The first formulation designed to address all 12 biological Hallmarks of Aging, now supported by 7+ years of R&D and randomized, placebo-controlled human clinical research, showing positive results for functional markers of cardiovascular and overall aging.
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“It has been a pleasure to watch NOVOS take a disciplined, biology-first approach in a space that too often prioritizes hype over evidence. What stood out to us was the seriousness of the scientific framework—mechanistic grounding, preclinical data, and an emerging human evidence base—combined with a willingness to engage in rigorous evaluation rather than shortcuts.”
– Dr. Doina Kulick, Lead Physician, Longevity Medicine Program at Mayo Clinic Arizona
The first formulation designed to address all 12 biological Hallmarks of Aging, now supported by 7+ years of R&D and randomized, placebo-controlled human clinical research, showing positive results for functional markers of cardiovascular and overall aging.
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Biotechnology rigor. 7+ years of R&D. A higher standard for longevity.
NOVOS Core Clinical is the first formulation designed around all 12 biological Hallmarks of Aging, developed with leading longevity scientists and physicians specializing in aging biology.
Backed by more than seven years of R&D, it has been evaluated in randomized, double-blind, placebo-controlled human clinical research demonstrating statistically significant effects across validated measures of endothelial function, arterial flexibility, and systolic blood pressure in the normal range, with effect sizes among the largest reported in published human research for a supplement, nutritional, or lifestyle intervention.
Built as a coordinated, multi-pathway system rather than a single-ingredient solution, NOVOS Core Clinical is designed to support multiple aging-related systems at once. In addition to cardiovascular outcomes, research has observed favorable shifts in biological age markers measured epigenetically and improvements in skin firmness in preliminary human studies, alongside customer-reported benefits such as steadier energy, mental clarity, mood balance, and sleep consistency†. The formulation is further supported by mechanistic studies and preclinical lifespan research, providing multi-level scientific evidence that NOVOS Core Clinical supports foundational aspects of healthy aging biology.*
†Customer-reported outcomes and small scale studies. Individual results will vary.
A system designed to support the biology of aging itself
Aging doesn’t happen in one place. It emerges from interconnected biological processes that influence cardiovascular function, cellular energy production, tissue renewal, and resilience across the body.
NOVOS Core Clinical was intentionally designed around the biology of aging itself — not individual symptoms — by supporting all 12 biological Hallmarks of Aging simultaneously. Developed with scientists and physicians affiliated with institutions including Harvard Medical School, MIT, and the Salk Institute, the formulation is built as a coordinated system designed for ingredient synergy rather than a collection of isolated or trendy ingredients.
Because these foundational systems shape how the body functions day to day, supporting them can influence performance, resilience, and overall well-being long before later-life outcomes become relevant.
Built on evidence, not theory
NOVOS Core Clinical is supported by multiple layers of research:
This multi-level approach reflects an uncommon standard of scientific validation for a nutritional formulation — testing the complete system rather than relying on individual ingredient claims.
What the formulation is designed to support
Cellular energy & metabolic efficiency
Supports mitochondrial and metabolic pathways involved in cellular energy production to help maintain stamina, clarity, and daily recovery.
Healthy cellular renewal
Supports the body’s natural renewal and turnover processes that help maintain tissue function over time.
Cellular resilience & stability
Supports DNA stability, cellular stress-response pathways, and healthy inflammatory balance to promote long-term cellular function.
Protein quality & cellular communication
Supports proteostasis, extracellular matrix structure, and intercellular signaling — helping tissues remain coordinated and responsive with age.
Why this approach is different
Most supplements focus on isolated ingredients or single outcomes, while few are rigorously evaluated as complete formulations in randomized, placebo-controlled human clinical trials using validated functional biomarkers.
NOVOS Core Clinical was designed to support the biology of aging as a connected system and evaluated as a complete formulation through mechanistic research, preclinical lifespan studies, and human clinical trials — not trends, theories, or ingredient-by-ingredient claims.*
Few dietary supplements are evaluated this way, testing the complete finished formula in humans rather than relying on ingredient-level assumptions.
*These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.
Each ingredient in NOVOS Core Clinical was selected based on scientific evidence and is either naturally present in human biology or derived from compounds found in nature. Together, they were chosen for their roles in aging-related biological pathways and for their established safety profiles in human research.
1. Calcium Alpha-Ketoglutarate (Ca-AKG) - A compound naturally present in human metabolism that supports mitochondrial energy production and cellular resilience.
2. Fisetin - A polyphenol found in strawberries and other fruits that supports cellular renewal and healthy inflammatory balance.
3. Pterostilbene - An antioxidant compound found in blueberries that supports cardiovascular and metabolic health.
4. Glucosamine Sulfate – Naturally occurring in connective tissues, supports joint and extracellular matrix integrity.
5. Glycine – An amino acid abundant in collagen that supports recovery, detoxification, and restorative sleep.
6. Magnesium Malate – A form of magnesium involved in ATP production that supports energy metabolism and muscle function.
7. L-Theanine – An amino acid found in green tea that supports calm focus and stress resilience.
8. Rhodiola Rosea – An adaptogenic root traditionally used to support stamina, mental performance, and stress response.
9. Gingerols & Shogaols – Bioactive compounds from ginger that support healthy inflammatory signaling and digestive comfort.
10. Hyaluronic Acid – A molecule naturally present in skin and joints that supports hydration, elasticity, and tissue resilience.
11. Vitamin C – An essential nutrient found in fruits and vegetables that supports collagen production, antioxidant protection, and synergizes with CaAKG.
12. Micro-dosed Lithium – A trace mineral found naturally in water and foods that supports neuronal signaling and mood balance.
These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.
Placebo-Controlled Human Clinical Trial Cardiovascular function was selected as the first human system to measure because vascular biology changes early with age and reflects whole-body resilience.
NOVOS Core Clinical was evaluated in a randomized, double-blind, placebo-controlled human clinical trial conducted by university researchers in adults aged 40+. The study assessed validated functional biomarkers commonly used in cardiovascular and aging research.
Compared with placebo, NOVOS Core Clinical demonstrated statistically significant differences across multiple measures of cardiovascular function:
Effect sizes across these independent cardiovascular biomarkers are among the largest reported in published human research for a nutritional intervention, supplement, or lifestyle modification, including aerobic exercise, providing rare human evidence that a multi-pathway formulation can measurably influence aging-related physiology.*
Individual responses vary. Not every person will experience the same magnitude of change.
Preclinical Lifespan Study (Animal Model)
In a controlled mouse lifespan study, animals receiving NOVOS Core Clinical lived over 18% longer on average than controls.
While animal studies do not predict human outcomes, lifespan models are a foundational step in aging research for evaluating long-term, system-level biological effects before human trials.
Mechanistic Research (Formulation Design)
NOVOS Core Clinical was developed through mechanistic research examining how ingredient combinations interact with aging-related biological pathways, including DNA protection, cellular senescence, cellular inflammation protection.
This work confirmed formulation design, dosing, and ingredient synergy, ensuring the product was built as an integrated system rather than a collection of isolated compounds.
👉 Explore the mechanistic studies
Epigenetic Aging Analysis
NOVOS has supported independent DNA methylation–based epigenetic age testing, which measures patterns in your DNA that scientists use to estimate biological age over time.
In an exploratory analysis of first-time NOVOS Core Clinical users tested before and after six months of use, follow-up results showed favorable directional shifts in these validated epigenetic biomarkers, consistent with a slower pace of age-related biological change. These tests are research tools used to study aging biology and do not diagnose disease or predict lifespan.*
This was an observational, real-world evaluation rather than a controlled clinical trial.
👉 Learn about our epigenetic research
Skin Elasticity Study (Instrument-Measured)
In a preliminary human study using an indentometer — a scientific device that objectively measures skin firmness — participants showed an average 22% increase in skin elasticity after six months, with some reporting visible improvements within weeks.
These findings suggest that supporting foundational biological pathways may also help maintain skin firmness, structure, and resilience over time.*
This was a small pilot evaluation intended to generate preliminary signals.
Why This Approach Is Different
Most supplements rely on ingredient-level claims. NOVOS Core Clinical has been rigorously evaluated as a complete formulation across mechanistic research, preclinical lifespan studies, and randomized, placebo-controlled human clinical research, reflecting how aging actually works: as an interconnected biological system rather than isolated symptoms.
*These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.
Supported by over 7 years of research, 400+ ingredient studies, and a rapidly expanding body of clinical and preclinical evidence.
Placebo-Controlled Human Clinical Trial
Read full clinical summary here
Preclinical Lifespan Study
Read full study details here
Epigenetic Aging Analysis
Learn more about epigenetic analysis and biological age measurement here
Skin Elasticity Assessment
Learn more about the skin health assessment here
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
Placebo-Controlled Human Clinical Trial
Read full clinical summary here
Preclinical Lifespan Study
Read full study details here
Epigenetic Aging Analysis
Learn more about epigenetic analysis and biological age measurement here
Skin Elasticity Assessment
Learn more about the skin health assessment here
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In Vitro Study
Read full study here
*Laboratory research only. These findings are from in vitro (cell-based) studies and do not demonstrate effects in humans. Results from laboratory models may not reflect how the product performs in the human body. This product is not intended to diagnose, treat, cure, or prevent any disease.
In a randomized, double-blind, placebo-controlled human clinical trial, NOVOS Core Clinical demonstrated statistically significant improvements versus placebo across validated cardiovascular biomarkers used in aging research.*
NOVOS Core Clinical supported healthy endothelial responsiveness with sustained effects measuring approximately 1.26x to 4.65x of leading studied supplements, outperforming tea polyphenols, cocoa flavanols, beetroot nitrates, and demonstrating effects comparable to those reported for weight loss, aerobic exercise, and resistance training.* Learn more.
NOVOS Core Clinical helped support healthy arterial flexibility with effect sizes exceeding those reported for magnesium and omega-3s, and comparable to published results for weight loss, DASH heart health diets, and structured exercise — an effect rarely observed with dietary supplements.* Learn more.
Supported ~8.5–8.7 mmHg differences in systolic blood pressure vs. placebo in adults already in the normal range, exceeding effect sizes reported for common supplements including beetroot/nitrate and potassium, and demonstrating magnitudes of support comparable to those observed for Mediterranean and DASH-style diets and High Intensity Interval Training (HIIT).* Learn more.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Cellular senescence balance
2. Protein quality control (proteostasis)
3. Autophagy & cellular recycling
4. Mitochondrial energy production
5. Nutrient sensing pathways
6. Gut microbiome balance
7. DNA integrity & maintenance
8. Epigenetic regulation
9. Stem cell health & renewal potential
10. Healthy inflammatory balance
11. Intercellular communication
12. Extracellular matrix & tissue structure
1. Cellular senescence balance
2. Protein quality control (proteostasis)
3. Autophagy & cellular recycling
4. Mitochondrial energy production
5. Nutrient sensing pathways
6. Gut microbiome balance
7. DNA integrity & maintenance
8. Epigenetic regulation
9. Stem cell health & renewal potential
10. Healthy inflammatory balance
11. Intercellular communication
12. Extracellular matrix & tissue structure
When you support the fundamental drivers of aging, you optimize how your cells function — and how you look and feel today and for years to come.
Clinically Studied in a Placebo-Controlled Human Trial
Benefits†
Aging Pathways Supported
†Based on a randomized double-blind placebo controlled human clinical study that measured statistically significant improvements vs. placebo for functional markers of blood flow (FMD), blood vessel elasticity (PWV), and maintenance of blood pressure already in the normal range. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on a placebo controlled human clinical study that observed statistically significant nutritional support vs. placebo for biological systems predictive of lifespan and healthspan. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Clinically Studied in a Placebo-Controlled Human Trial
Benefits†
Aging Pathways Supported
†Based on a randomized double-blind placebo controlled human clinical study that measured statistically significant improvements vs. placebo for functional markers of blood flow (FMD), blood vessel elasticity (PWV), and maintenance of blood pressure already in the normal range. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on customer-reported outcomes and human clinical research of individual component ingredients of the formulation. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Benefits†
Aging Pathways Supported
†Based on a placebo controlled human clinical study that observed statistically significant nutritional support vs. placebo for biological systems predictive of lifespan and healthspan. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Clinically observed biological shifts begin early
and build with consistent daily use.
Grounded in human clinical research and supported by mechanistic, preclinical lifespan, and epigenetic studies.
Within 2 hours: Clinical research observed early changes in vascular function biomarkers, including endothelial responsiveness and systolic blood pressure signaling.
Feel: Some users report subtle increases in mental clarity and drive after initial use.
Cellular support: Ingredients begin engaging antioxidant and cellular stress-response pathways that support system-level resilience.
Daily energy: More consistent energy as cellular energy pathways adapt to regular use.
Recovery & comfort: Users often report improved day-to-day physical comfort and easier recovery from activity.
Inflammatory balance: Supports healthy inflammatory signaling tied to resilience and repair.
Heart & vessels: Randomized, placebo-controlled human research demonstrated statistically significant differences in vascular aging biomarkers, including arterial flexibility (PWV) and support for healthy blood pressure already within the normal range.
Skin appearance: In a pilot human assessment using objective instrument measurements, participants showed measurable improvements in skin firmness and elasticity over six months, consistent with healthier-looking, more resilient skin.
System-wide longevity support: Ongoing use supports multiple core biological pathways associated with healthy aging through a coordinated, multi-system approach.
Pace of aging*: In epigenetic research testing, participants showed directional changes consistent with a slower pace of biological aging over time.
*Epigenetic analyses are research tools and do not diagnose disease or predict lifespan.
Within 2 hours: Clinical research observed early changes in vascular function biomarkers, including endothelial responsiveness and systolic blood pressure signaling.
Feel: Some users report subtle increases in mental clarity and drive after initial use.
Cellular support: Ingredients begin engaging antioxidant and cellular stress-response pathways that support system-level resilience.
Daily energy: More consistent energy as cellular energy pathways adapt to regular use.
Recovery & comfort: Users often report improved day-to-day physical comfort and easier recovery from activity.
Inflammatory balance: Supports healthy inflammatory signaling tied to resilience and repair.
Heart & vessels: Randomized, placebo-controlled human research demonstrated statistically significant differences in vascular aging biomarkers, including arterial flexibility (PWV) and support for healthy blood pressure already within the normal range.
Skin appearance: In a pilot human assessment using objective instrument measurements, participants showed measurable improvements in skin firmness and elasticity over six months, consistent with healthier-looking, more resilient skin.
System-wide longevity support: Ongoing use supports multiple core biological pathways associated with healthy aging through a coordinated, multi-system approach.
Pace of aging*: In epigenetic research testing, participants showed directional changes consistent with a slower pace of biological aging over time.
*Epigenetic analyses are research tools and do not diagnose disease or predict lifespan.
The Most Effective Longevity
Drink On The Market
A naturally occurring metabolic intermediate involved in mitochondrial energy production. Studied for cellular protection, metabolic health, and epigenetic support, with lifespan and healthspan benefits demonstrated in animals*
A plant polyphenol studied in aging research for its role in supporting cellular senescence balance and healthy inflammatory signaling. In animal models, fisetin has been associated with lifespan extension*
An amino acid naturally present in collagen and metabolism. Higher glycine levels are associated with cardiovascular health, balanced inflammatory signaling, and healthy glucose metabolism. Lifespan benefits have been observed in multiple species*
A compound found in blueberries with higher bioavailability than resveratrol. Supports healthy inflammatory balance, DNA stability, and epigenetic regulation. Related compounds have demonstrated lifespan effects in animal models*
An adaptogenic botanical containing salidroside and other bioactives studied for cellular stress resilience. Research suggests support for mitochondrial function, AMPK and sirtuin pathways, and healthy cellular aging processes*
Trace amounts of lithium naturally occur in food and water. Epidemiological and human studies associate low-dose lithium exposure with healthy brain aging and longevity trends. Lifespan effects have also been observed in multiple species*
Magnesium supports hundreds of enzymatic reactions involved in energy production and metabolic health, while malate participates in the Krebs cycle. Together they support cellular energy and resilience*
Commonly known for joint health, glucosamine is also studied for its role in healthy inflammatory balance and metabolic pathways that resemble calorie-restriction biology. Lifespan associations have been observed in animals and population studies*
A naturally occurring structural molecule that supports skin hydration and elasticity. Oral supplementation has been shown to improve skin appearance and texture over time*
A green tea amino acid that promotes calm focus and healthy stress response. Studied for supporting antioxidant defenses and longevity-related cellular pathways in preclinical research*
An essential antioxidant that supports collagen formation, cellular protection, and epigenetic enzyme activity. Works synergistically with other nutrients to maintain cellular integrity*
Bioactive compounds from ginger that support healthy inflammatory balance, metabolic function, and cellular antioxidant defenses*
A naturally occurring metabolic intermediate involved in mitochondrial energy production. Studied for cellular protection, metabolic health, and epigenetic support, with lifespan and healthspan benefits demonstrated in animals*
A plant polyphenol studied in aging research for its role in supporting cellular senescence balance and healthy inflammatory signaling. In animal models, fisetin has been associated with lifespan extension*
An amino acid naturally present in collagen and metabolism. Higher glycine levels are associated with cardiovascular health, balanced inflammatory signaling, and healthy glucose metabolism. Lifespan benefits have been observed in multiple species*
A compound found in blueberries with higher bioavailability than resveratrol. Supports healthy inflammatory balance, DNA stability, and epigenetic regulation. Related compounds have demonstrated lifespan effects in animal models*
An adaptogenic botanical containing salidroside and other bioactives studied for cellular stress resilience. Research suggests support for mitochondrial function, AMPK and sirtuin pathways, and healthy cellular aging processes*
Trace amounts of lithium naturally occur in food and water. Epidemiological and human studies associate low-dose lithium exposure with healthy brain aging and longevity trends. Lifespan effects have also been observed in multiple species*
Magnesium supports hundreds of enzymatic reactions involved in energy production and metabolic health, while malate participates in the Krebs cycle. Together they support cellular energy and resilience*
Commonly known for joint health, glucosamine is also studied for its role in healthy inflammatory balance and metabolic pathways that resemble calorie-restriction biology. Lifespan associations have been observed in animals and population studies*
A naturally occurring structural molecule that supports skin hydration and elasticity. Oral supplementation has been shown to improve skin appearance and texture over time*
A green tea amino acid that promotes calm focus and healthy stress response. Studied for supporting antioxidant defenses and longevity-related cellular pathways in preclinical research*
An essential antioxidant that supports collagen formation, cellular protection, and epigenetic enzyme activity. Works synergistically with other nutrients to maintain cellular integrity*
Bioactive compounds from ginger that support healthy inflammatory balance, metabolic function, and cellular antioxidant defenses*
Clinically Studied Formulation
3rd-Party Tested
Sugar-Free & Gluten-Free
Clinically Relevant Doses
Vegan & Clean Label
Developed by Scientists.
Formulated by a team of 7 scientists and physicians specializing in aging biology, with backgrounds at Harvard Medical School, MIT, and leading research institutions.
Trusted by Doctors.
Recommended by more than 1,500 MDs and clinicians, including physicians affiliated with Mayo Clinic.
Respected by the Press.
Featured by The Wall Street Journal as a longevity brand helping define the future of the field.
Recognized by Awards.
Recipient of multiple consumer and industry awards for innovation in science-based longevity.
Loved by our Community.
More than 10 million doses enjoyed worldwide by our growing global community.
When it comes to your future health, proof matters.
Core Clinical is science you can trust and results you can feel.
Backed by controlled human and preclinical research. Individual experiences may vary and are distinct from results observed in controlled clinical research.
NOVOS Core is rated 4.8 out of 5 stars. We have collected 1331 ratings.
The reason I first try the Novo’s Core was desperation to reduce my CRP (C-reactive Protein). I used anti inflammatory powder before from my local Herbal store, and it was good. My CRP number was 8.5 and after 28 days of using the powder from the local store it brings down to 1.0. I stopped couple of months and it went back up again to 8.1. after searching I’ve found Novo’s Core stating that it’s anti inflammatory drink. I ordered, start taking it. I did some blood work fifteen days later and it come down to .9. I’m trying to find out what causes my body’s inflammatory responses. I started Novo’s Core 2023 on and off now it looks different from the old one. Maybe it is just the packaging.
As a drink I blend with some fruits and it is delicious.
I’m 61 w/ chronic inflammation. Moving back to a colder climate moved me from less active to downright wanting to quit. I had to lean and hold on to railings, & the chronic pain in my hips, knees, hands & feet were making movement intolerable, so much so, I chose to sit more and more. In my quest for answers for anti-inflammatory care/cures, I stepped into the longevity world; something I balked at. After reading some testimonies on your product I decided to give them a try. I wish I had started them separately-but I took Core and Vital at the same time. On day 6, I got out of bed, and flew down the stairs…midway down I realized I didn’t need to hold on to the rail. And I ran up the stairs to be sure…The pain was 80% gone! * there may be permanent damage from the years of inflammation. It has been 9 days. I am almost pain free. I ate badly one day and thought I’d pay for it. I didn’t feel as good but wanted to see if this was just the improved food or the NOVOS. I am not going to “test” anymore. With NOVOS Core and Vital, I am not going to take this for granted. I am going to continue to improve my diet and exercise and see just how much healthier and stronger I can get! I am more focused, excited about life and my future. I am hoping more improvements will come. If they do, I’ll be sure to let you know. So grateful for the brave scientists who work with integrity to help humans live the rich life God intended for His kids. God bless you!
Fantastic product and fantastic customer service! I highly recommend the NOVOS line. I’ve been taking them for 6 months and can see (skin) and feel (energy levels, sense well being) the difference. Also, I prefer the Orange flavored Core vs the unflavored version.
Amazing product. I have a very senstive Gut. I always bloated after eating or without eating any
meal. When if i feel bloated i drink novos core it helps me a lot !! my Gut starts to digest better!! I feel my brain functions better because no more bloating!!!
I started taking Novo’s Core in July 2022. I was 68 years old and my TruMe age was 69 years. I took the test again in September 2024 and my TruMe age had fallen to 62.2 years. I also take NMN (the ingredient in Novo’s Boost) and other supplements, but Novos is the biggest change that I’ve made in that time. On the other hand my back and my shoulders are in much worse shape than they were in 2022.
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NOVOS Core Clinical is a dietary supplement, not a medication. If you take prescription medications or manage a medical condition, consult your healthcare professional before use, especially if you are pregnant or nursing, managing blood pressure, bleeding or clotting, or any chronic condition.
NOVOS Core Clinical is the daily foundation. It’s a comprehensive longevity formulation designed to support multiple aging-related biological pathways as a complete system.
Other NOVOS products are designed as targeted add-ons — for example, additional NAD+ or mitochondrial support — and can be layered on top of NOVOS Core Clinical depending on your goals.
Timelines vary by individual.
Some people report noticing day-to-day changes first, such as steadier energy or improved sleep consistency, within the first few weeks. Broader, longer-horizon changes associated with healthy aging biology typically build gradually over weeks to months and depend on baseline health and consistent use.
NOVOS Core Clinical is intended for adults. If you’re under 18, pregnant, or breastfeeding, consult a healthcare professional before use.
NOVOS Core Clinical is designed for one sachet daily. Some individuals choose to take up to two sachets per day. If increasing your intake, consider starting with one sachet for at least a week and consult your healthcare professional if you are sensitive to supplements.
There are two practical ways many people evaluate progress:
How you feel
Some people notice day-to-day changes such as steadier energy, sleep consistency, mood improvements, or overall resilience over time.
What you can measure
NOVOS Core Clinical is designed to support underlying biological systems associated with healthy aging, effects that may not always be immediately perceptible but can be observed through objective measures. In human clinical research, NOVOS Core Clinical demonstrated statistically significant benefits across validated functional biomarkers of cardiovascular function, including endothelial responsiveness, arterial flexibility, and support for healthy blood pressure already within the normal range.*
If you already track general wellness metrics, you may choose to monitor markers such as resting heart rate, sleep patterns, blood pressure, or routine labs with your clinician.
Because these changes reflect foundational physiology, benefits are often gradual and cumulative rather than instant.
NOVOS Core Clinical replaces the need to source and dose multiple individual supplements. Instead of assembling a complex stack, you get a single, research-driven formulation developed and evaluated as a complete system. You’re investing in clinical research, quality controls, and formulation design — often at a comparable or lower total cost than buying similar ingredients separately.
NOVOS Core Clinical contains 12 research-backed longevity ingredients:
The Orange flavor also includes erythritol, malic acid, stevia, and natural flavors. Core is vegan, non-GMO, sugar-free, and free from artificial colors and preservatives.
NOVOS Core Clinical is designed for adults of all ages who want to proactively support healthy aging.
NOVOS Core Clinical is free from:
It suits vegan, vegetarian, Mediterranean, keto, gluten-free, and NOVOS Longevity Diet guidelines.
A small percentage of users experience temporary stomach discomfort when starting Core. Taking it with food, splitting the dose, or mixing it with extra water typically resolves this within a few weeks.
NOVOS recommends avoiding Core during pregnancy and breastfeeding as a precaution.
No. Store Core Clinical at room temperature in a cool, dry place.
NOVOS CEO Chris Mirabile joins Tony Robbins, Mark Cuban, and leading longevity scientists in Longevity Hackers, a groundbreaking documentary that uncovers the science and biohacking secrets adding not just years but healthy, fulfilled years to life.
*These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease. *All statements reflect support for normal, healthy biological function and are not intended to diagnose, treat, cure, or prevent disease.
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