In 2026, the longevity supplement category — which NOVOS defined — is set to see continued growth. Among the available options, TMW Essential Longevity claims to target the 12 hallmarks of aging. But does it really deliver on that promise? Based on the available data, it’s a bold claim without published evidence to back it. While individual ingredients in the formula have some scientific support, the product as a whole has not undergone peer-reviewed, third-party clinical trials.
In contrast, NOVOS Core was developed by scientists to do one thing: measurably slow the biological aging process. It’s patent-pending and supported by peer-reviewed studies, and it’s the only consumer longevity supplement recognized by the Longevity Biotechnology Association.
Let’s look at how these two products compare — and why NOVOS Core is the clear choice for those serious about extending lifespan and healthspan.
Key Takeaways
- Longevity scientists developed NOVOS Core to target all 12 hallmarks of aging, and it’s backed by peer-reviewed data.
- TMW Essential Longevity uses trendy ingredients but lacks independent clinical validation.
- NOVOS Core offers transparent dosing and published validation.
- It’s the only consumer longevity supplement accepted into the Longevity Biotechnology Association and a finalist team for the XPRIZE for Healthspan Extension.
- TMW makes bold claims but provides no public studies or scientific rationale for its full formula.
Why Compare NOVOS Core and TMW Essential Longevity?
Celebrity- and lifestyle-backed longevity products get a lot of attention — see our related articles comparing NOVOS Core with Tally Health, IM8, and AG1, to name a few. But publicity and marketing do not make these products scientifically sound.Â
TMW Essential Longevity markets itself as an all-in-one supplement to support aging. But it doesn’t provide transparent dosing on all ingredients or peer-reviewed research on the full formulation.
NOVOS, by contrast, was developed by pioneering longevity experts from top institutions like Harvard and MIT. We’re not just riding the wave — we created the longevity supplement category itself.
This comparison helps readers spot the difference between hype and hard science.
NOVOS Core vs. TMW Essential Longevity: Ingredients Breakdown
The longevity supplement market is filled with impressive-sounding ingredient lists. But when it comes to real anti-aging effects, what matters is not trends, but rather, how well the ingredients work together, whether they’re clinically proven, and whether the formulation is backed by science. Here’s how NOVOS Core and TMW compare when it comes to mechanisms that matter most.
Ingredients Comparison
TMW Essential Longevity
- Vitamins: Vitamin C (300mg), vitamin D3 (40mcg), vitamin B12 (4.8mcg), niacin (16mg)
- Amino acids and nutrients: Glycine (425mg), magnesium (75mg), taurine (100mg)
- Polyphenols and antioxidants: Quercetin (100mg)
- Other compounds: Hyaluronic acid (100mg), beta glucans (150mg)
- Mushroom blend (450mg): Lions mane, chaga, agaricus
- Liposomal delivery blend (1,884mg): MCT oil, phosphatidylcholine, tapioca, gum acacia
NOVOS Core
- Contains 12 ingredients, each selected to target one or more hallmarks of aging
- Includes Ca-AKG (1,100mg), fisetin (100mg), glycine (2,000mg), pterostilbene (50mg), magnesium malate, L-Theanine, rhodiola rosea, vitamin C, and more
- Fully disclosed dosages
- Supported by human case studies and peer-reviewed publications
- Designed to work in synergy for comprehensive cellular rejuvenation
NAD+ Support
TMW includes 16mg of Nicotinamide (Vitamin B3) — a basic NAD+ precursor and recycler. While it plays a role in NAD+ metabolism, it’s less effective than NMN or NR in boosting NAD+ levels. NOVOS offers NMN separately through NOVOS Boost, maintaining optimal stability and allowing users to have total control over their NAD+ support.
Senolytics: Fisetin and Pterostilbene
Senolytics help clear senescent cells — the dysfunctional “zombie” cells that accumulate with age. NOVOS Core includes fisetin and pterostilbene, a superior resveratrol analog, both of which support cellular renewal and inflammation reduction. TMW includes quercetin, but without supporting senolytics like fisetin or bioavailability enhancers, its impact may be limited.
Calcium Alpha-Ketoglutarate (Ca-AKG)
Ca-AKG is one of NOVOS Core’s most powerful ingredients. This naturally occurring compound plays a crucial role in energy metabolism, mitochondrial function, and longevity. Research suggests that Ca-AKG may extend lifespan, improve metabolic flexibility, and support healthy aging by influencing key biological processes. It’s a key ingredient missing from TMW’s formula, which does not include any form of alpha-ketoglutarate.
Bottom Line
NOVOS Core is a precision-formulated supplement based on current longevity science. TMW Essential Longevity offers general wellness support but without the transparency or validation needed to claim it targets the full aging process.
Comparison at a Glance
| Category | NOVOS Core | TMW Essential Longevity |
| Price per Serving | ~$98/month (less with subscription) | ~$119.99/month (less with subscription) |
| Hallmarks of Aging Targeted | All 12, with published data | Claims 12, but no data |
| Scientific Validation | Peer-reviewed studies and human case studies | No peer-reviewed research or transparency |
| NAD+ Strategy | NMN provided separately in NOVOS Boost for stability and dosing | Liposomal nicotinamide (NAD+ precursor & recycler) |
| Senolytics | Fisetin + pterostilbene | Quercetin only |
| Ingredient Transparency | Full label with dosing | Some proprietary |
| Delivery Format | Sachets (orange or tropical flavor powder) | Packets (liposomal liquid) |
Third-Party Studies & Scientific Validation
NOVOS Core is a well-studied longevity supplement with real-world, published data:
- Lifespan extension in aged mice (world-record results)
- Reduced DNA damage and inflammation
- Improved skin firmness in human subjects
- Reduced Pace of Aging in a human case study
We are:
- The only consumer brand accepted into the Longevity Biotechnology Association
- One of just two consumer brands selected as a top-100 team for the XPRIZE for Healthspan Extension
TMW Essential Longevity has:
- No peer-reviewed studies evaluating the full Essential Longevity formulation
- Scientific advisors listed, but no published research linking them to product validation
- No independent, long-term clinical data showing an impact on biological aging or healthspan
Which Longevity Supplement Is Best?
TMW Essential Longevity is heavy on marketing, but it lacks the scientific validation seen with NOVOS Core. It includes trendy compounds without complete dosage transparency or validation and provides no proof that it works.
NOVOS Core is different. Developed by leading aging researchers, tested in both animals and humans, and aligned with the latest aging frameworks, it is the most scientifically credible option available today.
If you’re serious about slowing down biological aging, the choice is clear. Try NOVOS Core — and pair it with NOVOS Boost for complete NAD+ support.
FAQ About NOVOS Core vs. TMW Essential Longevity
What is the best supplement for longevity?
NOVOS Core — it’s science-backed, peer-reviewed, and targets all 12 hallmarks of aging.
Does TMW Essential Longevity work?
The ingredients are promising individually, but there’s no clinical data showing the full formula slows aging.
What makes a longevity supplement science-backed?
Peer-reviewed studies, transparent dosing, and a formulation based on aging biology. NOVOS Core checks all three boxes.
Can I take NOVOS and TMW together?
It’s unnecessary. NOVOS Core already covers all essential aging pathways precisely and transparently.
