Younger for Longer

01/10 Mitochondrial Dysfunction

During aging, mitochondria – the power plants of our cells – become dysfunctional.

02/10 Cellular Senescence

Senescent cells are former healthy cells that stopped dividing and secrete substances that damage healthy surrounding cells.

03/10 Loss of Proteostasis

Over time, more and more proteins accumulate inside and outside our cells, interfering with their proper functioning.

04/10 Altered Cellular Communication

When we get older, our cells become increasingly exposed to a hostile environment, characterized by inflammation, senescent cells, dysfunctional stem cells, and deleterious substances.

05/10 Genomic Instability

During aging, our DNA becomes damaged, and telomeres become shorter and dysfunctional, especially in stem cells and fast-dividing cells.

06/10 Epigenetic Alterations

During aging, the epigenome – the molecular machinery that regulates our genes’ activity – becomes disorganized.

07/10 Telomere Shortening

As we age, the ends of DNA, known as telomeres, get shorter and cannot protect DNA any longer.

08/10 Deregulated Nutrient Sensing

During aging, our cells become less tuned to nutrient signals, which disrupts a cell’s ability to produce energy.

09/10 Stem Cell Exhaustion

With age, stem cells become dysfunctional or die off, leading to our tissues being less replenished & maintained.

10/10 Crosslinking

As we grow older, sugar-derived bonds, or crosslinks, are formed between the proteins that make up our tissues, making tissues more stiff.