You may have heard of sirtuins, perhaps in the context of fasting, resveratrol, or various anti-aging headlines. But beyond the buzz, what do sirtuins actually do? And why are they getting so much attention in the longevity world?
Turns out, sirtuins work behind the scenes to switch on helpful genes, manage energy, and support cellular function under stress. However, they don’t work alone. They depend on specific nutrients, energy signals, and enough nicotinamide adenine dinucleotide (NAD+) to function.
If you’re curious about how sirtuins impact aging and longevity, this article is for you. We’ll explore the benefits of sirtuins, how they impact aging, and simple ways to support sirtuins through lifestyle and supplements — including NOVOS’ two-pronged approach with NOVOS Core and NOVOS Boost.
What Are Sirtuins & Why Are They Important?
Sirtuins are a family of seven proteins (SIRT1 through SIRT7) that play a key role in how our cells respond to aging and stress. They influence metabolism, DNA repair, inflammation, and energy production.
Here are a few fast facts about sirtuins:
- To function properly, sirtuins require NAD+, a molecule that declines with age.
- They’re activated by low-energy states like fasting, calorie restriction, and exercise.
- They regulate critical processes like inflammation control and genome stability.
Essentially, sirtuins help protect and maintain healthy cell function, especially under stress. For that reason, among others, they’ve caught the attention of researchers studying sirtuins in the context of longevity, aging, and disease.
Benefits of Sirtuins for Longevity
Sirtuins influence several critical pathways that affect how well we age. When functioning optimally, they may:
- Enhance DNA repair, protecting the genome from damage over time
- Regulate oxidative stress, mitochondrial health, and chronic inflammation.
- Support mitochondrial health and improve energy metabolism
- Protect against metabolic issues, cancer, and neurodegenerative conditions like Parkinson’s and Alzheimer’s
Research suggests that sirtuins play a protective role in lifespan and health span, helping people live both longer and healthier.
How To Support Sirtuin Activity Naturally
The body has natural ways to activate sirtuins, but you can also support them with healthy habits and the right nutrients.
Lifestyle Strategies
- Intermittent fasting and calorie restriction may stimulate sirtuin activity by mimicking energy stress. By cycling between periods of eating and fasting — such as eating within an 8-hour window or fasting one or two days a week — the body shifts from burning sugar to fat. This process of “metabolic switching” between primary fuel types in the body supports cellular repair, cellular stress resistance, and neuroplasticity.
- Regular exercise boosts mitochondrial function and supports sirtuin-related pathways. In particular, aerobic activity increases levels of sirtuins like SIRT1 and SIRT3 in muscle, which support mitochondrial energy production and reduce oxidative stress.
Nutritional Support
- Research shows that phytochemicals such as berberine, curcumin, fisetin, kaempferol, quercetin, and resveratrol can support sirtuin activity, mainly through SIRT1. Eating foods containing these phytochemicals — like berries, apples, strawberries, grapes, and shallots — may help reduce inflammation, boost antioxidants, and support healthy metabolism.
- Nicotinamide mononucleotide (NMN) helps increase levels of NAD+, which all sirtuins depend on to function. Because NAD+ declines with age, replenishing it with NMN can help restore sirtuin activity, enhance energy production, and promote cellular repair. Some foods — such as broccoli, cabbage, avocado, and tomatoes — contain small amounts of NMN or its precursors. However, the amounts are far lower than those used in supplements or clinical research.
- Other helpful nutrients include magnesium and glycine. Foods rich in both magnesium and glycine include legumes, nuts, and seeds. Dark chocolate offers a decent amount of magnesium but isn’t a notable source of glycine.
NOVOS Core & NOVOS Boost: A Multi-Pathway Approach to Sirtuin Support
While you can support sirtuin activity through a healthy diet and lifestyle choices, the right supplements can help ensure you’re getting consistent, effective doses. Instead of focusing on just one compound, food, or activity, NOVOS supplements support sirtuins by providing the nutrients they need to function. They also promote the broader cellular systems that sirtuins help regulate.
NOVOS Core
NOVOS Core includes 12 science-backed ingredients, several of which are particularly relevant for sirtuin support:
- Magnesium and glycine, which help regulate inflammation and energy metabolism
- Alpha-ketoglutarate, which supports mitochondrial health
- Pterostilbene, a polyphenol that activates sirtuins and has strong antioxidant properties
Together, these ingredients create a cellular environment that allows sirtuins to function optimally.
NOVOS Boost
NOVOS Boost delivers a pure form of NMN, a direct precursor to NAD+. As we age, NAD+ levels can drop by more than 50%. These declines impact the body’s ability to repair DNA, control inflammation, and maintain metabolic function — all processes regulated by sirtuins. Replenishing NAD+ with NMN helps keep these proteins active and effective. By restoring this critical molecule, NOVOS Boost supports all seven sirtuins and promotes healthier aging at the cellular level.
Why You Need Both
Sirtuins don’t work in isolation. They need fuel (NAD+) and the right internal environment to thrive. Combining NOVOS Core with NOVOS Boost provides comprehensive support — which is more effective than relying on a single ingredient like resveratrol or NMN alone. For example, while resveratrol may activate one sirtuin subtype, a well-rounded strategy nourishes multiple pathways simultaneously. This approach helps the body better respond to stress, repair damage, and maintain healthy function through the years.
Final Thoughts on Sirtuins & Aging
Sirtuins are promising targets in longevity research, but simply activating them isn’t enough. Enjoying the full benefits of sirtuins requires a combination of lifestyle strategies and high-quality supplements.
NOVOS Core helps lay the foundation with nutrients that support inflammation control, mitochondrial health, and cellular resilience. NOVOS Boost provides the NAD+ precursor that enables sirtuins to do their job. Best of all, it’s easy to integrate these supplements into your daily longevity routine:
- Simply add one sachet of NOVOS Core to your water, juice, smoothie, coffee, tea, yogurt, or oatmeal.
- Take two capsules of NOVOS Boost with or without food. You may take up to four capsules per day for an energy boost.
If you’re looking for science-backed tools for healthy aging, try NOVOS Core and NOVOS Boost as part of a comprehensive longevity plan.
