NOVOS Core is the first formulation designed around all 12 biological Hallmarks of Aging, developed with leading longevity scientists and physicians specializing in aging biology. Backed by more than seven years of R&D, it has been evaluated in randomized, double-blind, placebo-controlled human clinical research demonstrating statistically significant effects across validated measures of endothelial function, arterial flexibility, and systolic blood pressure in the normal range, with effect sizes among the largest reported in published human research for a supplement, nutritional, or lifestyle intervention. Built as a coordinated, multi-pathway system rather than a single-ingredient solution, NOVOS Core is designed to support multiple aging-related systems at once. In addition to cardiovascular outcomes, research has observed favorable shifts in biological age markers measured epigenetically and improvements in skin firmness in preliminary human studies, alongside customer-reported benefits such as steadier energy, mental clarity, mood balance, and sleep consistency†. The formulation is further supported by mechanistic studies and preclinical lifespan research, providing multi-level scientific evidence that NOVOS Core supports foundational aspects of healthy aging biology.* †Customer-reported outcomes and small scale studies. Individual results will vary.

A system designed to support the biology of aging itself Aging doesn’t happen in one place. It emerges from interconnected biological processes that influence cardiovascular function, cellular energy production, tissue renewal, and resilience across the body. NOVOS Core was intentionally designed around the biology of aging itself — not individual symptoms — by supporting all 12 biological Hallmarks of Aging simultaneously. Developed with scientists and physicians affiliated with institutions including Harvard Medical School, MIT, and the Salk Institute, the formulation is built as a coordinated system designed for ingredient synergy rather than a collection of isolated or trendy ingredients. Because these foundational systems shape how the body functions day to day, supporting them can influence performance, resilience, and overall well-being long before later-life outcomes become relevant. Built on evidence, not theory NOVOS Core is supported by multiple layers of research: Mechanistic studies to understand how it influences aging-related biological pathways Preclinical lifespan studies in mice, where animals receiving NOVOS Core lived over 18% longer on average (animal models do not predict human outcomes and are not indicative of impact on humans) Randomized, placebo-controlled human clinical research using validated functional biomarkers commonly applied in cardiovascular and aging science This multi-level approach reflects an uncommon standard of scientific validation for a nutritional formulation — testing the complete system rather than relying on individual ingredient claims. What the formulation is designed to support Cellular energy & metabolic efficiency Supports mitochondrial and metabolic pathways involved in cellular energy production to help maintain stamina, clarity, and daily recovery. Healthy cellular renewal Supports the body’s natural renewal and turnover processes that help maintain tissue function over time. Cellular resilience & stability Supports DNA stability, cellular stress-response pathways, and healthy inflammatory balance to promote long-term cellular function. Protein quality & cellular communication Supports proteostasis, extracellular matrix structure, and intercellular signaling — helping tissues remain coordinated and responsive with age. Why this approach is different Most supplements focus on isolated ingredients or single outcomes, while few are rigorously evaluated as complete formulations in randomized, placebo-controlled human clinical trials using validated functional biomarkers. NOVOS Core was designed to support the biology of aging as a connected system and evaluated as a complete formulation through mechanistic research, preclinical lifespan studies, and human clinical trials — not trends, theories, or ingredient-by-ingredient claims.* Few dietary supplements are evaluated this way, testing the complete finished formula in humans rather than relying on ingredient-level assumptions. *These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

Each ingredient in NOVOS Core was selected based on scientific evidence and is either naturally present in human biology or derived from compounds found in nature. Together, they were chosen for their roles in aging-related biological pathways and for their established safety profiles in human research. 1. Calcium Alpha-Ketoglutarate (Ca-AKG) - A compound naturally present in human metabolism that supports mitochondrial energy production and cellular resilience. 2. Fisetin - A polyphenol found in strawberries and other fruits that supports cellular renewal and healthy inflammatory balance. 3. Pterostilbene - An antioxidant compound found in blueberries that supports cardiovascular and metabolic health. 4. Glucosamine Sulfate - Naturally occurring in connective tissues, supports joint and extracellular matrix integrity. 5. Glycine - An amino acid abundant in collagen that supports recovery, detoxification, and restorative sleep. 6. Magnesium Malate - A form of magnesium involved in ATP production that supports energy metabolism and muscle function. 7. L-Theanine - An amino acid found in green tea that supports calm focus and stress resilience. 8. Rhodiola Rosea - An adaptogenic root traditionally used to support stamina, mental performance, and stress response. 9. Gingerols & Shogaols - Bioactive compounds from ginger that support healthy inflammatory signaling and digestive comfort. 10. Hyaluronic Acid - A molecule naturally present in skin and joints that supports hydration, elasticity, and tissue resilience. 11. Vitamin C - An essential nutrient found in fruits and vegetables that supports collagen production, antioxidant protection, and synergizes with CaAKG. 12. Micro-dosed Lithium - A trace mineral found naturally in water and foods that supports neuronal signaling and mood balance. These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

CLINICAL TRIAL & SCIENTIFIC EVIDENCE

Placebo-Controlled Human Clinical Trial Cardiovascular function was selected as the first human system to measure because vascular biology changes early with age and reflects whole-body resilience. NOVOS Core was evaluated in a randomized, double-blind, placebo-controlled human clinical trial conducted by university researchers in adults aged 40+. The study assessed validated functional biomarkers commonly used in cardiovascular and aging research. Compared with placebo, NOVOS Core demonstrated statistically significant differences across multiple measures of cardiovascular function: +3.4% improvement in endothelial function (Flow-Mediated Dilation, FMD) observed shortly after the first dose and sustained over six months −1.18 m/s difference in arterial stiffness (Pulse Wave Velocity) at six months −8.5 mmHg difference in systolic blood pressure, supporting healthy levels already within the normal range Effect sizes across these independent cardiovascular biomarkers are among the largest reported in published human research for a nutritional intervention, supplement, or lifestyle modification, including aerobic exercise, providing rare human evidence that a multi-pathway formulation can measurably influence aging-related physiology.* Individual responses vary. Not every person will experience the same magnitude of change. Preclinical Lifespan Study (Animal Model) In a controlled mouse lifespan study, animals receiving NOVOS Core lived over 18% longer on average than controls. While animal studies do not predict human outcomes, lifespan models are a foundational step in aging research for evaluating long-term, system-level biological effects before human trials. 👉 View the lifespan study Mechanistic Research (Formulation Design) NOVOS Core was developed through mechanistic research examining how ingredient combinations interact with aging-related biological pathways, including DNA protection, cellular senescence, cellular inflammation protection. This work confirmed formulation design, dosing, and ingredient synergy, ensuring the product was built as an integrated system rather than a collection of isolated compounds. 👉 Explore the mechanistic studies Epigenetic Aging Analysis NOVOS has supported independent DNA methylation–based epigenetic age testing, which measures patterns in your DNA that scientists use to estimate biological age over time. In an exploratory analysis of first-time NOVOS Core users tested before and after six months of use, follow-up results showed favorable directional shifts in these validated epigenetic biomarkers, consistent with a slower pace of age-related biological change. These tests are research tools used to study aging biology and do not diagnose disease or predict lifespan.* This was an observational, real-world evaluation rather than a controlled clinical trial. 👉 Learn about our epigenetic research Skin Elasticity Study (Instrument-Measured) In a preliminary human study using an indentometer — a scientific device that objectively measures skin firmness — participants showed an average 22% increase in skin elasticity after six months, with some reporting visible improvements within weeks. These findings suggest that supporting foundational biological pathways may also help maintain skin firmness, structure, and resilience over time.* This was a small pilot evaluation intended to generate preliminary signals. 👉 View the skin study details Why This Approach Is Different Most supplements rely on ingredient-level claims. NOVOS Core has been rigorously evaluated as a complete formulation across mechanistic research, preclinical lifespan studies, and randomized, placebo-controlled human clinical research, reflecting how aging actually works: as an interconnected biological system rather than isolated symptoms. *These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

Is NOVOS Core safe with medications?

NOVOS Core is a dietary supplement, not a medication. If you take prescription medications or manage a medical condition, consult your healthcare professional before use, especially if you are pregnant or nursing, managing blood pressure, bleeding or clotting, or any chronic condition.

How is NOVOS Core different from your other products?

NOVOS Core is the daily foundation. It’s a comprehensive longevity formulation designed to support multiple aging-related biological pathways as a complete system. Other NOVOS products are designed as targeted add-ons — for example, additional NAD+ or mitochondrial support — and can be layered on top of NOVOS Core depending on your goals.

How long until I notice results?

Timelines vary by individual. Some people report noticing day-to-day changes first, such as steadier energy or improved sleep consistency, within the first few weeks. Broader, longer-horizon changes associated with healthy aging biology typically build gradually over weeks to months and depend on baseline health and consistent use.

Are there any age related restrictions?

NOVOS Core is intended for adults. If you’re under 18, pregnant, or breastfeeding, consult a healthcare professional before use.

Can I take more than one sachet per day?

NOVOS Core is designed for one sachet daily. Some individuals choose to take up to two sachets per day. If increasing your intake, consider starting with one sachet for at least a week and consult your healthcare professional if you are sensitive to supplements.

How do I know it’s working?

There are two practical ways many people evaluate progress: How you feel Some people notice day-to-day changes such as steadier energy, sleep consistency, mood improvements, or overall resilience over time. What you can measure NOVOS Core is designed to support underlying biological systems associated with healthy aging, effects that may not always be immediately perceptible but can be observed through objective measures. In human clinical research, NOVOS Core demonstrated statistically significant benefits across validated functional biomarkers of cardiovascular function, including endothelial responsiveness, arterial flexibility, and support for healthy blood pressure already within the normal range.* If you already track general wellness metrics, you may choose to monitor markers such as resting heart rate, sleep patterns, blood pressure, or routine labs with your clinician. Because these changes reflect foundational physiology, benefits are often gradual and cumulative rather than instant.

How does the price compare to alternatives?

NOVOS Core replaces the need to source and dose multiple individual supplements. Instead of assembling a complex stack, you get a single, research-driven formulation developed and evaluated as a complete system. You’re investing in clinical research, quality controls, and formulation design — often at a comparable or lower total cost than buying similar ingredients separately.

What is NOVOS Core made of?

NOVOS Core contains 12 research-backed longevity ingredients: Vitamin C Magnesium Malate Calcium Alpha-Ketoglutarate Glycine Glucosamine Sulfate Rhodiola L-Theanine Hyaluronic Acid Fisetin Gingerol Pterostilbene Micro-dosed Lithium The Orange flavor also includes erythritol, malic acid, stevia, and natural flavors. Core is vegan, non-GMO, sugar-free, and free from artificial colors and preservatives.

Who is NOVOS Core for?

NOVOS Core is designed for adults of all ages who want to proactively support healthy aging. Younger users benefit from early support, while older adults may notice more immediate short-term effects.

Is NOVOS Core compatible with my diet or dietary restrictions?

NOVOS Core is free from: Dairy, gluten, soy, nuts, and shellfish Sugar, calories, and GMOs Preservatives and 14 EFSA-listed allergens It suits vegan, vegetarian, Mediterranean, keto, gluten-free, and NOVOS Longevity Diet guidelines.

Are there any side effects?

A small percentage of users experience temporary stomach discomfort when starting Core. Taking it with food, splitting the dose, or mixing it with extra water typically resolves this within a few weeks.

Can I take NOVOS Core while pregnant or breastfeeding?

NOVOS recommends avoiding Core during pregnancy and breastfeeding as a precaution.

Does NOVOS Core need refrigeration?

No. Store Core at room temperature in a cool, dry place.

NOVOS Core powder pouring from a sachet into a glass of water, with a Human Clinical Study Top Award Winner badge.

How to take NOVOS Core. Step 1: open one sachet, once a day, no pills, no stacking. Step 2: mix into water or your favorite drink. Step 3: drink.

In a cross-study analysis, NOVOS Core showed larger changes in cardiovascular markers than the average changes reported for exercise (HIIT, aerobic exercise, resistance training), diet (sodium reduction, Mediterranean diet) and omega-3. An exploratory cross-study comparison, not a head-to-head trial.

81% of NOVOS customers feel a difference within 2 weeks, shown alongside five customer reviews.

NOVOS Core Supplement Facts: serving size one packet (13 grams), 30 servings per container, listing Vitamin C, magnesium, calcium, glycine, malate, calcium alpha-ketoglutarate, glucosamine sulfate, rhodiola rosea, L-theanine, hyaluronic acid, fisetin, ginger, pterostilbene and lithium.

Five-star review from Grace D., a verified customer: I've never felt more energized or focused throughout the day.

Clinically Studied Longevity Formula

NOVOS Core

4.91,331 ratings

Support the biology of a longer, healthier life.*

All-In-One Longevity System. Our clinically studied foundational daily formulation supporting whole-body health at the system level.

All-day energy, no crash*
Support for restful sleep*
Clinically studied cardiovascular support*
Firmer, healthier-looking skin**
Total-body longevity, one daily drink*

Save up to 27%

Pause, skip, or cancel your subscription anytime from your account.

NOVOS Boost Add Boost for the ultimate combo Add

Free shipping – Subscribe to save – Flexible plans

Clinically evaluated benefits

NOVOS Core is designed to target all 12 Hallmarks of Aging. Its finished formula was studied in a randomized, double-blind, placebo-controlled human trial in healthy adults aged 40+, which showed benefits to cardiovascular aging markers. In a separate customer survey, 81% of NOVOS customers feel a difference within 2 weeks in sleep, mood, energy & skin. Preliminary results; manuscript under peer review. Survey results are self-reported. Individual results may vary.

Key ingredients

All 12 longevity ingredients in one daily serving, including Calcium Alpha-Ketoglutarate, Fisetin, Pterostilbene, Glycine, Magnesium Malate, L-Theanine and Micro-dosed Lithium. No proprietary blends – every dose disclosed.

How to use

Mix one sachet into water once a day. Dissolves easily. Most customers take NOVOS Core in the morning, though some prefer the evening, since better sleep is one of the changes customers mention most. Consistency matters more than the time of day.

Shipping & subscription

Free shipping on all subscriptions. Pause, skip, or cancel anytime from your account. HSA and FSA eligible.

Clean formulation

Sugar-free, vegan, gluten-free. No artificial sweeteners. Manufactured in the USA in a cGMP facility and third-party tested.

Still unsure? Try it first.1 Orange, 1 Tropical Passion, 1 UnflavoredNOVOS Core Sample Pack · $15.00Buy sample

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Cardiovascular support is based on a randomized, double-blind, placebo-controlled human trial in healthy adults aged 40+. Preliminary results; manuscript under peer review. Individual results may vary.
**Based on a pilot study (n=4) in which all participants improved skin firmness over six months, averaging 22%. Small sample size; preliminary.

Verified customer reviews

“It’s definitely doing something.”Virginia G. “More energy and less fatigue.”Harriet B. “My skin looks firmer and healthier.”Chris H. “My bio age reduced to 48.6.”Jeffrey B. “Waited so long for a product like yours.”Charlotte F. “It’s definitely doing something.”Virginia G. “More energy and less fatigue.”Harriet B. “My skin looks firmer and healthier.”Chris H. “My bio age reduced to 48.6.”Jeffrey B. “Waited so long for a product like yours.”Charlotte F.

Healthy aging

Designed to target all 12 root causes of aging at once.

Learn more

Improved skin

All pilot-study participants improved skin firmness.

Learn more

Better energy & recovery

Steadier, day-long energy. No caffeine, no crash.

Learn more

Improved sleep

Formulated with ingredients associated with restful sleep.

Learn more

Cardiovascular health

Rapid, durable support shown in a placebo-controlled human trial.

Learn more

81% of NOVOS customers feel a difference within 2 weeks.

*Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

Real Stories. Real Results.

“In a sea of generic supplement suppliers, NOVOS is a clear outlier.”

Julie G.

Ranked #2 in the world for slowed aging.

Miah K.

Ages 0.65 years for every year.

“NOVOS are pioneers in consumer longevity.”

Lil Eskey

Slowed her pace of aging by 22%.

Max D.

Summited Everest at a 0.71 pace of aging.

Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.

Developed with doctors and scientists from Harvard, MIT, and more.

More good years. Starting now.

NOVOS Core works on the biology of aging, with effects clinically shown to build from the first dose.

+3.9%

From the first dose

Cardiovascular function responds right away

In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, conducted at the University of Surrey, NOVOS Core showed benefits to cardiovascular function shortly after the very first dose.

Cardiovascular Learn more

Within days

A calmer, more rested feeling

NOVOS Core includes Glycine, an amino acid studied in connection with falling asleep more easily and feeling more refreshed in the morning, and L-Theanine, studied in connection with calm, steady focus.

Sleep & Mood · Focus Learn more

81%

The first few weeks

81% feel a difference at 2 weeks

Many customers report steadier energy and a calmer, more rested feeling after two weeks of daily use. NOVOS Core includes Rhodiola rosea, an adaptogen studied for its potential to support stamina, and magnesium, a cofactor in cellular energy production.

Energy · Stamina Learn more

The first few months

Skin, focus, and overall well-being

Skin, focus, and an overall sense of well-being are the changes customers mention building over the first months.

Skin · Focus Learn more

+2.9%

By six months

Longevity biomarkers improved vs. placebo

In a double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core showed benefits to cardiovascular aging markers at six months: blood vessel flexibility, circulation, and blood pressure (for blood pressures already in the normal range).

Cardiovascular · Longevity biomarkers Learn more

73%

Beyond six months

73% improved their pace of aging score

In a case study, a majority of participants slowed their biological pace of aging after using NOVOS Core + Boost daily for 6 months, as measured by the DunedinPACE epigenetic test.

Pace of aging Learn more

What sets NOVOS Core apart.

How NOVOS Core compares across the benefits that matter most.

Clinically studied Partial

Partial

PartialPartial

Partial1 pathway only

Not just made for longevity. Studied for it.

NOVOS Core has been tested across the full arc of longevity research: DNA, cells, animal lifespan, epigenetic biological age, and placebo-controlled human research.

Read the clinical trial

Cardiovascular · Randomized Human Trial

Rapid, durable cardiovascular benefits.

In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core produced statistically significant improvements at six months in endothelial function, arterial flexibility, and systolic blood pressure (among participants already within the normal range).

Manuscript under peer review. Learn more

Cells & DNA · In Vitro

Up to 77% more DNA protection.

NOVOS Core ingredients supported DNA integrity by up to 77% in irradiated skin cells. The NOVOS combination outperformed its individual ingredients.

In vitro study. Not indicative of human outcomes. Learn more

Lifespan · Animal

18% longer lifespan.

In aged mice, NOVOS Core extended lifespan by over 18%, the highest yet recorded for an over-the-counter supplement in aged-mouse models.

Animal study. Results may not translate to humans. Animal studies are not relied upon to support any representations of health benefit in humans. Learn more

Biological Age · Case Study

73% showed a slower pace of aging score.

In a 12-participant case study (ages 39–76), 73% reduced their DunedinPACE score. No participant’s score increased.

Case study, n=12; not a controlled trial. DunedinPACE is a research-use algorithm correlated with biological pace of aging, not a direct or definitive measure of aging. Individual results may vary. Learn more

Skin Firmness · Pilot

22% firmer skin.

In a 6-month pilot (n=4), every participant improved skin firmness, averaging 22% (range 12% to 40%).

Pilot study, n=4. Preliminary. Individual results may vary. Learn more

Most “Longevity Supplements” Are Not Actually Longevity Supplements

And are never tested as the product you actually take.

In a randomized, double-blind, placebo-controlled human trial, the complete NOVOS Core formulation provided nutritional support for biological systems predictive of lifespan and healthspan.*

That’s the difference between claiming longevity and demonstrating measurable results.

“This trial provides rare human evidence that a multi-pathway nutritional strategy can meaningfully influence cardiovascular aging biology itself.”

Dr. Christian HeissProfessor of Cardiovascular Medicine, University of Surrey

FMD

Blood Flow

Flow-mediated dilation

How well your arteries open when your body needs more blood. In the trial, FMD improved +2.9% vs placebo — a leading marker of endothelial and vascular health.

PWV

Blood Vessel Flexibility

Pulse wave velocity

How flexible your arteries are. PWV typically worsens about 1 m/s per decade; the trial showed a 1.2 m/s improvement vs placebo.

SBP

Blood Pressure

Systolic blood pressure

The pressure on your artery walls with every heartbeat. In the trial, systolic BP fell 6.1 mmHg vs placebo for blood pressure already in the normal range.

Member of / Selected for

Randomized, double-blind, placebo-controlled human clinical research in healthy adults 40+. Manuscript under peer review. Read the clinical trial

A NOVOS Core pack being poured into a glass of water

No proprietary blends Vegan · gluten-free · sugar-free · erythritol-free Naturally sweetened with stevia (unflavored does not contain stevia)

Active ingredients

Twelve ingredients
in one daily formula.

No proprietary blends. Every dose printed on the label. Patent pending.

Calcium Alpha-Ketoglutarate
Glycine
Pterostilbene
Fisetin
Malate
Magnesium
Glucosamine Sulfate
L-Theanine
Rhodiola Rosea
Hyaluronic Acid
Vitamin C
Ginger
Micro-dosed Lithium

See every ingredient and dose

Real scientists. Real doctors.

NOVOS is built with guidance from scientists and physicians from Harvard Medical School and MIT, whose expertise spans aging biology, genomics, neurobiology, nutrition, and clinical medicine.

Dr. Pamela MaherSalk Institute

Dr. J. Pedro MagalhãesHarvard Medical School

Dr. George ChurchHarvard Medical School · MIT

Dr. Robert LufkinUSC School of Medicine

Dr. Diogo BarardoUniversity of Singapore

Dr. Oliver MedvedikBiomedical Engineering · Cooper Union

Dr. Avi RosenbaumScientist and biotech consultant

Dr. Pamela MaherSalk Institute

Dr. J. Pedro MagalhãesHarvard Medical School

Dr. George ChurchHarvard Medical School · MIT

Dr. Robert LufkinUSC School of Medicine

Dr. Diogo BarardoUniversity of Singapore

Dr. Oliver MedvedikBiomedical Engineering · Cooper Union

Dr. Avi RosenbaumScientist and biotech consultant

8 yrsof research

7scientists & MDs formulated

7whole formulation studies

950+ingredient studies

1,800+verified clinicians recommend

3rdparty-tested for purity & potency

“NOVOS takes a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”

Dr. Doina Kulick, M.D.Lead Physician, Longevity Medicine · Mayo Clinic Arizona

Available at

Recommended by 1,800+ verified clinicians. Practitioner Program

Customer reviews.

4.9

Based on 1,331 ratings

· Ziizi

Best for inflammation

The reason I first try the Novo's Core was desperation to reduce my CRP (C-reactive Protein). I used anti inflammatory powder before from my local Herbal store, and it was good. My CRP number was 8.5 and after 28 days of using the powder from the local store it brings down to 1.0. I stopped couple of months and it went back up again to 8.1. after searching I've found Novo's Core stating that it's anti inflammatory drink. I ordered, start taking it. I did some blood work fifteen days later and it come down to .9. I'm trying to find out what causes my body's inflammatory responses. I started Novo's Core 2023 on and off now it looks different from the old one. Maybe it is just the packaging. As a drink I blend with some fruits and it is delicious.

· Jodie Johns

NOVOS: CORE & VITAL

I'm 61 w/ chronic inflammation. Moving back to a colder climate moved me from less active to downright wanting to quit. I had to lean and hold on to railings, & the chronic pain in my hips, knees, hands & feet were making movement intolerable, so much so, I chose to sit more and more. In my quest for answers for anti-inflammatory care/cures, I stepped into the longevity world; something I balked at. After reading some testimonies on your product I decided to give them a try. I wish I had started them separately-but I took Core and Vital at the same time. On day 6, I got out of bed, and flew down the stairs…midway down I realized I didn't need to hold on to the rail. And I ran up the stairs to be sure…The pain was 80% gone! * there may be permanent damage from the years of inflammation. It has been 9 days. I am almost pain free. I ate badly one day and thought I'd pay for it. I didn't feel as good but wanted to see if this was just the improved food or the NOVOS. I am not going to "test" anymore. With NOVOS Core and Vital, I am not going to take this for granted. I am going to continue to improve my diet and exercise and see just how much healthier and stronger I can get! I am more focused, excited about life and my future. I am hoping more improvements will come. If they do, I'll be sure to let you know. So grateful for the brave scientists who work with integrity to help humans live the rich life God intended for His kids. God bless you!

· Rick

Fantastic product and fantastic…

Fantastic product and fantastic customer service! I highly recommend the NOVOS line. I've been taking them for 6 months and can see (skin) and feel (energy levels, sense well being) the difference. Also, I prefer the Orange flavored Core vs the unflavored version.

· Semhar

NOVOS Core Orange flavour

Amazing product. I have a very senstive Gut. I always bloated after eating or without eating any meal. When if i feel bloated i drink novos core it helps me a lot !! my Gut starts to digest better!! I feel my brain functions better because no more bloating!!!

· Leonard

"Biological Age" is now almost 7 years younger

I started taking Novo's Core in July 2022. I was 68 years old and my TruMe age was 69 years. I took the test again in September 2024 and my TruMe age had fallen to 62.2 years. I also take NMN (the ingredient in Novo's Boost) and other supplements, but Novos is the biggest change that I've made in that time. On the other hand my back and my shoulders are in much worse shape than they were in 2022.

· Thomas Edward Grant

Take daily, receive monthly.

After being without for a couple of days, I feel like it's time to reorder Core.

Individual experiences may vary and are distinct from results observed in controlled clinical research.

Questions, answered.

Everything you need to know about NOVOS, the science, and getting started.

When will I feel results?

Many customers notice subtle changes in clarity and energy in the first few days. Broader changes (energy, sleep, skin) typically build over weeks to months. Biological-age changes develop over a longer horizon and depend on baseline health and consistent use. Individual results may vary.

What’s in NOVOS Core?

Twelve science-backed longevity ingredients in one daily drink mix. No proprietary blends, every dose disclosed. See the full ingredient and dose list.

Is it safe with my other supplements or medications?

NOVOS Core is formulated for tolerability and long-term daily use. If you take prescription medications or have a medical condition, share the ingredient list with your healthcare provider before starting.

What does it taste like?

Orange is a light citrus flavor, no artificial sweeteners. Tropical Passion is a bright passionfruit blend, equally light. Unflavored is neutral and disappears into smoothies, or any drink.

What if I’m sensitive to supplements?

Start with half a pack for the first week and build up. The formula is vegan, sugar-free, gluten-free, and free of artificial sweeteners. If sensitivities persist, consult your healthcare provider.

Can I cancel or pause my subscription?

Yes. You can pause, skip a delivery, or cancel anytime from your account. No phone calls, no lock-in.

Is NOVOS Core HSA/FSA eligible?

Yes. NOVOS Core may qualify for HSA/FSA reimbursement through our partner Truemed. Look for the Truemed option at checkout.

Who is NOVOS Core not for?

NOVOS Core is designed for healthy adults. It is not intended for anyone under 18, or for those who are pregnant or nursing. If you have a medical condition or take medications, talk with your healthcare provider first.

Where is it made?

NOVOS Core is manufactured in the U.S.A. in cGMP facilities, using rigorously tested ingredients from trusted partners worldwide.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

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Active ingredients

Every ingredient and dose.

No proprietary blends. Every ingredient and its exact dose is on the label, third-party tested for purity and potency.

Calcium Alpha-Ketoglutarate 1,100mg (231mg Calcium)
- Supports energy production
- Influences metabolism
- Mitigate inflammation
Glycine 2,000mg
- Improves sleep
- Supports cognitive function
- Promotes collagen synthesis
Pterostilbene 50mg
- Acts as an antioxidant
- Protects cells
- Enhances metabolism
Fisetin 100mg
- Acts as an antioxidant
- Manage oxidative stress
- Supports memory & learning
Malate 1,700mg (304mg Magnesium)
- Boosts energy
- Supports muscle function
- Enhances metabolism
Magnesium 304mg
- Supports muscle function
- Enhances bone health
- Regulates metabolism
Glucosamine Sulfate 1,000mg
- Supports joint health
- Promotes skin health
- Enhances mobility
L-Theanine 150mg
- Promotes relaxation
- Enhances focus
- Helps manage stress
Rhodiola Rosea 300mg
- Enhances performance
- Reduces fatigue
- Supports stress resistance
Hyaluronic Acid 100mg
- Hydrates skin
- Reduces wrinkles
- Supports joint health
Vitamin C 100mg
- Acts as an antioxidant
- Promotes collagen
- Enhances immune health
Ginger 100mg
- Manage inflammation
- Supports metabolic health
- Protect cells
Micro-dosed Lithium 20mg
- Stabilizes mood
- Enhances cognition
- Promotes neuroprotection

Supplement Facts

NOVOS Core

Serving size 11.9 g

Amount per serving	Amount	% Daily Value
Vitamin Cas Ascorbic Acid	100 mg	111%
Magnesiumas Magnesium Malate	304 mg	72%
Calciumas Calcium Alpha-Ketoglutarate	231 mg	18%
Glycine	2,000 mg	*
Malateas Magnesium Malate	1,700 mg	*
Calcium Alpha-Ketoglutarate	1,100 mg	*
GreenGrown® Glucosamine SulfateVegan	1,000 mg	*
Rhodiola Rosea Root Extract3% Rosavins & 1% Salidrosides	300 mg	*
L-Theanine	150 mg	*
Hyaluronic Acid	100 mg	*
Fisetin	100 mg	*
Organic Ginger Root Extract2% Gingerols	100 mg	*
Pterostilbene	50 mg	*
Lithium Aspartateproviding 1 mg of lithium	20 mg	*

* Daily Value not established.

Other Ingredients

Malic Acid, Natural Flavors, Sodium Bicarbonate, Silicon Dioxide, Calcium Silicate, Stevia.

EU Reference Intake

Per serving, as a percentage of EU Reference Intake.

Vitamin C · 100 mg125% RI
Magnesium · 304 mg81% RI
Calcium · 231 mg29% RI

GreenGrown® is a registered trademark of Ethical Naturals.

Lab TestedQuality certified · purity & potencyGMP RegisteredGood manufacturing practice

Read the full ingredients page

Key ingredients

Supplement Facts

NOVOS Core

Serving size 11.9 g

Amount per serving	Amount	% Daily Value
Vitamin Cas Ascorbic Acid	100 mg	111%
Magnesiumas Magnesium Malate	304 mg	72%
Calciumas Calcium Alpha-Ketoglutarate	231 mg	18%
Glycine	2,000 mg	*
Malateas Magnesium Malate	1,700 mg	*
Calcium Alpha-Ketoglutarate	1,100 mg	*
GreenGrown® Glucosamine SulfateVegan	1,000 mg	*
Rhodiola Rosea Root Extract3% Rosavins & 1% Salidrosides	300 mg	*
L-Theanine	150 mg	*
Hyaluronic Acid	100 mg	*
Fisetin	100 mg	*
Organic Ginger Root Extract2% Gingerols	100 mg	*
Pterostilbene	50 mg	*
Lithium Aspartateproviding 1 mg of lithium	20 mg	*

* Daily Value not established.

Other Ingredients

Malic Acid, Natural Flavors, Sodium Bicarbonate, Silicon Dioxide, Calcium Silicate, Stevia.

EU Reference Intake

Per serving, as a percentage of EU Reference Intake.

Vitamin C · 100 mg125% RI
Magnesium · 304 mg81% RI
Calcium · 231 mg29% RI

GreenGrown® is a registered trademark of Ethical Naturals.

Lab TestedQuality certified · purity & potencyGMP RegisteredGood manufacturing practice

NOVOS Core

Support the biology of a longer, healthier life.*

NOVOS Core benefit areas

Healthy aging

Improved skin

Better energy & recovery

Improved sleep

Cardiovascular health

Real Stories. Real Results.

Developed with doctors and scientists from Harvard, MIT, and more.

More good years. Starting now.

Cardiovascular function responds right away

A calmer, more rested feeling

81% feel a difference at 2 weeks

Skin, focus, and overall well-being

Longevity biomarkers improved vs. placebo

73% improved their pace of aging score

What sets NOVOS Core apart.

Not just made for longevity. Studied for it.

Rapid, durable cardiovascular benefits.

Up to 77% more DNA protection.

18% longer lifespan.

73% showed a slower pace of aging score.

22% firmer skin.

Most “Longevity Supplements” Are Not Actually Longevity Supplements

Blood Flow

Blood Vessel Flexibility

Blood Pressure

Twelve ingredientsin one daily formula.

Real scientists. Real doctors.

Independent Clinician Evaluations

Customer reviews.

Best for inflammation

NOVOS: CORE & VITAL

Fantastic product and fantastic…

NOVOS Core Orange flavour

"Biological Age" is now almost 7 years younger

Take daily, receive monthly.

Questions, answered.

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