Researching the best longevity supplement brands can feel overwhelming, especially with so many different options available. In our comparison series featuring various longevity supplements, we’ve looked at how other supplements compare to NOVOS Core — and the results may surprise you. The truth is, there’s only one product that meets all the criteria for being a true longevity supplement, and that’s NOVOS Core.
That said, we believe everyone should do their own research to understand the science (or lack thereof) behind different brands. This article looks at NOVOS Core versus AG1, a supplement brand that promises all-in-one nutrition with its daily drink powder. AG1 ingredients combine multivitamins, probiotics, greens, and superfoods. As you’ll see in this article, however, AG1 is not a longevity supplement. NOVOS Core is the clear choice for anyone looking to target the biological processes behind aging.
Related: Blueprint Comparison, Tally Health Comparison
Key Takeaways
- AG1’s clinical research shows no indicators of slower biological aging.
- NOVOS Core has evidence across multiple levels of longevity research, including human data on Pace of Aging reduction, improved skin firmness, and lab studies showing DNA damage reduction and lifespan extension.
- While AG1 offers a long list of vitamins, it lacks compounds like AKG, glycine, and fisetin, which target the hallmarks of aging.
- NOVOS Core provides transparent dosages, clinical evidence, and results backed by peer-reviewed research — qualities AG1 doesn’t claim.
- If your goal is long-term healthy aging, NOVOS Core is the best longevity supplement and a smarter, science-backed investment.
Why Compare NOVOS Core & AG1?
While both NOVOS Core and AG1 simplify daily health routines, their goals are fundamentally different. As our AG1 review shows, AG1 supports general nutrition and short-term wellness but is not a longevity supplement. NOVOS Core targets the biological mechanisms of aging to support long-term vitality and lifespan.
AG1, created by Athletic Greens, is a greens-based powder containing over 75 ingredients: vitamins, minerals, probiotics, and adaptogenic herbs. Its focus is general health — filling potential nutrient gaps, improving gut function, and supporting immunity.
NOVOS Core, on the other hand, is a longevity supplement formulated by a scientific board of aging researchers and clinicians. It’s built around one mission: to target the root biological causes of aging, from mitochondrial decline to cellular senescence. It uses compounds with evidence in human or animal longevity research, including NOVOS’ own research into the effects of our patent-pending formulations.
NOVOS Core vs. AG1 Ingredients: Comparison at a Glance
So, NOVOS Core isn’t simply an AG1 alternative. It’s the best supplement for longevity, in a class of its own. NOVOS Core is part of a broader movement in longevity science that aims to improve not just how long you live but also how well you age.
| Feature | NOVOS Core | AG1 |
| Scientific Backing | Formulated by longevity scientists and MDs, patent-pending | Developed by a wellness team with nutrition focus |
| Research Outcomes | Human and preclinical research targeting longevity pathways — including a reduction in Pace of Aging (DunedinPACE) in a human case study, improved skin firmness in a pilot, reduced DNA damage and cellular senescence in lab studies, and lifespan extension in aged mice. | Randomized controlled trials on nutrient status, microbiome, and bioavailability (AG1 Next Gen). Results show improved vitamin levels and gut composition but not aging-related endpoints. |
| Primary Focus | Cellular aging & longevity, which support overall wellness and healthy aging | General wellness, gut health, immunity, filling nutrient gaps |
| Secondary Focus | Short-term benefits (skin improvements, mood, focus and concentration, sleep, energy) | Morning routine |
| Ingredients Transparency | Fully disclosed with dosages, third-party tested | Disclosed but includes proprietary blends without dosages |
| Includes Longevity Nutrients | Yes: AKG, Glycine, Fisetin, Magnesium Malate | No: Focus on vitamins, probiotics, adaptogens |
| Delivery Format/Dosage | One daily sachet | Daily green powder |
| Cost (approx.) | ~$98/month or less with subscription | ~$99/month or less with subscription |
| Availability | Global | Global |
| Best For | Longevity-focused users seeking targeted aging support | Users seeking overall wellness in one powder |
What Makes NOVOS Core Different?
AG1’s “Next Gen” formula has been tested in a handful of basic clinical trials, but none with meaningful medical outcomes or improvements. The results they focus on — such as closing nutrient gaps or shifting the gut microbiome — can also be achieved by taking basic supplements or eating yogurt, for example. Despite heavy marketing, AG1’s science does not address the complex biology of aging in any substantive or measurable way.
NOVOS Core, however, has been studied for longevity-specific outcomes:
- An independently conducted human case study showing a statistically significant reduction in Pace of Aging (DunedinPACE)
- A pilot study with improved skin firmness
- Lab data demonstrating reduced DNA damage and cellular senescence.
- Preclinical work demonstrating how the NOVOS formulation has even extended lifespan in aged mice
NOVOS is in a class of its own as a longevity brand conducting real scientific trials — and delivering on them. Our supplements for longevity go beyond general wellness to slow the pace of aging. Here are some ways NOVOS Core stands out as the best longevity supplement available.
1. Designed for Longevity, Not Just Wellness
NOVOS Core targets all 12 scientifically recognized hallmarks of aging, including genomic instability, mitochondrial decline, inflammation, and loss of proteostasis. We chose each ingredient for its impact on these hallmarks, not simply for general nutrition.
AG1, while nutrient-dense, is not designed to support these aging pathways.
2. Fewer Ingredients, More Science
Instead of packing dozens of ingredients into one scoop, NOVOS Core focuses on a smaller set of compounds in precise dosages that have real longevity data behind them:
- Alpha-ketoglutarate (AKG): Supports mitochondrial efficiency and cellular energy
- Glycine: Promotes collagen health and healthy metabolism
- Fisetin: Helps clear senescent (aged) cells
- Magnesium malate: Aids cellular energy production and DNA repair
This targeted formulation ensures ingredients work synergistically at meaningful doses, not trace amounts hidden in a proprietary blend.
3. Proven Transparency and Clinical Data
Both AG1 and NOVOS Core disclose extensive ingredient details, but their transparency and research focus differ. AG1 Next Gen lists vitamin and mineral amounts while still grouping dozens of botanicals and probiotics under proprietary blends. Its research centers on nutrient absorption, microbiome balance, and filling dietary gaps. Placebo-controlled trials have not demonstrated medical outcomes or improvements in longevity.
NOVOS Core, by contrast, provides fully disclosed dosages for every ingredient and links each compound to specific mechanisms of aging. Its studies go beyond general nutrition, including human data on reduced Pace of Aging (DunedinPACE), improved skin firmness, and peer-reviewed lab findings on DNA damage and cellular senescence — outcomes directly relevant to longevity.
4. Designed by Scientists, Not Marketers
NOVOS was created by an interdisciplinary team of researchers and physicians specializing in the biology of aging. NOVOS’ scientific board includes biochemists, geneticists, and professors from leading institutions, such as Harvard, MIT, the University of Birmingham, and the University of Washington.
Many have received prestigious honors, including the Breakthroughs in Gerontology Award, the Alzheimer’s Association New Investigator Award, and the Ellison Medical Foundation New Scholar in Aging Award. Each PhD and MD on the team is a pioneer in the longevity field, with research featured by major outlets including TIME, Science, Scientific American, CNN, The Washington Post, and The New York Times.
AG1, in contrast, was built by wellness entrepreneurs. That difference matters when you’re looking for a longevity supplement, not just another multivitamin or greens mix.
Why Choose NOVOS Core as a Longevity Supplement?
If your goal is long-term healthspan and healthy aging, not just short-term energy, NOVOS Core is the optimal choice.
- Longevity-specific focus: Core addresses the biological root causes of aging.
- Evidence-based: Every ingredient is backed by peer-reviewed science. NOVOS is the only consumer supplement company accepted into the Longevity Biotechnology Association and one of just two selected among the top 100 teams in the $101 million XPRIZE for Healthspan Extension.
- Transparent: You know exactly what you’re taking and why.
- Sustainable routine: Take one sachet per day as part of your longevity routine, including a healthy diet, exercise, and stress management.
Notably, NOVOS scientists emphasize that while micronutrients are important for general wellness, they don’t directly slow aging. Longevity requires specific compounds that influence cellular pathways — such as mitochondrial function, senescence, and genomic stability. That’s why NOVOS Core focuses on ingredients like AKG, glycine, and fisetin rather than basic vitamins and minerals.
What’s the Best Longevity Supplement for You?
AG1 and NOVOS Core both promote health, but they serve different purposes. AG1 is a wellness powder that offers daily nutrition and gut support. NOVOS Core is a science-first longevity supplement that targets cellular aging at its roots.
If your focus is long-term vitality, cellular health, and slowing the biological clock, NOVOS Core offers more depth, transparency, and evidence — for roughly the same monthly cost.
Try NOVOS Core today, and take the next step in optimizing your longevity journey.
FAQ About NOVOS Core Vs. AG1
What’s the best longevity supplement brand in 2025?
Among the best longevity supplements available, NOVOS Core stands out for its focus on all 12 hallmarks of aging and transparent ingredient list. Most other products, including AG1, target general health rather than longevity.
What is a better alternative to AG1?
If your goal is cellular longevity rather than basic nutrition, NOVOS Core is the better option. It includes compounds like AKG, glycine, and fisetin that directly influence biological aging.
Is AG1 really worth it?
AG1 is nutrient-rich but expensive for what it provides. If you’re looking for a product to help you age well — one that provides longevity benefits over time — consider taking NOVOS Core.
Why avoid AG1?
Some users find AG1 unnecessary and costly if they’re already supplementing with vitamins or following a nutrient-dense diet. It also uses proprietary blends, meaning you don’t know the exact dosages of individual ingredients — making it harder to assess efficacy. Additionally, some users experience digestive upset, possibly due to AG1’s high dose of probiotics or its inclusion of stevia and soy.
AG1 says it’s clinically backed. Doesn’t that make it a longevity supplement, too?
No. AG1’s trials measure nutrient absorption, bioavailability, and microbiome shifts — valuable for wellness, but unrelated to aging speed. NOVOS Core’s research targets longevity markers like Pace of Aging, DNA damage, and cellular senescence, which directly reflect biological aging mechanisms.
What Is DunedinPACE?
Developed by researchers at Columbia, Duke, and Yale, DunedinPACE measures the rate at which a person is aging biologically — not just biological age. It’s one of the most precise tools for tracking how lifestyle and interventions like NOVOS Core can influence longevity over time.
