When skin looks healthier, firmer, and more youthful, that usually reflects something deeper than surface appearance alone.
Skin aging is driven not just by time, but by biology: oxidative stress, cellular wear, and the bodyโs ability to respond to damage over time. That is what makes a published 2024 study in Nutrients so notable. In a sophisticated 3D human keratinocyte model, researchers found that a NOVOS formulation containing NOVOS Core supported key biological processes relevant to skin health and aging biology.
This matters because skin is one of the most visible reflections of how the body is aging beneath the surface. And in this study, the findings suggest that a NOVOS formulation containing NOVOS Core may help support cellular processes relevant to skin health and aging biology, particularly under laboratory stress conditions.
You can find the NOVOS Core skin aging paper here: Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes.
Why this study stands out
A great deal of supplement marketing relies on theory, isolated ingredients, or low-value lab evidence. This study used a 3D human keratinocyte model, which the authors describe as more representative of tissue architecture and cell-to-cell interactions than conventional 2D cell culture systems. They specifically note that 3D systems help overcome key limitations of standard cell models. Ultimately, this is a more biologically meaningful preclinical model than many ingredient-marketing claims rely on.
In other words, this was not just an ingredient story. It was a formulation study in a more advanced skin model.
The NOVOS Core ingredients evaluated in the formulation
The paper lists NOVOS Core as containing 12 ingredients: pterostilbene, glucosamine sulfate, fisetin, glycine, lithium aspartate, calcium alpha-ketoglutarate, magnesium malate, vitamin C, L-theanine, hyaluronic acid, Rhodiola rosea root extract, and ginger root extract.
That multi-ingredient design is important. Skin aging is not driven by one pathway alone, so a formula designed to work across multiple biological targets is inherently more relevant than a one-note approach. The paper itself discusses the potential for multi-target and synergistic effects within the formula.
What the study found
The researchers examined markers related to oxidative stress and DNA damage response in human keratinocytes. According to the paper, a 24-hour treatment with the NOVOS formulation did not induce DNA damage in the model. More importantly, it significantly reduced DNA damage markers in cells later exposed to neocarzinostatin, a chemotherapeutic agent used to create genotoxic stress in the experiment.
The study also found reductions in intracellular hydrogen peroxide under pro-oxidant conditions, supporting the idea that the formulation helped counter oxidative stress in the model.
Taken together, these findings suggest that the NOVOS formulation helped support skin-cell resilience when the cells were challenged in a way designed to mimic biological stress relevant to aging research.
Why that matters for skin aging
Skin aging is not only about wrinkles or texture. It is also about what is happening at the cellular level long before those changes become more visible.
Oxidative stress and DNA damage response are deeply relevant to how skin ages over time. When a formulation shows support for these processes in a sophisticated preclinical skin model, that gives a more meaningful scientific basis for believing it may support healthier skin aging biology.
That is part of what makes NOVOS Core different. It was not designed as a trendy beauty ingredient or a superficial cosmetic add-on. It was designed as a science-based longevity formula, and this published study helps show why that systems-based approach may also matter for skin.
The advantage of a multi-compound formulation
One of the more compelling details in the paper is that the full NOVOS formulation appeared to show beneficial effects at lower cumulative concentrations than several of the simpler formulas the researchers compared it against. The authors suggest this may reflect synergistic interactions between compounds.
That is exactly the kind of result you would hope to see from a well-designed longevity formula: not just activity from one isolated ingredient, but coordinated effects from a broader formulation working across multiple pathways.
What this means for NOVOS Core
NOVOS Core is designed to support the biology of aging more broadly, and skin is one of the clearest external reflections of that biology.
This study supports the view that a NOVOS formulation containing NOVOS Core may help support skin-cell resilience and biological pathways relevant to healthy skin aging. Specifically, the paper found support for markers related to oxidative stress and DNA damage response in a 3D human skin-cell model.
For someone looking beyond surface-level skincare claims, that is the real takeaway: NOVOS Core is connected to published preclinical research showing support for deeper biological processes relevant to how skin ages.
The studyโs own limitations
The paper also openly acknowledged limitations. The authors said the study did not fully clarify the underlying cellular mechanisms responsible for the observed effects. They wrote that future work should include direct determinations of DNA damage and additional pathway-level analysis.
The bottom line
A published 2024 study in Nutrients found that a NOVOS formulation containing NOVOS Core supported markers related to oxidative stress and DNA damage response in a 3D human keratinocyte model. Researchers found that the formulation did not induce DNA damage on its own and significantly reduced DNA damage markers after a laboratory stress challenge.
The findings suggest that a NOVOS formulation containing NOVOS Core may help support cellular processes relevant to skin health and aging biology, particularly under laboratory stress conditions.
FAQ
Can NOVOS Core support skin aging biology?
A published preclinical study found that a NOVOS formulation containing NOVOS Core supported markers related to oxidative stress and DNA damage response in a 3D human skin-cell model.
Why is this more meaningful than a typical ingredient claim?
The authors used a 3D human keratinocyte model, which they describe as more representative of tissue complexity and cell interactions than conventional 2D culture systems.
What processes were studied?
The paper examined markers related to oxidative stress and DNA damage response, including intracellular hydrogen peroxide, 53BP1 foci, and ฮณ-H2AX foci.
Why does the full formula matter?
The authors suggest the full NOVOS formulation may have beneficial multi-target or synergistic effects, which may help explain why it performed well relative to simpler comparison formulas.
