Between ice baths, infrared light, peptide stacks, and detox plans, there’s no shortage of biohacking advice out there. But what actually works? For most of us, the best results don’t come from extremes, but rather from daily decisions that support how we age at the cellular level.
That’s the sweet spot where biohacking meets longevity, and it doesn’t have to be complicated. In this article, we explore four science-backed anti-aging hacks that improve healthspan and target biological aging, not just cosmetic signs of age. When paired with research-based support like NOVOS Core, these strategies can help you stack the odds in your favor.
What Is Biohacking?
While optimizing individual health is nothing new, notable public figures like Dave Asprey have popularized the concept of biohacking. In the context of aging, biohacking means using specific interventions to improve how your body and cells function over time. It can include diet, sleep, movement, light exposure, supplements, and more.
The goal isn’t to live forever (although Asprey has said he aims to live to 180 and beyond). For most of us, biohacking offers a way to slow the processes that contribute to aging. With the right consistent interventions, we may extend healthspan and reduce biological age (how your body is actually aging) compared to chronological age (how many birthdays you’ve had).
There’s also a difference between biohacking and longevity hacking. The first can sometimes look more like fads or short-term performance tweaks. The second prioritizes long-term cellular resilience. At NOVOS, we focus on the latter, with research-backed tools and support designed to help anyone live younger for longer.
Let’s explore four simple longevity hacks you can start implementing right away.
Longevity Hack #1: Smart Supplementation
Certain nutrients and compounds have been shown to address the root causes of age-related declines. From inflammation and mitochondrial function to senescent cell accumulation and reduced collagen production, the right supplements can influence the biological pathways that drive aging.
NOVOS Core is one of the only multi-ingredient longevity supplements designed around the 12 hallmarks of aging. Its formulation includes compounds like glycine, calcium alpha-ketoglutarate (Ca-AKG), hyaluronic acid, and fisetin, all of which have been studied for their impact on cellular aging.
- Calcium alpha-ketoglutarate (Ca-AKG): A 2020 study in Cell Metabolism found that Ca-AKG extended lifespan and improved healthspan in mice, even when started later in life. It influences inflammation and cellular energy pathways.
- Glycine: A Journals of Gerontology study showed that supplementing older adults with glycine and NAC improved mitochondrial function, reduced oxidative stress, and lowered biological age markers.
- Hyaluronic acid (oral): A 2022 randomized, double-blind trial in Skin Research & Technology reported significant improvements in skin hydration and elasticity within 12 weeks.
- Fisetin: In vitro studies and animal models have shown that fisetin clears senescent cells, one of the drivers of biological aging. Human studies are ongoing.
Pro tip: Supplements work best when you’re already supporting your body with good sleep, movement, and nutrition. Think of NOVOS Core as your foundation, not your fix-all.
Longevity Hack #2: Exercise That Supports Cellular Youth
You’ve heard it before, but it’s worth repeating: Exercise is one of the most powerful tools for slowing biological aging. What’s less often discussed is why.
Physical activity triggers a range of longevity-related processes, including:
- Autophagy, your cells’ built-in cleanup mechanism
- Mitochondrial biogenesis, which improves energy production and resilience
- The release of myokines, muscle-derived proteins that reduce inflammation and oxidative stress
In fact, higher levels of cardiorespiratory fitness (measured as VOâ‚‚ max) are associated with longer lifespan and lower risk of chronic disease. This guide from NOVOS explains why VOâ‚‚ max is one of the best fitness metrics to track as you age.
Pro tip: Combine strength training with short high-intensity interval training (HIIT) sessions and low-intensity daily movement like walking. One former pro athlete suggests incorporating one or two HIIT workouts per week, plus three or four days of low-intensity cardio exercise.
Longevity Hack #3: Hydration and a Longevity-Focused Diet
Mild dehydration is more common than you’d think. That’s especially true among older adults, including those in long-term care, hospitalized, or with limited mobility, who may not feel thirsty or drink enough throughout the day.
Water makes up about 60% of the adult body and is essential for everything from temperature regulation to nutrient transport. As we age, our water content gradually declines, and the risk of dehydration increases. When that happens, it can impact everything from blood pressure to cognition, especially if electrolytes drop, too.
Hydration is only one piece of the puzzle, however. A nutrient-dense, plant-forward diet is just as critical.
The NOVOS Longevity Diet emphasizes foods that nourish your microbiome, fight inflammation, and support metabolic health. Key components are:
- Colorful plants and polyphenols: Found in berries, leafy greens, teas, and herbs, these compounds combat oxidative stress and inflammation.
- Omega-3 fatty acids: These are linked to longer telomeres, reduced inflammation, and optimal immune function, among other benefits. Aim for fatty fish like salmon or plant sources like flax and chia.
- Low-glycemic whole foods: These stabilize blood sugar and support healthy insulin signaling.
Pro tip: Hydrate early in the day, especially after waking. Include mineral-rich fluids like herbal teas or water enhanced with natural electrolytes. For meals, eat a colorful plate — more variety in plants means more nutrients.
Longevity Hack #4: Prioritize High-Quality Sleep
Sleep gives our bodies much-needed periods of repair, regulation, and detoxification. Poor sleep has been linked to faster epigenetic aging, the early onset of disease, and a reduced lifespan.
Sleep also regulates:
- Melatonin, a hormone tied to circadian rhythm and antioxidant defense
- Glymphatic drainage, the brain’s overnight waste-removal system
- Hormones that control appetite, muscle repair, and inflammation
Note that evening use of devices that produce blue light, such as smartphones, can interfere with the brain’s production of melatonin before bed. To preserve the body’s natural sleep-wake cycle, consider using blue light-blocking glasses in the evening. Or, switch off screens altogether about an hour before bedtime.
Pro tip: Aim for about seven to eight hours of sleep with a consistent bedtime and wake time. Start winding down 60 to 90 minutes before bed to ease your body naturally into its sleep routine.
Longevity Is a Lifestyle, Not a Shortcut
Biohacking isn’t about following every tip and trick you come across online. It’s about incorporating longevity hacks that work.
Start with what’s sustainable. Smart supplementation, exercise, hydration, nutrient-rich food, and consistent sleep are powerful on their own — and even more so together.
If you’re ready to take a more proactive approach to aging, NOVOS Core offers a science-backed way to support multiple aging pathways at once. It’s one of the best anti-aging hacks you can incorporate every day to live healthier for longer.
FAQ: What People Ask About Longevity Hacks
What is biohacking for anti-aging?
Biohacking refers to lifestyle and supplement interventions that influence biological aging — from mitochondrial health to inflammation to cellular regeneration. Many biohacks target longevity pathways like NAD+, mTOR, and autophagy.
What is the best anti-aging hack?
There’s no single best anti-aging solution. But if you want to start somewhere, choose one small tweak you can make for your diet, hydration, fitness, and sleep. Small, daily habits add up over time.
Do longevity hacks really work?
Yes, if they’re evidence-based. Biological age markers like DNA methylation and epigenetic clocks have been shown to improve with changes in diet, exercise, and sleep.
What is the most powerful anti-aging supplement?
Look for formulations that combine multiple science-backed ingredients — like Ca-AKG, glycine, hyaluronic acid, and fisetin — that target aging pathways. NOVOS Core was designed with that whole-body approach in mind.
