Glycine
2000mg
- Supports recovery and restorative sleep
- An amino acid involved in the body's natural overnight wind-down
1,800+ Doctors & clinicians
10M+ Doses served
4.8/5 3,000+ reviews
Better sleep starts with how you age.
As the body ages, restful sleep is often the first thing to slip. NOVOS Core is a daily longevity drink built around the 12 Hallmarks of Aging, with ingredients like glycine that support calm and restorative rest. More mornings that feel like you.
Why sleep gets harder as you age
Sleep changes with age in measurable ways, and the shifts are easy to see in the structure of the night.
Less deep sleep
Deep slow-wave sleep, the most physically restorative stage, falls sharply between your twenties and your forties. By midlife, much of it is already gone.
A lighter, broken night
You wake more often and spend more total time awake before drifting back off, and that rises steadily decade after decade.
~50%
Deep, slow-wave sleep can fall by half or more between your 20s and your 40s
+10 min
More time spent awake at night, per decade, between ages 30 and 60
Sources: Van Cauter et al., JAMA 2000; Ohayon et al., Sleep 2004.
Together, that means fewer hours of deep, unbroken sleep, and a shorter overnight window for the repair work the body does while you rest.
Sleep is when the body does most of its restorative work.
Which raises the real question: can the systems behind restorative sleep be supported?
This is where NOVOS Core comes in.
Sleep and aging run on the same biology, and no single ingredient covers it. NOVOS Core takes a multi-system approach, supporting the circadian, cellular, and recovery pathways that age together.
A daily drink mix for sleep and longevity
NOVOS Core is a once-a-day drink mix. Stir one sachet into water with your morning routine, then get on with your day. The formula does the work in the background.
One sachet daily
Mixes in water
3 tasty flavors
Vegan & non-GMO
Ingredients chosen to support sleep, recovery, and how you age
NOVOS Core combines ingredients associated with the biological systems behind restorative sleep, overnight recovery, and healthy aging.
L-Theanine
150mg
- Supports calm focus and a healthy stress response
- Associated with relaxation without sedation
Rhodiola Rosea
300mg
- An adaptogenic root that supports a healthy stress response
- Traditionally used to support stamina and mental performance
Calcium Alpha-Ketoglutarate
1100mg
- Supports cellular energy and mitochondrial function
- Supports the body's repair pathways involved in recovery
Magnesium Malate
305mg
- A form of magnesium that supports energy metabolism
- Supports healthy muscle function
Fisetin
100mg
- A plant flavonoid that supports healthy cellular aging
- Part of the formula's multi-pathway approach to aging
Plus 6 more
6 more ingredients selected to support pathways associated with aging
Pterostilbene
Microdosed Lithium
Ginger Extract
Hyaluronic Acid
Vitamin C
Glucosamine Sulfate
12 ingredients. One drink.
One convenient drink instead of a nightstand stack, formulated with research-informed doses of ingredients chosen to support restorative sleep and healthy aging.
Created by Harvard & MIT scientists.
Backed by 7+ years of R&D and a completed randomized, placebo-controlled human clinical trial on cardiovascular markers in the finished formulation.
A completed human clinical study
Clinically studied. On the finished formula.
NOVOS Core was studied in a randomized, placebo-controlled trial measuring cardiovascular markers: endothelial function, arterial stiffness, and blood pressure in the normal range. Outcomes are cardiovascular, not sleep, but the same circulation and autonomic systems support overnight recovery.
FMD: Blood Circulation
NOVOS Core improved flow-mediated dilation (FMD) by +3.9% acutely and +2.9% sustained at 6 months (p < 0.0001), while placebo showed no change.
Baseline
5.6%
vs 5.1% placebo
1 hour
9.5%
vs 4.9% placebo
6 months
8.5%
vs 5.0% placebo
+3.9%
Endothelial function (1 hr)
Acute improvement in flow-mediated dilation vs. placebo
−1.18 m/s
Arterial stiffness
Reduction in pulse wave velocity at 6 months
−8.5 mmHg
Healthy blood pressure support
Change in participants whose blood pressure was already in the normal range
Effect Size
1.26× to 4.65×
leading studied dietary interventions.
Restorative sleep is what mornings are built from
When the body’s overnight recovery runs the way it should, mornings feel steadier. The kind of rested that doesn’t need a second coffee to get going.
NOVOS Core is designed to support the biology behind that recovery, night after night.
The biology underneath restorative sleep
Restorative sleep is the result of multiple systems syncing up at the right time:
Circadian rhythm
The internal clock that cues melatonin, body temperature, and the sleep-wake cycle. It weakens with age.
Autonomic nervous system
The wind-down pathway (shifting from sympathetic "go" to parasympathetic "rest") is what lets sleep deepen.
Inflammation & cortisol
Low-grade inflammation and elevated evening cortisol fragment sleep and blunt overnight recovery.
Cellular repair pathways
Mitochondrial function, NAD+ and glymphatic clearance: the overnight maintenance crew for the body and brain.
A more complete approach supports the underlying biology that makes deep, restorative sleep possible.
How to use
When to take it
NOVOS Core fits into your morning, not your bedtime. One simple step, then on with your day.
It supports the biology behind restorative sleep around the clock, so there is nothing to take before bed.
Once daily, in the morning
One serving a day, taken with your morning routine. Consistency is what supports the biological systems over time.
Mixed into water
Stir one scoop into a glass of cool water. No pills to swallow, no aftertaste to mask.
Not a nighttime sedative
NOVOS Core is not a sleep aid, melatonin, or sedative. It is a daily formula that supports the systems involved in restorative sleep and healthy aging.
How NOVOS Core is different from a sleep aid
Melatonin and sedatives
Act on a single night, and can leave you groggy.
NOVOS Core
Supports the systems behind restorative sleep and healthy aging, day after day.
What to expect
NOVOS Core works best with daily, consistent use. The biology takes time. Here is a sense of the arc.
01
First weeks
Some people notice calmer, steadier evenings.
02
First month
Many report waking more refreshed.
03
Over time
The deeper benefits of supporting healthy aging build gradually, and individual results may vary.
These statements have not been evaluated by the FDA. NOVOS Core is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Why people trust NOVOS Core
1,800+ Doctors
Recommended by physicians who understand the connection between restorative sleep and how we age.
Cardiovascular Clinical Trial
The finished formula was tested in a randomized, placebo-controlled human trial measuring cardiovascular markers. The trial did not evaluate sleep.
Trusted By The World's Best
Found at Mayo Clinic Store, Erewhon, Equinox, and Four Seasons.
HSA / FSA Eligible
Use your pre-tax HSA or FSA dollars at checkout. NOVOS Core qualifies as an eligible wellness expense.
- 30 servings per box
- Cancel or pause anytime
- Third-party tested for purity
- Sugar-free · Vegan · Non-GMO
Support How You Age – From the Inside
Choose from 3 tasty flavors
Choose Your Plan
Start Supporting Restorative Sleep
Secure checkout · Ships in 24–48h · Free shipping · HSA/FSA eligible · Cancel anytime
What people notice over time
What people report over time. Individual results may vary, and these reviews reflect personal experiences, not clinical outcomes.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
A Week to Calmness and Enhanced Endurance
“I have been on this for a week and I'm blown away already. I feel so calm, have sharper clarity of mind, less fatigue and more endurance into the evening hours. I can't imagine being without this.”
Beth P. Verified Customer
Sleeping better at 75
“What I notice the most is that I am sleeping better! I'm 75 and always get up to go to the bathroom, but now I get back to sleep with relative ease. That's a huge benefit.”
Derek H. Verified Customer
Aging in reverse
“So far so good. I am almost one month in using NOVOS Core and Boost. I sleep well and wake up refreshed. My energy has also increased.”
Jerome K. Verified Customer
Worth it!
“I've been using NOVOS Core for 4 weeks every day. I definitely have more energy and I feel that my sleep quality is noticeably better.”
Dai B. Verified Customer
So much energy
“I don't think I've felt this good since I was a kid. I have energy from morning to bedtime and sleep reasonably soundly, better than before.”
Julie G. Verified Customer
One month review
“I've been taking NOVOS Core for almost one month now. I wake up refreshed, with energy, and even noticed my mind is sharper. My stress levels are down.”
NOVOS Community Member Verified Customer
Common questions
How does NOVOS Core support sleep?
NOVOS Core supports the biological systems that make restorative sleep possible, including circadian regulation, autonomic balance, healthy circulation, and the cellular repair pathways that run overnight. It isn't a sedative and won't knock you out. Instead, it supports the underlying biology so your body can settle into deeper, more restorative sleep on its own.
Is this a sleep aid or sedative?
No. NOVOS Core contains no melatonin, no sedatives, and no stimulants. It supports the systems behind restorative sleep (circadian rhythm, autonomic balance, inflammation, and cellular repair) rather than forcing sleep chemically.
How is this different from melatonin or magnesium glycinate?
Single-ingredient sleep products target one lever, usually sleep onset. NOVOS Core supports the broader biology of restorative sleep: the systems that govern wind-down, sleep depth, and overnight recovery. It's designed for sustained daily use, not as an as-needed sleep aid.
What's the connection between sleep and longevity?
Most of the body's repair work (DNA repair, glymphatic clearance, immune regulation, memory consolidation) happens during restorative sleep. When sleep declines with age, those overnight processes get fewer hours to operate. Supporting restorative sleep is one of the most direct ways to support how you age.
How long before I notice changes?
Experiences vary. Some people notice easier wind-down and steadier mornings within a couple of weeks. Deeper changes in overnight recovery and daytime energy typically develop over several months as the formula supports the underlying biology. We recommend at least 30 days to evaluate.
What about the cardiovascular clinical trial?
NOVOS Core was studied in a randomized, placebo-controlled human clinical trial that measured cardiovascular markers: endothelial function, arterial stiffness, and blood pressure (in participants whose blood pressure was already in the normal range). The trial did not evaluate sleep, and we are not claiming sleep outcomes were clinically studied. Healthy circulation and autonomic balance support the biological systems involved in overnight recovery, which is why we consider the cardiovascular results relevant to long-term health.
Is NOVOS Core safe for long-term use?
Yes. Each ingredient is selected based on published research and safety data. NOVOS Core contains no stimulants, no sedatives, no proprietary blends, and no hidden ingredients. It's designed for sustained daily use.
What if it isn't right for me?
Reach out to our support team and we'll make it right. Subscriptions can be modified or cancelled anytime. No commitments, no fees. NOVOS Core is also HSA/FSA eligible.
Shipping and subscription details?
Subscription orders ship free and typically arrive within 24–48 hours of dispatch. You can pause, modify flavor, change cadence, or cancel anytime from your account.
Aging well starts at night
Restorative sleep is when the body recovers, repairs, and slows the processes that drive aging.
NOVOS Core supports the biology behind restorative sleep, so the recovery that should happen overnight actually does.
Support how you sleep, and how you age
Free shipping · HSA/FSA eligible · Cancel anytime
Recommended by 1,800+ Doctors & Clinicians