Calcium Alpha-Ketoglutarate
1,100 mg
How it Helps:
- Supports collagen synthesis
- Promotes skin elasticity & firmness
- Studied for cellular protection, metabolic health, and epigenetic support
The Science of Skin
Recommended by 2,000+ Doctors & CliniciansFeel confident now. Age better over time.
Most skincare is short-term. NOVOS Core supports the biological systems behind how your skin and face age — so you get visible firmness now and slower aging over time.
In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.
Pilot study, n=4. Range 12%–40%. Individual results may vary.
Over 15 million doses served · Recommended by 2,000+ Doctors & Clinicians
5x Awards in Skincare & Beauty
Recommended by 2,000+ Doctors & Clinicians. 15 million doses served. 50,000+ members worldwide.
Firmer skin starts underneath
Collagen and elastin live in the deeper layers of your skin, out of reach of topicals. NOVOS Core supports them from the inside.
No more juggling capsules, powders, and serums. One great-tasting daily drink with 12 ingredients at clinically relevant doses to support your skin from within.
Backed by 7+ years of R&D and a completed randomized, placebo-controlled human clinical trial on the finished formulation.
NOVOS Core
average improvement in skin firmness after 6 months
Pilot study, n=4. Range 12%–40%. Individual results may vary.
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Firmer, healthier-looking skin
Improved skin hydration and plumpness
A more youthful, rested appearance
Greater skin resilience over time
Visible improvements others notice
Most longevity supplements cite studies on individual ingredients. NOVOS Core is the only multi-ingredient formula tested as a complete product in a randomized, double-blind, placebo-controlled human trial.
Randomized controlled trial
Gold-standard design
Finished formula
Not just ingredients
Human data
Firmness & vascular
4.8/5
Average rating
3,000+ verified reviews
81%
Notice a difference
Reported by customers
96%
Would recommend
To a friend or family member
2,000+
Doctors recommend
Across the U.S.
Topical treatments work on the surface. Collagen feeds one pathway. NOVOS Core supports the biology before it shows.
Topical skincare & treatments
Works on the surface
Collagen supplements
One structural input
NOVOS Core
Multi-pathway skin + aging biology

In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.Pilot study, n=4. Range 12%–40%. Individual results may vary.
Choose from 3 tasty flavors
Choose Your Plan
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Experiences vary, but many customers report healthier-looking skin, more compliments, and a more youthful appearance.
My skin looks great
“The first thing I've noticed is my skin looks firmer and healthier, without even using creams! Will definitely continue using.”
Glowing skin
“Great product! I have been using it for nearly a year and have started to notice that my skin looks softer and smoother.”
Immediate skin benefits noticed
“Literally days after I started taking your product, I noticed the benefits in my skin.”
Compliments on my skin
“I am now 75 years old, and numerous people have commented that I appear much younger and praise the quality of my skin.”
Surprising benefits
“I have seen improvement in the appearance of my skin and have felt more energy. I just feel better day to day, and that's what keeps me coming back.”
Two month review
“I have been taking Core for two months. I feel a lot better. My skin is improving, and I have noticed my hair growing faster and thicker.”
Customer experiences are anecdotal. Individual results vary.
2,000+ Doctors
Recommended by physicians and clinicians who understand the science of skin aging.
Clinically Studied
Tested in a randomized, placebo-controlled study in healthy adults with preliminary skin firmness data.
Trusted By The World's Best
Found at Mayo Clinic Store, Bumrungrad International Hospital, Erewhon, and Four Seasons.
Science-Driven
Multi-pathway formula designed by longevity scientists to support skin health from within.
NOVOS Core includes ingredients associated with biological processes involved in aging, structure, and recovery.
Calcium Alpha-Ketoglutarate
1,100 mg
How it Helps:
Glycine
2,000 mg
How it Helps:
Glucosamine Sulfate
1,000 mg
How it Helps:
Hyaluronic Acid
100 mg
How it Helps:
Vitamin C
100 mg
How it Helps:
L-Theanine
150 mg
How it Helps:
Plus 6 more
Skin aging is influenced by more than what you apply topically. These biological processes are associated with how your skin maintains firmness, resilience, and a youthful appearance.
Topical skincare can’t reach these systems. NOVOS Core does.
Skin Structure & Extracellular Matrix
The scaffolding of your skin, collagen, elastin, and hyaluronic acid, determines firmness and resilience. Supporting these structures from within is key to maintaining a youthful appearance.
Circulation & Nutrient Delivery
Healthy circulation supports the delivery of oxygen and nutrients to your skin, processes associated with maintaining a healthy glow and supporting skin cell renewal.
Inflammation & Recovery Processes
Chronic low-grade inflammation is associated with accelerated skin aging. Supporting your body's recovery and inflammatory balance may help maintain skin health over time.
Changes in Underlying Tissue
Facial aging involves changes in bone density, fat distribution, and connective tissue beneath the surface, processes that topical products cannot address.
Designed to Meet the Highest Standards
Clinically Studied Formulation
Preliminary Human Data on Skin Firmness
Recommended by 2,000+ Doctors & Clinicians
Available at Mayo Clinic Store & Four Seasons
Vegan & Clean Label
NOVOS Core has been evaluated in two separate human studies on the finished formulation: a preliminary pilot study measuring skin firmness, and a randomized, double-blind, placebo-controlled trial measuring vascular markers associated with circulation.
22%
In an open-label pilot study (n=4) using an indentometer (a device that measures skin firmness), participants taking NOVOS Core experienced an average improvement of 22% in skin firmness after 6 months.
Open-label pilot study, n=4. Range 12%–40%. No placebo control. Individual results may vary.
In a randomized, double-blind, placebo-controlled trial, NOVOS Core showed statistically significant benefits over placebo on flow-mediated dilation (FMD).
Baseline
5.55%
vs 5.05% placebo
1 hour
8.95%
vs 4.85% placebo
6 months
8.1%
vs 4.95% placebo
Statistically significant vs. placebo at measured timepoints.
“It has been a pleasure to watch NOVOS take a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”
Dr. Doina Kulick, M.D.
Lead Physician, Longevity Medicine Program
Mayo Clinic Arizona
NOVOS Core was developed by a team of 7 scientists and physicians from leading institutions including Harvard Medical School, MIT, and other top scientific centers.
Rather than targeting just one pathway, the formulation was designed to support multiple biological processes associated with aging, skin health, and cellular renewal.

“I see NOVOS as inspiring — they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously.”

“It's the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”

“The study demonstrates that this multi-ingredient formulation exhibits synergistic effects rarely achieved by a nutritional supplement.”

“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”

“NOVOS has been using a novel science-based approach for developing its formulation. They are a leader in the longevity space.”
You can do everything right, skincare, diet, sleep, and still notice changes in your skin.
Skin feels less firm over time
Fine lines become more noticeable
Your face looks more tired than you feel
Results from topical products plateau
That’s because skin aging is not just a surface issue.
Mix one NOVOS Core sachet daily
Add to 6-8 oz of water, juice, or your morning smoothie.
Stir or shake
Dissolves easily. Available in Orange, Tropical Passion, or Unflavored.
Take consistently
Benefits build over time. Clinical results observed at 6 months of daily use.
Long-Term Value
Most products focus on short-term appearance. NOVOS Core is designed to support the biological processes associated with how your body, and your skin, age over time.
NOVOS Core was designed for people who want visible skin support today and a daily formula that also supports the biology of healthy aging over time.
NOVOS Core contains 12 research-backed longevity ingredients: Vitamin C, Magnesium Malate, Calcium Alpha-Ketoglutarate, Glycine, Glucosamine Sulfate, Rhodiola, L-Theanine, Hyaluronic Acid, Fisetin, Gingerol, Pterostilbene, and micro-dosed Lithium. The Orange flavor also includes erythritol, malic acid, stevia, and natural flavors. NOVOS Core is vegan, non-GMO, sugar-free, and free from artificial colors and preservatives.
Timelines vary by individual. Many users report changes in skin hydration, glow, and overall appearance within the first 4–8 weeks. Structural changes like firmness build more gradually — in a preliminary human study, participants experienced an average 22% improvement in skin firmness after 6 months. Because skin cells turn over slowly, we recommend committing to at least 90 days for a fair evaluation, and 6 months to see the kind of results measured in the study.
No. Store NOVOS Core at room temperature in a cool, dry place. Each sachet is individually sealed to protect the actives until you're ready to mix.
Your subscription delivers a fresh box of 30 sachets on the cadence you choose (monthly, semi-annually, or annually), plus free shipping, locked-in subscriber pricing, and access to our member resources. It's fully flexible — skip a shipment, change frequency, swap flavors, or cancel anytime in your account, no calls or emails required.
Aging is a biological process driven by measurable mechanisms — cellular senescence, mitochondrial decline, loss of protein homeostasis, and others — that researchers can now target. NOVOS Core was formulated to support multiple of these pathways simultaneously, and is the only multi-ingredient longevity formula evaluated as a finished product in a randomized, double-blind, placebo-controlled human trial. We don't promise to reverse time, but the science supporting interventions on the biology of aging is real and rapidly maturing.
Yes. NOVOS Core works from within to support the underlying biology of how skin ages — structure, hydration, circulation, and cellular renewal — and is designed to complement, not replace, your topical routine or aesthetic treatments. Most users keep using their favorite serums, retinols, and in-office treatments, and add NOVOS Core to support what's happening underneath. If you take prescription medications or manage a medical condition, consult your healthcare professional before use.
NOVOS Core is well tolerated by most users, but a small percentage notice mild, temporary stomach discomfort, bloating, or a light headache during the first week or two as the body adjusts. This is usually easy to resolve: take your sachet with food, mix it into 12–16 oz of water instead of 8, or split the sachet into two half-doses (morning and afternoon) for the first week before moving to a single daily serving. Most people find any initial discomfort settles within 1–2 weeks of consistent use. If symptoms persist or you take prescription medications, pause use and consult your healthcare professional.
Support the biological systems associated with how your skin and face age, for firmer, healthier-looking skin over time.
Recommended by 2,000+ Doctors & Clinicians