At what age should one take NMN? After all, NMN levels decline during aging, but are still fairly high when people are young (like in their twenties).
First, to our knowledge, there are no studies demonstrating potential adverse effects when taking NMN starting at a young age. NMN is a molecule with a very low side effect profile.
Second, in lifespan studies done in mice (as conducted by Professor David Sinclair – results not published yet), NMN is given during the whole lifespan (so from a young age) leading to an increased lifespan.
Various other studies done in young (or at least not middle-aged or old mice) show benefits from NMN. For example, in one study NMN is given over the course of 12 months to mice, starting from the age of 5 months (which would be relatively young mice) to 17 months of age (on average, mice grow around 24 months old):
Additionally, the daily dose of NMN we recommend is more at the low side (e.g. 250 mg per day), but is still high enough to be effective. Various studies done in humans administer NMN at around 250 mg per day, see for example the following studies:
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old men
Some NMN researchers also have voiced the following thoughts:
– It could be that during aging, the amount of NMN needs to be increased according to your age, like from 250 mg per day when you are young to 500 mg per day when you are middle-aged to 500 to 1000 mg per day when you are elderly.
– It could be that ideally NMN is taken as a preventive treatment, helping the body during its lifespan to be better able to maintain NAD levels for optimal cell repair, epigenetic maintenance, etc.
For further reference, please find below a link to a non-exhaustive list of scientific studies about each of NOVOS’ longevity ingredients, including NMN: