Interest in longevity supplements has skyrocketed in recent years — and with it, so has confusion. As part of our NOVOS comparison series, we’ve already looked at how NOVOS Core stacks up against the Blueprint protocol. This time, we’re comparing NOVOS Core and Tally Health.
Both promise to support long-term health and cellular resilience. But while Tally Health leans on its biological-age test, NOVOS goes further. We offer more clinically validated biological age testing and advanced longevity supplements, backed by transparent science and comprehensive research designed to slow aging at the cellular level.
Key Takeaways
- Tally Health includes a small handful of compounds aimed at general wellness, not all 12 hallmarks of aging.
- A team of longevity researchers created NOVOS Core. The formulation targets all 12 mechanisms of aging simultaneously using science-backed ingredients.
- NOVOS provides transparent dosages and publishes evidence from both placebo-controlled human clinical studies and preclinical animal research — something Tally lacks for its full formulation.
- NOVOS is the only consumer supplement brand accepted into the Longevity Biotechnology Association. It’s also one of just two consumer brands selected among the top 100 teams in the $101 million XPRIZE for Healthspan Extension competition.
- Both companies offer biological-age testing, but only NOVOS pairs it with a supplement that’s scientifically shown to influence aging mechanisms.
- For those seeking the best longevity supplement based on evidence, scope, accessibility, and value, NOVOS Core is the clear choice.
Why Compare NOVOS Core and Tally Health?
Both NOVOS and Tally aim to help people live longer, healthier lives. Yet their philosophies and formulations couldn’t be more different.
Tally Health combines a biological-age test with a supplement called the Daily Vitality Blend. Its appeal lies in data: You take a test, get your “Tally Age,” and track changes over time. The blend includes compounds such as resveratrol, quercetin, fisetin, spermidine, and alpha-ketoglutarate (AKG) — ingredients with some individual evidence for longevity.
However, the formula is limited in scope, addressing only a few mechanisms of aging. And it lacks published, peer-reviewed research on the full formulation’s outcomes. Additionally, some of its featured ingredients — such as spermidine and resveratrol — are still debated within the scientific community. Their effects on longevity are far less established than compounds like alpha-ketoglutarate (AKG) and fisetin, which have more substantial evidence supporting their roles in cellular health and lifespan extension.
In fact, in a human clinical trial, oral spermidine was found to not raise blood levels of spermidine or its metabolite, spermine, raising questions as to whether it is even bioavailable in the first place.
In contrast, a team of pioneering longevity experts developed NOVOS Core. This patent-pending formulation targets all 12 mechanisms of aging — from mitochondrial decline to DNA damage — with input from a diversity of scientific perspectives. Every ingredient is included at evidence-based dosages and supported by over 400 longevity-relevant scientific studies.
In short:
- Tally Health lets you track your biological age with less scientifically validated algorithms and offers simple supplements aimed at general wellness.
- NOVOS helps you not only track your biological age with the most clinically validated epigenetic algorithms but also improve it. Its formulations specifically target the root causes of aging and are scientifically validated in multiple university studies.
Comparison at a Glance
| Feature | NOVOS Core | Tally Health’s Vitality |
| Scientific Backing | Formulated by numerous longevity Ph.D.s and MDs | Formulated by one Ph.D. |
| Patentable Formulation | Yes, patent-pending | No |
| Key Ingredients | Glycine (2,000 mg), AKG (1,100 mg), Fisetin (100 mg), Pterostilbene (50 mg), Magnesium Malate, Rhodiola, Glucosamine, HA, Vit C, Ginger, L-Theanine, Micro-Dosed Lithium | AKG (1,000 mg), Quercetin (500 mg), Resveratrol (500 mg), Fisetin (100 mg), Spermidine (900 mcg) |
| Ingredients Transparency | Fully disclosed with dosages & 435+ citations | Disclosed dosages but limited formulation rationale |
| Total Longevity Actives | 6.9g | 2.1g |
| Includes Resveratrol | No, uses the more bioavailable pterostilbene instead | Yes, with no pterostilbene included |
| Targets All 12 Hallmarks of Aging | Yes | No |
| Peer-Reviewed or Clinical Studies | Yes (https://novoslabs.com/novos-formulation-evidence/) | No, ingredient-level references only |
| Delivery Format/Dosage | One daily sachet | 4 daily capsules |
| Cost | ~$98/month or less with subscription | $84 per month or less with subscription |
| Availability | Global | U.S. only |
| Best For | Longevity-focused users seeking targeted aging support | Users focused on tracking biological age |
Why Choose NOVOS Core as a Longevity Supplement?
Evidence is mounting that NOVOS Core is the best option in the world of longevity supplements. Here are some compelling reasons to add this convenient sachet to your daily routine.
1. Targets the Full Spectrum of Aging
NOVOS Core was the first consumer supplement designed to address all 12 hallmarks of aging, including mitochondrial dysfunction, DNA damage, cellular senescence, and chronic inflammation. These mechanisms directly impact stem cell health and regeneration, which are critical for tissue repair and long-term vitality. Tally’s formula addresses only a few of these pathways — missing key processes like those that preserve stem cell function and systemic resilience.
2. Grounded in Real Science
NOVOS Core’s formulation has been validated in multiple studies. It extended lifespan in aged mice by nearly 20% — more than any supplement ever studied. Human studies have also shown improved skin firmness, reductions in biological pace of aging, and reduced DNA damage and senescence.
Tally Health has not yet published peer-reviewed data showing clinical results from its supplement blend or its effect on biological age.
3. Transparent and Accessible
NOVOS Core lists every ingredient and dosage publicly. There are no proprietary blends or hidden additives, and its sachet format ensures precise, clean dosing. All ingredients undergo rigorous testing in third-party labs to guarantee the highest standards of purity and potency.
Tally Health discloses its ingredient amounts but offers limited insight into how they interact or why specific dosages were chosen.
4. Designed by Scientists, Not Marketers
NOVOS Core was developed by an interdisciplinary team, not a single figurehead or a group of marketers. Our team includes biochemists, geneticists, and professors from leading institutions such as Harvard, MIT, the University of Birmingham, and the University of Washington.
These experts have earned major honors, including the Breakthroughs in Gerontology Award, the Alzheimer’s Association New Investigator Award, and the Ellison Medical Foundation New Scholar in Aging Award. Their work has been featured by outlets like TIME, The New York Times, Scientific American, and BBC.
5. Value and Simplicity
At roughly $3 per day, NOVOS Core offers a comprehensive longevity supplement in one step. There’s no need for multiple bottles, capsules, or testing subscriptions to get measurable support for healthy aging.
6. Mission-Driven and Community-Focused
NOVOS is a Public Benefit Corporation committed to advancing public health and scientific understanding of aging. It also offers the NOVOS Age AI app, a free mobile tool available to everyone (no subscription required) that provides personalized aging insights. The company’s core belief is that longevity science should be accessible, transparent, and open to all.
7. Recognized by the Global Longevity Science Community
NOVOS is the only consumer brand accepted into the prestigious Longevity Biotechnology Association. This organization includes the world’s leading scientists, investors, and companies advancing human longevity.
It’s also one of only two consumer brands chosen as a top-100 team for the XPRIZE for Healthspan Extension. This $101 million, seven-year longevity competition seeks to identify and fund therapeutic solutions that support healthy human aging.
These honors underscore NOVOS’s role at the forefront of science-based longevity solutions. It’s not just a supplement brand but a serious player in the future of health.
What Others Say About NOVOS Core
When it comes to longevity, bold claims are common, but genuine validation is rare. NOVOS Core is one of the few longevity supplements with both independent studies and third-party recognition to back it up.
The NOVOS Core formulation has been included in multiple scientific investigations showing record-breaking lifespan extension in animals, statistically significant reductions in aging markers like DNA damage and senescence, and improvements to skin firmness and Pace of Aging in humans.
The media has taken notice, too:
- Forbes called NOVOS “a clear outlier in a sea of generic supplement suppliers.”
- The Wall Street Journal described NOVOS as “pioneers in consumer longevity, among the first to target 12 mechanisms of aging simultaneously.”
- Business Insider highlighted NOVOS as proof that “it doesn’t take millions of dollars or extreme routines to combat aging.”
This combination of peer-reviewed science and public trust sets NOVOS apart from hype-driven brands and single-founder experiments.
Real Longevity Relies on Evidence, Not Branding
NOVOS Core’s strength lies in its data, transparency, and focus on scientifically validated mechanisms that influence how we age.
If your goal is to both know your biological age and also change your biology for the better, NOVOS Core is the only longevity supplement designed to help you do it.
After all, longevity isn’t about celebrity endorsements or sleek marketing — it’s about science. Tally Health provides an age test and a small supplement blend. NOVOS delivers not only a biological age test but also a proven, comprehensive formulation built to slow biological aging safely and effectively.
Try NOVOS Core and experience evidence-based longevity made simple.
FAQ About NOVOS Core vs. Tally Health
What’s the best longevity supplement brand in 2025?
For transparency, published science, and formulation breadth, NOVOS Labs leads the field. Its supplement targets all 12 mechanisms of aging and has shown measurable biological impact in early research.
What is a better alternative to Tally Health?
NOVOS Core offers a complete formulation targeting all 12 causes of aging, scientific validation, and input from multiple scientists rather than a single founder.
How do you get your biological age tested?
Both NOVOS and Tally Health provide biological age tests. But only NOVOS gives you a way to slow biological aging at the cellular level. NOVOS Age uses next-generation epigenetic technology and pairs with NOVOS Core. Together, these longevity products provide a comprehensive approach to tracking and improving aging.
Which ingredients actually slow aging?
Compounds like AKG, glycine, fisetin, and magnesium support mitochondrial function, collagen integrity, and cellular renewal. These ingredients are all key to slowing biological aging and are foundational to NOVOS Core.
Is Tally Health worth the price?
If you’re primarily interested in testing your biological age, it can be informative. But for people who want to actively slow aging through clinically studied ingredients and multi-pathway support, NOVOS Core offers more value and evidence.
