Formulations aimed at the root causes of aging

Alpha-ketoglutarate (AKG) extends lifespan and healthspan in different species. In humans, alpha-ketoglutarate has shown to protect cells against damage and stressors. Alpha-ketoglutarate supports a healthy metabolism and a healthy epigenome.

Rhodiola extends lifespan in different species. Substances in Rhodiola, like salidroside, have shown to support nerve regeneration in animals, normal sirtuin and AMPK function in human cells, and help the body to manage senescent cells.

Large studies found that people who take glucosamine live longer. Glucosamine intake was also associated with better heart health. In animals, glucosamine extends lifespan. Glucosamine targets inflammaging at the cellular level, and helps the body to manage oxidative stress and support autophagy.

Vitamin C can help to maintain a proper epigenome, especially in combination with another longevity ingredient, alpha- ketoglutarate.

Pterostilbene, a natural substance found in blueberries, is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammaging at a cellular level and contribute to a healthy epigenome and DNA stability.

Fisetin has shown to extend lifespan in animals. Fisetin helps the body to manage senescent cells, and can combat inflammaging at the cellular level.

Various studies found that people who take micro doses of lithium live longer. In human studies, supplementing with microdosed lithium supports healthy brain aging. Micro doses of lithium extend lifespan in multiple species.

Ginger can protect cells against damage and has various longevity-promoting effects. In humans, ginger can target inflammaging at a cellular level, can help to maintain proper glucose levels and support a healthy metabolism, and help to mitigate oxidative damage in cells

Malate is a natural substance found in apples which has shown to extend lifespan in organisms. Malate can support healthy energy levels in humans.

People who supplement with magnesium have shown to have less DNA damage. Magnesium supports a healthy metabolism and targets inflammation at the cellular level.

Hyaluronic acid can reduce the appearance of wrinkles when taken orally. A component of hyaluronic acid, acetyl-glucosamine, has shown to extend lifespan in animals.

Theanine is one of the substances responsible for the healthy effects of green tea. Theanine can extend lifespan in different organisms. It can upregulate aging-protective proteins, like FOXO1 and antioxidative enzymes and can help the body to manage crosslinks.

In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.