The longevity supplement space is booming, and celebrity names are taking notice. David Beckham’s IM8 Longevity Powder has entered the market, claiming to target all 12 hallmarks of aging. But to date, no published research on the complete IM8 formula supports that claim.

By contrast, NOVOS Core was specifically developed by longevity researchers to target all 12 hallmarks of aging — and it’s the first and only supplement with published, peer-reviewed data and human studies supporting this claim. Before you invest in any “anti-aging” blend, it’s worth comparing how these two supplements measure up.

Quick Overview

• Scientists developed NOVOS Core to target all 12 mechanisms of aging using clinically studied, synergistic ingredients.
• IM8 lists two small 12-week clinical trials and highlights academic collaborations but not peer-reviewed outcomes for the full Longevity formula. It also costs more per serving than NOVOS Core.
• NOVOS Core is the only consumer brand accepted into the prestigious Longevity Biotechnology Association and one of just two selected as a top-100 team for the XPRIZE for Healthspan Extension.
• NOVOS Core pairs with NOVOS Boost for NAD+ support — a more controlled approach than embedding NMN directly into a multi-compound powder.

NOVOS Core Vs. IM8 Daily Ultimate Longevity Powder: Comparison at a Glance

Category	Feature	NOVOS Core	IM8 Daily Ultimate Longevity Powder
Pricing & Focus	Monthly Cost	~$98 with subscription	~$119 with subscription
	Cost Per Serving	~$3.27	~$3.97
Science & Dosing	Number of Hallmarks Targeted	All 12 (validated by longevity researchers and supported by published data)	Claims to target all 12, but only NOVOS has published data supporting this claim
	Published Research on Complete Formula	Multiple published studies; double-blind human clinical trial; patent pending	No peer-reviewed studies on complete formula; two small trials are ongoing, and no outcomes are published
	Third-Party Tested	Yes	Yes — NSF Certified for Sport
	Scientific Development	Formulated with an advisory team of longevity scientists and physicians, including George Church, Matt Kaeberlein, and Pamela Maher; ingredients drawn from 950+ peer-reviewed studies	Advisory panel of physicians and researchers, including affiliations with Cedars-Sinai, Mayo Clinic, and a former NASA Chief Scientist; research partnership with University of Oxford
Key Mechanisms Supported	NAD+ Support	Works synergistically with NOVOS Boost (NMN), separated for optimal stability and absorption	NMN (300 mg) included in formula but lacks supporting cofactors for sustained NAD+ metabolism
	Senolytics	Fisetin + pterostilbene — a more bioavailable analog of resveratrol — plus synergistic support from rhodiola	Uses older resveratrol form (250 mg) with quercetin and fisetin, but limited data on combined efficacy
	Autophagy/Metabolic Support	AKG, magnesium malate, L-theanine, and rhodiola — clinically studied to promote cellular renewal and mitochondrial health	Includes spermidine (3 mg) — questionable bioavailability and benefits
Product Format & Experience	Delivery Format	One daily sachet (unflavored, orange, and limited-time tropical passion)	Daily flavored powder (açaí berry pomegranate)
	Best Suited For	Individuals seeking a scientifically validated, affordable longevity stack	Consumers drawn to celebrity-backed products with added NMN but limited proof of full-system benefits

*Information in table current as of July 2026. See what’s in NOVOS Core.

NOVOS Core vs IM8 Ingredients: What’s in Each

Both NOVOS and IM8 list their active ingredients and doses openly. However, only NOVOS has published data evaluating the complete formulation’s impact on biological aging. Remember, when evaluating longevity supplements, it’s not about trendy ingredients — it’s about what’s actually proven to work.

Cellular Foundation

IM8 combines glycine (3 g) and taurine (2 g) to support basic cellular energy and detoxification. These are beneficial, foundational nutrients, but they primarily address short-term vitality rather than deeper longevity mechanisms.

NOVOS Core takes a more integrative approach. It includes glycine (2,000 mg) for collagen and detoxification support, but it goes further with ingredients that support mitochondrial function, energy metabolism, and oxidative resilience. For example: 

• Magnesium malate (305 mg) and L-theanine promote cellular energy and calm.
• Calcium alpha-ketoglutarate (Ca-AKG) has been associated with lifespan extension in animal studies. Animal studies are not relied upon to support any representations of health benefit in humans.
• Vitamin C (100 mg) supports the epigenome and helps restore balance, especially in combination with AKG.
• Rhodiola rosea protects against neurotoxins and oxidative stress. 

These ingredients collectively help maintain youthful cellular performance across multiple aging pathways rather than offering surface-level nutritional support.

Senolytics & Cellular Protection

Senolytics help clear senescent cells, the “zombie” cells that accumulate with age and drive inflammation. Both NOVOS Core and IM8 include senolytic compounds, but the quality and effectiveness of these choices differ.

NOVOS Core combines fisetin (100 mg) and pterostilbene (50 mg), a more stable, bioavailable analog of resveratrol. Pterostilbene offers superior absorption and a longer half-life, making it more likely to reach target tissues at effective levels. In contrast, resveratrol has been shown in recent studies to fail at extending lifespan, partly due to its rapid breakdown in the body (half-life of about 14 minutes).

IM8, on the other hand, uses resveratrol (250 mg), quercetin (250 mg), and fisetin (100 mg). There’s little evidence that this specific combination, at these doses, produces synergistic effects or meaningfully targets all hallmarks of aging.

NAD+ Precursors

NAD+ (nicotinamide adenine dinucleotide) is essential for cellular repair and mitochondrial function. Levels decline with age, driving interest and research in precursors like NMN and NR.

IM8 includes NMN (300 mg) directly in its mix — a convenient but potentially unstable choice, as NMN can degrade when exposed to moisture, light, or heat.

NOVOS takes a different approach. Rather than embedding NMN into Core, it offers NOVOS Boost, a standalone NMN formulation that allows for controlled dosing and purity. This approach maintains NMN stability and allows users to control their NAD+ support for optimal results.

Spermidine

IM8 includes compounds like spermidine (3 mg) and dihydroberberine (100 mg), which are often promoted for supporting autophagy and glucose metabolism. However, the science tells a different story. 

A human clinical trial found that oral spermidine does not raise blood levels of spermidine or spermine, casting doubt on its bioavailability and benefits. That’s why NOVOS made a deliberate decision not to include spermidine in its formulations. 

Related: NOVOS Core vs. AG1: What’s the Best Supplement for Longevity?

IM8 Clinical Trials vs NOVOS Third-Party Studies

In a market full of lofty longevity claims, few products have the data to back them up. NOVOS Core is a patent-pending formulation that stands apart. Supported by independent research, human cellular studies, a scientific advisory board, and coverage from leading media outlets, NOVOS Core is the most scientifically validated longevity supplement available today. 

Scientific Validation

NOVOS Core’s formulation has been featured in multiple studies showing lifespan extension in animals, measurable reductions in DNA damage and inflammation, and improved skin firmness in human subjects. 

In research, the Core formulation has been associated with notable lifespan extension in an aged mouse model and with changes in markers such as DNA damage and inflammation. Animal studies are not relied upon to support any representations of health benefit in humans. In a human case study, NOVOS was associated with a reduction in biological Pace of Aging.

IM8 emphasizes its collaboration with experts from Cedars-Sinai, NASA, and Oxford and notes that its ingredients are clinically validated for individual effectiveness. The company also states that all formulas undergo third-party testing and carry NSF Certified for Sport verification.

However, to date, no peer-reviewed or published studies have evaluated the complete IM8 formulation or demonstrated that it influences biological aging. Two small, 12-week trials (one for the Longevity formulation and one for the Daily Essentials Powder) listed on the National Library of Medicine remain ongoing, with results pending.

Real-World Results

Everyday users of NOVOS Core report results comparable to high-profile biohackers. At under $100 per month, Core offers research-backed benefits that others spend thousands trying to replicate. Individual results will vary.

Related: NOVOS Core vs. Tally Health: What’s the Best Supplement for Longevity?

IM8 Alternative: Why Compare NOVOS Core and IM8?

Celebrity-backed health products often command attention before the science catches up. IM8, fronted by Beckham and branded as the “world’s first longevity formulation,” leans heavily on its lifestyle branding alongside scientific claims.

In reality, NOVOS was the first to define the longevity supplement category, designed specifically to target the biological root causes of aging. Backed by an interdisciplinary team of experts in aging biology, nutrition, and biochemistry, NOVOS prioritizes science over marketing. Our mission has always been clear: develop a formulation studied for its influence on biological aging markers through peer-reviewed research and real-world data.

That distinction — marketing versus measurable science — forms the core of this comparison. NOVOS is also helping shape the future of longevity science:

• We’re the only consumer brand accepted into the prestigious Longevity Biotechnology Association (LBA), an industry body made up of the world’s top longevity researchers, investors, and companies.
• NOVOS is one of just two consumer brands selected as a top-100 team for the XPRIZE for Healthspan Extension. 
• We’re backed by a team of pioneering longevity scientists, including George Church and Matt Kaeberlein. Meet the scientists and explore their published research.

Is IM8 Worth It? Which Longevity Supplement Is Best?

Both IM8 and NOVOS Core aim to simplify longevity into a daily routine. But only one does so with extensive scientific validation and published research on the complete formula.

IM8 offers a high-profile celebrity partnership and features trending compounds like spermidine. However, it currently lacks published, long-term data or evidence showing a reduction in biological age.

NOVOS Core, by contrast, is a patent-pending formulation created by longevity scientists. It has been tested in laboratories, studied in humans, and continually refined to target all 12 mechanisms of aging, making it one of the most scientifically grounded longevity supplements available today.

Of the two, NOVOS Core is the only formula with published research on its complete formulation. Ready to simplify your longevity routine? Try NOVOS Core today, and pair it with NOVOS Boost for optimal NAD+ support.

FAQ About NOVOS Core Vs. IM8

What is the best supplement for longevity?

Supported by independent research, human cellular studies, a scientific advisory board and coverage from leading media outlets, NOVOS Core is among the most extensively studied longevity supplements available today.

Is IM8 a good supplement?

IM8 includes promising ingredients, but to date, it lacks published studies on its full formulation, making it difficult to verify long-term efficacy.

Can you slow aging without prescription drugs?

Yes. Nutrients like NMN, AKG, and fisetin, combined with lifestyle factors such as exercise, sleep, and caloric balance, can influence biological aging markers.

What makes a longevity supplement “science-backed”?

Published studies, transparent dosing, and third-party validation. NOVOS meets all three criteria.

Can you combine NOVOS Core with other supplements like IM8 or AG1?

NOVOS Core already targets all 12 mechanisms of aging, so additional longevity formulas are redundant. It’s safe to take Core with general nutrition products.

Related: NOVOS Core Vs. Blueprint: Which Longevity Supplement Stack Is Right for You?

FAQs