Rutin and Longevity
Summary
- Rutin is a plant-derived flavonoid (phytonutrient) widely studied for antioxidant and anti-inflammatory activity.
- Rutin is found in foods such as buckwheat and various fruits.
- Preclinical research suggests rutin may support cellular defenses against oxidative stress and inflammation-related signaling.
- Human research has evaluated rutin for effects on select cardiometabolic biomarkers in specific populations.
- Rutin is also being explored in preclinical studies for pathways relevant to healthy aging biology.
Rutin Impacts Aging Via
- Autophagy dysregulation
- Inflammaging
- Deregulated nutrient sensing
- Altered cellular communication
- Loss of proteostasis
- Mitochondrial dysfunction
The role of Rutin in aging and longevity
Rutin has attracted interest in healthy aging research because oxidative stress and chronic, age-associated inflammation are common features of aging biology.
Preclinical longevity evidence has also emerged in model organisms. In mice, long-term administration of sodium rutin was reported to extend lifespan and improve healthspan-related measures, including positive impacts on liver health, alongside findings consistent with enhanced cellular maintenance pathways. (R)
In Drosophila melanogaster, rutin showed a hormetic (dose-dependent) pattern: moderate doses were associated with improved longevity outcomes, while higher doses were detrimental, highlighting the importance of dose when interpreting preclinical longevity findings. (R)
A comprehensive analysis of the scientific literature further highlights that rutin can influence inflammatory signaling pathways in experimental models, including pathways linked to NF-κB and MAPK, which are often discussed in the context of metabolic regulation. (R)
Rutin has also been studied for its potential to support cellular antioxidant defense signaling. In laboratory models, rutin-related formulations have been reported to activate antioxidant response pathways associated with Nrf2/HO-1 signaling. (R)
In preclinical research, rutin has been reported to modulate oxidative stress and inflammation-related mechanisms, including changes in NF-κB–associated signaling and regulation of microRNA expression in stress models. (R)
In animal models of aging-related stress, rutin has been associated with higher antioxidant enzyme activity (e.g., superoxide dismutase, glutathione peroxidase, and glutathione S-transferase) and with changes in gene expression linked to oxidative stress responses. (R)
Additional preclinical studies also report that rutin can influence inflammation-related pathways, including modulation of matrix metalloproteinase expression (MMP-2 and MMP-9), alongside shifts in oxidative stress markers. (R)
Overall, most of these findings come from preclinical and experimental research. Human studies of rutin have focused more narrowly on specific cardiometabolic biomarkers and do not yet establish broad healthy-aging effects across all populations.
Rutin in Humans
A full daily serving of NOVOS Vital provides 560 mg of rutin. Human clinical studies have evaluated rutin at doses close to this range (most commonly ~500 mg/day) in specific populations and endpoints, with outcomes measured over 6–12 weeks.
In adults with type 2 diabetes, a double-blind, randomized, placebo-controlled trial found that 500 mg/day of rutin for 3 months was associated with improvements in multiple cardiometabolic biomarkers. Compared with placebo, the rutin group showed reductions in fasting blood glucose, insulin, and HbA1c, alongside improved insulin sensitivity metrics (including HOMA-IR and QUICKI). The study also reported improvements in select lipid-related measures (including LDL cholesterol and total cholesterol) and shifts in inflammation/oxidative stress markers (lower IL-6 and MDA, higher total antioxidant capacity). (R)
In a separate double-blind, placebo-controlled trial in adults with type 2 diabetes, 500 mg/day of rutin for 3 months was associated with improvements in blood pressure–related measures (SBP, DBP, MAP, pulse pressure, and heart rate). The study also reported increases in select antioxidant enzymes (including GPx and SOD) and improvements in several quality-of-life domains. (R)
Rutin has also been studied in healthy adults at the same dose range. In a 6-week randomized placebo-controlled study in healthy women, 500 mg/day of rutin increased circulating levels of flavonoid metabolites (reflecting absorption and metabolism), while markers of systemic antioxidant capacity and several urinary oxidative stress markers did not show clear differences versus placebo. (R)
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Body composition evidence from a rutin derivative
A related, more water-soluble derivative, monoglucosyl rutin (MR), has been studied for abdominal fat outcomes. In a double-blind, randomized, placebo-controlled trial in Japanese adults (BMI 23–30), MR at 200 mg/day or 400 mg/day for 8 weeks was associated with a reduction in abdominal visceral fat area measured by CT, compared with placebo. (R)
NOVOS VITAL & Rutin
NOVOS Vital contains 560 mg of this powerful ingredient, rutin, along with six other scientifically researched ingredients that target vital organ health. Together, these ingredients are designed to support key aspects of whole-body health, including brain, eye, gut, kidney, liver, muscle, and cardiovascular function. NOVOS Vital is a low calorie and low sugar chew that provides a healthy alternative for a sweet treat.
