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The Perfect Balance: Optimizing Longevity Through Exercise

Exercise for longevity

Physical activity is crucial for maintaining good health and longevity. The human body is designed to move, and exercise provides numerous benefits for both physical and mental well-being. However, with various types of exercise available, it can be challenging to know which forms are most beneficial and how to strike the right balance. This article will delve into the science behind the different types of exercise, their impacts on healthspan and lifespan, and how to optimize your workout routine for longevity.

The Scientific Evidence for Exercise Extending Lifespan

C. elegans Studies

The nematode worm, C. elegans, is a popular model organism in aging research due to its short lifespan. Research has shown that physical activity, in the form of mechanical stimulation, can extend the lifespan of these worms (Hahm et al., 2015).

Rodent Studies

Several studies conducted on rodents spanning decades, primarily mice and rats, have shown that exercise can increase their lifespan. For instance, a study (Holloszy, 1993) found that rats subjected to lifelong voluntary exercise had a 15% increase in median lifespan compared to sedentary control animals. This, combined with similar results across other species, suggests that exercise has conserved effects on longevity across species.

Human Studies

Observational Studies

Large-scale observational studies have consistently demonstrated a link between increased physical activity and longer lifespans in humans. A study (Arem et al. 2015) found that engaging in the recommended levels of physical activity was associated with a 31% lower risk of all-cause mortality, while higher levels of activity (3-5 times the recommended amount) reduced the risk by 39%.

Intervention Studies

Although fewer in number, intervention studies have also clearly shown positive effects of exercise on human lifespan. A meta-analysis (Sofi et al., 2011) found that regular physical activity reduced the risk of all-cause mortality by 22% in older adults.

The Different Forms of Exercise and Their Relation to Longevity

Steady-State Cardio or Aerobic Exercise

Steady-state cardio, also known as aerobic exercise, involves activities like running, cycling, and swimming at a moderate intensity for an extended period. This form of exercise helps improve cardiovascular health, lowers blood pressure, and increases lung capacity (Myers et al., 2002). A study (Lee et al., 2019) found that running reduced the risk of all-cause mortality by 27%, while walking reduced it by 20%.


Walking is a low-impact form of aerobic exercise that can help maintain mobility, support heart health, and reduce the risk of chronic disease (Murphy et al., 2007).

High-Intensity Interval Training (HIIT Workout)

HIIT consists of short bursts of high-intensity exercise followed by recovery periods of low-intensity activity. HIIT workouts have been shown to improve cardiovascular fitness, increase fat loss, and enhance muscle endurance (Gibala et al., 2006).

Strength Training / Weight Lifting

Strength training involves using resistance, such as weights or bodyweight, to build muscle mass and increase strength. It supports bone health, aids in injury prevention, and contributes to better balance and coordination (Wolff et al., 1999). A study (Stamatakis et al., 2018) found that individuals who participated in resistance training had a 23% reduced risk of all-cause mortality and a 31% reduced risk of cancer-related mortality.

Isometric Exercises; Planks, Glute Bridges and More

Isometric exercises like planks and glute bridges involve maintaining a static position while contracting the muscles. These exercises help to improve muscle strength and endurance and can contribute to better posture and core stability (Park et al., 2016).

Isotonic Exercises; Muscle Tension With Exercises Like Squats or Hammer Curls  

Isotonic exercises involve moving a joint through its full range of motion while maintaining constant muscle tension.  Incorporating isotonic exercises, such as hammer curls, bicep curls, and squats, can help improve flexibility, joint health, and muscle strength (Bird et al., 2005).


Yoga combines physical postures, breathing exercises, and meditation to promote flexibility, balance, and stress reduction. Studies have shown that yoga can help reduce chronic pain, improve mental health, and support cardiovascular health (Ross et al., 2013).

Pilates; Reformer, Mat and More

Pilates is a form of low-impact exercise that focuses on core strength, flexibility, and muscular endurance. Research has shown that Pilates can improve posture, balance, and overall well-being (Wells et al., 2014). Pilates has multiple variations, including classical mat Pilates, reformer Pilates, chair Pilates, and tower Pilates, which can provide additional variety and challenge.


Engaging in sports like soccer, basketball, or tennis can provide a combination of cardiovascular, strength, and flexibility benefits, depending on the specific sport (Sallis et al., 1998).

The Benefits of Exercise for Longevity

Cardiovascular Health

Regular exercise has been shown to improve cardiovascular health by reducing the risk of heart disease, stroke, and high blood pressure (Thompson et al., 2003).

Weight Management

Engaging in physical activity helps burn calories and maintain a healthy body weight, including a reduction in visceral fat, which is essential for overall health and longevity (Warburton et al., 2006).

Mental Health

Exercise can help combat stress, anxiety, and depression, contributing to improved mental well-being and quality of life (Fox, 1999).

Immune Function

Regular physical activity can support the immune system, helping the body fight off infections and illness (Nieman et al., 2011).

Reduced Risk of Chronic Diseases

Exercise has been linked to a lower risk of developing chronic conditions such as diabetes, obesity, and certain cancers (Booth et al., 2012).

How Much Exercise? Finding the Right Balance

Minimum Effective Dose

To maximize the benefits of exercise while minimizing the time and effort required, research suggests that engaging in 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity per week, along with two days of strength training, can provide significant health benefits (Haskell et al., 2007)[15].

Ideal Amount and Types of Exercise

For maximum benefits, a combination of aerobic, strength, and flexibility exercises should be incorporated into an individual’s workout routine. A balanced approach to exercise, combining aerobic and resistance training, may provide the most significant benefits for lifespan extension. Research (Kekäläinen et al. 2019) showed that a combination of both types of exercise was associated with a 42% lower risk of all-cause mortality compared to a sedentary lifestyle. This approach could involve 3-5 days of aerobic exercise, 2-3 days of strength training, and daily stretching or yoga (American College of Sports Medicine, 2013).

Overtraining and Its Effects

Engaging in too much exercise or not allowing adequate recovery time can lead to overtraining, a state in which the body cannot fully recover from exercise-induced stress. Overtraining can negatively impact overall health, increase the risk of injury, and impair immune function (Kreher et al., 2012). While moderate and vigorous exercise has been shown to have numerous health benefits, excessive exercise can pose risks. For example, study (O’Keefe et al., 2012) found that extreme endurance exercise, such as marathon running, could be associated with increased cardiovascular risk and potential heart damage.

What Epigenetics Tells Us Is The Right Amount of Exercise For Longevity

A 2023 paper investigated the exact amount of exercise needed to minimize epigenetic age (Fox, et al., 2023). The findings were aligned with our advice that too much is just as bad as too little: the ideal number of daily steps is somewhere around 11,247, after which aging re-accelerates (the inflection point). In terms of daily MET hours, a unit of measurement for power output, the amount is 34.7 MET hours. And in terms of average daily % moderate-to-vigorous intensity exercise, the ideal amount is 5.9%.

The Power of Exercise

Physical activity is essential for maintaining health and promoting longevity. By incorporating a balanced mix of aerobic, strength, and flexibility exercises into a weekly routine, individuals can optimize their physical and mental well-being. By understanding the science behind these different forms of exercise and their respective benefits, it is possible to create a well-rounded fitness regimen that supports a healthy lifespan and an improved quality of life.

Interested in learning more? Find out about how exercise impacts the hallmarks of aging in this article.


  1. Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002). Exercise capacity and mortality among men referred for exercise testing. New England Journal of Medicine, 346(11), 793-801.
  2. Gibala, M. J., Little, J. P., Macdonald, M. J., & Hawley, J. A. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology, 590(5), 1077-1084.
  3. Wolff, I., van Croonenborg, J. J., Kemper, H. C., Kostense, P. J., & Twisk, J. W. (1999). The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporosis International, 9(1), 1-12.
  4. Park, S. Y., Son, W. M., & Kwon, O. S. (2016). Effects of whole body vibration training on body composition, skeletal muscle strength, and cardiovascular health. Journal of Exercise Rehabilitation, 12(6), 573-578.
  5. Bird, S. P., Tarpenning, K. M., & Marino, F. E. (2005). Designing resistance training programs to enhance muscular fitness: a review of the acute program variables. Sports Medicine, 35(10), 841-851.
  6. Ross, A., & Thomas, S. (2010). The health benefits of yoga and exercise: a review of comparison studies. Journal of Alternative and Complementary Medicine, 16(1), 3-12.
  7. Wells, C., Kolt, G. S., & Bialocerkowski, A. (2012). Defining Pilates exercise: A systematic review. Complementary Therapies in Medicine, 20(4), 253-262.
  8. Sallis, J. F., Haskell, W. L., Wood, P. D., Fortmann, S. P., Rogers, T., Blair, S. N., & Paffenbarger, R. S. (1985). Physical activity assessment methodology in the Five-City Project. American Journal of Epidemiology, 121(1), 91-106.
  9. Murphy, M. H., Blair, S. N., & Murtagh, E. M. (2009). Accumulated versus continuous exercise for health benefit: a review of empirical studies. Sports Medicine, 39(1), 29-43.
  10. Thompson, P. D., Buchner, D., Piña, I. L., Balady, G. J., Williams, M. A., Marcus, B. H., … & Wenger, N. K. (2003). Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Circulation, 107(24), 3109-3116.
  11. Warburton, D. E., Nicol, C. W., & Bredin, S. S. (2006). Health benefits of physical activity: the evidence. Canadian Medical Association Journal, 174(6), 801-809.
  12. Fox, K. R. (1999). The influence of physical activity on mental well-being. Public Health Nutrition, 2(3a), 411-418.
  13. Nieman, D. C., & Wentz, L. M. (2019). The compelling link between physical activity and the body’s defense system. Journal of Sport and Health Science, 8(3), 201-217.
  14. Booth, F. W., Roberts, C. K., & Laye, M. J. (2012). Lack of exercise is a major cause of chronic diseases. Comprehensive Physiology, 2(2), 1143-1211.
  15. Haskell, W. L., Lee, I. M., Pate, R. R., Powell, K. E., Blair, S. N., Franklin, B. A., … & Bauman, A. (2007). Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation, 116(9), 1081-1093.
  16. American College of Sports Medicine. (2013). ACSM’s guidelines for exercise testing and prescription. Lippincott Williams & Wilkins.
  17. Kreher, J. B., & Schwartz, J. B. (2012). Overtraining syndrome: a practical guide. Sports Health, 4(2), 128-138.
  18. Holloszy, J. O. (1993). Exercise increases average longevity of female rats despite increased food intake and no growth retardation. Journal of Gerontology, 48(3), B97-B100.
  19. Hahm, J. H., Kim, S., DiLoreto, R., Shi, C., Lee, S. J., Murphy, C. T., & Nam, H. G. (2015). C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nature Communications, 6, 8919.
  20. Arem, H., Moore, S. C., Patel, A., Hartge, P., Berrington de Gonzalez, A., Visvanathan, K., … & Matthews, C. E. (2015). Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Internal Medicine, 175(6), 959-967.
  21. Sofi, F., Valecchi, D., Bacci, D., Abbate, R., Gensini, G. F., Casini, A., & Macchi, C. (2011). Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. Journal of Internal Medicine, 269(1), 107-117.
  22. Lee, D. H., Lavie, C. J., & Vedanthan, R. (2019). Optimal dose of running for longevity: is more better or worse? Journal of the American College of Cardiology, 73(20), 2634-2636.
  23. Stamatakis, E., Lee, I. M., Bennie, J., Freeston, J., Hamer, M., O’Donovan, G., … & Tipton, K. (2018). Does strength promoting exercise confer unique health benefits? A pooled analysis of data on 11 population cohorts with all-cause, cancer, and cardiovascular mortality endpoints. American Journal of Epidemiology, 187(5), 1102-1112.
  24. Kekäläinen, T., Kokko, K., Sipilä, S., & Walker, S. (2019). Effects of a 9-month resistance training intervention on quality of life, sense of coherence, and depressive symptoms in older adults: randomized controlled trial. Quality of Life Research, 28(3), 767-776.
  25. O’Keefe, J. H., Patil, H. R., Lavie, C. J., Magalski, A., Vogel, R. A., & McCullough, P. A. (2012). Potential adverse cardiovascular effects from excessive endurance exercise. Mayo Clinic Proceedings, 87(6), 587-595.
  26. Fox, F., Liu, D., Breteler, B., Aziz, N. (2023). Physical activity is associated with slower epigenetic ageing–Findings from the Rhineland study. Aging Cell, doi 10.1111 acel.13828.

*We are currently working on providing full citations, which will be available soon.

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