The Science of Skin

Recommended by 2,000+ Doctors & Clinicians

Skin that ages slower starts inside.

Feel confident now. Age better over time.

Most skincare is short-term. NOVOS Core supports the biological systems behind how your skin and face age — so you get visible firmness now and slower aging over time.

In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.

Pilot study, n=4. Range 12%–40%. Individual results may vary.

Clinically Studied
Formulated by Scientists
Patent Pending
HSA/FSA Eligible
4.8 · 3,000+ Reviews

Over 15 million doses served · Recommended by 2,000+ Doctors & Clinicians

A woman with healthy, radiant skin

5x Awards in Skincare & Beauty

Beacon award Beauty Awards Future50 award Science of Skin award Wellness Choice award

Recommended by 2,000+ Doctors & Clinicians. 15 million doses served. 50,000+ members worldwide.

Woman holding a NOVOS Core box

Firmer skin starts underneath

Creams sit on top, but firm skin is built below.

Collagen and elastin live in the deeper layers of your skin, out of reach of topicals. NOVOS Core supports them from the inside.

Skip the complicated beauty supplement routine. One clinically dosed drink.

No more juggling capsules, powders, and serums. One great-tasting daily drink with 12 ingredients at clinically relevant doses to support your skin from within.

Created by Harvard & MIT scientists.

Backed by 7+ years of R&D and a completed randomized, placebo-controlled human clinical trial on the finished formulation.

NOVOS Core box, sachet and drink

NOVOS Core

Firmer skin, clinically studied, from $2.63/day

22%

average improvement in skin firmness after 6 months

Pilot study, n=4. Range 12%–40%. Individual results may vary.

One-time$109 · $3.63/day
Monthly subscriptionSave 10% · $98
Annual Best valueSave 27% · $2.63/day
Drink Your Skincare

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What people notice

Firmer, healthier-looking skin

Improved skin hydration and plumpness

A more youthful, rested appearance

Greater skin resilience over time

Visible improvements others notice

Woman with radiant skin
NOVOS Core supplement

The only multi-ingredient longevity formula with randomized clinical trial evidence on the finished product.

Most longevity supplements cite studies on individual ingredients. NOVOS Core is the only multi-ingredient formula tested as a complete product in a randomized, double-blind, placebo-controlled human trial.

Randomized controlled trial

Gold-standard design

Finished formula

Not just ingredients

Human data

Firmness & vascular

4.8/5

Average rating

3,000+ verified reviews

81%

Notice a difference

Reported by customers

96%

Would recommend

To a friend or family member

2,000+

Doctors recommend

Across the U.S.

This isn’t another skincare product

Topical treatments work on the surface. Collagen feeds one pathway. NOVOS Core supports the biology before it shows.

Topical skincare & treatments

Works on the surface

  • Targets visible signs at the surface
  • Requires ongoing application or visits
  • Doesn't address underlying skin biology
  • Limited reach beyond the outer skin layers

Collagen supplements

One structural input

  • Supplies one structural protein
  • Targets a single pathway
  • Doesn't support cellular renewal or circulation
  • Limited impact on broader skin aging

NOVOS Core

Multi-pathway skin + aging biology

  • Supports multiple biological pathways of skin aging
  • Multi-ingredient, clinically studied formula
  • Supports firmness, hydration, and cellular renewal
  • 22% average improvement in skin firmness at 6 months
NOVOS Core product and lifestyle photography
Firmer, Healthier SkinDeep HydrationHealthy CirculationCellular RenewalCollagen SupportLong-Term Vitality
  • 30 servings per box
  • Cancel or pause anytime
  • Third-party tested for purity
  • Sugar-free · Vegan · Non-GMO

Support Your Skin From Within

22%

In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.Pilot study, n=4. Range 12%–40%. Individual results may vary.

Choose from 3 tasty flavors

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Real people. Real visible changes.

Experiences vary, but many customers report healthier-looking skin, more compliments, and a more youthful appearance.

My skin looks great

“The first thing I've noticed is my skin looks firmer and healthier, without even using creams! Will definitely continue using.”
Chris H. Verified Customer

Glowing skin

“Great product! I have been using it for nearly a year and have started to notice that my skin looks softer and smoother.”
Nasifeh A. Verified Customer

Immediate skin benefits noticed

“Literally days after I started taking your product, I noticed the benefits in my skin.”
Maria K. Verified Customer

Compliments on my skin

“I am now 75 years old, and numerous people have commented that I appear much younger and praise the quality of my skin.”
Leonard M. Verified Customer

Surprising benefits

“I have seen improvement in the appearance of my skin and have felt more energy. I just feel better day to day, and that's what keeps me coming back.”
Tucker D. Verified Customer

Two month review

“I have been taking Core for two months. I feel a lot better. My skin is improving, and I have noticed my hair growing faster and thicker.”
Sheri L. Verified Customer

Customer experiences are anecdotal. Individual results vary.

Why people trust NOVOS Core

2,000+ Doctors

Recommended by physicians and clinicians who understand the science of skin aging.

Clinically Studied

Tested in a randomized, placebo-controlled study in healthy adults with preliminary skin firmness data.

Trusted By The World's Best

Found at Mayo Clinic Store, Bumrungrad International Hospital, Erewhon, and Four Seasons.

Science-Driven

Multi-pathway formula designed by longevity scientists to support skin health from within.

Supporting how your body ages, at multiple levels

NOVOS Core includes ingredients associated with biological processes involved in aging, structure, and recovery.

Calcium Alpha-Ketoglutarate ingredient source

Calcium Alpha-Ketoglutarate

1,100 mg

How it Helps:

  • Supports collagen synthesis
  • Promotes skin elasticity & firmness
  • Studied for cellular protection, metabolic health, and epigenetic support
Glycine ingredient source

Glycine

2,000 mg

How it Helps:

  • Improves collagen synthesis
  • Improves skin firmness & strength
Glucosamine Sulfate ingredient source

Glucosamine Sulfate

1,000 mg

How it Helps:

  • Improves skin hydration
  • Improves skin appearance
  • Studied for healthy inflammatory balance and calorie-restriction-like metabolic pathways
Hyaluronic Acid ingredient source

Hyaluronic Acid

100 mg

How it Helps:

  • Helps reduce size of wrinkles
  • Improves skin suppleness
  • Increases skin radiance
Vitamin C ingredient source

Vitamin C

100 mg

How it Helps:

  • Helps to maintain a proper epigenome
L-Theanine ingredient source

L-Theanine

150 mg

How it Helps:

  • Helps lower stress and anxiety
  • Improves sleep quality
  • Helps the body to manage crosslinks

Plus 6 more

6 more longevity ingredients to target the drivers of aging

Magnesium Rhodiola Rosea Root Extract Fisetin Organic Ginger Root Extract Pterostilbene Lithium Aspartate

Facial aging goes beyond the surface

Skin aging is influenced by more than what you apply topically. These biological processes are associated with how your skin maintains firmness, resilience, and a youthful appearance.

Topical skincare can’t reach these systems. NOVOS Core does.

Skin Structure & Extracellular Matrix

Skin Structure & Extracellular Matrix

The scaffolding of your skin, collagen, elastin, and hyaluronic acid, determines firmness and resilience. Supporting these structures from within is key to maintaining a youthful appearance.

Circulation & Nutrient Delivery

Circulation & Nutrient Delivery

Healthy circulation supports the delivery of oxygen and nutrients to your skin, processes associated with maintaining a healthy glow and supporting skin cell renewal.

Inflammation & Recovery Processes

Inflammation & Recovery Processes

Chronic low-grade inflammation is associated with accelerated skin aging. Supporting your body's recovery and inflammatory balance may help maintain skin health over time.

Changes in Underlying Tissue

Changes in Underlying Tissue

Facial aging involves changes in bone density, fat distribution, and connective tissue beneath the surface, processes that topical products cannot address.

Designed to Meet the Highest Standards

Clinically Studied Formulation

Preliminary Human Data on Skin Firmness

Recommended by 2,000+ Doctors & Clinicians

Available at Mayo Clinic Store & Four Seasons

Vegan & Clean Label

Studied across skin firmness and circulation

NOVOS Core has been evaluated in two separate human studies on the finished formulation: a preliminary pilot study measuring skin firmness, and a randomized, double-blind, placebo-controlled trial measuring vascular markers associated with circulation.

22% average improvement in a preliminary pilot study

22%

In an open-label pilot study (n=4) using an indentometer (a device that measures skin firmness), participants taking NOVOS Core experienced an average improvement of 22% in skin firmness after 6 months.

Open-label pilot study, n=4. Range 12%–40%. No placebo control. Individual results may vary.

Vascular markers associated with blood flow

In a randomized, double-blind, placebo-controlled trial, NOVOS Core showed statistically significant benefits over placebo on flow-mediated dilation (FMD).

Baseline

5.55%

vs 5.05% placebo

1 hour

8.95%

vs 4.85% placebo

6 months

8.1%

vs 4.95% placebo

Statistically significant vs. placebo at measured timepoints.

“It has been a pleasure to watch NOVOS take a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”

Dr. Doina Kulick, M.D.

Lead Physician, Longevity Medicine Program

Mayo Clinic Arizona

Endorsed by Scientists and Physicians Studying Aging at Its Core

NOVOS Core was developed by a team of 7 scientists and physicians from leading institutions including Harvard Medical School, MIT, and other top scientific centers.

Rather than targeting just one pathway, the formulation was designed to support multiple biological processes associated with aging, skin health, and cellular renewal.

“I see NOVOS as inspiring — they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously.”
Dr. George Church, PhDHarvard Medical School & MIT Professor
“It's the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”
Dr. Robert Lufkin, MDUSC School of Medicine Professor
“The study demonstrates that this multi-ingredient formulation exhibits synergistic effects rarely achieved by a nutritional supplement.”
Dr. Satomi MiwaLecturer for Translational Biology of Aging, Newcastle University
“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”
Dr. Pamela Maher, PhDSalk Institute & University of British Columbia
“NOVOS has been using a novel science-based approach for developing its formulation. They are a leader in the longevity space.”
Dr. J. Pedro de Magalhães, PhDHarvard Medical School, University of Birmingham

Why your skin may not reflect how healthy you are

You can do everything right, skincare, diet, sleep, and still notice changes in your skin.

Close-up of skin texture

Skin feels less firm over time

Close-up of fine lines

Fine lines become more noticeable

Close-up of eye area

Your face looks more tired than you feel

Portrait with eyes closed

Results from topical products plateau

That’s because skin aging is not just a surface issue.

How to Use

1

Mix one NOVOS Core sachet daily

Add to 6-8 oz of water, juice, or your morning smoothie.

2

Stir or shake

Dissolves easily. Available in Orange, Tropical Passion, or Unflavored.

3

Take consistently

Benefits build over time. Clinical results observed at 6 months of daily use.

Mixing a NOVOS Core sachet
Abstract cellular network

Long-Term Value

Feel confident now. Age better over time.

Most products focus on short-term appearance. NOVOS Core is designed to support the biological processes associated with how your body, and your skin, age over time.

NOVOS Core was designed for people who want visible skin support today and a daily formula that also supports the biology of healthy aging over time.

Common questions

What's in NOVOS Core?

NOVOS Core contains 12 research-backed longevity ingredients: Vitamin C, Magnesium Malate, Calcium Alpha-Ketoglutarate, Glycine, Glucosamine Sulfate, Rhodiola, L-Theanine, Hyaluronic Acid, Fisetin, Gingerol, Pterostilbene, and micro-dosed Lithium. The Orange flavor also includes erythritol, malic acid, stevia, and natural flavors. NOVOS Core is vegan, non-GMO, sugar-free, and free from artificial colors and preservatives.

When do I see results?

Timelines vary by individual. Many users report changes in skin hydration, glow, and overall appearance within the first 4–8 weeks. Structural changes like firmness build more gradually — in a preliminary human study, participants experienced an average 22% improvement in skin firmness after 6 months. Because skin cells turn over slowly, we recommend committing to at least 90 days for a fair evaluation, and 6 months to see the kind of results measured in the study.

Do I need to refrigerate it?

No. Store NOVOS Core at room temperature in a cool, dry place. Each sachet is individually sealed to protect the actives until you're ready to mix.

What does my subscription include?

Your subscription delivers a fresh box of 30 sachets on the cadence you choose (monthly, semi-annually, or annually), plus free shipping, locked-in subscriber pricing, and access to our member resources. It's fully flexible — skip a shipment, change frequency, swap flavors, or cancel anytime in your account, no calls or emails required.

Is it really possible to slow down aging?

Aging is a biological process driven by measurable mechanisms — cellular senescence, mitochondrial decline, loss of protein homeostasis, and others — that researchers can now target. NOVOS Core was formulated to support multiple of these pathways simultaneously, and is the only multi-ingredient longevity formula evaluated as a finished product in a randomized, double-blind, placebo-controlled human trial. We don't promise to reverse time, but the science supporting interventions on the biology of aging is real and rapidly maturing.

Can I use NOVOS Core alongside my retinol, Botox, or regular skincare routine?

Yes. NOVOS Core works from within to support the underlying biology of how skin ages — structure, hydration, circulation, and cellular renewal — and is designed to complement, not replace, your topical routine or aesthetic treatments. Most users keep using their favorite serums, retinols, and in-office treatments, and add NOVOS Core to support what's happening underneath. If you take prescription medications or manage a medical condition, consult your healthcare professional before use.

Are there any side effects?

NOVOS Core is well tolerated by most users, but a small percentage notice mild, temporary stomach discomfort, bloating, or a light headache during the first week or two as the body adjusts. This is usually easy to resolve: take your sachet with food, mix it into 12–16 oz of water instead of 8, or split the sachet into two half-doses (morning and afternoon) for the first week before moving to a single daily serving. Most people find any initial discomfort settles within 1–2 weeks of consistent use. If symptoms persist or you take prescription medications, pause use and consult your healthcare professional.

Support your skin from within.

Support the biological systems associated with how your skin and face age, for firmer, healthier-looking skin over time.

Recommended by 2,000+ Doctors & Clinicians

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