Fisetin Benefits and Its Impact on Longevity

Curious about the benefits of fisetin? Fisetin is a natural compound found in fruits like strawberries and apples. It has gained attention for its ability to eliminate senescent “zombie” cells, protect the brain, and extend lifespan in animal models. As one of the most powerful natural senotherapeutics, fisetin helps regulate inflammation, improve memory, and support skin health — making it a key ingredient in NOVOS Core’s longevity formulation.

Fisetin Anti-Aging Impacts Aging Via

• Cellular senescence
• Altered intercellular communication
• Loss of proteostasis
• Regulating cellular metabolism through the activation of AMPK and inhibition of mTOR pathways
• Modulating gene expression related to cell cycle control and apoptosis

What is Fisetin?

This powerful plant compound goes beyond its antioxidant benefits—fisetin also offers notable anti-inflammatory effects. Found in fruits and vegetables like strawberries, apples, and cucumbers, fisetin is key player in maintaining optimal health. Backed by scientific research, its benefits are more than promising: supporting brain function, enhancing overall wellness, and strengthening your defenses against disease.

Exploring the connection between fisetin and our golden years.

Fisetin isn’t a new discovery—it’s been in the fruits and vegetables we eat every day, like strawberries, apples, grapes, onions, and cucumbers. As researchers continue to uncover the complex relationship between antioxidants and free radicals, fisetin has proven to be a key component in supporting cellular health.

Fisetin is a flavonoid. Flavonoids are substances that give fruits and vegetables their bright colors (like yellow, orange and blue) and play a major role in conferring the health benefits that we get from eating more vegetables and fruits. The importance of fisetin supplements lies in their dosage and bioavailability, as fisetin alone has poor absorption but can be enhanced when combined with fats.

Fisetin eliminates senescent cells

Fisetin is probably most known for its impact on senescent cells : studies showed that this substance can reduce the accumulation of senescent cells (). Picture fisetin working like a cellular maintenance team, clearing away aging cells that compromise your overall health.Senescent cells accumulate everywhere in the body during aging.

Senescent cells were previously normal cells that became too damaged. Normally, when a cell is too damaged, it kills itself, but senescent cells don’t do that.

Instead of dying, they keep lingering around in the body; a zombie cell, so to speak.

Senescent cells secrete all kinds of substances that damage the healthy surrounding cells, like inflammatory substances (cytokines and chemokines), substances that break down the glue that holds the cells together (matrix metalloproteinases), and growth factors that accelerate aging. By cutting off inflammation’s fuel supply, Fisetin slows the injury response and gives the body a break from perpetual repair mode.

Senescent cells contribute to the aging process by damaging healthy cells. In addition, they disrupt the function of stem cells, which are essential for creating new cells to repair and maintain organs and tissues.

Reducing the senescent cell burden can lead to reduced inflammaging (low-grade inflammation that increases during aging) and enhanced function of stem cells .

Substances that can eliminate senescent cells are called “senolytics”. Fisetin has been extensively studied and proven to be a powerful senolytic. Research shows that cancer cells struggle to survive in the presence of fisetin, indicating its potential in slowing the progression of cancer. 

Fisetin versus quercetin

Alongside fisetin, quercetin is another well-known senolytic. While these two compounds share similar structures, fisetin appears to be the most potent and safest among natural senolytics. (R):

Fisetin is far better at destroying senescent cells (red bar) than other substances, such as quercetin curcumin or EGCG.

The conclusion of the researchers was the following:

“Fisetin had the most potent senotherapeutic effects in several cell types in vitro and showed strong anti-geronic effects in vivo”.

Lifespan extension benefits of fisetin

Scientists demonstrated that fisetin can extend median and maximum lifespan in mice, even when taken late in a mouse’s life (equivalent to 50 or 60 years old for a human) (R): Fisetin helps improve blood vessel function by promoting their expansion, allowing increased blood flow—benefiting both heart health and overall well-being.

Fisetin extends lifespan (red graph) versus control group (black graph) in mice. Source image: Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018

Another study showed that fisetin reduced the impact of aging in a mouse model of accelerated aging. 

Old mice receiving fisetin were better in navigating a maze and in recognizing objects, which translates into improved cognition and memory:

More than a senolytic: other anti-aging and fisetin skin benefits

Fisetin has many other beneficial effects on the aging process besides eliminating senescent cells .

For example, fisetin inhibits the mTOR pathway (R), which plays an important role in aging and is where many of the health benefits behind fasting are derived. Fisetin can also reduce oxidative stress (R).

Fisetin can reduce inflammaging (aging-related low-grade inflammation) by inhibiting pro-inflammatory enzymes and substances, like lipoxygenases and NF-kB (R,R). With Fisetin working to restrain the NF-κB pathway, the inflammation that follows gets put on a shorter leash.

Fisetin offers more than just internal benefits—it also provides notable skin advantages. Studies show that fisetin can help reduce wrinkle formation and minimize visible signs of skin aging .

Fisetin has many other beneficial effects on the aging process besides eliminating senescent cells.

One way it can achieve this is by reducing the amount of matrix metalloproteinases (MMPs) (R,R). At the cellular level, you’ll find MMPs – proteins that serve as biological recyclers, breaking down the fiber-like networks that envelop our cells. The extracellular matrix consists of collagen, elastin, hyaluronic acid, glycosaminoglycans (GAGs), and many other molecules that glue the cells together to firm tissues (like the skin) and organs. An overactivity or overproduction of matrix metalloproteinases plays a role in wrinkle formation.

Fisetin supports various aspects of brain function, from focus to memory, helping to slow the aging process and keep your mind sharp (R). For example, fisetin can improve memory formation in mice(R,R).

NOVOS Core contains 100 mg of fisetin per sachet.

The Dynamic Duo of Brain Protection and Cognitive Ability

As we age, cognitive decline is a natural part of the process, but research suggests fisetin could serve as a protective neurological shield, potentially reducing the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s.

In animal models, fisetin has already demonstrated impressive benefits for memory and cognitive function — raising the question, could it have similar effects in humans, helping to maintain sharper focus and mental clarity? With its anti-inflammatory properties, fisetin protects brain cells from inflammation-related damage, promoting brain health. Additionally, its antioxidant capabilities defend against free radicals, helping to prevent cognitive decline.

Kim et al. In a crucial experiment, investigators stimulated mouse macrophages with LPS and observed the remarkable outcome: fisetin halted the escalation of NF-κB and JNK MAPKs, all while allowing ERK signaling to proceed without hindrance.

NOVOS CORE & Fisetin