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NOVOS Age vs. Other Biological Age Clocks

NOVOS Age vs. Other Biological Age Clocks

We cover every dimension that matters when comparing biological age clocks.
AttributeNOVOS Age ClockSaliva-based Clock by Celebrity Scientist's New StartupOther tests
Tissue CollectionBlood from a small poke of a finger, a method that is more accurate than via salivaSaliva from a cheek swab, a method that is generally not very accurateBlood collection methods that are invasive and far more uncomfortable that via small pokes of fingers
Sample SizeSamples from more than 20,000 humansSamples from more than 8,000 humansSamples typically from fewer than 2,500 humans
DNA Methylation TechnologyBuilt using the modern MethylationEPIC array that measures 850,000 DNA sites and tests your sample on that same technologyBuilt using the modern MethylationEPIC array that measures 850,000 DNA sites but does not test your sample on that same technologyBuilt using older arrays that only capture 27,000-450,000 DNA sites
Chronological Age Range8-102 years18-100 yearsLess expansive age range often lacking individuals 90+ years of age
DiversitySignificant diversity across ethnicity, race, and sex, all supported by many peer reviewed publicationsDiversity across ethnicity, race, and sex, but without support of peer reviewed publicationsInsufficient representation across ethnicity, race, and sex and without support of peer reviewed publications
Test ReliabilityOptimized to be reliable across repeat measurements, with published and peer reviewed best-in-class ICC values (accuracy) >.96 for all three algorithmsClaims of being optimized to be reliable across repeat measurements without disclosing ICC valuesExhibit high test-retest error rates
Model Type3rd generation (latest) clock, the only one trained on longitudinal analysis (people across their lifetimes), the best way to track biological age as shown in publications and tested via peer reviewSelf-claimed "novel" method-based model that lacks publications, peer review, and head-to-head comparisons against other clocks1st generation (oldest) model trained to simply estimate chronological age instead of biological aging
Outputs and AnalysisThree: 1) 3rd generation Pace of Aging via DunedinPACE, 2) Biological Age, and 3) Telomere LengthOne: A less accurate output of biological age A single, less accurate output of biological age
Creators of ClockA top team of Duke University and Columbia University scientists with peer reviewed publicationsA start up company without publication of the algorithms, thus lacking scientific scrutiny
Number of Studies45+ published studies by 30+ longevity scientists' labs across the worldZero published studies
Immune Cell ControlsPublished and Patented Advanced 12-cell immune deconvolution methods (cell changes won't impact accuracy, which is common in saliva and makes blood samples better)No controlsNo controls
Studies that prove accuracy in different ethnic groupsAlgorithms validated in the Family and Community Health Study of African American Families study, MESA (Multi-ethnic Study of Atherosclerosis), Cebu Longitudinal Health and Nutrition Survey (CLHNS Phillipines), Northern Finland Birth Cohort 1966 Study, Health and Retirement Study, the Normative Aging Study, the Framington Heart cohort, TILDA (the Irish Longitudinal Study of Aging), and many more.No studiesNo studies
Studies that show relatonship to outcomesAlgorithms have been validated in the Health and Retirement Study, the Normative Aging Study, the Framington Heart cohort and more. No studiesNo studies
Studies that show change with validated anti-aging interventionsThe only algorithm proven to respond in a significant way to validated anti-aging interventions such as caloric restriction (Published in Nature)No studiesNo studies
Include Clinical Covariates21 clinical covariates and telomere lengthNo clinical covariatesNo clinical covariates
Comparisons to other algorithmsComparisons in the FHS study and in the Health and Retirement Study show superior resultsNo published comparisonsNo published comparisons
Shares actual data on precision (ICC values)See ICC values with comparisons in the FHS study.No dataNo data

 

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