The Science
The science behind NOVOS Core
What real longevity research looks like.
“Longevity” is everywhere in health and wellness — yet most products have never been studied for their effect on aging biology.
NOVOS Core is the exception. It has been evaluated in a randomized, double-blind, placebo-controlled clinical trial, preclinical lifespan studies, biological pace-of-aging research, and mechanistic studies.
Randomized human clinical trial
NOVOS Core is one of the only longevity supplements ever evaluated in a randomized, double-blind, placebo-controlled clinical trial measuring biomarkers of cardiovascular aging.
Why this matters
Most supplement studies measure proxy biomarkers in blood tests. The NOVOS Core clinical trial instead measured direct physiological functions of the cardiovascular system — reflecting how well it is actually functioning, not just biochemical markers.
Measured endpoints
Flow-mediated dilation
Measures endothelial function and blood vessel circulation capacity, which declines with age.
Pulse wave velocity
Measures the flexibility of blood vessels, which declines with age.
Systolic blood pressure
Measures blood pressure, which increases with age.
Improvements in endothelial function were observed both immediately after the first dose (1 hour) and sustained after six months of supplementation, suggesting NOVOS Core has both immediate and long-term biological effects.
“Taken together, improvements across endothelial function, arterial flexibility, and systolic blood pressure point to a coherent pattern consistent with a favorable shift in vascular aging biology.”
Professor Christian Heiss
Professor of Cardiovascular Medicine, University of Surrey
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Primary Endpoint
FMD: the study's primary endpoint
Flow-mediated dilation (FMD) measures the ability of blood vessels to expand in response to increased blood flow — a key indicator of endothelial health and vascular function.
NOVOS Core significantly improved FMD both acutely (within 1 hour) and after 6 months of daily use, while the placebo group showed no meaningful change.
Baseline
5.55%
vs 5.05% placebo
1 hour
8.95%
vs 4.85% placebo
6 months (fasted)
8.1%
vs 4.95% placebo
* p < 0.0001 vs. placebo (statistical significance)
Baseline Age Equivalence
40–60+
years
FMD levels typically observed in mid-to-late adulthood
NOVOS Age Equivalence
20–30+
years
Levels typically observed in younger adult populations
Age-equivalent ranges are descriptive comparisons based on published reference values for FMD in healthy populations (Holder et al., 2021; Maruhashi et al., 2020).
This study did not assess clinical outcomes. These results do not imply diagnosis, treatment, cure, prevention of disease, or reduction in disease risk.
Data from a double-blind, randomized, placebo-controlled clinical trial in healthy adults aged 40+. Error bars represent 95% confidence intervals.
Why cardiovascular aging matters
Cardiovascular aging is one of the most important biological drivers of lifespan and healthspan.
Declines in endothelial function, decreased arterial flexibility, and rising blood pressure are strongly associated with aging and long-term health outcomes.
Improving these systems is therefore considered a key target in longevity research.
Comparison with published interventions
NOVOS Core clinical trial results vs. established health interventions*
The magnitude of improvement observed in the NOVOS Core clinical trial ranks among the strongest ever reported for a nutritional intervention targeting cardiovascular aging.
And dozens of other lifestyle interventions and supplements that the NOVOS Core study outperformed.
Importantly, these improvements were observed in healthy adults already within normal ranges, where further improvements are typically more difficult to achieve.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The problem with most “science-based” supplements
Many supplement brands describe themselves as “science-backed.” In reality, that usually means something very different.
Cherry-picked studies
Citing research on individual ingredients — not their actual formula.
Scientific theater
Hiring a spokesperson and using clinical-sounding language.
Influencer claims
Personal routines positioned as scientific evidence.
Extremely few study the actual formula they sell — yet biological interactions between ingredients can produce very different outcomes.
What happens when ingredients are combined?
Additive
1 + 1 = 2
Synergistic
1 + 1 = 3
Antagonistic
1 + 1 = –0.5
Why combination formulas must be tested
A large study in Switzerland tested many combinations of longevity ingredients and measured their effects on animal lifespan. The results were surprising.
Results of longevity compound combinations
61%
of combinations performed equal to or worse than the best single ingredient.
15%
of combinations reduced lifespan.
Synergy cannot be assumed. It must be tested.
Most supplement companies never test their combinations. NOVOS did.
Phelps, Grace B, et al. “Comprehensive Evaluation of Lifespan-Extending Molecules in C. Elegans.” Aging Cell, 24 Jan. 2025.
The NOVOS philosophy: measure the stack
NOVOS Core contains 12 ingredients designed to influence biological processes associated with aging. This approach is known as rational polypharmacy.
But instead of assuming synergy, NOVOS researchers chose to test the full formulation.
The resulting NOVOS research program spans
This is biotech-level research applied to natural supplements — extraordinarily rare in the industry.
NOVOS is the only consumer brand accepted into the Longevity Biotechnology Association, Healthy Longevity Medicine Society, and is one of only two supplement brands accepted to compete in the $101M XPRIZE for Healthspan.
The NOVOS research journey
7+ years of R&D spanning cellular, animal lifespan, and human clinical research.
-
01
2019–2021
Formulation research
Two years of evaluating compounds, mechanisms, and safety profiles across longevity pathways.
-
02
2021–2024
Mechanistic & cellular studies
Laboratory research examining how the combined formulation influences aging biology at the cellular level.
-
03
2024
Human epigenetic aging research
Evaluating the impact on biological pace of aging using the DunedinPACE epigenetic clock.
-
04
2025
Mouse lifespan study
Animal research observing lifespan extension with the full formulation in aged mice.
-
05
2026
Human randomized clinical trial
Double-blind, placebo-controlled trial measuring biomarkers of cardiovascular aging.
A closer look at the evidence
Human biological aging research
Participants taking NOVOS Core with NOVOS Boost for six months were evaluated using the DunedinPACE epigenetic aging clock, which measures rate of biological aging.
73%
slowed their pace of aging
8%
average slowdown
0%
had accelerated aging
Pace of biological aging — 8% average slowdown vs. baseline
Epigenetic clocks are widely used research tools that estimate biological aging from DNA methylation patterns. These observational results are exploratory, not diagnostic or predictive of individual outcomes. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Skin structural aging
Using an indentometer to measure skin firmness, researchers evaluated the impact of six months of NOVOS Core supplementation.
+22%
average skin firmness improvement
Indentometer testing provides quantifiable insight into structural skin properties over time. These results are preliminary. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Lifespan research
A study in aged mice observed a median lifespan extension of more than 18% — among the largest percentage increases in aged mouse lifespan ever achieved from a nutritional supplement.
+18%
median lifespan extension
Animal lifespan studies are a foundational step in aging science. Results in animal models do not necessarily predict human outcomes. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Mechanistic studies
Laboratory research examined how the combined formulation influences biological processes associated with aging.
Cellular senescence
Reduction in aged, non-dividing cells that can cause cellular inflammation.
See the researchCellular protection
Protection of human skin cells from chemotherapy-induced DNA double strand breaks.
See the researchOxytosis / ferroptosis
Reduced oxidative cell death pathways linked to neurological aging.
See the researchLaboratory research only, from in vitro (cell-based) studies. Results from laboratory models may not reflect how the product performs in the human body. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
NOVOS Core: the first to target the
12 Hallmarks of Aging
Aging is driven by multiple interacting biological processes. Interventions targeting a single pathway may have limited impact on whole-body aging biology. NOVOS Core was designed to influence 12 aging pathways simultaneously through a carefully designed combination of ingredients.
Tap any hallmark to learn more
Genomic instability
DNA damage accumulates over time, leading to mutations that impair cellular function and increase disease risk.
Telomere attrition
Protective chromosome caps shorten with each cell division, eventually triggering cellular senescence.
Epigenetic alterations
Changes in gene expression patterns without DNA mutations disrupt cellular identity and function.
Loss of proteostasis
The cell's ability to maintain properly folded proteins declines, leading to toxic aggregates.
Deregulated nutrient sensing
Cellular nutrient pathways become dysregulated, disrupting metabolism and growth signaling.
Mitochondrial dysfunction
Energy-producing organelles become less efficient, increasing oxidative stress.
Cellular senescence
Cells permanently stop dividing but resist death, secreting inflammatory signals.
Stem cell exhaustion
Regenerative capacity declines as stem cell pools diminish and lose function.
Altered intercellular communication
Cell-to-cell signaling deteriorates, disrupting tissue coordination and immune function.
Inflammaging
Low-grade systemic inflammation increases with age, damaging tissues and accelerating aging.
Microbiome dysbiosis
Gut microbial diversity declines, affecting metabolism, immunity, and brain function.
Impaired autophagy
The cell's recycling system slows, allowing damaged components to accumulate.
How NOVOS Core targets aging biology
Tap an ingredient to see which hallmarks of aging it targets
Vitamin C targets 2 hallmarks of aging
Magnesium targets 5 hallmarks of aging
Glycine targets 8 hallmarks of aging
Calcium Alpha-Ketoglutarate targets 4 hallmarks of aging
GreenGrown® Glucosamine Sulfate targets 4 hallmarks of aging
Rhodiola Rosea Root Extract targets 2 hallmarks of aging
L-Theanine targets 3 hallmarks of aging
Hyaluronic Acid targets 4 hallmarks of aging
Fisetin targets 7 hallmarks of aging
Organic Ginger Root Extract targets 5 hallmarks of aging
Pterostilbene targets 7 hallmarks of aging
Lithium Aspartate targets 7 hallmarks of aging
Built by longevity scientists
NOVOS was founded with a team of scientists and physicians from:
2 years
Evaluating compounds, pathways, and safety profiles before finalizing the formulation.
12 hallmarks
Designed to influence all hallmarks of aging simultaneously.
Patents
First patent for the NOVOS Core formulation filed in 2020.
“I see NOVOS as inspiring — they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously.”
“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”
“NOVOS has been using a novel science-based approach for developing its formulation. They are a leader in the longevity space.”
“NOVOS Core has been reviewed by scientists within the aging research community to ensure the most effective and safest ingredients.”
“NOVOS Core is among the most powerful longevity formulations available.”
“It's the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”
What experts are saying
Recognized by clinicians and institutions
“I was pleasantly surprised that the study showed both an acute improvement after the first dose and sustained improvement at six months. That kind of consistency is not common in supplement trials.”
“The magnitude of improvement observed in the study is notable compared with what is typically reported for nutritional interventions.”
The scientific approach behind NOVOS has drawn attention from physicians and health institutions worldwide.
2,000+ MDs & clinicians share NOVOS Core without compensation
“It has been a pleasure to watch NOVOS take a disciplined, biology-first approach, combined with a willingness to engage in rigorous evaluation rather than shortcuts, in a space that too often prioritizes hype over evidence.”
NOVOS products are now available at world class hospitals and wellness retailers.
“NOVOS are pioneers in consumer longevity and among the first to develop a comprehensive approach that targets 12 mechanisms of aging simultaneously.”
“A recent study places Novos Core as a leader among consumer antiaging interventions.”
“A multi-ingredient longevity supplement made by the biotechnology company NOVOS may help improve markers of vascular aging.”
The bottom line
What makes NOVOS Core different
Others cherry-pick.
Most supplement brands cite studies on individual ingredients — not their actual formula.
NOVOS tests.
7+ years of R&D — from cells to clinical trials on the real product.
Results speak.
Among the strongest results ever reported — in biological aging, cardiovascular function, and animal lifespan studies.
Experts agree.
2,000+ MDs & clinicians recommend NOVOS Core — without compensation.
The future of longevity science
This is only the beginning.
Ongoing research
Future studies will evaluate how NOVOS Core influences additional organ systems and aging biomarkers beyond cardiovascular function.
Advancing the field
By publishing openly and inviting scrutiny, NOVOS aims to raise the evidence standard for the entire longevity industry.
Longevity science is still evolving.
NOVOS is committed to evolving with it — through research, not assumptions.
12 ingredients. 12 hallmarks.
One daily sachet.
Each NOVOS Core sachet delivers a precise combination of longevity ingredients backed by peer-reviewed research and tested in a randomized clinical trial.