Choosing the best longevity supplement brands can feel overwhelming — especially when one of them claims to “reverse aging” with a $2 million-a-year biohacking routine. If you’ve seen headlines about the Bryan Johnson Blueprint or its new “Longevity Mix,” you’ve probably wondered how it stacks up against science-backed supplements like NOVOS Core.
In this comparison, we’ll look at two angles:
- Philosophy: How the NOVOS and Blueprint protocols differ in purpose and practicality
- Product: How the Blueprint Longevity Mix compares to NOVOS Core
Both share a mission: to slow aging and improve long-term health. But only one takes an evidence-based, accessible path to help you do it safely.
Key Takeaways
- Blueprint is Bryan Johnson’s personal $2M-per-year longevity experiment focused on prescriptions, data tracking, and self-experimentation.
- NOVOS Core delivers a simplified daily supplement designed by aging researchers to support healthspan safely and affordably. It’s a science-backed, third-party recognized longevity solution that’s helping real people outperform high-cost protocols with proven results — at a fraction of the price.
- The Blueprint Longevity Mix drink forms only one small part of Johnson’s larger protocol.
- NOVOS Core offers transparent, science-backed methods that target the biological root causes of aging.
- For most people, NOVOS provides a practical, accessible path to longevity without the costly labs, prescriptions, or extreme lifestyle demands.
Why Compare NOVOS and Blueprint?
The Blueprint Project has become a high-profile experiment in extreme longevity. Tech entrepreneur Bryan Johnson follows an algorithmic lifestyle of sleep tracking, medical testing, and carefully timed meals — all designed to maintain the biological age of an 18-year-old.
It’s fascinating, but it’s also personal science, not public health. Much of Johnson’s regimen involves prescription drugs, experimental compounds, and frequent medical supervision. Experts have described the Blueprint approach as unproven and potentially unsustainable. As one longevity scientist explains, the regimen requires such intense discipline that fewer than 2% of Americans are likely to follow through on it for the long haul.
NOVOS, on the other hand, represents the opposite end of the spectrum — a scientifically validated, accessible longevity solution built by researchers, not influencers. Its mission is to give people a safe, evidence-backed way to improve their lifespan and healthspan without needing a medical team or a million-dollar budget.
The fundamental differences are:
- Blueprint is about one man’s experiment in extreme control.
- NOVOS is about scalable, science-based longevity for everyone.
Ingredients Comparison: NOVOS Core Vs. Blueprint Longevity Mix
Both routines rely on overlapping compounds linked to longevity — alpha-ketoglutarate (AKG), glycine, magnesium, and L-theanine, among others. However, Bryan Johnson’s Blueprint and NOVOS Core differ in context and formulation quite a bit.
The Blueprint Longevity Mix
Bryan Johnson’s Longevity Mix is a multinutrient drink available in two flavors. It’s designed to simplify his supplement load. Unlike his broader Blueprint protocol — which involves over 100 pills, prescription drugs like rapamycin, and frequent medical testing — this specific drink mix lists most of its ingredients and dosages on the label.
Each serving contains compounds like:
- Creatine monohydrate (2,500 mg)
- Calcium alpha-ketoglutarate (Ca-AKG) (2,000 mg)
- Taurine (1,500 mg)
- Glycine (1,200 mg)
- L-Lysine HCl (1,000 mg)
- Glucosamine sulfate (750 mg)
- L-Glutathione reduced (250 mg)
- L-Theanine (200 mg)
- Sodium hyaluronate (120 mg)
- Magnesium citrate, vitamin C, and calcium in bioavailable forms
It’s vegan, gluten-free, non-GMO, and made without artificial ingredients. And while Blueprint also sells standalone products like collagen and ashwagandha + rhodiola, they’re intended to complement his strict routine rather than replace it. That routine is part of a much larger personal protocol that includes prescription and experimental compounds not available to the general public.
NOVOS Core
NOVOS Core condenses what decades of aging research suggest works best into one simple, daily sachet available in unflavored and orange varieties. Its formulation is the first of its kind, designed to target the 12 Mechanisms (causes) of Aging. A patent was filed on NOVOS Core, because of its novel approach to aging and its efficacy. It features 12 synergistic, science-based ingredients chosen for their safety, evidence, and ability to target multiple hallmarks of aging.
Some of these include:
- Glycine: Supports collagen, detoxification, and metabolic balance
- Alpha-Ketoglutarate (AKG): Supports mitochondrial function and cellular longevity
- Fisetin: Helps clear senescent cells that drive aging
- Hyaluronic acid: Enhances hydration and skin elasticity
- Magnesium malate and L-theanine: Promote energy, calm, and resilience
None of the ingredients requires a prescription. NOVOS Core lists all active ingredients and dosages openly.
NOVOS Vs. Blueprint Protocol: Comparison at a Glance
| Feature | NOVOS | Blueprint (Bryan Johnson) |
| Scientific Backing | Aging researchers | Self-experimentation + curated literature |
| Ingredients Transparency | Fully disclosed actives and dosages | Partially disclosed |
| Includes AKG, Glycine, Magnesium Malate | Yes | Yes |
| Includes Prescription Drugs | No | Yes |
| Includes NAD Precursors (e.g., NMN, NR) | Yes, NOVOS Boost | Some |
| Delivery Format/Dosage | One sachet per day | 100+ pills, powders, diagnostics |
| Cost | ~$98/month or less with subscription | ~$2M/year (approximate) |
| Availability | Global | Drink mix available; full regimen proprietary |
| Best For | Longevity-focused individuals seeking ease & science | Hardcore biohackers replicating Johnson’s experiment |
Science, Simplicity & Accessibility
Both Blueprint and NOVOS share an interest in longevity science, but their approaches to applying it couldn’t be more different.
Blueprint’s system demands a level of constant data tracking and self-experimentation that few people can realistically maintain. It’s experimental, pharmaceutical, and highly individualized. Even Johnson himself calls it “an algorithmic lifestyle,” not a supplement plan.
By contrast, NOVOS Core was developed by some of the world’s top scientists in the biology of aging. Every ingredient targets multiple hallmarks of aging in one simple step.
It’s the difference between hiring a full-time lab team versus following a proven, peer-reviewed roadmap. One drink a day is all it takes to incorporate NOVOS Core into your routine.
Recent research supports several of NOVOS Core’s key ingredients:
- Studies show AKG may help maintain mitochondrial function and extend lifespan in animal models.
- Glycine may improve metabolic health and collagen formation.
- Fisetin demonstrates senolytic activity, helping cells renew more efficiently.
Furthermore, in one study, NOVOS Core extended the lifespan of aged mice by nearly 20% — more than any supplement ever studied. Other research shows its ingredient combinations help maintain healthy DNA and support the body’s ability to clear senescent cells.
These characteristics make NOVOS unique among the best supplements for longevity. It’s practical, affordable, and rooted in real human science, not hype.
What Others Say About NOVOS Core
When it comes to longevity supplements, bold claims are common — but real-world validation is rare. NOVOS Core is an exception. From breakthrough scientific studies and major media nods to user results that rival high-profile biohackers, NOVOS Core consistently proves its worth. Here’s a look at what the research, press, and real people are saying about the supplement that’s redefining what’s possible in healthy aging.
Scientific Backing
The NOVOS Core formulation has been involved in multiple scientific studies to date, finding world-record-breaking animal lifespan extension; statistically significant reductions in mechanisms of aging that include DNA damage, cellular senescence, cellular inflammation, and more; improvements to skin firmness in humans; and even reductions in Pace of Aging in a human case study. Blueprint has zero scientific studies to validate it.
Case Studies
NOVOS Core customers have outperformed Bryan Johnson on numerous occasions and been recognized by the press. This is on less than $100 per month instead of $2M per year and at tremendous personal sacrifice.
Third-Party Recognition
Third parties, like The Wall Street Journal, Forbes, and Business Insider, acknowledge NOVOS’ leadership in the field of longevity:
- “In a sea of generic supplement suppliers with just a packaging and marketing department, NOVOS’ commitment to research is a clear outlier.” — Forbes
- “Novos are pioneers in consumer longevity and among the first to develop a comprehensive approach that targets 12 mechanisms of aging simultaneously.” — WSJ: The Future of Everything
- “In a groundbreaking study, NOVOS Core extended aged mouse lifespan by 18% — more than any supplement ever studied.” — WSJ
- Referring to NOVOS: “Maybe it doesn’t take millions of dollars, over 100 daily supplements, and a team of 30 doctors to combat the aging process.” — Business Insider
- “Wealthy men are spending millions to lower their biological ages and live longer. These women are beating them with cheaper solutions [NOVOS].” — Fortune
Real Longevity Relies on Evidence, Not Extremes
The future of longevity isn’t reserved for billionaires or biohackers. It’s based on accessible, evidence-based science that anyone can research and implement.
At NOVOS, our ecosystem of supplements, at-home aging tests, and educational resources empowers you to take control of your health.
If you admire Blueprint’s ambition but want something sustainable, safe, and scientifically vetted, NOVOS Core is your go-to longevity supplement. Along with a longevity diet, regular exercise, sleep, and other lifestyle factors, it can help you live younger for longer — without the labs, drugs, or million-dollar price tag.
Ready to simplify your longevity routine? Try NOVOS Core today.
FAQ About NOVOS Core Vs. the Blueprint Protocol
Is NOVOS Core similar to Bryan Johnson’s Blueprint stack?
They share overlapping ingredients like AKG and glycine. But NOVOS Core delivers a science-backed, affordable, daily solution without the need for prescriptions or testing.
What’s the best longevity supplement brand in 2025?
It depends on your goals. But for transparency, formulation, and scientific credibility, NOVOS is unmatched. NOVOS Labs invented the category of addressing aging by targeting all mechanisms of aging simultaneously. And we have more research backing our impact on the aging process than any other “longevity” company.
What supplements are in Bryan Johnson’s routine?
Over 100 pills and powders — including NMN, glycine, magnesium, collagen, 17-alpha-estradiol, and rapamycin — many of which require prescriptions or carry unknown long-term risks.
What are the cons of the Blueprint diet?
It’s costly and rigid, making it impractical for most people. It also relies on pharmaceuticals not suitable for the general public, with high risk profiles. Its results haven’t been replicated in any controlled studies.
Is the Blueprint stack worth it?
For most people, no. While it’s an intriguing individual case study, it’s not a sustainable, universal, or medically supported plan for daily longevity.
Can you slow aging without prescription drugs?
Yes — through science-backed lifestyle choices and supplements like NOVOS Core that target biological aging at the cellular level.
How much does Blueprint cost?
Reports estimate Johnson spends around $2 million annually on his regimen, including diagnostics, testing, and custom compounds.
