN promotes rejuvenation of the blood vessels in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects | NMN promotes blood vessel health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging | NMN promotes blood vessel health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging | NMN supports healthy mitochondrial function in mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow | NMN promotes mesenchymal stem cell health in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice | NMN supports a healthy glucose metabolism. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | NAD+ controls neural stem cell fate in the aging brain | NMN supports healthy brain aging in rodents. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. | |
Nicotinamide mononucleotide (NMN) | Animal | NAD+ Repletion Rescues Female Fertility during Reproductive Aging | NMN can support proper fertility and egg cell function in aging mice. | Learn More | In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes. |