Hyaluronic acid is a key structural molecule in the skin that supports hydration, elasticity, and firmness. About half of the body’s total hyaluronic acid is located in the skin, but levels decline significantly with age, particularly due to sun exposure, with reductions of up to 75 percent. Oral supplementation can restore hyaluronic acid levels, improving skin moisture, suppleness, appearance, and joint health. It also supplies acetyl-glucosamine, a compound shown to extend lifespan in organisms by reducing protein accumulation, a key contributor to aging. Medium molecular weight forms are preferred for absorption, while very low molecular weight forms may cause irritation.

This Article Covers:

• What is Hyaluronic Acid? 
• What Are The Benefits of Hyaluronic Acid? 
• How Should Hyaluronic Acid be Supplemented? 
• How Could Hyaluronic Acid Consumption Extend Lifespan? 
• Why is Hyaluronic Acid included in NOVOS Core?

What Are The Benefits Of Hyaluronic Acid? 

How Does Hyaluronic Acid Consumption Improve Skin Health? 

Hyaluronic Acid has been shown to improve skin health:

• Reduces Wrinkles 
• Supports Joint Function and Cartilage Health 
• Enhances Skin Hydration, Texture, and Radience   

Oral ingestion of hyaluronic acid increases skin levels (R, R, R). It reduces wrinkles, improves suppleness, enhances moisture and radiance, and also supports joint health by replenishing cartilage stores. 

How Should Hyraluroic Acid be Supplemented? 

Hyaluronic acid is commonly used in skin creams to improve skin hydration and appearance. However, most topically applied hyaluronic acid does not penetrate beyond the surface layers of the skin (R). As a result, hyaluronic acid in skin creams mainly hydrates the outermost layers by attracting and retaining water. However, newer formulations have been developed with smaller hyaluronic acid molecules that can penetrate the skin barrier (R). These low molecular weight forms are designed to cross the skin barrier more effectively. Hyaluronic acid is also used in injectable treatments to improve skin firmness and support rejuvenation.

How Could Hyaluronic Acid Consumption Extend Lifespan? 

Hyaluronic acid may support longevity through mechanisms that go beyond skin appearance, especially by influencing proteostasis and inflammation, two core processes that deteriorate with age.

Hyaluronic acid is built from repeating sugar units, including N-acetylglucosamine (GlcNAc). In model organisms, GlcNAc supplementation has been shown to slow aging and extend lifespan by improving endoplasmic-reticulum protein homeostasis and activating protein quality-control programs (eg, ER-associated degradation, proteasomal activity, and autophagy), which helps reduce the burden of misfolded /aggregating proteins, a hallmark of aging (R).

Researchers believe that acetyl-glucosamine extends lifespan by activating the unfolded protein response (UPR). This response is triggered when cells detect a buildup of damaged or misfolded proteins. Protein accumulation is a known contributor to the aging process. Acetyl-glucosamine helps reduce this buildup by triggering the cell’s internal repair mechanisms.

Beyond GlcNAc, there is also direct evidence in Caenorhabditis elegans that hyaluronan-based interventions can increase lifespan. In one study, sodium hyaluronate supplementation was reported to extend worm lifespan by ~27%, alongside improvements in antioxidant/anti-ageing readouts (R). Separately, a longevity-screening study that prioritized extracellular-matrix “matreotype” signatures identified compounds linked to more youthful matrix states, reporting lifespan extension in worms of ~35% under specific experimental conditions (R). Together, these findings support the idea that hyaluronan-related biology can influence aging trajectories in a whole organism, though effects can vary with strain, dose, and study design.

In one study, scientists made a special line of mice that were genetically programmed to produce more hyaluronan (the same substance as hyaluronic acid), using a hyaluronan-producing gene from the naked mole-rat, a species known for unusual longevity. These mice ended up with higher levels of hyaluronan in multiple tissues and, compared with normal mice, showed signs of better aging biology, including lower inflammation across the body, better gut barrier function with age, and a longer lifespan and improved healthspan (R).

The researchers also concluded that these benefits were linked to having more high-molecular-mass hyaluronan, rather than being something unique to the naked mole-rat gene itself.

How does hyaluronic acid impact aging in humans?

At a dose matching one sachet of NOVOS Core, hyaluronic acid was evaluated in a long-term randomized, double-blind clinical trial in healthy volunteers. Across the intervention, it produced statistically significant improvements in key skin-aging readouts, including higher stratum corneum hydration, brighter skin tone, increased epidermal thickness, and preservation of dermal density versus placebo, supporting a hydration and structure-oriented rationale for skin health (R).

At higher daily intakes consistent with two NOVOS Core sachets, hyaluronic acid has been tested in multiple randomized, double-blind, placebo-controlled trials (typically 6–12 weeks) in adults with dry or aging skin. Across studies, the most consistent significant signals include higher stratum corneum hydration/moisture, reduced water loss through the skin barrier, improved elasticity readouts, and better wrinkle/roughness-related measures, alongside improved self-reported skin luster/suppleness/firmness (R;R;R;R;R;R)

In parallel, in knee-focused trials (≈8 weeks to 12 months) in adults with knee osteoarthritis or knee discomfort, hyaluronic acid produced significant reductions in pain and stiffness scores and improvements in function indices, with lower use of painkillers  in some studies (R;R;R).

NOVOS CORE & Hyaluronic Acid Supplementation