As more people look beyond the surface to target aging at its root, pterostilbene is one of the ingredients gaining attention in longevity circles. This powerful polyphenol offers promising longevity benefits with even greater bioavailability than its cousin resveratrol. But with both typical and oral options available, which form delivers better results?
Let’s explore the science and compare benefits — while introducing how NOVOS Core provides a comprehensive longevity formula that delivers this compound in its most impactful form.
Key Takeaways
- Oral pterostilbene offers whole-body anti-aging benefits, including brain, metabolism, and heart support, with higher oral bioavailability than resveratrol.
- Topical pterostilbene may help reduce photoaging, acne, and wrinkles.
- Both forms can be useful, depending on the goal.
- NOVOS Core includes pterostilbene as part of a synergistic regimen to slow biological aging and support visible improvements in skin and vitality.
What Is Pterostilbene?
Pterostilbene is a naturally occurring polyphenol found in certain vegetables and fruits, especially blueberries. Structurally similar to resveratrol, it differs in one key area: bioavailability. Thanks to its lipophilic structure, pterostilbene is more stable and more easily absorbed by human cells.
This enhanced bioavailability is what makes pterostilbene such a compelling longevity ingredient. In fact, oral bioavailability is roughly 80%, compared to just 20% for resveratrol. It’s one reason we included it in NOVOS Core instead of resveratrol.
Beyond absorption, pterostilbene is known for reducing inflammatory cytokines, combating oxidative stress, and activating longevity-related pathways. These mechanisms are central to slowing the biological aging process and supporting healthy mitochondrial function, DNA stability, and cellular repair.
Oral Pterostilbene: Systemic Longevity Support
When taken orally, pterostilbene enters systemic circulation and affects tissues throughout the body. Due to its long half-life and efficient distribution, it accumulates in critical organs, such as the brain, heart, and liver — which often decline in function with age. (For targeted organ support, consider NOVOS Vital longevity gummies.)
Science-Backed Benefits
- Anti-inflammatory effects: Oral pterostilbene has been shown to reduce oxidative stress markers and oxidative injury.
- Cognitive support: Pterostilbene crosses the blood-brain barrier and may protect neurons, enhance memory, and slow the progression of neurodegenerative changes.
- Metabolic health: Pterostilbene improves insulin sensitivity and blood sugar control by enhancing insulin signaling and activating AMPK, a key enzyme that boosts glucose uptake and fat metabolism.
- Cardiovascular support: Recent research highlights the role of anthocyanin-rich berries like blueberries — natural sources of pterostilbene — in improving vascular health. Clinical studies suggest that blueberry intake may enhance endothelial function, modestly lower blood pressure, and improve arterial stiffness in at-risk populations.
NOVOS Core Synergy
NOVOS Core includes a precise dose of 50 mg of pure pterostilbene in every daily sachet. But it doesn’t work alone. NOVOS Core also includes other clinically studied compounds, such as glycine, magnesium, hyaluronic acid, vitamin C, and alpha-ketoglutarate. Together, these ingredients work synergistically to combat all 12 root causes of aging.
When taken consistently, NOVOS Core not only supports biological age reduction but may also lead to visible benefits, such as improved skin texture, energy, and cognitive clarity.
Topical Pterostilbene: Targeted Skin Health
Topical pterostilbene is typically formulated into creams or serums. When applied directly to the skin, it penetrates the epidermis to deliver targeted results.
Dermatological Benefits
- Reduces redness and inflammation: In diabetic animal models, pterostilbene accelerated wound healing by reversing diabetes-induced epigenetic changes in hematopoietic stem cells. This effect led to reduced oxidative stress, improved mitochondrial function, and lower inflammation in immune cells — outperforming resveratrol in restoring skin repair pathways,
- UV protection: Pterostilbene shows promise in combating photoaging, potentially outperforming resveratrol.Â
- Improves skin elasticity: It’s been shown to enhance skin elasticity and reduce the appearance of fine lines and wrinkles, resulting in firmer, more youthful-looking skin.
- Antimicrobial action: Topical pterostilbene has shown potential in treating resistant skin infections like MRSA.
While a pterostilbene cream won’t influence biological aging in the same systemic way as an oral supplement, it can offer cosmetic and protective benefits for the skin.
Which Is Better? Oral vs. Topical Pterostilbene
Your choice depends entirely on your goal. Some people use both topical and oral applications of pterostilbene.
Oral pterostilbene enables you to:
- Support your brain, heart, and metabolism
- Lower internal inflammation and oxidative stress
- Activate longevity pathways at the cellular level
- Slow biological aging and extend healthspan
When combined with a full-spectrum longevity formula like NOVOS Core, oral pterostilbene becomes even more effective. The synergistic ingredients in NOVOS Core work at a cellular level to address the complex, interconnected mechanisms of aging.
Topical pterostilbene may be appropriate if you want to:
- Improve skin texture, tone, and resilience
- Target acne, sun damage, or redness
- Defend your skin against environmental stressors
- See localized cosmetic results from a powerful antioxidant
Ultimately, combining both oral and topical forms may deliver the best of both worlds. However, to slow the aging process from the inside out, oral delivery through a clinically backed pterostilbene supplement like NOVOS Core is your most powerful option.
Target Aging From the Inside Out
Pterostilbene is a science-backed molecule that supports healthy aging across multiple systems. Its benefits span from DNA repair and mitochondrial support to inflammation reduction and cognitive protection.
Topical forms of pterostilbene deliver localized skin benefits, improving complexion, strengthening skin integrity, and reducing signs of aging. But if you’re aiming for true longevity support, oral delivery offers systemwide effects.
NOVOS Core provides bioavailable pterostilbene in a carefully designed formula that works with your biology — not just to reduce the appearance of aging but also to slow aging itself.
Start your longevity journey with NOVOS Core today.
FAQ About Pterostilbene
What is the best source of pterostilbene?
While blueberries contain trace amounts, the most effective source is a standardized pterostilbene supplement like the one used in NOVOS Core.
What are the benefits of pterostilbene topical?
Topical use may reduce UV damage, inflammation, and collagen degradation, making it useful for acne, redness, and aging skin.
What is the oral bioavailability of pterostilbene?
It’s approximately 80%, making it far more bioavailable and effective than resveratrol.
How long does it take for NOVOS Core to work?
Some users see benefits after just two weeks, with positive changes in energy levels and mood. Benefits compound over time; after six months of consistent NOVOS Core usage, users typically see a measurable improvement in biological aging.
Is pterostilbene better than resveratrol?
Yes. Its chemical structure allows for better absorption, offering better absorption and significant longevity benefits.
Can pterostilbene be used on the skin?
Yes, especially in skincare formulas targeting inflammation, aging, and environmental damage.
