The minimum recommended dose of NMN is 2 capsules (2 × 125 mg of NMN) per day, 1 to 2 times daily. We advise to take between 250 mg and 500 per day on a regular basis.
Regarding NMN dosing, some people refer to Harvard Professor David Sinclair who takes a very high dose of 1,000 mg per day, and believe one also needs to take such a high dose.
1,000 mg per day of NMN is a very high dose, and is the maximum dose we would recommend. Lower doses, like 250 mg per day, are adequate for health benefits.
A study at Washington University found that 250 mg of NMN per day improved insulin sensitivity in elderly prediabetic women after ten weeks (R).
A study in Japan tested the safety of NMN up to 500 mg. The results of this study demonstrated that NMN up to 500 mg is safe and well-tolerated (R).
Studies in animals hint that too much NMN can also have side effects. In humans, probably taking more than 1000 mg per day could lead to an increased risk of side-effects, such as too much reductive stress.
We explain more about NMN dosing in our article about Professor David Sinclair’s supplement regimen: