NOVOS Core+Boost

Healthy aging

Aging is complex.

Scientists have identified twelve underlying biological processes that drive how our bodies change over time. NOVOS Core is designed to target all 12 at once, rather than a single pathway.

• Genomic
• Cellular
• Metabolic
• Systemic

• Most supplements address one mechanism. Aging runs on many at once.
• NOVOS Core is formulated to target all 12 Hallmarks of Aging together.

Reference: López-Otín et al., “Hallmarks of Aging: An expanding universe” (Cell, 2023).

Pilot study · Skin firmness

All participants improved skin firmness over 6 months

In a pilot study (n=4), all participants who took NOVOS Core daily for six months improved skin firmness, averaging 22% (range 12% to 40%), as measured by a medical doctor using the industry standard indentometer device by Courage + Khazaka.

• n=4
• 6 months
• Avg 22%

Methods

Pilot study in four participants taking NOVOS Core daily for six months. Skin firmness measured by indentometer. The small sample size means results should be read as preliminary observations. NOVOS is planning a larger dermatological study.

• All four participants improved skin firmness
• Average improvement 22%, ranging from 12% to 40%
• With only four participants, these are preliminary observations

Pilot study (n=4). Small sample size; individual results may vary. A larger dermatological study is planned.

Energy

Many customers report steadier energy throughout the day

In a self-reported customer survey, 81% of NOVOS customers feel a difference within 2 weeks across six areas of daily wellbeing, including energy. Steadier energy is among the changes customers commonly report within Month 1.

• Rhodiola Rosea
• Magnesium Malate
• Self-reported
• 81% feel a difference
• Month 1+

NOVOS Core includes Rhodiola Rosea, an adaptogen studied in connection with fatigue resistance and stamina, and Magnesium Malate, a form of magnesium that acts as a cofactor in cellular (ATP) energy production.

• Energy is one of the most frequently mentioned benefits in NOVOS Core reviews
• The reported quality is steady, day-long energy, not a stimulant spike
• NOVOS Core contains no caffeine

Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

Sleep & Mood

Better sleep is one of the changes customers report most

Better sleep is among the most frequently mentioned benefits in NOVOS Core reviews, and one of the six areas of wellbeing in the survey where 81% of NOVOS customers feel a difference within 2 weeks. NOVOS Core is formulated with ingredients commonly associated with calm and restful sleep.

• Self-reported
• Glycine
• L-Theanine
• Magnesium
• Micro-dosed Lithium

NOVOS Core includes Glycine, L-Theanine, micro-dosed lithium, and Magnesium Malate, ingredients widely studied in connection with relaxation and restful sleep.

• Sleep is one of the most-mentioned benefits across NOVOS Core customers
• Customers describe a calmer, well-rested quality rather than sedation
• Many notice changes to sleep within the first few weeks

Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

Cell study · DNA integrity

NOVOS Core ingredients supported DNA integrity in irradiated skin cells

In an in vitro study, ingredients in NOVOS Core supported DNA integrity, with up to 77% protection in human skin cells exposed to irradiation (for example, UV rays).

• In vitro
• Skin cells
• Irradiation challenge

Methods

Laboratory study in skin cells exposed to irradiation. Researchers measured the degree to which NOVOS Core ingredients supported DNA integrity against the irradiation challenge.

• Ingredients when combined in NOVOS Core supported DNA integrity by up to 77% under irradiation
• DNA integrity is one mechanism studied in skin, cellular, and whole body aging
• A laboratory readout, measured in human cells (in vitro) rather than in people (in vivo)

In vitro laboratory study; results may not translate to human outcomes. Individual results may vary.

Animal study · Lifespan

NOVOS Core extended lifespan by over 18% in aged mice

In a study of aged mice (equivalent to starting at 60 human years), NOVOS Core extended lifespan by over 18%, a record for an over-the-counter supplement in aged-mouse models.

• Aged mice
• Newcastle University
• +18%

Methods

Lifespan study in aged mice (equivalent to starting around 60 human years), conducted at Newcastle University. Across separately published animal studies (different protocols and mouse strains, not head-to-head), popular NAD+ boosters such as nicotinamide riboside have shown only modest 0 to 5% lifespan increases in similar aged-mouse models.

• Over 18% lifespan extension, a record for an over-the-counter supplement in aged-mouse models
• Comparator NAD+ boosters: 0 to 5% in separately published studies (not head-to-head)
• Animal findings do not directly translate to humans

Animal studies are not relied upon to support any representations of health benefit in humans. Not a head-to-head comparison. Results may not translate to humans.

Case study · Pace of aging

73% reduced their biological pace of aging score

In a case study of 12 participants ages 39 to 76 who used NOVOS Core and NOVOS Boost daily for six months, 73% showed a measurable reduction in their DunedinPACE score. No participant’s score increased.

• n=12
• Ages 39–76
• 6 months

Methods

Case study conducted February to August 2022. 12 participants (6 male, 6 female, ages 39 to 76) received epigenetic test kits plus six months of daily NOVOS Core and NOVOS Boost. Kit shipment and blood analysis conducted by a third-party lab. Pace of aging measured by the DunedinPACE algorithm from Columbia University and Duke University researchers.

• 73% showed a measurable reduction in pace of aging
• Average reduction in aging was 8.7%, equivalent to 1 month per year
• 100% of participants maintained or slowed their pace of aging; no participant’s pace of aging increased

Case study, n=12; not a controlled trial. DunedinPACE is a research-use algorithm by Columbia University and Duke University researchers correlated with biological pace of aging, not a direct or definitive measure of aging. Individual results may vary.

Case study · Pace of aging

73% improved their biological pace of aging (measured by DunedinPACE)

In a case study of 12 participants (ages 39 to 76) using NOVOS Core and NOVOS Boost daily for six months, 73% showed a measurable reduction in biological aging pace on the DunedinPACE algorithm. No participant’s pace increased.

• n=12
• Ages 39–76
• 6 months

Methods

Case study conducted February to August 2022. 12 participants (6 male, 6 female, ages 39 to 76) received epigenetic test kits plus six months of daily NOVOS Core and NOVOS Boost. Kit shipment and blood analysis conducted by a third-party lab. Pace of aging measured by the DunedinPACE algorithm from Columbia University and Duke University researchers.

• 73% showed a measurable reduction in pace of aging
• Average reduction in aging was 8.7% equivalent to 1 month per year
• 100% of participants maintained or slowed their pace of aging; no participant’s pace of aging increased

Case study; not a clinical trial and does not establish causation. DunedinPACE is a research biomarker that estimates pace of biological aging, not a direct measure of biological age or clinical outcomes. Results may not be typical.

Randomized human trial · Cardiovascular

NOVOS Core provides rapid and durable support for healthy endothelial function

In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core showed benefits to flow-mediated dilation (a measure of healthy endothelial function), with statistically significant differences versus placebo observed during the trial and sustained at six months (p < 0.0001).

• Randomized
• Placebo-controlled
• Double-blind

Methods

Single-center, double-blind, randomized, placebo-controlled trial in generally healthy adults aged 40 and older. Participants took one serving of NOVOS Core daily for six months. Senior author: Prof. Christian Heiss, Professor of Cardiovascular Medicine, University of Surrey.

• Benefits to flow-mediated dilation observed versus placebo, achieved at one hour after first dose, and sustained at six months, fasted
• Approximately 2 to 5 times greater effect in support of healthy endothelial function than the most effective studied supplements (polyphenols, cocoa, and beet root)
• Effects observed in already-healthy adults, who are typically more difficult to achieve benefits in than sick populations

Individual responses vary. Not every person will experience the same magnitude of change. Comparator estimates derived from published human RCTs and meta-analyses; no head-to-head comparisons were conducted. Individual results may vary.

Randomized human trial · Cardiovascular

NOVOS Core Improved Three Markers of Cardiovascular Aging

Versus placebo in generally healthy adults ages 40 to 65, with measurements taken at baseline, one hour, and six months.

• Randomized
• Placebo-controlled
• Double-blind
• Under peer review

Endothelial function over the trial

FMD measured at baseline, 1 hour, and 6 months. Significant vs placebo at both.

Systolic Blood Pressure: NOVOS Core vs. Placebo

Change from baseline at six months. Both groups stayed within the normal range.

How NOVOS Core compares

Outperformed Most Single-Ingredient Supplements Across Every Major Vascular Aging Marker Studied

Based on comparisons with published studies of nutritional interventions. These were not head-to-head trials. No two people respond precisely the same way to nutritional interventions. Individual results will vary, and some may experience no benefit.

“Taken together, improvements across endothelial function, arterial flexibility, and systolic blood pressure point to a coherent pattern consistent with a favorable shift in vascular aging biology.”

Professor Christian Heiss, MD · University of Surrey · Professor of Cardiovascular Medicine, Associate Head of Medical School Senior Author of the NOVOS Core study

Click-through evidence · Cellular energy and endurance

Cellular energy and endurance

NAD+ is the molecule your cells use to turn food into usable energy. Levels fall as we age. NOVOS Boost is made with human clinically studied NMN, which your body uses to support its own NAD+ production.

• Human NMN research
• 250 mg per serving
• No caffeine, no stimulants

In a published human study of NMN supplementation, researchers observed that after 30 days, 67% of participants in the 600 mg and 900 mg groups showed measurable changes in walking distance (up to 38%); the trial also reported up to 50% improvement by day 60.

NOVOS Core also includes Rhodiola Rosea, an adaptogen studied in connection with fatigue resistance and stamina, and Magnesium Malate, a form of magnesium that acts as a cofactor in cellular (ATP) energy production. Energy is one of the most frequently mentioned benefits in NOVOS Core reviews, and the reported quality is steady, day-long energy rather than a stimulant spike. Neither product contains caffeine.

Published research on the NMN ingredient, not on NOVOS Boost, and conducted at daily doses of 600 mg to 900 mg. NOVOS Boost provides 250 mg per 2-capsule serving; recommended range 250 mg to 500 mg per day. Study population results are not a guarantee of individual outcomes. Individual results may vary. Customer-reported energy is based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing).

Click-through evidence · DNA repair and metabolic health

DNA repair and metabolic health

NMN is a building block of NAD+, an important molecule that enzymes need in order to support healthy DNA, maintain the epigenome, and ensure cellular integrity. NAD+ also sits at the center of how cells sense and use nutrients. That machinery changes with age.

• Human NMN research
• Telomere markers
• 300 mg/day, 90 days
• 10 weeks

In a published human study of men aged 40 to 60, researchers reported significant changes in telomere-length markers in peripheral blood mononuclear cells at the 300 mg/day NMN dose over a 90-day observation period.

In a laboratory study conducted by Ichor Life Sciences, the combination of the ingredients in NOVOS Core and the NMN in NOVOS Boost showed an average 68% reduction in DNA oxidative damage from irradiation in human endothelial cells.

In a human trial, NMN supplementation was associated with a 25% change in muscle insulin sensitivity markers after 10 weeks in older adults, along with enhanced metabolic signaling and physical activity.

Published research on the NMN ingredient, not on NOVOS Boost. Single study, small sample size; replication pending. The Ichor study is an in vitro laboratory study; results may not translate to human outcomes. Study population results are not a guarantee of individual outcomes. Individual results may vary.

Timeline · Within weeks

Supports higher NAD+ levels

NAD+ is a molecule cells rely on for energy production and DNA repair, and it declines with age. NOVOS Boost supplies NMN, a direct precursor your body uses to make its own NAD+.

• NAD+ metabolism
• Human NMN research

Human studies of NMN have shown increases in blood NAD+ and related NAD+ metabolites, typically observed within weeks of daily supplementation.

Published research on the NMN ingredient, not on NOVOS Boost. Study population results are not a guarantee of individual outcomes. Individual results may vary.