01
Lines that stay
Expression lines settle into place as the collagen network thins and the skin loses its ability to spring back.
Benefit / Skin
Skin is an organ.
Feed it like one.
What shows on the surface is the last step of a process that starts several layers down, in cells that build collagen, hold water and defend themselves against damage. NOVOS works on that layer.
Hydration
Elasticity
Firmness
Barrier
Tone
Surface
Texture, tone and the light your skin reflects back
Barrier
Moisture held in, irritants kept out
Dermis
Collagen and elastin, the scaffolding that gives skin its bounce
Microvessels
Blood flow delivering oxygen and nutrients to every cell
Cellular layer
Energy, repair and renewal happening below anything you can see
Surface to cellular layer
Human study on NOVOS Core
Third-party tested, every batch
Scientific advisors from Harvard and MIT
Doses printed, no proprietary blends
The vocabulary
What people usually mean by aging skin
Four different biological processes, four different vocabularies. Naming them precisely is the first step to knowing which one you are actually trying to change.
02
Firmness that fades
Along the jaw and cheeks, structure gives way before tone does. It reads as softness rather than wrinkles.
03
A tired-looking tone
Dull, uneven color often traces back to circulation and slower turnover rather than surface dryness.
04
Slower recovery
A late night, a long flight or a day in the sun takes longer to fade from your face than it used to.
The map
Six systems decide how skin ages
Not six ingredients. Six processes. Select one to see what it governs and which part of the NOVOS system touches it.
Hydration
Hyaluronic acid binds many times its weight in water inside the dermis. As levels drop with age, skin holds less and looks flatter. Supporting it from the inside keeps the reservoir topped up rather than sealing moisture at the surface.
NOVOS Core
Direct. Hyaluronic acid plus glycine
NOVOS Vital
Indirect. Barrier and inflammation support
NOVOS Boost
Indirect. Cellular energy for repair
NOVOS Bar
Supportive. Whole-food fats and fiber
Collagen structure
Collagen is roughly one third glycine by weight, and vitamin C is a required cofactor for the enzymes that assemble it. Without both, the raw material and the assembly line run short at the same time.
NOVOS Core
Direct. Glycine plus vitamin C
NOVOS Vital
Indirect. Protects existing collagen
NOVOS Boost
Indirect. Fibroblast energy supply
NOVOS Bar
Direct. Plant protein and amino acids
Circulation
Skin is fed entirely through microvessels. When flow drops, delivery drops, and tone follows. Nitric oxide and vascular support are the quiet part of a complexion conversation.
NOVOS Core
Direct. Vascular and nitric oxide support
NOVOS Vital
Indirect. Rutin supports vessel integrity
NOVOS Boost
Indirect. NAD+ dependent vascular function
NOVOS Bar
Supportive. Polyphenol-rich ingredients
Oxidative defense
Sunlight, pollution and normal metabolism all generate reactive molecules. Carotenoids accumulate in skin over weeks of consistent intake and add a modest, measurable layer of defense underneath your sunscreen.
NOVOS Core
Supportive. Broad antioxidant coverage
NOVOS Vital
Direct. Lutein, zeaxanthin, carotenoids
NOVOS Boost
Indirect. Supports repair capacity
NOVOS Bar
Direct. Astaxanthin and whole-food polyphenols
Inflammatory load
Chronic low-level inflammation accelerates the breakdown of collagen and elastin. Reducing that background load is less visible than any single ingredient story, and probably more important.
NOVOS Core
Direct. Multiple anti-inflammatory pathways
NOVOS Vital
Direct. Carotenoids and botanicals
NOVOS Boost
Indirect. Cellular maintenance
NOVOS Bar
Direct. Fiber and prebiotic support
Cellular energy
Building collagen and repairing damage costs energy. NAD+ levels decline with age, and every repair process in skin depends on cells having enough of it to do the work.
NOVOS Core
Supportive. Broad longevity pathways
NOVOS Vital
Indirect. Reduces oxidative burden
NOVOS Boost
Direct. NMN for NAD+ support
NOVOS Bar
Supportive. Steady nutrient delivery
Chapter 01 / NOVOS Core
The foundation, and the one with human skin data
Core is a twelve-ingredient formula built around the biology of aging rather than the appearance of it. Skin happens to be where that work becomes visible first.
6 MONTHS · HUMAN STUDY
22%
average increase in skin firmness after ~180 days of daily NOVOS Core.
What the research actually looked at
Four participants (two male, two female) took Core daily for 6 months while firmness was measured for both facial cheeks with an indentometer. Firmness improved for every cheek and all subjects.
Averages, not guarantees. Individual results may vary.
Five ingredients doing the visible work
Holds water inside the dermis
Hyaluronic acid
A single gram binds up to six liters of water. Oral hyaluronic acid has been studied for skin moisture and, in several trials, for the appearance of fine lines around the eyes.
HUMAN PRELIMINARY STUDY- What was measured
- Corneometry for skin moisture and photographic wrinkle scoring across multiple randomized trials of oral hyaluronic acid.
- How strong is it
- Consistent direction of effect across trials, though sample sizes are modest and the effect is gradual rather than dramatic.
Required cofactor for collagen synthesis
Vitamin C
The enzymes that stabilize collagen cannot function without it. This is settled biochemistry rather than a marketing claim, which is exactly why it belongs at a meaningful dose.
HUMAN PRELIMINARY STUDY- What was measured
- Prolyl and lysyl hydroxylase activity in collagen assembly, plus dietary intake associations with skin appearance in population studies.
- How strong is it
- The cofactor role is established. The size of the cosmetic benefit from supplementation depends heavily on your starting status.
The most abundant amino acid in collagen
Glycine
Roughly every third residue in the collagen triple helix is glycine. Typical diets supply less than the body uses for connective tissue turnover.
Early evidence- What was measured
- Collagen amino acid composition and glycine balance studies estimating a shortfall relative to synthesis demand.
- How strong is it
- Strong mechanistic rationale, with human skin endpoints still limited. Labeled early rather than proven.
Feeds the pathway that makes your own hyaluronic acid
Glucosamine
Glucosamine is an early substrate in the route cells use to build hyaluronic acid and other glycosaminoglycans, supplying raw material for the ones your skin makes itself.
Early evidence- What was measured
- Glycosaminoglycan synthesis in cell and tissue models, plus small studies on skin moisture and fine line appearance with oral glucosamine.
- How strong is it
- The biosynthetic pathway is well described. Human skin endpoints are limited in number and size, so this is labeled early.
Supports collagen and cellular maintenance
Ca-AKG
Alpha-ketoglutarate sits at the center of cellular metabolism and is used by the same enzyme family involved in collagen hydroxylation.
Small pilot- What was measured
- Biological age markers in a small human pilot, alongside animal healthspan work and metabolic pathway analysis.
- How strong is it
- Promising and mechanistically coherent, but the human skin evidence specifically is early.
Chapter 02 / NOVOS Vital
Carotenoids build a reserve in the tissue itself
Eat them consistently and lutein and zeaxanthin accumulate in skin over several weeks, sitting in tissue and absorbing energy that would otherwise cause damage. Vital adds that carotenoid layer alongside rutin for vessel integrity and inulin for the gut side of the inflammation story — the sun-exposure and daily-load formula.
This is not sun protection
An internal antioxidant reserve is a layer under your sunscreen, never a replacement for it.
Chapter 03 / NOVOS Boost
Repair costs energy, and NAD+ is the currency
Every collagen fiber a fibroblast builds and every strand of damaged DNA it repairs runs on cellular energy. NAD+ levels fall as we age, and the repair budget falls with them. Boost supplies NMN, a direct NAD+ precursor.
NMN
NAD+
DNA repair · mitochondrial output · fibroblast activity
Where the evidence stands
Human trials show NMN raises blood NAD+ levels. The link from higher NAD+ to visible skin change is supported mostly by laboratory and animal work.
Chapter 04 / NOVOS Bar
The same nutrition, arriving as food
Amino acids for collagen, astaxanthin for oxidative defense, fiber for the gut side of inflammation. Bar delivers them in a matrix of whole ingredients rather than a capsule — protein arriving with fat and fiber is absorbed on a gentler curve, and the polyphenols come along with it.
Side by side
Which formula touches which goal
Direct means the formula was built for that outcome. Supportive and indirect mean it helps without being the main lever.
Start with NOVOS Core
Start with NOVOS Core
Start with NOVOS Vital
Start with NOVOS Core
Start with NOVOS Boost
Start with NOVOS Bar
NOVOS Core: Not applicable
NOVOS Vital: Not applicable
NOVOS Boost: Not applicable
NOVOS Bar: Direct
Two directions
Inside and outside solve different problems
From the inside
- Supplies the raw materials for collagen synthesis
- Raises antioxidant levels within the tissue itself
- Supports circulation that feeds every skin cell
- Moves slowly and measures in months
ideally
From the outside
- Blocks UV before it reaches living tissue
- Seals water at the surface within minutes
- Treats a specific area you can point at
- Shows results quickly, then plateaus
What to expect
Skin works on its own timeline
Weeks 1–4
Hydration and comfort shift first. Skin feels less tight, and makeup sits differently. Little of this is visible in a photograph yet.
Weeks 4–8
Carotenoid and antioxidant levels in tissue continue building. Tone and texture may start to read more even.
8–12+ weeks
Firmness and elasticity measures move on the timescale the human study followed — gradual, cumulative change from consistent daily use rather than a single visible turning point.
In their words
What people notice first
“Three months in and the difference is in how my skin recovers. A bad week no longer shows on my face for a fortnight.”
Marcus Reid, 45 “I started for the longevity side of it. The skin change was the part my friends noticed first.”
Anita Raghavan, 38 “Nothing dramatic in month one. By month three my skin holds moisture in a way it has not for years.”
Mei Tanaka, 52 Scientific advisory
Reviewed by researchers in aging biology
Genomics pioneer whose laboratory studies the genetics of aging and reprogramming.
Harvard Medical School, a leading researcher in the genetics and biology of aging.
Salk Institute for Biological Studies and University of British Columbia, researching natural compounds and cellular protection.
Questions
Frequently asked questions
How long before I notice anything in my skin?
Skin works on its own schedule. The outer layer turns over roughly every four weeks in younger adults and more slowly with age, and the deeper collagen network remodels over months, not days. In the NOVOS Core human study, hydration and elasticity measures moved over 90 days. A fair expectation is subtle changes in comfort and hydration in the first month, with texture and firmness taking two to three months of consistent daily use.
Can a supplement actually change skin, or is this just hydration?
Skin is a living organ fed by blood, not by the surface. Nutrients that reach it through circulation influence the raw materials for collagen, the antioxidant reserves in the tissue and the water held between cells. That said, nothing taken by mouth replaces sun protection or a good topical routine. The honest framing is that inside and outside work on different parts of the same problem.
Which product should I start with?
Most people start with Core. It is the formula with the human skin data behind it and it covers the widest set of pathways at once. If your main concern is sun-exposed skin and carotenoid status, Vital layers on top. If your concern is cellular energy and NAD+, Boost is the addition. Bar is for people who want the nutrition to arrive as food.
Do I still need sunscreen?
Yes. Dietary carotenoids build a small amount of antioxidant reserve in skin tissue, which is measurable but modest. It is not a sun protection factor and it does not filter UV the way sunscreen does. Treat internal antioxidant support as one more layer under your daily SPF, never as a replacement for it.
What does the evidence actually cover?
NOVOS Core has a human study measuring hydration, elasticity and firmness over 90 days. Individual ingredients such as hyaluronic acid, vitamin C, glycine, lutein and astaxanthin have their own published literature, some of it strong and some of it early. Where a claim rests on a small pilot, a lab model or a single trial, this page labels it that way rather than rounding it up.
Can I take these together?
Yes. Core, Vital, Boost and Bar were designed as a system with non-overlapping roles, so stacking them does not double up on the same compounds. If you take prescription medication, are pregnant or nursing, or manage a health condition, speak with your clinician before starting anything new.
Is this vegan, and how is it tested?
The formulas are plant-based and free of animal-derived collagen. Every batch is third-party tested for identity, purity and contaminants. Certificates of analysis are available, and the ingredient doses are printed rather than hidden inside a proprietary blend.
What if it does not work for me?
Biology varies. Baseline nutrient status, sun exposure, sleep, smoking and genetics all move the outcome, which is why the studies report averages rather than guarantees. NOVOS offers a money-back guarantee so a three month trial costs you time rather than certainty.
Start with Core
Start with Core.
Start with NOVOS Core for the foundation with human skin data. Layer Vital, Boost or Bar as your goals call for it.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.