Choosing the best longevity supplement brands can feel overwhelming — especially when one of them claims to “reverse aging” with a $2 million-a-year biohacking routine. If you’ve seen headlines about the Bryan Johnson Blueprint or its new “Longevity Mix,” you’ve probably wondered how it stacks up against science-backed supplements like NOVOS Core.
In this comparison, we’ll look at two angles:
- Philosophy: How the NOVOS and Blueprint protocols differ in purpose and practicality
- Product: How the Blueprint Longevity Mix compares to NOVOS Core
Both share a mission: to slow aging and improve long-term health. But only one takes a human clinical study-backed, accessible path to help you do it without excessive cost or sacrifice.
Key Takeaways
- Blueprint is Bryan Johnson’s personal $2M-per-year longevity experiment focused on prescriptions, data tracking, and self-experimentation.
- NOVOS Core delivers a simplified daily supplement designed by aging researchers to support healthspan safely and affordably. NOVOS Core has been evaluated in a placebo-controlled human clinical study and is recognised by third parties in the longevity field. Individual results will vary, with some obtaining no benefit.
- The Blueprint Longevity Mix drink forms only one small part of Johnson’s larger protocol.
- NOVOS Core offers transparent, science-backed methods that target the biological root causes of aging.
- For most people, NOVOS provides a practical, accessible path to longevity without the costly labs, prescriptions, or extreme lifestyle demands.
Why Compare NOVOS Core and Blueprint Longevity Mix?
The Blueprint Project has become a high-profile experiment in extreme longevity. Tech entrepreneur Bryan Johnson follows an algorithmic lifestyle of sleep tracking, medical testing, and carefully timed meals — all designed to maintain the biological age of an 18-year-old.
It’s fascinating, but it’s also personal science, not public health. Johnson’s wider regimen involves extensive diagnostics, medical supervision, and compounds that are not available as consumer supplements. Those elements sit outside the scope of this product comparison. Experts have described the Blueprint approach as unproven and potentially unsustainable. As one longevity scientist explains, the regimen requires such intense discipline that fewer than 2% of Americans are likely to follow through on it for the long haul.
NOVOS, on the other hand, represents the opposite end of the spectrum — a scientifically validated, accessible longevity solution built by researchers, not influencers. Its mission is to give people an evidence-backed way to support healthspan without needing a medical team or a large budget.
The fundamental differences are:
- Blueprint is about one man’s experiment in extreme control.
- NOVOS is about scalable, science-based longevity for everyone.
Blueprint Longevity Mix Ingredients vs NOVOS Core Ingredients
Both routines rely on overlapping compounds linked to longevity — alpha-ketoglutarate (AKG), glycine, magnesium, and L-theanine, among others. However, Bryan Johnson’s Blueprint and NOVOS Core differ in context and formulation quite a bit.
Blueprint Longevity Mix Ingredients List and Dosages
Bryan Johnson’s Longevity Mix is a multinutrient drink available in two flavors. It’s designed to simplify his supplement load. Unlike the broader Blueprint protocol, which involves a large daily pill count and frequent medical testing, this specific drink mix lists most of its ingredients and dosages on the label. Those Blueprint Longevity Mix ingredients are set out below.
Each serving contains compounds like:
- Creatine monohydrate (2,500 mg)
- Calcium alpha-ketoglutarate (Ca-AKG) (2,000 mg)
- Taurine (1,500 mg)
- Glycine (1,200 mg)
- L-Lysine HCl (1,000 mg)
- Glucosamine sulfate (750 mg)
- L-Glutathione reduced (250 mg)
- L-Theanine (200 mg)
- Sodium hyaluronate (120 mg)
- Magnesium citrate, vitamin C, and calcium in bioavailable forms
It’s vegan, gluten-free, non-GMO, and made without artificial ingredients. And while Blueprint also sells standalone products like collagen and ashwagandha + rhodiola, they’re intended to complement his strict routine rather than replace it. That routine is part of a much larger personal protocol that includes prescription and experimental compounds not available to the general public.
NOVOS Core Ingredients and Dosages
NOVOS Core condenses what decades of aging research suggest works best into one simple, daily sachet available in unflavored and orange varieties. Its formulation is the first of its kind, designed to target the 12 Mechanisms (causes) of Aging. A patent was filed on NOVOS Core, because of its novel approach to aging and its efficacy. It features 12 synergistic, science-based ingredients chosen for their safety, evidence, and ability to target multiple hallmarks of aging.
Some of these include:
- Glycine: Supports collagen, detoxification, and metabolic balance
- Alpha-Ketoglutarate (AKG): Supports mitochondrial function and cellular longevity
- Fisetin: Helps clear senescent cells that drive aging
- Hyaluronic acid: Enhances hydration and skin elasticity
- Magnesium malate and L-theanine: Promote energy, calm, and resilience
None of the ingredients requires a prescription. NOVOS Core lists all active ingredients and dosages openly.
NOVOS Core vs Blueprint Longevity Mix: Comparison at a Glance
| Feature | NOVOS | Blueprint (Bryan Johnson) |
| Scientific Backing | Aging researchers | Self-experimentation + curated literature |
| Ingredients Transparency | Fully disclosed actives and dosages | Partially disclosed |
| Includes AKG, Glycine, Magnesium Malate | Yes | Yes |
| Includes NAD Precursors (e.g., NMN, NR) | Yes, NOVOS Boost | Some |
| Delivery Format/Dosage | One sachet per day | 100+ pills, powders, diagnostics |
| Cost | ~$98/month or less with subscription | ~$2M/year (approximate) |
| Availability | Global | Drink mix available; full regimen proprietary |
| Best For | Longevity-focused individuals seeking ease & science | Hardcore biohackers replicating Johnson’s experiment |
No two people react precisely the same way to nutritional interventions. Individual results will vary with some obtaining no benefit.
Is Blueprint Longevity Mix Worth It? Science, Simplicity and Cost
Both Blueprint and NOVOS share an interest in longevity science, but their approaches to applying it couldn’t be more different.
Blueprint’s system demands a level of constant data tracking and self-experimentation that few people can realistically maintain. It’s experimental, pharmaceutical, and highly individualized. Even Johnson himself calls it “an algorithmic lifestyle,” not a supplement plan.
By contrast, NOVOS Core was developed by some of the world’s top scientists in the biology of aging. Every ingredient targets multiple hallmarks of aging in one simple step.
It’s the difference between hiring a full-time lab team versus following a proven, peer-reviewed roadmap. One drink a day is all it takes to incorporate NOVOS Core into your routine.
Recent research supports several of NOVOS Core’s key ingredients:
- Studies report that AKG is associated with mitochondrial function markers and with lifespan differences in animal models. Animal studies are not relied upon to support any representations of health benefit in humans.
- Glycine has been studied in relation to metabolic markers and collagen formation.
- Fisetin demonstrates senolytic activity in research settings.
In one study, NOVOS Core was associated with a lifespan difference of approximately 18% in an aged mouse model compared with controls. Animal studies are not relied upon to support any representations of health benefit in humans. Other research shows its ingredient combinations help maintain healthy DNA and support the body’s ability to clear senescent cells.
These characteristics make NOVOS unique among the best supplements for longevity. It’s practical, affordable, and rooted in real human science, not hype.
What Others Say About NOVOS Core
When it comes to longevity supplements, bold claims are common — but real-world validation is rare. NOVOS Core is an exception. This section sets out the published research, the media coverage, and the customer results that have been recorded to date. Here’s a look at what the research, press, and real people are saying about the supplement that’s redefining what’s possible in healthy aging.
Scientific Backing
The NOVOS Core formulation has been involved in multiple scientific studies to date. Most recently, NOVOS Core was studied by University of Surrey in a double-blind, randomized, placebo-controlled human clinical trial, which found some of the most significant positive effects ever achieved by a longevity supplement for biomarkers associated with healthspan and lifespan. Those markers include improvements in blood vessel flexibility, endothelial function, and systolic blood pressure for blood pressures already within the normal range. You can learn more about the study here.
Additionally, scientists have found that NOVOS Core achieved one of the largest animal lifespan extensions that a supplement has ever achieved; statistically significant reductions in mechanisms of aging that include DNA damage in a peer-reviewed in vitro study, and improvements to markers of cellular senescence, cellular inflammation, and more. A preliminary human study measured changes in skin firmness, and a human case study recorded a statistically significant reduction in biological Pace of Aging. These are measured changes in physiological biomarkers, not disease outcomes. Individual results will vary. You can learn more about the NOVOS Core scientific studies here.
As of the date of this article’s publication, we are not aware of any scientific studies that Blueprint has run on their Longevity Mix formula, which includes thorough analysis of the Blueprint website, product pages, and press.
Case Studies
Some NOVOS Core customers have recorded lower age-matched biological Pace of Aging scores than Bryan Johnson on the public Rejuvenation Olympics leaderboard (as measured by epigenetic testing), and been recognized by the press for it. For example, Fortune Magazine published the article, “This 55-year-old single mom makes less than $100k per year and is reverse aging without spending millions. Here’s her daily routine,” and Fortune Well published “Wealthy men are spending millions to lower their biological ages and live longer. These women are beating them with cheaper solutions.” Healf has published the article, “The Lady Aging Slower Than Bryan Johnson: Meet Julie Gibson Clark.” This is on less than $100 per month instead of $2M per year and at tremendous personal sacrifice. These are individual results from epigenetic testing, not a controlled comparison. Individual results will vary, with some obtaining no benefit.
Third-Party Recognition
Third parties, like The Wall Street Journal, Forbes, and Business Insider, acknowledge NOVOS’ leadership in the field of longevity:
- “In a sea of generic supplement suppliers with just a packaging and marketing department, NOVOS’ commitment to research is a clear outlier.” — Forbes
- “Novos are pioneers in consumer longevity and among the first to develop a comprehensive approach that targets 12 mechanisms of aging simultaneously.” — WSJ: The Future of Everything
- “In a groundbreaking study, NOVOS Core extended aged mouse lifespan by 18% — more than any supplement ever studied.” — WSJ
- Referring to NOVOS: “Maybe it doesn’t take millions of dollars, over 100 daily supplements, and a team of 30 doctors to combat the aging process.” — Business Insider
- “Wealthy men are spending millions to lower their biological ages and live longer. These women are beating them with cheaper solutions [NOVOS].” — Fortune
The Best Blueprint Longevity Mix Alternative for Most People
The future of longevity isn’t reserved for billionaires or biohackers. It’s based on accessible, evidence-based science that anyone can research and implement.
At NOVOS, our ecosystem of supplements, at-home aging tests, and educational resources empowers you to take control of your health.
If you admire Blueprint’s ambition but want something sustainable, safe, and scientifically vetted, NOVOS Core is your go-to longevity supplement. Along with a longevity diet, regular exercise, sleep, and other lifestyle factors, it can help you live younger for longer — without the labs, drugs, or million-dollar price tag.
Ready to simplify your longevity routine? Try NOVOS Core today.
FAQs
The drink mix lists creatine monohydrate, calcium alpha-ketoglutarate, taurine, glycine, L-lysine, glucosamine sulfate, glutathione, L-theanine and sodium hyaluronate, with dosages on the label.
Pricing is set by Blueprint and changes over time. Check the current price on their site, then compare it against the cost per serving of any alternative.
That depends on your goals and budget. The drink mix is one part of a much larger personal protocol, so the product alone will not replicate protocol-level results.
NOVOS Core is a single daily sachet with fully disclosed actives, designed by aging researchers and evaluated in a double-blind human clinical study.
Yes. Both include alpha-ketoglutarate, glycine, magnesium and L-theanine, though the formulations, dosages and overall approach differ.
The label lists glycine at 1,200 mg and taurine at 1,500 mg per serving. NOVOS Core lists its own actives and dosages openly.
Many people do, through diet, exercise, sleep and a daily supplement routine. Speak with your healthcare provider about what suits your circumstances.
Important comparison note: This article compares NOVOS Core with publicly available information about Bryan Johnson’s Blueprint, including Blueprint Longevity Mix and the broader Bryan Johnson protocol. It is important to distinguish between the product Blueprint sells and the protocol Bryan Johnson personally follows. Blueprint Longevity Mix is a consumer drink mix. Johnson’s personal longevity routine has involved a far broader and more intensive regimen, including strict lifestyle practices, extensive diagnostics, medical oversight, and, at various points, prescription drugs, hormone-related interventions, and gene therapy. Results associated with Johnson’s personal protocol should not be assumed to come from Blueprint Longevity Mix, nor should consumers assume that using the product alone would replicate those results. References to Bryan Johnson, Blueprint, and Rejuvenation Olympics are for nominative, comparative purposes only. NOVOS is not affiliated with, endorsed by, or sponsored by Bryan Johnson, Blueprint, Continuance, LLC, or Rejuvenation Olympics. Individual biological age and Pace of Aging results are not controlled head-to-head clinical comparisons.
