Biohacking promises everything from sharper focus to a longer life. However, navigating the world of wearable tech, cold plunges, and endless supplement stacks can leave you feeling more stressed than optimized.
Here’s the truth: Biohacking doesn’t have to be complicated. When it comes to longevity, there are a handful of evidence-based supplements that deliver real results — no red light panels or IV drips required.
Let’s cut through the noise and explore the best supplements for biohacking, the science behind them, and how NOVOS Core offers a smarter, simpler approach to aging well.
Key Takeaways
- Biohacking doesn’t require dozens of pills or expensive tech.
- Science-backed ingredients like AKG, NMN, glycine, and fisetin support core aging pathways, including mitochondrial health, senescence, and inflammation.
- NOVOS Core combines 12 clinically studied compounds into one daily sachet, simplifying your supplement routine while targeting the biology of aging.
- NOVOS Boost adds NMN for additional NAD+ support, enhancing energy metabolism and cellular repair.
- With expert-formulated dosages and third-party testing, NOVOS offers a practical, sustainable biohacking protocol and longevity routine designed for real life.
What Is Biohacking?
If you’re familiar with Dave Asprey, then you might already understand what biohacking is. Biohacking is the practice of using science, technology, and lifestyle interventions to optimize physical and cognitive performance. At its core, it’s about self-experimentation — finding ways to improve how you feel, think, and age.
While the biohacking space has expanded to include everything from nootropics to cryotherapy, many people turn to supplements as a foundational tool. For some, the protocol includes mega-dosing dozens of pills daily. For others, it means stacking peptides, NAD+ infusions, or exotic adaptogens.
However, the best biohacking protocols don’t rely on the number of capsules you take. They depend on how well your choices align with biology — and the evidence behind them. As we discuss in this article, there’s a difference between biohacking and longevity hacking.
- Biohacking may tout popular fads or performance tweaks.
- Longevity hacking — our priority at NOVOS — focuses on cellular resilience and research-backed support to help people live younger for longer.
Related: What Anti-Aging Supplements Does Dave Asprey Take?
Why Supplements Are Popular Among Biohackers
Biohackers often use supplements to:
- Boost mitochondrial function and energy
- Support brain health and neuroplasticity
- Improve sleep quality and circadian rhythms
- Increase stress resilience and immune balance
- Slow biological aging at the cellular level
But not all supplements are equally effective. Many common biohacking stacks include overlapping ingredients, underdosed compounds, or nutrients with limited evidence.
Others chase the latest trends without regard for safety or long-term data. That’s why more experts are shifting toward targeted, validated formulations — fewer pills with more significant impact.
6 Science-Backed Supplements That Support Biohacking Goals
Below are six compounds commonly used in the biohacking world, each supported by preclinical or clinical research and included in NOVOS Core or NOVOS Boost.
1. Calcium Alpha-Ketoglutarate (AKG)
AKG is a molecule involved in the Krebs cycle and epigenetic regulation that has been shown to extend lifespan and healthspan in animal models. It plays a crucial role in aging regulation, cellular health, and metabolism. Age-related AKG declines may also contribute to metabolic dysfunction and increased susceptibility to age-related diseases.
2. Glycine
This non-essential amino acid plays a crucial role in collagen synthesis, detoxification, and methylation — all essential for healthy aging. Research shows that glycine supports muscle health, recovery, and sleep. It may help prevent muscle breakdown by boosting growth pathways and blocking muscle-wasting signals. Some studies also suggest glycine may improve power output, reduce lactic acid during intense exercise, and promote better sleep.
3. Fisetin
Fisetin is a flavonoid found in strawberries and apples that has demonstrated senolytic activity — meaning it helps remove senescent cells. Senescent cells, often called “zombie cells,” accumulate with age and contribute to inflammation and tissue dysfunction. In animal studies, fisetin supplementation has been shown to extend lifespan and improve markers of healthspan. Human clinical trials are underway to confirm its effects. NOVOS Core includes a standardized dose of fisetin to support cellular renewal.
4. Magnesium
Magnesium is essential for over 300 enzymatic reactions, including those involved in energy production, DNA repair, and nervous system function. Low magnesium levels are associated with increased inflammation, poor sleep, and accelerated biological aging.
Magnesium malate is one of 12 key ingredients in NOVOS Core. Each sachet provides 2,000 mg — including 305 mg of magnesium and 1,220 mg of malate — a dose much higher than typical supplements. Core also includes extra malate in its other ingredients for added support.
5. NMN (Nicotinamide Mononucleotide)
NMN is a precursor to NAD+, a molecule that declines with age but is essential for DNA repair and mitochondrial health. NOVOS Boost provides a clean, well-absorbed form of NMN, designed to work in tandem with NOVOS Core to support healthy aging at the cellular level. By boosting NAD+, NOVOS Boost helps enhance energy, metabolism, and cognition.
6. Pterostilbene
Pterostilbene is a polyphenol structurally similar to resveratrol but with superior bioavailability. It supports antioxidant defenses, reduces oxidative stress, and influences gene expression — mechanisms that are deeply involved in longevity. Its synergy with NMN and other compounds makes it a valuable addition to a minimalist biohacking approach.
Why NOVOS Core Is the Smarter Stack
NOVOS Core combines 12 ingredients into a single daily sachet, each chosen to target one or more of the root causes of aging, including mitochondrial dysfunction, cellular senescence, epigenetic drift, inflammation, and nutrient sensing deregulation. Developed by a team of longevity scientists and researchers from institutions like Harvard and MIT, it is one of the few longevity supplements grounded in aging biology, not wellness trends.
This streamlined formulation reduces the need for separate capsules, minimizes guesswork, and helps users stay consistent — which is essential for long-term results. It’s also third-party tested for purity and potency.
How NOVOS Compares to Traditional Biohacking Protocols
The average high-level biohacking routine can cost between $1,000 to $5,000 per month, factoring in personalized diagnostics, red light therapy, wearable devices, IV infusions, and stacks of supplements. It also demands hours of daily time and an obsessive mindset.
By contrast, the NOVOS protocol costs less than $4 per day, takes under a minute to take, and offers a foundation rooted in science, not self-experimentation.
Here’s a side-by-side comparison:
| Protocol | Daily Cost | Time Commitment | Sustainability |
| DIY Biohacking Stack | $1,000+ | Several hours daily | Low |
| NOVOS Core & Boost | ~$3-$4 | A minute or two daily | High |
A Sustainable, Science-First Approach to Biohacking
You don’t need 80 supplements, red light panels, or cryotherapy chambers to support longevity. The most effective interventions are often the simplest, especially when supported by evidence from aging research.
With a daily sachet of NOVOS Core and the targeted addition of NOVOS Boost, you can support key longevity pathways without the complexity, cost, or confusion of traditional biohacking.
Try NOVOS Core and Boost
Ready to biohack longevity the smart way? Start with a protocol that works with your body’s natural systems. NOVOS Core and Boost provide a simple, science-backed foundation to help you live younger, longer.
FAQ About Biohacking Supplements
What are the best supplements for biohacking?
The most effective biohacking supplements target core aging pathways. Top choices include NMN, glycine, calcium alpha-ketoglutarate (AKG), magnesium, fisetin, and pterostilbene — all found in NOVOS Core or Boost.
Do I need to take dozens of supplements to see results?
No. In fact, taking too many can lead to redundancy or negative interactions. NOVOS simplifies longevity hacking by combining 12 science-backed ingredients into one daily sachet, targeting multiple aging mechanisms with fewer products and a lower cost.
How is NOVOS different from other biohacking supplements?
Unlike typical stacks, NOVOS is formulated by longevity scientists to address the root causes of aging. It’s third-party tested, based on peer-reviewed research, and designed for long-term use and daily consistency.
Can NOVOS Core replace my current supplement routine?
In many cases, yes. NOVOS Core is designed to cover multiple functions — mitochondrial health, inflammation, senescence, and more — reducing the need for separate products. Check with your doctor for your specific health needs.
Is NOVOS safe to take daily?
Yes. NOVOS Core and Boost use ingredients shown to be safe and effective in human or preclinical studies. They’re also third-party tested for purity and quality.
