Question 1

DESCRIPTION

Accepted Answer

NOVOS Core Clinical is the first formulation designed around all 12 biological Hallmarks of Aging, developed with leading longevity scientists and physicians specializing in aging biology. Backed by more than seven years of R&D, it has been evaluated in randomized, double-blind, placebo-controlled human clinical research demonstrating statistically significant effects across validated measures of endothelial function, arterial flexibility, and systolic blood pressure in the normal range, with effect sizes among the largest reported in published human research for a supplement, nutritional, or lifestyle intervention. Built as a coordinated, multi-pathway system rather than a single-ingredient solution, NOVOS Core Clinical is designed to support multiple aging-related systems at once. In addition to vascular outcomes, research has observed favorable shifts in biological age markers measured epigenetically and improvements in skin firmness in preliminary human studies, alongside customer-reported benefits such as steadier energy, mental clarity, mood balance, and sleep consistency†. The formulation is further supported by mechanistic studies and preclinical lifespan research, providing multi-level scientific evidence that NOVOS Core Clinical supports foundational aspects of healthy aging biology.* †Customer-reported outcomes and small scale studies. Individual results will vary.

Question 2

HOW IT WORKS

Accepted Answer

A system designed to support the biology of aging itself Aging doesn’t happen in one place. It emerges from interconnected biological processes that influence vascular function, cellular energy production, tissue renewal, and resilience across the body. NOVOS Core Clinical was intentionally designed around the biology of aging itself — not individual symptoms — by supporting all 12 biological Hallmarks of Aging simultaneously. Developed with scientists and physicians affiliated with institutions including Harvard Medical School, MIT, and the Salk Institute, the formulation is built as a coordinated system designed for ingredient synergy rather than a collection of isolated or trendy ingredients. Because these foundational systems shape how the body functions day to day, supporting them can influence performance, resilience, and overall well-being long before later-life outcomes become relevant. Built on evidence, not theory NOVOS Core Clinical is supported by multiple layers of research: Mechanistic studies to understand how it influences aging-related biological pathways Preclinical lifespan studies in mice, where animals receiving NOVOS Core Clinical Clinical lived over 18% longer on average (animal models do not predict human outcomes and are not indicative of impact on humans) Randomized, placebo-controlled human clinical research using validated functional biomarkers commonly applied in cardiovascular and aging science This multi-level approach reflects an uncommon standard of scientific validation for a nutritional formulation — testing the complete system rather than relying on individual ingredient claims. What the formulation is designed to support Cellular energy & metabolic efficiency Supports mitochondrial and metabolic pathways involved in cellular energy production to help maintain stamina, clarity, and daily recovery. Healthy cellular renewal Supports the body’s natural renewal and turnover processes that help maintain tissue function over time. Cellular resilience & stability Supports DNA stability, cellular stress-response pathways, and healthy inflammatory balance to promote long-term cellular function. Protein quality & cellular communication Supports proteostasis, extracellular matrix structure, and intercellular signaling — helping tissues remain coordinated and responsive with age. Why this approach is different Most supplements focus on isolated ingredients or single outcomes, while few are rigorously evaluated as complete formulations in randomized, placebo-controlled human clinical trials using validated functional biomarkers. NOVOS Core Clinical was designed to support the biology of aging as a connected system and evaluated as a complete formulation through mechanistic research, preclinical lifespan studies, and human clinical trials — not trends, theories, or ingredient-by-ingredient claims.* Few dietary supplements are evaluated this way, testing the complete finished formula in humans rather than relying on ingredient-level assumptions. *These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

Question 3

INGREDIENTS

Accepted Answer

Each ingredient in NOVOS Core Clinical was selected based on scientific evidence and is either naturally present in human biology or derived from compounds found in nature. Together, they were chosen for their roles in aging-related biological pathways and for their established safety profiles in human research. 1. Calcium Alpha-Ketoglutarate (Ca-AKG)  - A compound naturally present in human metabolism that supports mitochondrial energy production and cellular resilience. 2. Fisetin  - A polyphenol found in strawberries and other fruits that supports cellular renewal and healthy inflammatory balance. 3. Pterostilbene - An antioxidant compound found in blueberries that supports vascular and metabolic health. 4. Glucosamine Sulfate - Naturally occurring in connective tissues, supports joint and extracellular matrix integrity. 5. Glycine - An amino acid abundant in collagen that supports recovery, detoxification, and restorative sleep. 6. Magnesium Malate - A form of magnesium involved in ATP production that supports energy metabolism and muscle function. 7. L-Theanine - An amino acid found in green tea that supports calm focus and stress resilience. 8. Rhodiola Rosea - An adaptogenic root traditionally used to support stamina, mental performance, and stress response. 9. Gingerols & Shogaols - Bioactive compounds from ginger that support healthy inflammatory signaling and digestive comfort. 10. Hyaluronic Acid - A molecule naturally present in skin and joints that supports hydration, elasticity, and tissue resilience. 11. Vitamin C - An essential nutrient found in fruits and vegetables that supports collagen production, antioxidant protection, and synergizes with CaAKG. 12. Micro-dosed Lithium - A trace mineral found naturally in water and foods that supports neuronal signaling and mood balance. These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

Question 4

CLINICAL TRIAL & SCIENTIFIC EVIDENCE

Accepted Answer

Placebo-Controlled Human Clinical Trial  Cardiovascular function was selected as the first human system to measure because vascular biology changes early with age and reflects whole-body resilience. NOVOS Core Clinical was evaluated in a randomized, double-blind, placebo-controlled human clinical trial conducted by university researchers in adults aged 40+. The study assessed validated functional biomarkers commonly used in cardiovascular and aging research. Compared with placebo, NOVOS Core Clinical demonstrated statistically significant differences across multiple measures of vascular function: +3.4% improvement in endothelial function (Flow-Mediated Dilation, FMD) observed shortly after the first dose and sustained over six months −1.18 m/s difference in arterial stiffness (Pulse Wave Velocity) at six months −8.5 mmHg difference in systolic blood pressure, supporting healthy levels already within the normal range Effect sizes across these independent vascular biomarkers are among the largest reported in published human research for a nutritional intervention, supplement, or lifestyle modification, including aerobic exercise, providing rare human evidence that a multi-pathway formulation can measurably influence aging-related physiology.* 👉 Read the clinical trial summary  Individual responses vary. Not every person will experience the same magnitude of change. Preclinical Lifespan Study (Animal Model) In a controlled mouse lifespan study, animals receiving NOVOS Core Clinical lived over 18% longer on average than controls. While animal studies do not predict human outcomes, lifespan models are a foundational step in aging research for evaluating long-term, system-level biological effects before human trials. 👉 View the lifespan study Mechanistic Research (Formulation Design)  NOVOS Core Clinical was developed through mechanistic research examining how ingredient combinations interact with aging-related biological pathways, including DNA protection, cellular senescence, cellular inflammation protection. This work confirmed formulation design, dosing, and ingredient synergy, ensuring the product was built as an integrated system rather than a collection of isolated compounds. 👉 Explore the mechanistic studies Epigenetic Aging Analysis NOVOS has supported independent DNA methylation–based epigenetic age testing, which measures patterns in your DNA that scientists use to estimate biological age over time. In an exploratory analysis of first-time NOVOS Core Clinical users tested before and after six months of use, follow-up results showed favorable directional shifts in these validated epigenetic biomarkers, consistent with a slower pace of age-related biological change. These tests are research tools used to study aging biology and do not diagnose disease or predict lifespan.* This was an observational, real-world evaluation rather than a controlled clinical trial. 👉 Learn about our epigenetic research Skin Elasticity Study (Instrument-Measured) In a preliminary human study using an indentometer — a scientific device that objectively measures skin firmness — participants showed an average 22% increase in skin elasticity after six months, with some reporting visible improvements within weeks. These findings suggest that supporting foundational biological pathways may also help maintain skin firmness, structure, and resilience over time.* This was a small pilot evaluation intended to generate preliminary signals. 👉 View the skin study details  Why This Approach Is Different  Most supplements rely on ingredient-level claims. NOVOS Core Clinical has been rigorously evaluated as a complete formulation across mechanistic research, preclinical lifespan studies, and randomized, placebo-controlled human clinical research, reflecting how aging actually works: as an interconnected biological system rather than isolated symptoms. *These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.

Question 5

Is NOVOS Core Clinical safe with medications?

Accepted Answer

NOVOS Core Clinical is a dietary supplement, not a medication. If you take prescription medications or manage a medical condition, consult your healthcare professional before use, especially if you are pregnant or nursing, managing blood pressure, bleeding or clotting, or any chronic condition.

Question 6

How is NOVOS Core Clinical different from your other products?

Accepted Answer

NOVOS Core Clinical is the daily foundation. It’s a comprehensive longevity formulation designed to support multiple aging-related biological pathways as a complete system. Other NOVOS products are designed as targeted add-ons — for example, additional NAD+ or mitochondrial support — and can be layered on top of NOVOS Core Clinical depending on your goals.

Question 7

How long until I notice results?

Accepted Answer

Timelines vary by individual. Some people report noticing day-to-day changes first, such as steadier energy or improved sleep consistency, within the first few weeks. Broader, longer-horizon changes associated with healthy aging biology typically build gradually over weeks to months and depend on baseline health and consistent use.

Question 8

Are there any age related restrictions?

Accepted Answer

NOVOS Core Clinical is intended for adults. If you’re under 18, pregnant, or breastfeeding, consult a healthcare professional before use.

Question 9

Can I take more than one sachet per day?

Accepted Answer

NOVOS Core Clinical is designed for one sachet daily. Some individuals choose to take up to two sachets per day. If increasing your intake, consider starting with one sachet for at least a week and consult your healthcare professional if you are sensitive to supplements.

Question 10

How do I know it’s working?

Accepted Answer

There are two practical ways many people evaluate progress: How you feel Some people notice day-to-day changes such as steadier energy, sleep consistency, mood improvements, or overall resilience over time. What you can measure NOVOS Core Clinical is designed to support underlying biological systems associated with healthy aging, effects that may not always be immediately perceptible but can be observed through objective measures. In human clinical research, NOVOS Core Clinical demonstrated statistically significant benefits across validated functional biomarkers of cardiovascular function, including endothelial responsiveness, arterial flexibility, and support for healthy blood pressure already within the normal range.* If you already track general wellness metrics, you may choose to monitor markers such as resting heart rate, sleep patterns, blood pressure, or routine labs with your clinician. Because these changes reflect foundational physiology, benefits are often gradual and cumulative rather than instant.

Question 11

How does the price compare to alternatives?

Accepted Answer

NOVOS Core Clinical replaces the need to source and dose multiple individual supplements. Instead of assembling a complex stack, you get a single, research-driven formulation developed and evaluated as a complete system. You’re investing in clinical research, quality controls, and formulation design — often at a comparable or lower total cost than buying similar ingredients separately.

Question 12

What is NOVOS Core Clinical made of?

Accepted Answer

NOVOS Core Clinical contains 12 research-backed longevity ingredients: Vitamin C Magnesium Malate Calcium Alpha-Ketoglutarate Glycine Glucosamine Sulfate Rhodiola L-Theanine Hyaluronic Acid Fisetin Gingerol Pterostilbene Micro-dosed Lithium The Orange flavor also includes erythritol, malic acid, stevia, and natural flavors. Core is vegan, non-GMO, sugar-free, and free from artificial colors and preservatives.

Question 13

Who is NOVOS Core Clinical for?

Accepted Answer

NOVOS Core Clinical is designed for adults of all ages who want to proactively support healthy aging. Younger users benefit from early support, while older adults may notice more immediate short-term effects.

Question 14

Is NOVOS Core Clinical compatible with my diet or dietary restrictions?

Accepted Answer

NOVOS Core Clinical is free from: Dairy, gluten, soy, nuts, and shellfish Sugar, calories, and GMOs Preservatives and 14 EFSA-listed allergens It suits vegan, vegetarian, Mediterranean, keto, gluten-free, and NOVOS Longevity Diet guidelines.

Question 15

Are there any side effects?

Accepted Answer

A small percentage of users experience temporary stomach discomfort when starting Core. Taking it with food, splitting the dose, or mixing it with extra water typically resolves this within a few weeks.

Question 16

Can I take NOVOS Core Clinical while pregnant or breastfeeding?

Accepted Answer

NOVOS recommends avoiding Core during pregnancy and breastfeeding as a precaution.

Question 17

Does NOVOS Core Clinical need refrigeration?

Accepted Answer

No. Store Core Clinical at room temperature in a cool, dry place.

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