NOVOS is rooted in science, supported by studies validating its patent-pending formulations and ingredients

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NOVOS Studies | direct studies done on NOVOS

General Studies | 190+ ingredient studies

Bonus Resources | PDF and other overviews

Note: for an overview of the 10 principles that make up our unique approach to longevity formulations click here.

Scientific studies done on NOVOS Formulations

Study 1: NOVOS Core improves skin suppleness in humans

Participants who took NOVOS Core for 6 months all showed improvements in skin firmness as measured by an indentometer.

An indentometer is a device that measures skin suppleness and firmness.

Besides these objective measurements, participants also mentioned noticeable improvements in their skin, such as improved elasticity, smoothness, and firmness.

Results

The study was a small pilot study, done in 4 patients. The device used to test is a state-of-the-art device used for scientific studies.

Gray bars show skin firmness before taking NOVOS (the higher the bar, the less firm the skin is). Orange bars show skin firmness after taking NOVOS 6 months (the lower the bar, the more firm the skin).

NOVOS users saw a minimum improvement of 12%, max of 40% and an average of 22% in skin firmness.

NOVOS is planning to conduct an additional and more extensive dermatological study with more participants.

Ingredients improving skin health

These results on skin health are not that surprising given NOVOS Core contains various longevity ingredients that are also known to improve skin health, such hyaluronic acid, alpha ketoglutarate, glycine, vitamin C, and glucosamine.

Oral hyaluronic acid improves skin health and reduces wrinkles. Hyaluronic acid is a component of the extracellular matrix, the “glue” that keeps skin cells sticking together.

Alpha ketoglutarate improves skin stem cell health, and plays a role in collagen production. Alpha ketoglutarate also works together with vitamin C, given vitamin C also improves collagen production. Additionally, alpha ketoglutarate and vitamin C both work synergistically to improve the epigenome, including that of skin cells. Alpha ketoglutarate can also extend lifespan.

Glucosamine is a component of the extracellular matrix, and glycine is an important building block of collagen.

These are some examples of how ingredients in NOVOS can improve skin health.

Not just addressing signs of aging, but the underlying causes

What is even more important is that all these ingredients inhibit fundamental aging mechanisms and have shown to extend lifespan in various species.

In other words, NOVOS Core is the only skin supplement that actually addresses the root causes of aging, including skin aging.

Study 2: NOVOS Core significantly reduces DNA damage in human cells after irradiation

A study found that a combination of the 12 ingredients in NOVOS Core and the nicotinamide mononucleotide (NMN) in NOVOS Boost significantly protects cells against DNA damage over a wide dose range.

The study was done by Ichor Life Sciences, an independent third-party US-based lab specialized in DNA damage, cellular senescence, and aging.

In the study, HUVEC cells (human umbilical vein endothelial cells) were treated with the 13-ingredient NOVOS formulation and then irradiated. Irradiation typically causes pronounced DNA damage. However, the cells exposed to NOVOS before irradiation had significantly less DNA damage after being exposed to radiation, as measured via 8-hydroxy-2′-deoxyguanosine (8-OHdG or 8-oxodG) levels. 8-OHdG is a measure of oxidative DNA damage. When DNA gets damaged, 8-OHdG is formed.

Treating cells with NOVOS was able to reduce DNA damage as measured by 8-OHdG by up to 77% and on average 68% compared to controls:

Irradiated cells treated with the NOVOS formulation (orange bars; different concentrations of NOVOS ranging from 50.0uM to 0.2 uM) showed significantly less DNA damage (as measured by 8-OHdG levels; the lower the bars, the less DNA damage) versus irradiated cells that weren’t treated with the NOVOS formulation (gray bars).

Researchers demonstrated that the NOVOS formulation protects against DNA damage over a wide range of doses, an effect mediated by DNA protective effects of multiple NOVOS ingredients at different doses and synergy between ingredients.

Study 3: NOVOS ingredients demonstrate synergistic senostatic effects on senescent human cells

This study was conducted at the Ageing Research Laboratories at Newcastle University (UK), specialized in cellular senescence and aging. The study was done under the guidance of Professor Von Zglinicki, Professor for Cell Gerontology.

The study found that the combination of multiple NOVOS ingredients could help the body better deal with senescent cells.

Senescent cells occur during aging and play an important role in the aging process. These cells accumulate various forms of damage, including DNA and epigenetic damage, and secrete substances that harm healthy surrounding cells.

Research has shown that countering senescent cells using senostatic drugs (which suppress senescent cells) can support the body to deal better with aging. In the study, researchers using cell size as marker for the senescent phenotype found that specific NOVOS ingredients had a senostatic effect, while not impacting normal, non-senescent cells:

The cell size of senescent cells is reduced with NOVOS ingredients (orange line, on the right). Normal cells are not impacted (blue line), demonstrating that the combination of specific NOVOS ingredients targets senescent cells and not normal healthy cells.

A senostatic effect comprising a reduction in senescent cell size has also been observed with rapamycin, a prescription drug associated with increased longevity in multiple animal models:

The cell size of senescent cells is reduced by rapamycin (orange graph, on the right). Rapamycin, not being a senolytic, has however senomorphic effects.

Normal non-senescent cells were not impacted by the NOVOS formulation, demonstrating that specific NOVOS ingredients used in a synergistic combination can impact senescent cells while not impacting healthy cells — a common pitfall of “senolytic” molecules which seek to destroy senescent cells.

190+ Studies Supporting NOVOS Selection of Ingredients

Click on an ingredient name to get a non-exhaustive list of representative scientific studies:

You can download a brief description of our ingredients and their health effects below:

Science-Packet Download

Table overview of scientific studies for NOVOS ingredients

Ingredient	Study Type	Study Link	Outcome (FDA Conform)	Hallmark	Learn More	Summary
Glycine	Human	Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetes	Supports a healthy anti-inflammatory status and promotes a healthy glucose metabolism.	Altered cellular communication.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	D-Glucosamine supplementation extends life span of nematodes and of ageing mice	Increase in lifespan (6% increase in males and 4% in female mice).		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	The metabolic response to ingested glycine	Glycine supports healthy levels of glucose.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats	Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats.	Median lifespan increased from 88 to 113 weeks (28%) and maximum lifespan increased from 91 weeks to 119 weeks (31%) versus the control group in rats.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris	Higher levels of glycine are associated with improved heart health.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis	Higher levels of glycine are associated with healthy glucose metabolism.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance	Higher levels of glycine are associated with healthy liver metabolism.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance	Higher levels of glycine are associated with healthy metabolism.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes	Higher levels of glycine are associated with healthy metabolism.	Deregulated nutrient sensing.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Neuroprotective effects of glycine for therapy of acute ischaemic stroke	Glycine helps to support brain health.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults	Glycine maintains healthy cognition in young and midle-aged people.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Glycine metabolism in skeletal muscle	Glycine supports healthy muscle function during physiological stress.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation	Glycine infusions improve oxidative stress.	Altered cellular communication.	Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Human	Taking a supplement of glycine, a food additive, helps to prevent degenerative diseases such as arthrosis or osteoporosis	Glycine supports healthy joints and bones.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Dietary Glycine Supplementation Extends Lifespan of Genetically Heterogeneous Mice	Median lifespan was increased in mice by 3.7% in females and 1.3% inmales, and the 90th percentile lifespan was increased by 1.8% in females and 3.6% in males.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion	A 19% increase in lifespan in C elegans worms.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan	Improving glycine metabolism extends lifespan in Drosophila.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats	Glycine promotes a healthy metabolism in rats.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Dietary glycine blunts lung inflammatory cell influx following acute endotoxin	Glycine promotes a healthy inflammatory response in lungs in rats.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats	Glycine supports eye health in rats.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Glycine	Animal	Dietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride Channel	Glycine improves joint health in rodents.		Learn More	Glycine has shown to extend lifespan in different species. In humans, higher glycine levels are associated with heart health, combating inflammaging at the cellular level, and supporting glucose metabolism.
Alpha-ketoglutarate	Human	Calcium Alpha-Ketoglutarate Supplementation Reduces Epigenetic Age in Humans	A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation.	Epigenetic dysregulation.	Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test	A small clinical trial showed reduction of epigenetic age after alpha-ketoglutarate supplementation.	Epigenetic dysregulation.	Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	α-ketoglutarate for myocardial protection in heart surgery	Alpha-ketoglutarate supports heart health during physiological stress.	Mitochondrial dysfuction.	Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Addition of α-Ketoglutarate to Blood Cardioplegia Improves Cardioprotection	Alpha-ketoglutarate supports heart health during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Renal Effects of a-Ketoglutarate Early After Coronary Operations	Alpha-ketoglutarate supports healthy kidney function during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery	Alpha-ketoglutarate suports healthy muscle function during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Alpha-ketoglutarate and postoperative muscle catabolism	Alpha-ketoglutarate suports healthy muscle function during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Prevention of decrease of protein synthesis after total hip replacement	Alpha-ketoglutarate suports healthy muscle function during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Binding of phosphate in chronic hemodialysis patients	Alpha-ketoglutarate suports healthy kidney function during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Improvement of arginine levels in malnourished hemodialsysis patients	Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	alpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolism	Alpha-ketoglutarate supports a healthy amino acid metabolism during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Treatment of hyperphosphataemia in haemodialysis patients	Alpha-ketoglutarate supports a healthy phosphate metabolism during physiological stress.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Telopeptide of type I collagen in postmenopausal women with osteopenia	Alpha-ketoglutarate supports healthy bones.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Human	Alfa ketoglutarate (AKG) inhibit osteoporoses development in postmenopausal women	Alpha-ketoglutarate supports healthy bones.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice	Lifespan and healthspan extension in mice.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	Lifespan and healthspan extension in mice.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR	Lifespan exention in C elegans by 50%.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK	15% lifespan extension in Drosophila.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Effects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies. Ukr Biochem J. 2018	Females had 23% and 11% longer mean lifespan and 22% and 19% longer maximum lifespan on food supplemented with alpha-ketoglutarate compared to controls.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Dietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster)	Diet with 10 mM AKG improved climbing activity in middle-aged flies.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Dietary alphaketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner. J Therm Biol. 2016	Improves cold tolerance and antioxidant system capacity in Drosophila.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations	Alpha-ketoglutarate rejuvenates mesenchymal stem cells and supports healthy aging of bones in mice.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-ketoglutarate stabilizes redox homeostasis and elasticity in aged mice	Alpha-ketoglutarate supports healthy blood vessel elasticity in mice.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice	Alpha-ketoglutarate supports healthy blood vessel elasticity in elderly mice.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats	Alpha-ketoglutarate supports healthy blood vessels and a healthy fat metoblism in obese rats.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Alpha-ketoglutarate	Animal	Alpha-Ketoglutarate: Physiological Functions and Applications	Review article.		Learn More	Alpha-ketoglutarate extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism, a healthy epigenome, and proper bone and muscle health as you age.
Rhodiola rosea	Human	The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials	Rhodiola rosea supports healthy cognition and normal energy levels.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Human	Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty	Rhodiola rosea helps to maintain normal energy levels under stressful conditions.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Human	Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results	Rhodiola rosea promotes healthy muscle function during intensive exercise.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Human	Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial	Rhodiola promotes healthy energy levels.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction	Rhodiola rosea extends lifespan in fruit flies.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1	Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Plant adaptogens increase lifespan and stress resistance in C. elegans	Rhodiola rosea extends lifespan and improves stress resistance in C elegans worms.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Rhodiola: a promising anti-aging Chinese herb	Rhodiola rosea has anti-aging properties.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae	Rhodiola rosea extends lifespan in yeast.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects	Rhodiola rosea supports normal brain function during physiological stress in rats.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat	Rhodiola rosea supports normal brain function during physiological stress in rats.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea	Rhodiola rosea supports normal brain function during physiological stress in fruit flies.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats	Salidroside, a component in Rhodiola, supports healthy regeneration of nerves.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo	Salidroside, a component in Rhodiola, supports healthy regeneration of nerves.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes	Rhodiola supports healthy metabolism in rats		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway	Review/meta-analysis.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Rhodiola rosea	Animal	Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms	Rhodiola promotes healthy cognition and memory in rodents.		Learn More	Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells. Rhodiola rosea fosters healthy cognitive function like memory and concentration.
Glucosamine	Human	Total mortality risk in relation to use of less-common dietary supplements.	Glucosamine is associated with reduced mortality in humans.	Decreased mortality.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Use of glucosamine and chondroitin in relation to mortality.	Glucosamine is associated with reduced mortality in humans.	Decreased mortality.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank	Glucosamine is associated with improved heart health in humans.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Glucosamine/Chondroitin and Mortality in a US NHANES Cohort	Glucosamine is associated with improved heart health and reduced mortality in humans.	Decreased mortality.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Oral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox State	Glucosamine promotes heart health.	Altered intercellular communication.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Association between use of specialty dietary supplements and C-reactive protein concentrations. American Journal of Epidemiology, 2012	Glucosamine supports a healthy inflammatory status.	Altered intercellular communication.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation	Glucosamine supports a healthy inflammatory status.	Altered intercellular communication.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study	Glucosamine has been associated with healthy colon cell growth.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study	Glucosamine has been associated with healthy colon cell growth.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort	Glucosamine has been associated with healthy lung cell growth.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Human	Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial	Glucosamine improves skin health during aging.	Altered intercellular communication.	Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Animals	D-Glucosamine supplementation extends life span of nematodes and of ageing mice	10% lifespan extension in mice.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Animals	Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction	30% lifespan extension in C elegans.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Animals	Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome	Glucosamine promotes a healthy anti-inflammatory response.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Animals	Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis	Glucosamine promotes a healthy anti-inflammatory response and supports healthy blood vessels.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Glucosamine	Animals	Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: Evidence for a protective role for glucosamine in atherosclerosis	Glucosamine helps to maintain healthy blood vessels.		Learn More	In animals, glucosamine extends lifespan. Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.
Vitamin C	Human	Impact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of Stay	Vitamin C supports a healthy recovery after trauma.		Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Human	Vitamin C: An Epigenetic Regulator	Vitamin C promotes a healthy epigenome.	Epigenetic alterations.	Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Human	The role of vitamin C in epigenetic regulation	Vitamin C promotes a healthy epigenome.	Epigenetic alterations.	Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Human	Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine	Vitamin C promotes a healthy epigenome and works synergistically with alpha-ketoglutarate.	Epigenetic alterations.	Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Human	Reprogramming the Epigenome With Vitamin C	Vitamin C promotes a healthy epigenome.	Epigenetic alterations.	Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Animal	Vitamin C and Lifespan in Model Organisms	Vitamin C extends lifespan in C elegans.		Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Animal	Vitamin C, Aging and Alzheimer’s Disease	Vitamin C has anti-aging effects.		Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Animal	Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function	Vitamin C supports healthy brain function in mice exposed to physiological stress.		Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Vitamin C	Animal	Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation	Vitamin C supports healthy regeneration of nerves in rodents.		Learn More	Vitamin C helps to maintain physical resilience as you age and works together with alpha ketoglutarate (AKG) to support the epigenome.Vitamin C is shown to support mitochondrial health, a known hallmark of youth.
Pterostilbene	Human	Analysis of Safety from a Human Clinical Trial with Pterostilbene	Pterostilbene is safe to take (based on hepatic, renal and glucose markers).		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Human	Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial	Pterostilbene supports healthy blood pressure levels.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Human	Combination of pterostilbene and nicotinamide riboside (NR) in ALS	Pterostilbene, in combination with an NAD-booster, supports healthy lung function and muscle function under physiological stress.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Human	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study	Pterostilbene, in combination with an NAD-booster, increases NAD+ levels in humans safely and sustainably.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans	Pterostilbene increases lifespan in C elegans.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Effect of resveratrol and pterostilbene on aging and longevity	Review article.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Low-dose Pterostilbene, but Not Resveratrol, Is a Potent Neuromodulator in Aging and Alzheimer's Disease	Pterostilbene supports healthy brain aging in an accelerated-aging mice model.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study	Pterostilbene supports healthy brain and cognitive function in aged rats.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats	Pterostilbene promotes healthy DNA stabilization and protects the brain against physiological stress in rats.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice	Pterostilbene supports normal brain function during physiological stress in rodents.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging	Pterostilbene promotes normal brain function in aging rats.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway	Pterostilbene promotes healthy blood vessel function.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model	Pterostilbene supports heart health during physiological stress.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats	Pterostilbene helps to maintain normal liver function during physiological stress in rats.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver	Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet	Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats	Pterostilbene helps to maintain a healthy metabolism in rats fed an obesogenic diet.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Pterostilbene	Animal	Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2	Pterostilbene helps to maintain a healthy glucose metabolism under physiological stress in rodents.		Learn More	Pterostilbene is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability. Pterostilbene helps to maintain healthy blood pressure levels, as well as supports proper lung and heart function.
Fisetin	Human	Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients	Fisetin supports a healthy inflammatory response.	Altered intercellular communication	Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Human	Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial	Fisetin can support brain health under physiological stress.	Altered intercellular communication	Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Human	At least 16 clinical trials with fisetin in humans are underway.			Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin is a senotherapeutic that extends health and lifespan	Lifespan extension in mice.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan	Lifespan extension in Saccharomyces cerevisiae by 55%.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse	Lifespan extension.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Sirtuin activators mimic caloric restriction and delay ageing in metazoans	Lifespan extension.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Preventing and Treating Neurological Disorders with the Flavonol Fisetin	Fisetin can help to support normal brain function during aging.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function	Fisetin can help to support normal brain function during aging.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo.	Fisetin supports blood vessel health in mice.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice	Fisetin supports brain aging in mice.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes	Fisetin supports a healthy metabolism in mice.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia	Fisetin supports brain and vascular health in rodents.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Fisetin regulates obesity by targeting mTORC1 signaling	Fisetin promotes a healthy metabolism in mice fed a hig-fat diet.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice	Fisetin promotes healthy brain aging in mice.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Fisetin	Animal	The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice	Fisetin helps to maintain normal brain function in rodents under physiological stress.		Learn More	Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level. Fisetin is shown to support brain function as well as maintain a healthy inflammatory response as you age.
Micro-dosed Lithium	Human	Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials	Lithium is associated with reduced all-cause death in people with mood disorders.	Decreased mortality.	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study	Lithium is associated with improved brain aging.	Decreased mortality.	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Low-dose lithium uptake promotes longevity in humans and metazoans	Low-dose lithium increases lifespan in C elegans and is associated with reduced mortality in humans.	Decreased mortality.	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018	Higher levels of lithium in tap water are associated with reduced mortality in humans.	Decreased mortality.	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in Texas	Higher levels of lithium in drinking water are associated with reduced mortality and improved metabolic health in humans.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies	Higher levels of lithium in drinking water are associated with healthier mood.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions	Higher levels of lithium in the drinking water are associated with less crime stemming from drug addictions.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Lithium in drinking water and suicide prevention: The largest nationwide epidemiological study from Japan	Higher levels of lithium in the drinking water are associated with a healthier mood.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users	Microdosed lithium can support healthy mood.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Association of Lithium in Drinking Water With the Incidence of Dementia	Higher levels of lithium in the drinking water supports healthy brain aging.	Improved proteostasis	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial	Lithium intake is associated with improved cognition and healthy brain aging.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease	Microdosed lihium supports healthy brain aging.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits	Lithium supports healthy brain aging.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis	Lithium supports healthy brain aging.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial	Lithium supports healthy brain aging.	Improved proteostasis	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's diseaser	Lithium supports healthy brain aging.	Altered intercellular communication	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Increase of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease.	Lithium supports healthy brain aging.	Altered intercellular communication	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium	Lithium supports healthy brain aging.	Telomere attrition	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	The polygenic nature of telomere length and the anti-ageing properties of lithium	Lithium supports healthy aging.	Telomere attrition	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment	Lithium supports healthy aging.	Telomere attrition	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder	Lithium supports healthy aging.	Telomere attrition	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Human	Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients	Lithium supports healthy aging.	Telomere attrition	Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Low-dose lithium uptake promotes longevity in humans and metazoans	36% lifespan extension in C elegans.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Lithium treatment and mechanisms of aging	Nature Review article on the role of lithium treatment in aging.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans	46% lifespan increase in C elegans.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans	10% lifespan increase in C elegans.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis	Lithium extends lifespan in Drosophila.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans	Up to 46% median increase of lifespan in C elegans, probably by improving epigenetic health.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model	Long-term microdosed lithium improves brain health in mice.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease	Microdosed lithium improves brain health.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death	Microdosed lithium supports brain health under physiological stress.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model	Lithium helps to support proper protein metabolism in the brain in mice.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Micro-dosed Lithium	Animal	NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats	Lithium helps to support proper protein metabolism in the brain in rats.		Learn More	Various studies found that people who regularly consume micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species. Micro-dosed lithium is shown to promote healthy cellular communication, epigenetic stablity and telomere length — 3 major hallmarks of youth.
Ginger	Human	Metanalysis: The effect of Ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis	Ginger promotes a healthy anti-inflammatory response and healthy metabolism.	Altered cellular communication	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Human	Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial	Ginger promotes a healthy cholesterol metabolism.	Deregulated nutrient sensing	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Human	Effect of ginger and fasting blood supar, HbA1c and lipids in diabetes patients	Ginger helps to maintain a healthy glucose metabolism.	Deregulated nutrient sensing	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Human	The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med, 2014	Ginger helps to maintain a healthy glucose metabolism.	Deregulated nutrient sensing	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Human	Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence	Ginger reduces oxidative stress and supports a healthy anti-inflamamtory status.	Altered cellular communication	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Human	Effects of a ginger extract on knee pain in patients with osteoarthritis	Ginger supports healthy joints.	Altered cellular communication	Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Animal	Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction	Lifespan extension in Drosophila.		Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Animal	Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions	Lifespan extension in Drosophila.		Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Animal	Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation	Ginger strongly protects mice against lethal doses of radiation.		Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Animal	Protective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in Rats	Ginger can support healthy brain aging in rats.		Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Ginger	Animal	Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response	Ginger can support a healthy inflammatory response in mice under physiological stress.		Learn More	Ginger protects cells against damage and has various longevity-promoting effects. In humans, ginger helps to maintain proper glucose and lipid levels, as well as a healthy inflammatory response. Ginger also helps to mitigate oxidative damage in cells.Ginger promotes healthy nutrient sensing, an important pathway to maintain metabolic function as you age.
Malate (as magnesium malate)	Human	Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study	Malate can support normal energy levels.	Deregulated nutrient sensing	Learn More	Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health.
Malate (as magnesium malate)	Animal	Malate and Fumarate Extend Lifespan in Caenorhabditis elegans	14% increase in lifespan in C elegans.		Learn More	Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate helps to support normal energy levels. Malate also promotes mitochondrial health.
Magnesium (as magnesium malate)	Human	Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies	Magnesium promotes a healthy metabolism.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Low serum magnesium concentrations predict cardiovascular and all-cause mortality.	Magnesium promotes healthy cardiovascular function and reduces all cause mortality.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man	Magnesium supports healthy DNA.	Genomic instability	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Acute and chronic oral magnesium supplementation: effects on endothelial function, exercise capacity, and quality of life in patients with symptomatic heart failure	Magnesium supports heart health.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Role of magnesium in genomic stability.	Magnesium supports healthy DNA.	Altered cellular communication	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.	Magnesium conributes to a normal anti-inflammatory response.	Deregulated nutrient sensing	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial	Magnesium supports a healthy glucose metabolism.	Deregulated nutrient sensing	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study	Magnesium supports a healthy glucose metabolism.	Deregulated nutrient sensing	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials	Magnesium supports a healthy glucose metabolism.	Mitochondrial dysfunction	Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Modern Nutrition in Health and Disease.	Magnesium supports a healthy metabolism.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Magnesium Role in Health and Longevity	Magnesium supports a healthy metabolism.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Magnesium for the prevention and treatment of cardiovascular disease			Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Human	Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies			Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Animal	Dietary magnesium supplementation improves lifespan in a mouse model of progeria	Magnesium extends lifespan in an accelerated aging mice model.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Animal	Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function	Magnesium can help to maintain proper mitochondrial function.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Animal	Dietary magnesium supplementation improves lifespan in a mouse model of progeria	Magnesium can slow down aging in an accelerated aging mice model.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Magnesium (as magnesium malate)	Animal	Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats	Magnesium can support blood vessel health.		Learn More	People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism, heart health, as well as normal levels of blood sugar and a healthy inflammatory response. Magnesium promotes genomic stablity, maintaining healthy DNA as you age.
Hyaluronic acid	Human	Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period	Hyaluronic acid taken orally improves the appearance of wrinkles, skin luster and elasticity.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study	Oral hyaluronic acid improves the appearance of wrinkles, hydration of skin and elasticity.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Effects of low molecular weight hyaluronic acid by oral intake to beautify skin: -Placebo-controlled double-blind comparative study-	Oral hyaluronic acid improves skin moisture, elasticity and the appearance of wrinkles.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Ingested hyaluronan moisturizes dry skin	Oral hyaluronic acid improves skin moisture.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Oral hyaluronan relieves knee pain: a review	Oral hyaluronic acid supports healthy knee joints.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Oral hyaluronan for the treatment of knee osteoarthritis: A systematic review	Oral hyaluronic acid supports healthy knee joints.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Human	Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period	Oral hyaluronic acid supports healthy knee joints.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Animal	Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life	A component of hyaluronic acid (acetyl-glucosamine) extends lifespan in mice and C elegans.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Animal	Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway	Low-molecular-weight hyaluronan can cross the gut lining and is absorbed into the bloodstream.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
Hyaluronic acid	Animal	Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs	Oral hyaluronic acid is systemically absorbed.		Learn More	Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals. Hyaluronic acid also promotes joint health as you age.
L-theanine	Human	Theanine consumption, stress and anxiety in human clinical trials: A systematic review	Theanine contributes to a healthy response to stress.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Human	Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 2019	Theanine contributes to a healthy response to stress.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Human	Theanine reduces psychological and physiological stress responses	Theanine contributes to a healthy response to stress.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Human	Salivary cortisol and alpha-amylase responses to repeated bouts of downhill running	Theanine contributes to a healthy response to stress.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Human	Acute effects of theanine, caffeine and theanine-caffeine combination on attention.	Theanine supports healthy cognition.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Human	Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis	Theanine supports healthy cognition.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	l-Theanine extends lifespan of adult Caenorhabditis elegans	L-theanine extends lifespan in C elegans.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice	L-theanine extends lifespan in mice under stressful conditions.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	L-Theanine attenuates liver aging by inhibiting advanced glycation end products in D-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation	L-theanine improves liver aging during physiological stress in aging rats.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Prevention of brain aging by green tea components: Role of catechins and theanine	L-theanine supports healthy brain aging.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways	L-teanine supports healthy brain aging.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness	L-theanine supports brain stem cell health and proper neurogenesis.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Daily oral intake of L-theanine prevents the decline of 5-bromo-20 -deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress	L-theanine supports brain health under physiological stress in mice.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory	L-theanine improves healthy cognitive development and neurogenesis in young ice.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro Study	L-theanine supports joint health.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
L-theanine	Animal	Modulation of irinotecan-induced genomic DNA damage by theanine	L-theanine helps to protect DNA against damage in mice.		Learn More	Theanine is one of the substances responsible for the healthy effects of green tea. Theanine extends lifespan in different organisms. It upregulates aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks. L-theanine helps to support cognitive functions such as focus and attention, while maintaining normal levels of psychological and physiological stress.
Nicotinamide mononucleotide (NMN)	Human	Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men	NMN given to humans is safe.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women	NMN promotes a healthy glucose metabolism.	Deregulated nutrient sensing	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old men	NMN promotes healthy muscles in old men.	Mitochondrial dysfunction	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study	NMN supports exercise endurance.	Deregulated nutrient sensing	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	NAD⁺ metabolism: a therapeutic target for age-related metabolic disease	During aging, NAD+ levels decline.	Deregulated nutrient sensing	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE 7, e42357 (2012).	During aging, NAD+ levels decline.	Deregulated nutrient sensing	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Human	In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl Acad. Sci. USA 112, 2876–2881 (2015).	During aging, NAD+ levels decline.	Deregulated nutrient sensing	Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice	NMN supports healthy brain aging and blood vessels in mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects	NMN promotes neurvascular rejuvenation in aged mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice	NMN promotes rejuvenation of the blood vessels in aging mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects	NMN promotes blood vessel health in aging mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging	NMN promotes blood vessel health in aging mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging	NMN supports healthy mitochondrial function in mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow	NMN promotes mesenchymal stem cell health in aging mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice	NMN supports a healthy glucose metabolism.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	NAD+ controls neural stem cell fate in the aging brain	NMN supports healthy brain aging in rodents.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.
Nicotinamide mononucleotide (NMN)	Animal	NAD+ Repletion Rescues Female Fertility during Reproductive Aging	NMN can support proper fertility and egg cell function in aging mice.		Learn More	In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.