Calcium Alpha-Ketoglutarate
1,100 mg
How it Helps:
- Supports collagen synthesis
- Promotes skin elasticity & firmness
- Helps reduce hair graying
Recommended by 2,000+ Doctors & Clinicians
How you age determines how you look
People who age more slowly often look younger for their age.
NOVOS Core supports biological processes associated with aging – helping your body, and your appearance, age better over time.
Pilot Study · n=4
In a small 4-person pilot study, participants saw an average 22% improvement in skin firmness after 6 months (range 12%–40%).
Preliminary, directional finding. Individual results may vary. Larger study planned.
Tested in a randomized, placebo-controlled human clinical trial
Over 15 million doses served · Recommended by 2,000+ Doctors & Clinicians
A daily longevity drink mix
NOVOS Core is a once-a-day drink mix designed to support multiple biological processes associated with healthy aging, skin firmness, circulation, and cellular vitality.
Why some people look younger than their age
Not everyone ages the same way. Some people maintain a more youthful appearance for longer. While genetics play a role, research shows they explain only part of the story.
20–40%
of how old you look is determined by genetics
60–80%
is influenced by your biology, lifestyle & environment
Landmark Study
Perceived Age as a Biomarker of Aging
This study followed 1,826 Danish twins aged 70+. Even among genetically identical twins, the one who looked older had a significantly higher risk of mortality.
Perceived age was also linked to physical fitness, cognitive function, and markers of biological aging – how you look reflects how your body is aging beneath the surface.
If facial aging were purely genetic, identical twins would age the same. They don’t.
Aging is modifiable
The processes driving how you age — and how you look — are not fixed.
Face reflects biology
Your face is not separate from your biology. It's a visible expression of it.
The NOVOS approach
By supporting cellular-level aging processes, NOVOS Core helps preserve a more youthful appearance.
Facial aging is more than skin
Changes in appearance are driven by multiple biological systems working together:
Skin structure & elasticity
Collagen, elastin and hydration networks shape firmness and surface quality over time.
Circulation & nutrient delivery
Vascular function brings oxygen and nutrients to skin tissue — fueling repair and tone.
Inflammation & recovery
Low-grade inflammation accelerates visible aging; recovery pathways help offset it.
Underlying tissue changes
Fat pads, fascia and bone shift with age — driving contour and structure beneath the skin.
That’s why focusing only on the surface often leads to limited results.
A more complete approach supports the biological systems involved in how the face ages.
Pilot Study · n=4 · Preliminary
An early signal on skin firmness
In a small 4-person pilot study using an indentometer, participants taking NOVOS Core saw an average improvement of 22% in skin firmness after 6 months (range 12%–40%).
We consider this a directional, early signal — not clinical proof. A larger study is planned to validate the finding.
Pilot study, n=4. Range 12%–40%. Individual results may vary. This is a preliminary finding and is separate from the randomized, placebo-controlled trial referenced elsewhere on this page.
22%
Average improvement (preliminary)
Skin firmness · Indentometer measurement
After 6 months of daily use
Recognized across longevity and skincare
NOVOS Core has received multiple skincare and beauty awards for its science-driven approach to supporting both long-term health and skin-related outcomes.
AI-Powered
Try FaceAge – It’s Free
How old does your face say you are?
FaceAge uses AI to estimate how your appearance compares to your chronological age – giving you a new way to see how you’re aging.
Track changes over time and see how your biology shows up in your face.
✓ No account needed
✓ Results in seconds
Randomized, Placebo-Controlled Trial
Backed by clinical research on key aging systems
NOVOS Core was studied in a randomized, placebo-controlled human clinical trial – showing improvements in cardiovascular markers linked to circulation.
Circulation delivers oxygen and nutrients throughout the body – including to the tissues that influence how your face and skin age.
Supporting these foundational systems means supporting both health and appearance.
FMD: Blood Circulation
NOVOS Core improved flow-mediated dilation (FMD) by +3.9% acutely and +2.9% sustained at 6 months (p < 0.0001), while placebo showed no change.
Baseline
5.55%
vs 5.05% placebo
1 hour
8.95%
vs 4.85% placebo
6 months
8.1%
vs 4.95% placebo
* p < 0.0001 vs. placebo. Data from randomized, double-blind, placebo-controlled trial.
+3.9%
Endothelial function (1 hr)
Acute improvement in flow-mediated dilation vs. placebo
−1.18 m/s
Arterial stiffness
Reduction in pulse wave velocity at 6 months
−8.5 mmHg
Systolic blood pressure
Reduction in adults within the normal range
Effect Size
1.26× to 4.65×
leading studied dietary interventions — comparable to aerobic exercise and resistance training.
Randomized, placebo-controlled human study in healthy adults aged 40+. Effect sizes compared to published results for other studied dietary interventions.
Healthy circulation delivers oxygen and nutrients to skin tissue — making vascular function a direct upstream driver of how skin looks and ages.
Supporting how your body ages – at multiple levels
NOVOS Core includes ingredients associated with biological processes involved in aging, structure, and recovery.
Glycine
2,000 mg
How it Helps:
- Improves collagen synthesis
- Improves skin firmness & strength
Glucosamine Sulfate
1,000 mg
How it Helps:
- Improves skin hydration
- Improves skin appearance
- Helps reduce wrinkles
Hyaluronic Acid
100 mg
How it Helps:
- Supports skin hydration and elasticity
- Oral supplementation has been shown to improve skin appearance and texture over time
Vitamin C
100 mg
How it Helps:
- Supports collagen formation, cellular protection, and epigenetic enzyme activity
L-Theanine
150 mg
How it Helps:
- Supports calm focus and stress resilience
- Improves sleep quality
- Helps the body to manage crosslinks
Plus 6 more
6 more longevity ingredients to target the drivers of aging
Magnesium
Rhodiola Rosea Root Extract
Fisetin
Organic Ginger Root Extract
Pterostilbene
Lithium Aspartate
Rather than targeting a single pathway, NOVOS Core supports multiple systems involved in how the body – and face – age.
12 ingredients. One drink.
Replace a complicated daily stack with one convenient, great-tasting drink mix – formulated with clinically relevant doses of every ingredient.
Created by Harvard & MIT scientists.
Backed by 7+ years of R&D and a completed randomized, placebo-controlled human clinical trial on the finished formulation.
What people notice over time
Individual experiences vary, but many customers report changes in vitality, appearance, and how others perceive their age.
Legitimate research
“I compared the research behind Core's ingredients to other longevity supplements and chose Core. Now I've gotten to the point where I look forward to the orange flavor every morning.”
Healthier skin without creams
“The first thing I've noticed is my skin looks firmer and healthier, without even using creams! Will definitely continue using.”
Biological age dropped 8 years
“I tested my biological age before starting NOVOS Core – I was 1.8 years younger than my chronological age. Six months later, I repeated the test and was 8.4 years younger.”
Glowing skin
“Great product! I have been using it for nearly a year and have started to notice that my skin looks softer and smoother.”
Two month review
“I have been taking the Core for two months. I feel a lot better. My skin is improving, my energy seems to be getting better and I have noticed my hair growing faster and thicker.”
Immediate skin benefits
“Literally days after I started taking your product, I noticed the benefits in my skin.”
Why people trust NOVOS Core
2,000+ Doctors
Recommended by physicians who understand the connection between biological aging and appearance.
Clinically Studied
Tested in a randomized, placebo-controlled study on the finished formulation.
Trusted By The World's Best
Found at Mayo Clinic Store, Erewhon, Equinox, and Four Seasons.
Science-Driven
Multi-pathway formula designed by longevity scientists, not marketers.
- 30 servings per box
- Cancel or pause anytime
- Third-party tested for purity
- Sugar-free · Vegan · Non-GMO
Support How You Age – From the Inside
22%
Average improvement in skin firmness after 6 months in a pilot study.Pilot study, n=4. Range 12%–40%. Individual results may vary. Preliminary, directional finding — a larger study is planned.
Choose from 3 tasty flavors
Choose Your Plan
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Common questions
How does NOVOS Core affect appearance?
NOVOS Core supports biological processes associated with aging — including systems involved in skin structure, circulation, and recovery. In a small 4-person pilot study, participants saw an average 22% improvement in skin firmness after 6 months (range 12%–40%). This is a preliminary, directional finding, separate from our randomized, placebo-controlled trial on cardiovascular markers. Individual results may vary. A larger study is planned.
Is this a skincare product?
No. NOVOS Core is a longevity supplement that supports the biological systems involved in how you age. Changes in appearance are a downstream effect of supporting these underlying processes – not the result of topical treatment.
How is this different from collagen supplements?
Collagen supplements target one pathway. NOVOS Core supports multiple biological systems involved in aging – including those that affect skin structure, tissue integrity, and cellular processes. It's a more complete approach to how the body ages.
How does NOVOS Core compare to other longevity supplements?
Most longevity supplements rely on single ingredients or mechanistic and animal data. NOVOS Core is the only multi-ingredient longevity formula with a published randomized, placebo-controlled human clinical trial on the finished formula — showing improvements in cardiovascular markers associated with healthier aging. Effect sizes were 1.26× to 4.65× leading studied dietary interventions, comparable to aerobic exercise and resistance training.
How long before I notice changes?
Experiences vary. Some people notice improvements in energy and vitality within weeks. Visible changes in skin and appearance typically develop over several months as the formula supports underlying biological processes. We recommend at least 30 days to evaluate.
What is FaceAge?
FaceAge is an AI-powered tool developed by NOVOS that analyzes facial features to estimate how your appearance compares to your chronological age. It's a way to track changes over time and see how your biology may be reflected in your face.
Is NOVOS Core safe for long-term use?
Yes. Each ingredient is selected based on published research and safety data. NOVOS Core contains no stimulants, no proprietary blends, and no hidden ingredients. It's designed for sustained daily use.
Aging well shows
Looking younger isn’t just about appearance – it reflects how your body is functioning over time.
NOVOS Core is designed to support the biological processes associated with aging, helping you maintain both long-term health and a more youthful appearance.
Support how you age – and how you look
Recommended by 2,000+ Doctors & Clinicians