About NOVOS
NOVOS is a science-first longevity biotechnology company building the world’s most rigorously validated system for supporting healthspan and longevity, starting with aging itself.
Explore Our Science
The Problem
Aging is the primary driver of decline in health and function, yet most health solutions focus on managing symptoms rather than addressing the biology that causes aging in the first place.
For decades, supplements and wellness products have relied on isolated ingredients, untested combinations, and theoretical benefits, rarely evaluated as complete systems in rigorous studies.
We believed longevity — and you — deserved a different standard.
The Approach
NOVOS was founded to do what consumer health had never done: treat aging as a biological process that can be measured, targeted, and improved.
We design formulations and tools based on the fundamental mechanisms of aging, then validate them through mechanistic studies, preclinical research, and human trials. Not as individual ingredients, but as integrated systems.
Our Standards
These standards guide every decision we make, from research to formulation to education.
Proof
Our founders, driven by personal health journeys and profound scientific expertise, established NOVOS with the determination to address aging at its root.
Founder & CEO
After surviving a brain tumor, Chris Mirabile began questioning why medicine waits for disease instead of protecting health earlier.
That question led him to collaborate with leading scientists from Harvard, MIT, the Salk Institute, and beyond to build NOVOS: a company dedicated to preserving health before decline begins.
What started as a personal journey became a commitment to helping people extend both longevity and quality of life through better science, better tools, and better standards.
Scientific Leadership
Formulations and tools shaped with researchers from Harvard, MIT, the Salk Institute, and beyond.
“I see NOVOS as inspiring — they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously.”
“NOVOS has been using a novel science-based approach for developing its formulation. [They are] a leader in the longevity space.”
“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”
“It’s the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”
Behind every data point is a human story. Better aging should be something you can feel, track, and prove.
Julie Gibson Clark, 55, ages at 0.665 years per year, using NOVOS Core, a healthy diet, and exercise.
Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.
Miah Konkle combines NOVOS Core and Boost with a science-driven longevity routine to support healthy aging.
Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.
Lil Eskey improved her Pace of Aging from 0.99 to 0.77 through six months of NOVOS products, daily movement, and whole-food nutrition.
Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.
Raymond Singh, 68, improved his Pace of Aging from 0.98 to 0.92 while using NOVOS Core and Boost alongside decades of strength training.
Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.
Max DiSesa uses the full NOVOS regimen (Core, Boost, Vital, and Age) and his latest test measured a Pace of Aging of 0.71.
Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.Evidence, Not Assumptions
3 Powerful Formulas. 20 Innovative Ingredients. 500+ Studies. View our growing record of direct and indirect NOVOS studies.
Clinical Study · NOVOS Core
Cardiovascular disease is the leading cause of age-related death worldwide, while better cardiovascular health is associated with substantially longer life expectancy. In a randomized, double-blind, placebo-controlled human clinical trial, NOVOS Core showed rapid and sustained support for cardiovascular function.
In a recent study of aged mice, NOVOS Core increased lifespan by 18%, surpassing all previously studied supplements in similar research, including NAD+ boosters like nicotinamide riboside.
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In just 6 months, 73% of NOVOS Core and NOVOS Boost users experienced a significant reduction in their biological aging pace, with an average slowdown of 8.7% which works out to be 31.75 days younger per year. Nobody’s aging sped up.
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Ingredients in NOVOS Core reduced the size of human senescent cells (cells that age and become toxic) by approximately 50% in an in-vitro study, offering effects comparable to a pharmaceutical longevity drug, rapamycin*.
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After 6 months, all participants experienced increased skin firmness by an average of 22%, enhancing both appearance and feel.
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NOVOS Core users ranked (#2, #5, and #7) for lowest rates of aging in a global competition that uses the DunedinPACE algorithm created by Duke and Columbia scientists to measure epigenetic changes.
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Ingredients in NOVOS Core were able to prevent DNA damage by up to 77% in skin cells exposed to irradiation (e.g., UV rays) in an in-vitro study. In another human skin cell study, DNA was protected from moderate and high intensity chemo drugs.
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NOVOS Core’s ingredients reduced unwanted cell death processes called oxytosis/ferroptosis by 50%, while also reducing cellular inflammation, in an in-vitro human cellular study.
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NOVOS is founded. Vision established: target aging biology, not symptoms.
First formulations designed with scientific advisors. Early human testing begins.
Expanded testing, brand launch, and educational platform created.
NOVOS Core and Boost launch to early adopters. First in vitro aging studies completed and show reduced DNA damage.
NOVOS Age biological age test launches. Studies show reduced cellular senescence.
Case studies show slowed biological aging. Peer-reviewed in vitro study shows reduced DNA damage from chemotherapeutics.
NOVOS Core demonstrates ~20% lifespan extension in aged mice, and in vitro study shows reduced ferroptosis and cellular inflammation. NOVOS Vital is launched.
Launch of the world's first longevity bar. NOVOS enters Mayo Clinic retail.
NOVOS completes double-blind, placebo-controlled human clinical research on Core — evidence for a complete system associated with healthspan and lifespan.
Combats the 12 root causes of aging.
NOVOS is a Public Benefit Corporation, legally committed to balancing profit with purpose: advancing human health, longevity research, and public education alongside commercial success.
We donate a portion of profits and equity to nonprofits advancing longevity research, including the Lifespan Research Institute (LRI), and support initiatives like the Dog Aging Project — helping dogs live longer, healthier lives while accelerating insights into human aging.
Longevity should benefit everyone.
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Comprehensive daily support for energy, sleep, focus, and whole-body resilience—targeting all 12 Hallmarks of Aging.
From $2.60/day.Start with Core
Targeted support for cellular energy, healthy metabolism, and staying strong as you age.
From $1.05/day.Shop Boost
Daily support for seven key organ systems, with clinically studied ingredients for cardiovascular and whole-body health.
From $1.63/day.Shop Vital
Protein, fiber, superfoods, and key longevity nutrients for the days a full meal is hard to get to.
$3.60 per bar with subscription.Shop Bar
See how you are aging with Biological Age, Pace of Aging, Organ Ages, and Telomere Length—all from one blood sample.
$349 single kit.Shop Age