Millions of adults struggle with sleep, whether that means falling asleep, staying asleep, or waking too early. According to the National Heart, Lung, and Blood Institute, one in three adults does not consistently get enough restorative sleep to support long-term health and performance.
As we age, sleep problems often become more common. It’s not simply a lifestyle issue. Sleep challenges can be driven by biological changes that happen at the cellular level. These include inflammation, mitochondrial decline, and disrupted circadian rhythms, which make it more difficult to experience deep, restorative sleep.
Rather than treating just the symptoms, NOVOS Core supports the biological systems that regulate sleep. It helps your cells function more efficiently, reducing the root causes of poor sleep quality.
Key Takeaways
- As we age, biological changes — including reduced melatonin, increased inflammation, and disrupted mitochondrial function — interfere with deep, restorative sleep.
- Most traditional sleep aids focus on short-term sedation, not long-term sleep quality or cellular repair.
- NOVOS Core includes glycine, magnesium malate, fisetin, AKG, and other ingredients that address the root causes of poor sleep by supporting circadian rhythms, autophagy, and mitochondrial health.
- By working with the body’s natural sleep systems rather than sedating them, NOVOS Core promotes lasting improvements in sleep quality and overall healthspan.
Why Sleep Quality Declines With Age
Several aging-related processes contribute to disrupted sleep patterns and reduced sleep quality.
- Circadian rhythm changes: As we age, our internal clock becomes less consistent, making it harder to fall and stay asleep, according to the Sleep Foundation.
- Reduced melatonin production: The body produces less melatonin over time, making it harder to initiate sleep.
- Inflammaging: Chronic low-grade inflammation that increases with age can interfere with sleep signaling and brain function.
- Chronic conditions: As the Harvard Division of Sleep Medicine explains, chronic health issues often disrupt sleep as people age. These include arthritis, heart failure, depression, and conditions like sleep apnea or restless legs syndrome. Many of these go undiagnosed or untreated, making deep, restful sleep even more challenging to get.
- Changing sleep patterns: The MedlinePlus Medical Encyclopedia notes that older adults tend to wake up more frequently, fall asleep more slowly, and spend less time in deep, dreamless sleep. They’re often lighter sleepers and may wake up three or four times a night due to discomfort, anxiety, or needing to use the bathroom.
The Lifespan Impact of High-Quality Sleep
Sleep isn’t just about feeling rested. It’s essential for long-term health. One study found that adhering to a low-risk sleep pattern — for instance, getting seven to eight hours of sleep nightly — may lead to gains in life expectancy.
Deep sleep plays a key role in:
- Repairing cells and tissues
- Balancing the immune system
- Supporting brain detox through the glymphatic system
- Enhancing memory and cognitive function
- Regulating hormones and metabolism
The Sleep Foundation emphasizes that consistent, high-quality sleep leads to systemic health benefits, from improved memory and focus to a stronger immune response and a lower risk of disease.Â
How Can Supplements Support Better Sleep?
While melatonin and calming teas are popular, they generally work by temporarily sedating you. They don’t address the cellular dysfunction that causes sleep issues in the first place.
Common Sleep Aids & Their Limitations
| Supplement | Typical Role | Limitation |
| Melatonin | Helps reset the sleep-wake cycle | Doesn’t reduce inflammation or support mitochondrial health |
| Generic magnesium | Supports relaxation | Effectiveness depends on form and dosage; doesn’t support autophagy or mitochondrial repair |
| Antihistamines | Create sedation | Can impair cognitive function, lead to tolerance, and reduce sleep quality |
| Herbal blends | Offer mild calming | Lack robust clinical data and have variable effects |
To improve sleep with age, supplements should:
- Reduce systemic inflammation
- Enhance mitochondrial performance
- Support circadian gene expression
- Promote cellular cleanup through autophagy
These are the systems NOVOS Core is designed to support.
Best Supplements for Sleep: Ingredients That Work (Found in NOVOS Core)
NOVOS Core combines ingredients selected to support deep, consistent, and biologically regenerative sleep.
| NOVOS Core Ingredient | What It Targets | How It Supports Sleep |
| Magnesium Malate | Mitochondrial dysfunction, nutrient sensing, inflammaging | Supports relaxation, calms nervous system, aids ATP production for overnight repair |
| Alpha-Ketoglutarate (AKG) | Mitochondrial dysfunction, inflammaging, epigenetic alterations | Improves mitochondrial function and reduces systemic inflammation linked to poor sleep |
| Glycine | Mitochondrial dysfunction, epigenetic alterations, autophagy, nutrient sensing, inflammaging | Promotes deeper, more restful sleep; regulates circadian rhythms and supports detox |
| Fisetin | Inflammaging, senescence, altered communication, autophagy | Reduces brain and body inflammation that disrupts sleep; clears senescent cells |
| Pterostilbene | Mitochondrial dysfunction, epigenetic alterations, nutrient sensing, inflammaging | Helps regulate sleep via circadian gene expression and antioxidant support |
| Glucosamine Sulfate | Proteostasis, mitochondrial dysfunction, autophagy | Supports cell cleanup during sleep, enhances tissue repair cycles |
| Lithium (low-dose) | Epigenetic alterations, telomere shortening, autophagy | May support mood stability and sleep-wake cycles (circadian support) |
| Vitamin C | Mitochondrial dysfunction, epigenetic alterations | Antioxidant protection during sleep, supports immune system recovery |
| Ginger Extract | Inflammaging, nutrient sensing, microbiome dysbiosis | Reduces systemic inflammation that interferes with sleep quality |
| Rhodiola Rosea | Inflammaging, microbiome dysbiosis | Adaptogen that calms stress and supports resilience under sleep-disrupting pressure |
NOVOS Core vs. Common Sleep Supplements
Most sleep supplements work by sedating the brain. They help you fall asleep quickly but often don’t improve the depth or quality of sleep. Melatonin, antihistamines, and herbal blends are short-term tools. They don’t address inflammation, mitochondrial dysfunction, or the circadian disruption that worsens with age. Over time, they may lose effectiveness or cause side effects like grogginess, dependency, or next-day fatigue.
NOVOS Core takes a different approach. It supports the biological systems that regulate sleep, such as cellular energy production, inflammation control, and nighttime tissue repair. Instead of forcing sleep through sedation, it improves how your body produces, maintains, and recovers during rest. The result is deeper, more restorative sleep without the crash or grogginess.
By addressing the root causes of poor sleep, NOVOS Core not only helps you rest better but also supports long-term healthspan. Its effects go beyond sleep, with additional benefits for cognition, metabolism, mood, and aging itself.
Try NOVOS Core for Lasting Sleep and Healthspan Support
Improving sleep as we age demands more than quick fixes. It requires restoring the balance and function of the biological systems that govern sleep.
NOVOS Core does precisely that. Its ingredients are scientifically backed for supporting mitochondrial performance, reducing inflammation, clearing senescent cells, and promoting cellular resilience — all of which contribute to better sleep and longer-term vitality.
If you’re ready to go beyond melatonin and support your sleep from the inside out, try NOVOS Core today.
FAQ on Supplements for Sleep
What is the most powerful supplement for sleep?
It depends on the root cause. For age-related sleep disruption, ingredients like glycine, magnesium malate, and fisetin (found in NOVOS Core) target inflammation, mitochondrial health, and circadian regulation.
Which supplements should I take for sleep?
Look for options that reduce inflammation, improve cellular energy, and support autophagy. NOVOS Core combines these functions in one science-backed formula.
What vitamin deficiency causes insomnia?
Magnesium deficiency is common, especially in older adults. NOVOS Core includes magnesium malate, a well-absorbed form that supports energy and sleep.
Do any supplements actually improve sleep quality?
Yes. Supplements that support mitochondrial repair, inflammation reduction, and circadian regulation can enhance both sleep depth and duration. NOVOS Core is designed to address all three.
