As more people aim to not only live longer but also feel their best as they age, longevity supplements have become increasingly popular. After all, science-backed formulations that target the biology of aging can help you live younger for longer. However, as we’ve explored in our comparison series, not all longevity formulations are the same or have the science to back them up.
In this article, we’ll compare NOVOS Core and Timeline’s Mitopure® Softgels. Whereas Mitopure focuses on mitochondrial energy with a single molecule, NOVOS takes a holistic approach to aging at the cellular level — targeting all 12 root causes of aging.
Related: NOVOS Core vs. Blueprint, IM8, AG1, Elysium, and Tally Health
Key Takeaways
- NOVOS Core targets all 12 mechanisms of aging using 12 clinically studied ingredients.
- Timeline Mitopure focuses on mitochondrial renewal through a single compound: Urolithin A.
- NOVOS offers transparent dosages, peer-reviewed data, and measurable human outcomes in Pace of Aging, DNA damage, and skin firmness.
- Timeline’s Urolithin A shows benefits for muscle performance and mitochondrial efficiency but does not directly measure aging biomarkers.
- NOVOS delivers broader, more comprehensive longevity support at a lower monthly cost.
Why Explore Timeline Alternatives?
Timeline’s notoriety is tied to Urolithin A, a molecule derived from ellagitannins that stimulates mitophagy, the process of cleaning up damaged mitochondria. Research has shown that Urolithin A promotes mitochondrial function, helping to increase energy production. It’s also crucial for muscle recovery, as it alleviates exercise-induced inflammation and promotes the repair and energy metabolism of muscle cells.
But mitochondrial dysfunction is just one of the 12 recognized causes of aging. Timeline focuses solely on this pathway, limiting its overall longevity potential.
By contrast, NOVOS Core incorporates ingredients that target all 12 root causes of aging, including not only mitochondrial health but also DNA damage, cellular senescence, chronic inflammation, and impaired nutrient sensing. It’s a more comprehensive system designed to influence how well we age.
NOVOS Core vs. Timeline Mitopure Ingredients
What’s in your longevity supplement? Let’s take a closer look at the key ingredients in NOVOS Core vs. Timeline Mitopure.
NOVOS Core
NOVOS Core distills decades of aging science into a single, convenient daily sachet with clinically studied ingredients in precise dosages that work synergistically. Available in unflavored, orange, and limited-time tropical passion varieties, Core is a patent-pending formulation that has defined longevity supplements as a category.
Some of these ingredients include:
- Glycine: Supports collagen, detoxification, and metabolic balance
- Alpha-Ketoglutarate (AKG): Supports mitochondrial function and cellular longevity
- Fisetin: Helps clear senescent cells that drive aging
- Hyaluronic acid: Enhances hydration and skin elasticity
- Magnesium malate and L-theanine: Promote energy, calm, and resilience
Timeline Mitopure Softgels
Timeline’s active ingredient is Mitopure, a proprietary form of Urolithin A. As a postbiotic, Urolithin A is a beneficial compound produced by microbes. It’s been clinically demonstrated to improve mitochondrial health and muscle performance.
As we age — starting as early as our 30s — our mitochondria, the “power plants” inside our cells, begin to deteriorate in function and number. With this decline comes fatigue, reduced endurance, and slower cellular repair.
Mitopure works by activating mitophagy, a natural process in which the body identifies and recycles damaged mitochondria, supporting the regeneration of healthier, more efficient mitochondria. However, as Mitopure focuses narrowly on this one cellular pathway, it doesn’t address other drivers of aging that are also critical to long-term health and longevity.
Longevity Supplements Comparison at a Glance
| Category | NOVOS Core | Timeline Mitopure Softgels |
| Primary Focus | Whole-body longevity; targets all 12 mechanisms of aging | Mitochondrial renewal via mitophagy |
| Key Ingredients | Glycine, AKG, Fisetin, Magnesium Malate, L-Theanine, Hyaluronic Acid, Rhodiola | Urolithin A (Mitopure®) |
| Mechanisms Addressed | Cellular senescence, inflammation, DNA repair, mitochondrial health | Mitochondrial renewal (mitophagy) only |
| Ingredient Transparency | All ingredients and dosages disclosed | Single active ingredient; formulation proprietary but dosage disclosed |
| Scientific Validation | Human and animal studies show extended lifespan, improved skin firmness, reduced Pace of Aging | Pre-clinical and clinical human studies show improved mitochondrial efficiency and endurance |
| Dosage | 1 daily sachet | 2 daily softgels |
| Price | $98 per month or less with subscription | $125 per month or less with subscription |
| Best Suited For | Individuals seeking holistic longevity support and biological-age improvement | Consumers focused mainly on energy, endurance, and muscle recovery |
Scientific Validation: What’s Measured, What’s Proven
Both NOVOS Core and Timeline Mitopure are supported by research. However, they differ in what they measure and what they demonstrate.
NOVOS Core
NOVOS Core is backed by a growing body of scientific evidence exhibiting:
- Aged mouse lifespan extension
- Slower Pace of Aging (a validated measure of biological age) in a human case study
- Reductions in DNA damage of human cells after irradiation and improved ability to deal with senescent cells
- Improvements in skin firmness
In short, rather than targeting a single mechanism, NOVOS Core aims to support aging on all fronts, making it the best longevity supplement for long-term healthspan.
NOVOS is also the only consumer brand accepted into the Longevity Biotechnology Association (LBA), an industry body comprising the world’s top longevity researchers, investors, and companies. Our team includes award-winning longevity scientists, such as George Church and Matt Kaeberlein, with published research appearing in reputable journals like GeroScience and Brain Plasticity.
Timeline
Timeline has invested extensively in Urolithin A research, with peer-reviewed studies showing:
- Improved mitochondrial efficiency and muscle performance in older adults
- Enhanced endurance and recovery
- Potential benefits for immune function and skin aging
Still, Timeline has not published evidence showing reductions in biological age, senescence, or aging biomarkers. So, although the science supports Timeline’s benefits for energy and muscle health, its scope remains limited, focusing on only one aging pathway: mitophagy.
Media Mentions of NOVOS Core
Third parties, like The Wall Street Journal, Forbes, and Business Insider, have recognized NOVOS as a pioneer in the longevity field:
- “In a sea of generic supplement suppliers with just a packaging and marketing department, NOVOS’ commitment to research is a clear outlier.” — Forbes
- “NOVOS are pioneers in consumer longevity and among the first to develop a comprehensive approach that targets 12 mechanisms of aging simultaneously.” — WSJ: “The Future of Everything”
- “In a groundbreaking study, NOVOS Core extended aged mouse lifespan by 18% — more than any supplement ever studied.” — WSJ
- Referring to NOVOS: “Maybe it doesn’t take millions of dollars, over 100 daily supplements, and a team of 30 doctors to combat the aging process.” — Business Insider
- “Wealthy men are spending millions to lower their biological ages and live longer. These women are beating them with cheaper solutions [NOVOS].” — Fortune
What’s the Best Longevity Supplement?
If your goal is to support your whole body’s long-term health and not just mitochondrial energy, NOVOS Core is the optimal choice in longevity supplements. It’s a scientifically backed formulation that targets all 12 causes of aging, not just one, with published studies, peer-reviewed data, and human case-study results. It also costs less than Timeline Mitopure and delivers more value with its synergistic ingredients.
Ready to invest in your long-term health? Try NOVOS Core today.
Longevity Supplements FAQ: NOVOS Core vs. Timeline Mitopure
What’s the difference between NOVOS Core and Timeline Mitopure?
Timeline focuses on mitophagy through Urolithin A. NOVOS addresses all 12 aging mechanisms for whole-body longevity support.
Can I take both supplements together?
It’s not necessary. NOVOS already includes mitochondrial support through AKG, rhodiola, and magnesium malate.
Does Timeline reduce biological age?
Not based on current research. It improves mitochondrial health, but no published data links it to slower aging or lifespan extension.
Is NOVOS scientifically proven?
Yes. NOVOS Core has shown benefits in peer-reviewed studies, including reductions in DNA damage and Pace of Aging.
What’s the best supplement for longevity?
For comprehensive aging support backed by science, NOVOS Core is the best longevity supplement available today.
