Scientific evidence behind NOVOS

Table of Contents

Navigate directly to a specific study.

• Study 1: NOVOS Core extends lifespan
• Study 2: NOVOS slows pace of aging
• Study 3: NOVOS improves skin
• Study 4: NOVOS protects DNA
• Study 5: NOVOS clears senescence
• Table: 950+ ingredient studies
• Bonus Resource: Downloadable PDF

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Study 1: NOVOS Core Outperforms All Other Supplements & Leading Longevity Treatments at Extending Lifespan in Aged Mice

A new study conducted at Newcastle University’s Biosciences Institute by a team of esteemed researchers, including Dr. Thomas von Zglinicki, Professor of Cellular Gerontology with over 43,000 citations, and Dr. Satomi Miwa, Lecturer on the Translational Biology of Aging with over 10,000 citations. This research compared NOVOS Core against both a senolytic drug combination (a “positive control” of interventions previously shown to extend mouse lifespan) and a negative control group with no intervention.

In total, 38 male mice, aged 20 months at the beginning of the study, were divided into three groups: a negative control group, a group receiving NOVOS Core, and a senolytic group. While NOVOS Core was administered daily, the senolytic treatment involved two rounds of injections. Health markers such as frailty and cognitive function were assessed every two months, adding valuable insights into NOVOS Core’s impact on overall healthspan.

Key Findings from the Study

The study on NOVOS Core, the patent-pending longevity formula, uncovered several notable results, adding significant depth to the scientific understanding of its impact on aging and healthspan. Here’s a breakdown of the key findings:

Note: C = negative control, DS = Dietary Supplement (NOVOS Core), SEN = R&D Rx Senolytic

1. 18% Lifespan Extension in Aged Mice
   NOVOS Core extended lifespan by 18% in aged mice, equivalent to starting treatment in human 60-year-olds. This impressive relative increase surpasses the results of any supplement ever studied in aged mice, highlighting NOVOS Core’s effectiveness in promoting longevity even when interventions begin later in life. The longevity benefits exceed those of other well-known interventions, such as NR (nicotinamide riboside), glucosamine, and others.
   
2. A Powerful, Accessible Alternative to Complex Medical Interventions
   The study underscores that NOVOS Core’s natural, multi-ingredient formula can produce better lifespan extension results than invasive longevity treatments like TERT gene therapy, senolytic drugs like the combination of dastatanib and quercetin, and hormone therapies like 17-alpha-estradiol. These findings suggest that effective longevity interventions can be beneficial even when started later in life.
   
3. Comparable to R&D Senolytics but with Enhanced Safety
   In the study, NOVOS Core matched the lifespan extension benefits of prescription-grade R&D senolytic injections of navitoclax combined with BAM15, . In addition to these longevity benefits, NOVOS Core delivers real-world health improvements that enhance everyday well-being. Unlike many of these treatments, which can be invasive or carry potential side effects, NOVOS Core follows a gentler approach by leveraging senostatic effects—reducing the size and slowing the formation of senescent cells rather than eliminating them outright. Research shows that not all senescent cells are harmful, and selectively preserving certain senescent cells can benefit health. This balanced approach provides a safer, more sustainable way to support longevity.

4. Targeting All Twelve Mechanisms of Aging
   NOVOS Core’s unique formulation addresses all twelve scientifically recognized Mechanisms of Aging, a comprehensive approach that goes beyond the narrow focus of many supplements and therapies. This multi-target strategy enables NOVOS Core to deliver health benefits across various aging pathways, setting it apart from and outperforming single-ingredient treatments like NR, NMN, or even more advanced approaches such as gene therapy.

5. Reduction in Frailty and Cognitive Decline
   In addition to extending lifespan, NOVOS Core provided consistent, long-term improvements in health markers, including reductions in frailty and preservation of cognitive function. While trending towards statistical significance, the study authors suggested that starting the intervention earlier may yield even stronger results.

6. Enhanced Healthspan: Real-World Benefits for Everyday Well-Being
   Beyond longevity, the same mechanisms contributing to lifespan extension also support quality of life. These include improvements in skin health, sleep quality, energy levels, mood, and cognition—all areas in which NOVOS Core users have consistently reported positive changes.

The Implications for Human Health

Although this study was conducted in mice, its findings hold promising implications for human health. NOVOS Core was developed using human research and is specifically formulated to target the same biological pathways that drive aging in humans. The lifespan extension observed in this study is encouraging, but the immediate health benefits that NOVOS Core users report—such as enhanced energy, mood, and cognitive function—are already making a difference in daily life.

In essence, NOVOS Core is not just about extending lifespan; it’s about enhancing healthspan—the quality of life in the years we live. As research in longevity science progresses, we’re excited to see NOVOS Core establish itself as a leading, over-the-counter intervention in the anti-aging field.

Read the preprint of the study here.

Study 2: Statistically Significant Reduction of Biological Pace of Aging with NOVOS Core and Boost

NOVOS initiated a case study from February 2022 to August 2022. For the study, 12 participants were provided with an epigenetic test kit (the same test behind NOVOS Age), plus six months’ daily use of NOVOS Core and NOVOS Boost. The population was composed of six males and six females aged 39 to 76.

Participants were instructed to submit a blood sample for epigenetic testing prior to ever having used NOVOS Core or Boost, then to begin taking one sachet of Core and two pills of Boost (250 mg NMN dosage) daily. They were also asked not to make any significant changes to their lifestyles unless medically necessary and to notify the NOVOS R&D team if any significant changes had taken place.

After six months, eleven subjects submitted a blood sample for follow-up epigenetic testing. One male participant dropped out due to lack of compliance.

Principal Component DunedinPACE clock outputs were compared for each subject’s start and end samples. The group had a statistically significant reduction in biological pace of aging, with eight of the eleven subjects (73%) reducing their pace of aging well beyond the test’s error margin. The average percentage change was minus 6.1% and one participant’s result was minus 14%.

Among the small group who did not improve, there was no statistical change, meaning they maintained their pace of aging, which might indicate a positive result. Their longevity might have worsened had they not taken NOVOS products. Zero participants had an increase in their pace of aging.

Note that the p-value for the results, at 0.001, far exceeds the minimum benchmark of statistical significance of 0.05. In other words, the results are 50 times less likely to be by random chance than what scientists ordinarily require to consider something as “statistically significant” (i,e., it is not coincidental).

Extending beyond the case study, multiple anecdotal customer accounts reflect similar outcomes. One verified customer had this to say: “I tested my biological age with an epigenetic test prior to starting NOVOS Core. I was 1.8 years younger than my chronological age. I started daily NOVOS Core packets, and six months later, I repeated the test. I was 8.4 years younger than my chrono age! I am excited about the results!” (Amy B., MSN, APRN, FNP-C.)

Another said this: “I took a blood epigenetic test before starting on NOVOS. I was 72 years old and the result said bio age 71. I then took Core and Boost consistently over 6 months, made sure not to add or remove any other supplements or make any significant lifestyle changes, then retested. I turned 73 and the result came back as bio age 63 – minus 10 years! I asked the lab to check if there were any errors in their analysis. To my delight, there wasn’t! Over those 6 months I noticed subtle improvements in my energy and got compliments from friends and family on my complexion. Here I am two years later and I’m still being complimented on my skin.” (Len M., New York)

The impressive results come after remarkable results from two studies demonstrating that the combination of ingredients in NOVOS Core and NOVOS Boost protect human cells against DNA damage and cellular aging (senescence). PR Newswire: Original Article

Study 3: NOVOS Core improves skin suppleness in humans

Participants who took NOVOS Core for 6 months all showed improvements in skin firmness as measured by an indentometer. 

An indentometer is a device that measures skin suppleness and firmness. 

Besides these objective measurements, participants also mentioned noticeable improvements in their skin, such as improved elasticity, smoothness, and firmness. 

Results

The study was a small pilot study, done in 4 patients. The device used to test is a state-of-the-art device used for scientific studies.

NOVOS users saw a minimum improvement of 12%, max of 40% and an average of 22% in skin firmness. 

NOVOS is planning to conduct an additional and more extensive dermatological study with more participants.

Ingredients improving skin health

These results on skin health are not that surprising given NOVOS Core contains various longevity ingredients that are also known to improve skin health, such hyaluronic acid, alpha ketoglutarate, glycine, vitamin C, and glucosamine. 

Oral hyaluronic acid improves skin health and reduces wrinkles. Hyaluronic acid is a component of the extracellular matrix, the “glue” that keeps skin cells sticking together. 

Alpha ketoglutarate improves skin stem cell health, and plays a role in collagen production. Alpha ketoglutarate also works together with vitamin C, given vitamin C also improves collagen production. Additionally, alpha ketoglutarate and vitamin C both work synergistically to improve the epigenome, including that of skin cells. Alpha ketoglutarate can also extend lifespan.

Glucosamine is a component of the extracellular matrix, and glycine is an important building block of collagen. 

These are some examples of how ingredients in NOVOS can improve skin health. 

Not just addressing signs of aging, but the underlying causes

What is even more important is that all these ingredients inhibit fundamental aging mechanisms and have shown to extend lifespan in various species.  

In other words, NOVOS Core is the only skin supplement that actually addresses the root causes of aging, including skin aging.

Study 4: NOVOS Core significantly reduces DNA damage in human cells after irradiation

A study found that a combination of the 12 ingredients in NOVOS Core and the nicotinamide mononucleotide (NMN) in NOVOS Boost significantly protects cells against DNA damage over a wide dose range. 

The study was done by Ichor Life Sciences, an independent third-party US-based lab specialized in DNA damage, cellular senescence, and aging.

In the study, HUVEC cells (human umbilical vein endothelial cells) were treated with the 13-ingredient NOVOS formulation and then irradiated. Irradiation typically causes pronounced DNA damage. However, the cells exposed to NOVOS before irradiation had significantly less DNA damage after being exposed to radiation, as measured via 8-hydroxy-2′-deoxyguanosine (8-OHdG or 8-oxodG) levels. 8-OHdG is a measure of oxidative DNA damage. When DNA gets damaged, 8-OHdG is formed. 

Treating cells with NOVOS was able to reduce DNA damage as measured by 8-OHdG by up to 77% and on average 68% compared to controls:

Researchers demonstrated that the NOVOS formulation protects against DNA damage over a wide range of doses, an effect mediated by DNA protective effects of multiple NOVOS ingredients at different doses and synergy between ingredients.

Study 5: NOVOS ingredients demonstrate synergistic senostatic effects on senescent human cells

This study was conducted at the Ageing Research Laboratories at Newcastle University (UK), specialized in cellular senescence and aging. The study was done under the guidance of Professor Von Zglinicki, Professor for Cell Gerontology.

The study found that the combination of multiple NOVOS ingredients could help the body better deal with senescent cells.

Senescent cells occur during aging and play an important role in the aging process. These cells accumulate various forms of damage, including DNA and epigenetic damage, and secrete substances that harm healthy surrounding cells. 

Research has shown that countering senescent cells using senostatic drugs (which suppress senescent cells) can support the body to deal better with aging. In the study, researchers using cell size as marker for the senescent phenotype found that specific NOVOS ingredients had a senostatic effect, while not impacting normal, non-senescent cells:

A senostatic effect comprising a reduction in senescent cell size has also been observed with rapamycin, a prescription drug associated with increased longevity in multiple animal models:

Normal non-senescent cells were not impacted by the NOVOS formulation, demonstrating that specific NOVOS ingredients used in a synergistic combination can impact senescent cells while not impacting healthy cells — a common pitfall of “senolytic” molecules which seek to destroy senescent cells. 

950+ Longevity-relevant Scientific Studies Behind Ingredients in NOVOS’ Formulations

You can download a brief description of our ingredients and their health effects below: