Apple Cider Vinegar and Longevity

Apple Cider Vinegar Impacts Aging Via

• Inflammaging

Apple cider vinegar (ACV) is made from fermented apple juice, yeast and sugar. It is packed with nutrients and vitamins such as pectin, niacin, and vitamins B and C. ACV also contains small amounts of minerals like magnesium, potassium, calcium, and iron. It is a popular ingredient used in salad dressing and cooking. ACV has long been believed to confer health benefits since its popularity in the late 1950s. Today, with advances in scientific research, there is evidence that ACV possesses antioxidant properties and protects the health of our body against age-related oxidative stress and functional damage.

The role of Apple Cider Vinegar in aging and longevity

The aging process is characterized by a gradual decline of the body’s functions and an increased risk of age-related chronic diseases such as cardiovascular disease and neurodegenerative disease. Since ACV gained popularity as a health supplement, more scientific evidence has surfaced to support health claims, such as its beneficial effect against age-related oxidative stress and maintaining cholesterol and glucose levels in the blood.

Apple Cider Vinegar for weight management and metabolic health

There are many claims of presumed health benefits of ACV, one of which is weight management. One famously cited clinical trial on the effect of ACV on weight loss was conducted in 2009 on 175 participants in Japan. The researchers found a significant decrease in body weight and BMI after daily vinegar consumption for 12 weeks. (Kondo et al., 2009) More recently, in 2018, researchers conducted a clinical trial and found evidence that consuming ACV daily for 12 weeks with a balanced diet can significantly decrease cholesterol levels in the blood and reduce body weight, BMI and hip circumference. (Khezri et. al., 2018)

Aside from weight loss, the researchers discovered in this same 2018 study that there was a significant decrease in total cholesterol and fat levels in participants’ blood. These results provide evidence that ACV supports metabolic health by maintaining fat and cholesterol levels.

Apple Cider Vinegar on cardiovascular health

Cholesterol metabolism changes due to aging, causing a higher accumulation of low-density lipoproteins (LDL), commonly known as “bad” cholesterol. The increased accumulation of LDL in the body is associated with an increased risk of cardiovascular disease. Consolidated data from nine clinical trials concluded that consuming ACV daily for one to three months helps to promote cardiovascular health by decreasing cholesterol and fasting plasma glucose levels in the blood. (Hadi et al., 2021)

The risk of cardiovascular disease increases with age due to chronic inflammation (inflammaging), which is a hallmark of aging. Research across 25 different clinical trials revealed that ACV consumption for one to three months can support cardiovascular health during aging by maintaining fasting blood glucose and total cholesterol levels. (Tehrani et. al., 2023)

Apple Cider Vinegar on brain health

Alzheimer’s disease (AD) is an age-related neurodegenerative disease. Oxidative stress is one of the significant markers of AD. Researchers used cellular and animal models to discover that ACV consumption for two months can boost brain health by improving cognitive function, increasing antioxidant markers, and decreasing oxidative stress markers. In this same study, the researchers found that ACV displayed best-in-class performance against oxidative stress in brain cells when compared to compounds with similar neuroprotective properties. (Tripathi and Mitra Mazumder, 2022)

Apple Cider Vinegar on kidney health

Aging is associated with changes in kidney function and structural alterations. Oxidative stress is a key driver in these age-related alterations. Scientists have found that ACV plays a protective role to support kidney health against oxidative stress. Researchers supplemented the study subjects with ACV for seven days and found that ACV helps to promote healthy kidney aging by targeting oxidative stress systems. (Asejeje et. al., 2020)

The scientists of this study then examined blood and kidney samples from the study subjects. They measured kidney function markers from the blood samples, including urea, creatinine, sodium, and potassium ions. The analysis revealed that ACV supplementation helped to maintain normal levels of kidney function markers to support healthy kidneys.

NOVOS VITAL & Apple Cider Vinegar

References

Asejeje, F. O., Ighodaro, O. M., Asejeje, G. I., & Adeosun, A. M. (2020). Protective role of apple cider vinegar (APCV) in CCl4-induced renal damage in Wistar rats. Metabolism open, 8, 100063. https://doi.org/10.1016/j.metop.2020.100063

Hadi, A., Pourmasoumi, M., Najafgholizadeh, A., Clark, C. C. T., & Esmaillzadeh, A. (2021). The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC complementary medicine and therapies, 21(1), 179. https://doi.org/10.1186/s12906-021-03351-w

Kondo, T., Kishi, M., Fushimi, T., Ugajin, S., & Kaga, T. (2009). Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Bioscience, biotechnology, and biochemistry, 73(8), 1837–1843. https://doi.org/10.1271/bbb.90231

Khezri, S., Saidpour, A., Hosseinzadeh, N., & Amiri, Z. (2018). Beneficial effects of Apple Cider Vinegar on weight management, Visceral Adiposity Index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial. Journal of Functional Foods, 43, 95–102. https://doi.org/10.1016/j.jff.2018.02.003

Tehrani, S. D., Keshani, M., Rouhani, M. H., Moallem, S. A., Bagherniya, M., & Sahebkar, A. (2023). The effects of apple cider vinegar on cardiometabolic risk factors: A systematic review and meta-analysis of clinical trials. Current medicinal chemistry, 10.2174/0929867331666230822102021. Advance online publication. https://doi.org/10.2174/0929867331666230822102021

Tripathi, S., & Mitra Mazumder, P. (2022). Comprehensive investigations for a potential natural prophylaxis-A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress. Drug development research, 83(1), 105–118. https://doi.org/10.1002/ddr.21849