The longevity supplement space is booming, and celebrity names are taking notice. David Beckham’s IM8 Longevity Powder has entered the market, claiming to target all 12 hallmarks of aging — but that claim doesn’t hold up. IM8 addresses only a handful of these mechanisms, and there’s no published evidence that it influences all 12.
By contrast, NOVOS Core was specifically developed by longevity researchers to target all 12 hallmarks of aging — and it’s the first and only supplement with published, peer-reviewed data and human studies supporting this claim. Before you invest in any “anti-aging” blend, it’s worth comparing how these two supplements measure up.
Related: NOVOS Core Vs. Blueprint: Which Longevity Supplement Stack Is Right for You?
Key Takeaways
- Scientists developed NOVOS Core to target all 12 mechanisms of aging using clinically studied, synergistic ingredients.
- IM8 lists two small 12-week clinical trials and highlights academic collaborations but not peer-reviewed outcomes for the full Longevity formula. It also costs more per serving than NOVOS Core.
- Unlike IM8, NOVOS Core is the only consumer brand accepted into the prestigious Longevity Biotechnology Association and one of just two selected as a top-100 team for the XPRIZE for Healthspan Extension.
- NOVOS Core pairs with NOVOS Boost for NAD+ support — a more controlled approach than embedding NMN directly into a multi-compound powder.
Why Compare NOVOS and IM8?
Celebrity-backed health products often command attention before the science catches up. IM8, fronted by Beckham and branded as the “world’s first longevity formulation,” leans heavily on its lifestyle branding alongside scientific claims.
In reality, NOVOS was the first to define the longevity supplement category — built by scientists, not celebrities, and designed specifically to target the biological root causes of aging. Backed by an interdisciplinary team of experts in aging biology, nutrition, and biochemistry, NOVOS prioritizes science over marketing. Our mission has always been clear: Develop a formulation that’s proven to influence biological aging markers through peer-reviewed research and real-world results.
That distinction — marketing versus measurable science — forms the core of this comparison. While IM8 relies on branding and celebrity backing, NOVOS is helping shape the future of human longevity:
- We’re the only consumer brand accepted into the prestigious Longevity Biotechnology Association (LBA), an industry body made up of the world’s top longevity researchers, investors, and companies.
- NOVOS is one of just two consumer brands selected as a top-100 team for the XPRIZE for Healthspan Extension.
- We’re backed by a team of pioneering longevity scientists, including George Church and Matt Kaeberlein. Meet the scientists and explore their published research.
NOVOS Core vs. IM8: Ingredients Breakdown
Both NOVOS and IM8 list their active ingredients and doses openly. However, only NOVOS has published data evaluating the complete formulation’s impact on biological aging. Remember, when evaluating longevity supplements, it’s not about trendy ingredients — it’s about what’s actually proven to work.
Cellular Foundation
IM8 combines glycine (3 g) and taurine (2 g) to support basic cellular energy and detoxification. These are beneficial, foundational nutrients, but they primarily address short-term vitality rather than deeper longevity mechanisms.
NOVOS Core takes a more integrative approach. It includes glycine (2,000 mg) for collagen and detoxification support, but it goes further with ingredients that support mitochondrial function, energy metabolism, and oxidative resilience. For example:
- Magnesium malate (305 mg) and L-theanine promote cellular energy and calm.
- Calcium alpha-ketoglutarate, or Ca-AKG (1,100 mg), has been shown in animal studies to extend lifespan.
- Vitamin C (100 mg) supports the epigenome and helps restore balance, especially in combination with AKG.
- Rhodiola rosea protects against neurotoxins and oxidative stress.
These ingredients collectively help maintain youthful cellular performance across multiple aging pathways rather than offering surface-level nutritional support.
Senolytics & Cellular Protection
Senolytics help clear senescent cells, the “zombie” cells that accumulate with age and drive inflammation. Both NOVOS Core and IM8 include senolytic compounds, but the quality and effectiveness of these choices differ.
NOVOS Core combines fisetin (100 mg) and pterostilbene (50 mg), a more stable, bioavailable analog of resveratrol. Pterostilbene offers superior absorption and a longer half-life, making it more likely to reach target tissues at effective levels. In contrast, resveratrol has been shown in recent studies to fail at extending lifespan, partly due to its rapid breakdown in the body (half-life of about 14 minutes).
IM8, on the other hand, uses resveratrol (250 mg), quercetin (250 mg), and fisetin (100 mg). There’s little evidence that this specific combination, at these doses, produces synergistic effects or meaningfully targets all hallmarks of aging.
NAD+ Precursors
NAD+ (nicotinamide adenine dinucleotide) is essential for cellular repair and mitochondrial function. Levels decline with age, driving interest and research in precursors like NMN and NR.
IM8 includes NMN (300 mg) directly in its mix — a convenient but potentially unstable choice, as NMN can degrade when exposed to moisture, light, or heat.
NOVOS takes a different approach. Rather than embedding NMN into Core, it offers NOVOS Boost, a standalone NMN formulation that allows for controlled dosing and purity. This approach maintains NMN stability and allows users to control their NAD+ support for optimal results.
Spermidine
IM8 includes compounds like spermidine (3 mg) and dihydroberberine (100 mg), which are often promoted for supporting autophagy and glucose metabolism. However, the science tells a different story.
A human clinical trial found that oral spermidine does not raise blood levels of spermidine or spermine, casting doubt on its bioavailability and benefits. That’s why NOVOS made a deliberate decision not to include spermidine in its formulations.
Related: NOVOS Core vs. AG1: What’s the Best Supplement for Longevity?
NOVOS Core Vs. IM8 Daily Ultimate Longevity Powder: Comparison at a Glance
| Category | Feature | NOVOS Core | IM8 Daily Ultimate Longevity Powder |
| Pricing & Focus | Price per Serving | ~$98/month or less with subscription | ~$119/month with subscription |
| Science | Number of Hallmarks Targeted | All 12 (validated by longevity researchers and supported by published data) | Claims to target all 12, but only NOVOS has published data supporting this claim |
| Third-Party Testing & Published Research | Multiple published studies, patent filed, ongoing human research | No peer-reviewed studies on the complete formula; two small trials are ongoing, and no outcomes are published | |
| Key Mechanisms Supported | NAD+ Support | Works synergistically with NOVOS Boost (NMN), separated for optimal stability and absorption | NMN (300 mg) included in formula but lacks supporting cofactors for sustained NAD+ metabolism |
| Senolytics | Fisetin + pterostilbene — a more bioavailable analog of resveratrol — plus synergistic support from rhodiola | Uses older resveratrol form (250 mg) with quercetin and fisetin, but limited data on combined efficacy | |
| Autophagy/Metabolic Support | AKG, magnesium malate, L-theanine, and rhodiola — clinically studied to promote cellular renewal and mitochondrial health | Includes spermidine (3 mg) — questionable bioavailability and benefits | |
| Product Format & Experience | Delivery Format | One daily sachet (unflavored, orange, and limited-time tropical passion) | Daily flavored powder (açaí berry pomegranate) |
| Best Suited For | Individuals seeking a scientifically validated, affordable longevity stack | Consumers drawn to celebrity-backed products with added NMN but limited proof of full-system benefits |
Third-Party Studies & Scientific Validation
In a market full of lofty longevity claims, few products have the data to back them up. NOVOS Core is a patent-pending formulation that stands apart. Supported by independent research, human cellular studies, a scientific advisory board, and coverage from leading media outlets, NOVOS Core is the most scientifically validated longevity supplement available today.
Scientific Validation
NOVOS Core’s formulation has been featured in multiple studies showing lifespan extension in animals, measurable reductions in DNA damage and inflammation, and improved skin firmness in human subjects.
Core has shown a world-record lifespan extension in aged mice and improved markers like DNA damage and inflammation. In a human case study, NOVOS even demonstrated a reduction in biological Pace of Aging — proof that it doesn’t just promise longevity but delivers measurable impact.
IM8 emphasizes its collaboration with experts from Cedars-Sinai, Yale, NASA, and Oxford and notes that its ingredients are clinically validated for individual effectiveness. The company also states that all formulas undergo third-party testing and carry NSF Certified for Sport verification.
However, to date, no peer-reviewed or published studies have evaluated the complete IM8 formulation or demonstrated that it influences biological aging. Two small, 12-week trials (one for the Longevity formulation and one for the Daily Essentials Powder) listed on the National Library of Medicine remain ongoing, with results pending.
Real-World Results
Everyday users of NOVOS Core are seeing results that rival high-profile biohackers — without extreme regimens, lab testing, or multimillion-dollar costs. At under $100 per month, Core offers scientifically proven benefits that others spend thousands trying to replicate.
Related: NOVOS Core vs. Tally Health: What’s the Best Supplement for Longevity?
Which Longevity Supplement Is Best?
Both IM8 and NOVOS Core aim to simplify longevity into a daily routine. But only one does so with extensive scientific validation and proven impact.
IM8 offers a high-profile celebrity partnership and features trending compounds like spermidine. However, it currently lacks published, long-term data or evidence showing a reduction in biological age.
NOVOS Core, by contrast, is a patent-pending formulation created by longevity scientists, not marketers. It has been tested in laboratories, studied in humans, and continually refined to target all 12 mechanisms of aging, making it one of the most scientifically grounded longevity supplements available today.
For those serious about improving how they age, NOVOS Core is the best supplement for longevity. Ready to simplify your longevity routine? Try NOVOS Core today, and pair it with NOVOS Boost for optimal NAD+ support.
FAQ About NOVOS Core Vs. IM8
What is the best supplement for longevity?
The best longevity supplement is one supported by independent research and designed to target multiple biological aging pathways. NOVOS Core fits that definition.
Is IM8 a good supplement?
IM8 includes promising ingredients but lacks published studies on its full formulation, making it difficult to verify long-term efficacy.
Can you slow aging without prescription drugs?
Yes. Nutrients like NMN, AKG, and fisetin, combined with lifestyle factors such as exercise, sleep, and caloric balance, can influence biological aging markers.
What makes a longevity supplement “science-backed”?
Published studies, transparent dosing, and third-party validation. NOVOS meets all three criteria.
Can you combine NOVOS Core with other supplements like IM8 or AG1?
While it’s safe to take Core with general nutrition products, stacking it with IM8 is unnecessary. Core already targets all 12 mechanisms with precise, science-based dosing.
