How to live longer? And how to improve your stem cell health?
This critical scientific overview of “Life Force” explores some of the topics covered by Tony Robbins, including stem cell therapies, nutrition, and achieving optimal health.
Tony Robbins is a well-known bestselling author and productivity coach.
Peter Diamandis is a medical doctor and aerospace engineer, bestselling author, co-founder of Singularity University and founder of the XPRIZE, while Dr. Hariri is a surgeon and biotech entrepreneur who is currently CEO of Celularity, a stem cell company.
They co-wrote a book on longevity; more specifically about the latest breakthroughs in medicine and biotechnology to slow down aging, prevent disease, and maximize energy and strength.
According to the authors, “Life Force will show you how you can wake up every day with increased energy, a more bulletproof immune system, and the know-how to help turn back your biological clock. This is a book for everyone, from peak performance athletes, to the average person who wants to increase their energy and strength, to those looking for healing.”
Life Force – How to live longer, healthier
It’s well-known that Tony Robbins has been very interested in health and longevity (R). And so are we!
After all, you can’t be productive and be the best version of yourself if you don’t also focus on keeping your body and brain healthy.
Tony Robbins emphasizes a healthy diet and supplements for a long, healthy life. We wrote about the best longevity diet here, and we explain what we believe are the best, science-based anti-aging supplements here.
Besides nutrition and supplements, Tony Robbins also recommends many other things to improve health and longevity, like improving sleep and having a positive mindset.
In this regard, we highlighted 50 of the best tips to sleep here.
And to improve positive thinking, we gathered dozens of tips here. Happiness is something you can learn!
Tony Robbins and longevity biotechnology
Besides lifestyle, Tony Robbins also focuses on novel biotechnologies to extend lifespan.
Given Tony Robbins’ investments in several stem cell companies, it’s clear that Tony Robbins is a big proponent of stem cell therapies for longevity. He also receive stem cell therapies (R).
Stem cells create novel cells and maintain cells. For example, mesenchymal stem cells create fat cells, bone cells and cartilage cells. Skin stem cells create skin cells, gut stem cells create gut cells, and so on.
When we age, stem cell function, and the amount of stem cells in our body declines (as we explain here). This leads to our tissues being less replenished with novel cells, and being less properly maintained.
This contributes to wrinkles, a decline in muscle function, reduced blood vessel health, and so on.
So fixing your stem cells is clearly very important.
Stem cell therapies and longevity
However, improving stem cell health is easier said than done.
The old idea was to just inject stem cells into your body. These stem cells would travel to places where they are needed in the body, and settle there (a process called “grafting”), start dividing and create novel cells that would replace the damaged or disappeared cells.
After many years of research, however, it became clear that it’s not that straightforward (R).
Stem cells are very fragile, and when injecting them into the body, many of them already die because of the change in temperature, shear stress, and change in pH (acidity).
Many stem cells injected into the blood also get trapped into the lungs, and thus do not reach the places where they are needed. Furthermore, this trapping of stem cells in the lungs can block blood vessels in the lungs, causing pulmonary embolism (R).
The very few cells that survive and do reach the tissues, do not graft well; they cannot nestle themselves well into the tissues.
And the very few cells that do graft, often do not live long; after a few hours or days most of them die off.
Luckily, there are ways to deal with this.
Novel kinds of stem cell therapies
To improve the survival and grafting of stem cells, one can genetically reprogram stem cells to become stronger and more resistant to being injected or transplanted.
Stem cells can also be genetically modified so they graft better, and can survive longer in often hostile (e.g. in an old or pro-inflammatory) environment.
One can also use younger stem cells, like stem cells derived from the placenta or umbilical cord. These cells seem to be stronger and graft better, and also suffer less from immune rejection. That is what Celularity is exploring.
Also, the stem cell therapies Fountain is offering come from the placenta (R).
Beyond stem cell therapies
Scientists are also starting to look beyond stem cells. Scientists saw that despite stem cells not grafting and staying only for a short while in the body, some stem cell therapies could lead to beneficial effects (R).
Scientists believe this because during the brief period in the body, stem cells secrete substances, like exosomes, that can lead to beneficial effects (R).
Exosomes are small particles, released by cells, that contain proteins, peptides, RNA and other molecules. Exosomes can travel to neighboring cells or can be carried via the bloodstream to reach cells all over the body. The cells take up the exosomes and their cargo is released in these cells.
Some scientists call exosomes “stem cell 2.0” therapy.
Another approach is to expose our cells, including our stem cells, to factors that can rejuvenate stem cells. One way is by exposing them to “young blood factors”; these are substances found in young blood (or that are actually absent in old blood) which can rejuvenate tissues.
How to improve stem cell health?
The therapies Tony Robbins invests in to improve stem cell health are very novel and also very costly.
After all, it’s not easy to come by young placental stem cells, extract them, multiply them and then reintroduce them into the body.
Are there ways to improve stem cell health in general? For example by taking small oral molecules?
Yes! Various substances have been shown to be able to support stem cell health. They can do this in various ways, for example by protecting stem cells against DNA damage, reducing inflammation which impedes stem cell functioning, lengthening the telomeres of stem cells, helping to maintain the epigenome in stem cells, and so on.
We listed for you some of the most interesting science-based supplements to boost stem cell health.
Science-based supplements to improve stem cell health
It should therefore also not be surprising that AKG has shown to increase lifespan and healthspan in different organisms (R).
You can learn more about alpha-ketoglutarate and longevity here.
2. NMN (nicotinamide mononucleotide)
NMN is a substance that increases NAD levels in our cells. NAD is a pivotal molecule to protect and repair DNA and the epigenome, including in stem cells.
Learn more about the anti-aging effects of NMN here.
Glycine is a naturally-occuring substance in our body; in fact, it’s an amino acid. However, during aging, levels of glycine decline.
Learn more about the anti-aging effects of glycine here.
4. Low-dose lithium
Lithium is a mineral found everywhere in nature.
Low-dose lithium can lengthen telomeres. Fast-dividing cells like stem cells need long telomeres to keep dividing, as we explain here.
Learn more about lithium and longevity here.
Learn more about glucosamine and longevity here.
Fisetin has shown to reduce aging-related increase in inflammation and lower toxic substances senescent cells secrete which damage stem cells (R).
We explain more about fisetin and longevity here.
7. Vitamin C
We go deeper into the role of vitamin C and longevity here.
We very much applaud books like “Life Force”.
Not only can such books improve the health of many people, and potentially extend their lifespan; they can also generate more awareness around longevity and slowing down aging.
Tony Robbins both embraces “low-tech” and “high-tech” approaches to longevity. The low-tech approaches are things like food, supplements, proper sleep, stress reduction and other lifestyle interventions.
The high-tech approach involves things like novel stem cell therapies.
It’s clear that the future of longevity will follow these two approaches; both will be very important to lead a long, healthy life, as we explain here.
If you are interested in other books about longevity, we listed the best books here.